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Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 206-209Reducing pain is the first phase of treatment in dentistry. Pain can be reduced by application of peroral analgetic medicines such as paracetamol, although on certain circumstances such as pulpitis pain, this is less helpful. Eugenol is often used to alleviate acute pulpitis pain by dentists, while latex of Jatropha curcas is one of the most popular analgetic agent used by people. The objective of this study was to compare the analgetic effect of the latex of J. curcas with paracetamol by the hot plate test. Thirty male mices aged 2-3 months old, weight 20-30 grams were devided into 5 group. The lyophilized latex of J. curcas was diluted into 5, l0, and 15 % respectively, and the dose was 5 mg/Kg BW. The dose of paracetamol (positive control) was 1,3 mg/Kg BW and sterile aquabidest (negative control) was I,3 mg/Kg BW. All agents were administered orally. Analgetic activity was evaluated after 3, 6, and 24 hours. The test was considered positive if the latent time of the test group was equal or 3 times higher than the control group. Data was analized by 1 way Anova. Had it been a difference, research wool be continued using HSD test (p<0,05).172. Latex of J. curcas has the same analgetic effect as paracetamol on 3 and 6 hours observation, but was reduced on 24 hours observation. |
