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Coarse-grained modelling of DNA and DNA self-assembly

Thomas E. Ouldridge ([Springer, ], 2012)

 Abstrak

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker. The first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

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 Metadata

No. Panggil : e20425067
Entri utama-Nama orang :
Subjek :
Penerbitan : Berlin : [Springer, ], 2012
Sumber Pengatalogan: LibUI eng rda
Tipe Konten: text
Tipe Media: unmediated
Tipe Pembawa: online resource
Deskripsi Fisik:
Tautan: http://link.springer.com/book/10.1007%2F978-3-642-30517-7
Lembaga Pemilik:
Lokasi:
  • Ketersediaan
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e20425067 TERSEDIA
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