ABSTRAK
Latar belakang : Reaksi simpang yang terjadi akibat penggunaan OAEberpengaruh terhadap kualitas hidup pasien epilepsi. Angka kejadian reaksisimpang akibat penggunaan OAE dilaporkan mencapai 80%. Sampai saat inibelum didapatkan studi atau instrumen yang valid dalam menilai reaksi simpangpada penggunaan OAE di Indonesia. Tujuan dari studi ini adalah melakukanvalidasi terhadap kuesioner Liverpool Adverse Events Profile (LAEP) versibahasa Indonesia dan mendapatkan prevalensi reaksi simpang serta faktor yangberpengaruh.Metode penelitian : Dilakukan studi observasional potong lintang pada pasienepilepsi dengan dosis OAE yang stabil di poliklinik epilepsi rumah sakit CiptoMangunkusumo. Kuesioner diterjemahkan dari versi bahasa Inggris ke bahasaIndonesia dan dilakukan penerjemahan kembali ke bahasa aslinya untuk menilaiketepatan dari bahasa. Validitas dan reliabilitas diuji dengan menggunakankoefisien korelasi Spearman dan cronbach?s alpha. Faktor yang dianalisis adalahdurasi epilepsi, onset epilepsi, frekuensi bangkitan, tipe epilepsi, etiologi epilepsi,sindrom epilepsi, jumlah OAE, durasi OAE dan komorbiditas.Hasil : Didapatkan 19 variabel pertanyaan yang valid dengan rentang koefisienkorelasi 0,465 sampai 0,690. Cronbach?s alpha 0,846. Prevalensi reaksi simpangpada pasien epilepsi yaitu 91%. Reaksi simpang yang sering terjadi adalahkelelahan (67,8%), mengantuk (66,7%), gangguan daya ingat (62,2%) dankesulitan berkonsentrasi (56,7%). Variabel klinis yang berpengaruh terhadapkejadian reaksi simpang yaitu politerapi (p=0.022).Kesimpulan : Kuesioner Liverpool Adverse Events Profile versi bahasa Indonesiamerupakan instrumen yang valid dan reliabel dalam menilai reaksi simpang padapenggunaan OAE pada pasien epilepsi. Politerapi merupakan faktor yangberpengaruh terhadap kejadian reaksi simpang.
ABSTRACT
Background : Adverse effects (AE) of antiepileptic drugs (AEDs) affect thequality of life of patients with epilepsy. The prevalence of AE of AEDs in patientswith epilepsy is up to 80%. There are no studies nor validated instruments inmeasuring AE of AEDs in patients with epilepsy in Indonesia. This study aimedto validate the Indonesian version of The Liverpool Adverse Events Profile(LAEP) also to determine the prevalence of AE of AEDs in patients with epilepsyand related factors.Methods : An observational cross-sectional study was carried out on epilepsyoutpatients clinic in Cipto Mangunkusumo Hospital. Patient treated with a stabledose of AED were enrolled. The questionnaire was translated from the Englishversion into Indonesian version and then was back-translated to examine itsaccuracy. The validity and reliability was tested by Spearman correlationcoefficient and cronbach?s alpha. The Indonesian version of LAEP was selfadministeredby the patient. The analyzed factors consisted of epilepsy duration,onset of epilepsy, seizure frequency, type of epilepsy, etiology and epilepsysyndrome, number of AEDs, AEDs duration and comorbidity.Results : All of the 19 variable of questions were valid, with range of correlationcoefficient from 0.465 to 0.690. The cronbach?s alpha was 0.846. Ninety patientswere enrolled. The prevalence of AE of AEDs in patients with epilepsy was 91%.The most common AE were tiredness (67.8%), sleepiness (66.7%), memoryproblems (62.2%) and difficulty in concentrating (56.7%). Clinical variables thatinfluenced the AE was polytherapy.Conclusion : The Indonesian version of the Liverpool Adverse Events Profile is avalid and reliable instrument in assessing AE of AEDs in patients with epilepsy.Almost all of the patients in this study experienced an AE. Polytherapy was therelated factors of AE of AEDs. |
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