Mitochondrially-encoded adenosine triphosphate synthase 6 gene haplotype variation among world population during 2003-2013 / Steven, Yoni F Syukriani, Julius B Dewanto
Steven;
Yoni F Syukriani
Julius B Dewanto
(Universitas Padjadjaran. Faculty of Medicine ; Universitas Padjadjaran. Department of Forensic and Legal Medicine ; Universitas Padjadjaran. Department of Biochemistry, 2016)
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Background: Adaptation and natural selection serve as an important part of evolution. Adaptation in molecular levelcan lead to genetic drift which causes mutation of genetic material; one of which is polymorphism of mitochondrialDNA (mtDNA). The aim of this study is to verify the polymorphism of mitochondrially-encoded AdenosineTriphosphate synthase6gene (MT-ATP6) as one of mtDNA building blocks among tropic, sub-tropic, and polar areas.Methods: This descriptive quantitative research used 3,210 mtDNA sequences, taken from GenBank, as secondary datafrom 27 different populations. The data were grouped into 3 population groups based on the climates of their location.After grouping, the sequences were then aligned and trimmed using Unipro EUGENE, and analyzed by Arlequin andMitoTool. Results: Results demonstrated 21 haplotypes distributed among 3 populations with variations between eachclimate population. In the tropic and sub-tropic populations, the dominant haplotype is h1 while h6 is dominant in thepolar population. Conclusions: There is a variation of haplotype polymorphism between tropic, sub-tropic, and polarclimate population. |
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Penerbitan : | [Place of publication not identified]: Universitas Padjadjaran. Faculty of Medicine ; Universitas Padjadjaran. Department of Forensic and Legal Medicine ; Universitas Padjadjaran. Department of Biochemistry, 2016 |
Sumber Pengatalogan : | LibUI eng rda |
ISSN : | 23563656 |
Majalah/Jurnal : | Makara Journal of Health Research |
Volume : | Vol. 20, No. 2, Agustus 2016: Hal. : 41-47 |
Tipe Konten : | text |
Tipe Media : | computer |
Tipe Carrier : | online resource |
Akses Elektronik : | http://journal.ui.ac.id/index.php/health/article/view/5526 |
Institusi Pemilik : | Universitas Indonesia |
Lokasi : | Perpustakaan UI, Lantai 4, R. Koleksi Jurnal |
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Tidak ada ulasan pada koleksi ini: 20442260 |