Cytotoxic and anti-Inflammatory activities of garcinia xanthochymus extracts on cell lines
Hanisuhana Hamidon;
Muhammad Taher; Juliana Md Jaffri; Tg Muhamad Faris Syafiq tg Zakaria; Wan MAW Sulaiman; Deny Susanti; Solachuddin JA Ichwan
([Faculty of Pharmacy International Islamic University Malaysia;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy, International Islamic University Malaysia. Faculty of Pharmacy], 2016)
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| Objective: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti- inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.; |
| No. Panggil : | J-Pdf |
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| Penerbitan : | [Place of publication not identified]: [Faculty of Pharmacy International Islamic University Malaysia;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy;International Islamic University Malaysia. Faculty of Pharmacy, International Islamic University Malaysia. Faculty of Pharmacy], 2016 |
| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| J-Pdf | 03-20-335614602 | TERSEDIA |
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| Tidak ada ulasan pada koleksi ini: 20426819 |
