Cytotoxic and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines / Hanisuhana Hamidon, Muhammad Taher, Juliana Md Jaffri, Tg Muhamad Faris Syafiq Tg Zakaria, Wan MAW Sulaiman, Deny Susanti, Solachuddin JA Ichwan, Zainul A Zakaria
Hanisuhana Hamidon
(International Islamic University Malaysia. Faculty of Pharmacy ; International Islamic University Malaysia. Faculty of Science ; International Islamic University Malaysia. Faculty of Dentistry ; Universiti Putra Malaysia. Faculty of Medicine and Health Sciences, 2016)
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| Objective: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This studywas conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines.Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethaneand methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma usingMTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxideproduction in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and antiinflammatorystudy showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxicactivity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem barkdichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner.Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment ofcancer and inflammation. |
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| Penerbitan : | [Place of publication not identified]: International Islamic University Malaysia. Faculty of Pharmacy ; International Islamic University Malaysia. Faculty of Science ; International Islamic University Malaysia. Faculty of Dentistry ; Universiti Putra Malaysia. Faculty of Medicine and Health Sciences, 2016 |
| Sumber Pengatalogan : | LibUI eng rda |
| ISSN : | 23563656 |
| Majalah/Jurnal : | Makara Journal of Health Research |
| Volume : | Vol. 20, No. 1, April 2016: Hal. : 11-17 |
| Tipe Konten : | text |
| Tipe Media : | computer |
| Tipe Carrier : | online resource |
| Akses Elektronik : | http://journal.ui.ac.id/index.php/health/article/view/5599 |
| Institusi Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 4, R. Koleksi Jurnal |
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| Tidak ada ulasan pada koleksi ini: 20442268 |
