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Perbedaan ekspresi 5?-reduktase tipe 1 pada adenokarsinoma prostat tipe asinar dan hiperplasia prostat = Differential expression of 5 reductase type 1 in adenocarcinoma acinar of the prostat and benign prostatic hyperplasia

Gultom, Fajar Lamhot; ([Publisher not identified] , 2016)

 Abstrak

ABSTRAK
Latar belakang: Hiperplasia prostat dan adenokarsinoma prostat keduanya
sangat dipengaruhi oleh hormon androgen terutama dihidrotestosteron
(DHT) berasal dari konversi testosteron (T) dikatalisator oleh enzim 5α-
reduktase (5αR). Terapi hormonal merupakan salah satu modalitas terapi
kedua penyakit ini dengan menghambat enzim 5αR tipe1dan tipe 2. Tujuan
penelitian ini untuk mengetahui perbedaan ekspresi 5αR1 antara
adenokarsinoma prostat tipe asinar dan hiperplasia prostat, serta melihat
ekspresi 5αR1 berdasarkan skor Gleason.
Metode: Penelitian menggunakan metode potong lintang. Sampel terdiri
atas 20 kasus adenokarsinoma prostat tipe asinar dan 20 kasus hiperplasia
prostat. Dilakukan pulasan 5αR1 dan penilaian pulasan dengan
menggunakan histoscore.
Hasil: Mean area sel tumor sebanyak 11,63% dan sel epitel di hiperplasia
prostat 26,54%. Terdapat perbedaan kadar PSA antara adenokarsinoma
prostat dengan hiperplasia prostat (p=0,00). Ekspresi 5αR1 di sitoplasma
dan inti didapatkan perbedaan antara adenokarsinoma prostat dengan
hiperplasia prostat (p=0,00). Ekspresi 5αR1 lemah terbanyak didapatkan
pada adenokarsinoma prostat.
Kesimpulan: Ekspresi dan total area pulasan intensitas 5αR1 pada
hiperplasia prostat lebih tinggi. Peningkatan skor Gleason cenderung diikuti
penurunan ekspresi 5αR1.
ABSTRACT
Background: Acinar adenocarcinoma and BPH both are strongly
influenced by androgen hormone especially dihydrotestosterone (DHT)
from convertion of testosterone (T) catalize by 5α-reductase (5αR) enzyme.
Hormonal therapy is one of treatment modality for these condition by
inhibiting 5αR type 1 and type 2 enzyme. The aim of this study is to know
differential expression of 5αR1 between acinar adenocarcinoma and BPH
and also expression 5αR1 based on Gleason score.
Method: This was cross-sectional study on 20 cases acinar adenocarcinoma
and 20 cases BPH stained with 5αR1 antibody. The appraisal was done with
estimating histoscore.
Result: Mean area of tumor cells is 11,63% and epithelial cells in BPH
26,54%. There was statistically significant levels of PSA between acinar
adenocarcinoma and BPH (p=0,00). Cytoplasmic and nuclear expression of
5αR1 were statistically significant different between acinar adenocarcinoma
and BPH (p=0,00). Low intensity expression of 5αR1 in acinar
adenocarcinoma was the most commonly found.
Conclusion: Total area of expression 5αR1 in BPH are higher. hiperplasia
prostat lebih tinggi. The higher Gleason score tends followed by declining
expression of 5αR1.;

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No. Panggil : SP-pdf
Entri utama-Nama orang :
Entri tambahan-Nama badan :
Subjek :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2016
Program Studi :
Bahasa : ind
Sumber Pengatalogan :
Tipe Konten : text
Tipe Media : computer
Tipe Carrier : online resources
Deskripsi Fisik : xii, 43 pages : illustration ; 28 cm + appendix
Naskah Ringkas :
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
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