Formation and cooperative behaviour of protein complexes on the cell membrane
by Ksenia Guseva (Springer, 2012)
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| With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process. |
 Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane.pdf :: Unduh |
| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| e20425134 | 20-23-83555806 | TERSEDIA |
| Ulasan: |
| Tidak ada ulasan pada koleksi ini: 20425134 |
