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Objective: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells.Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibitapoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyze thecorrelation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by GleasonScore. This was a cross-sectional, retrospective analytical study on 31 formalin-fixed, paraffin-embedded tissue thatmeets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3.Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data fromthe cases’s reports. The correlation of their expression with respect to Gleason score was analyzed with Pearson’scorrelation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression(r = 0.379; p = 0.018). However, their correlation was stronger in intermediate-grade group (r = 0.73; p = 0.01) and thecorrelation was much weaker in high-grade group (r = 0.04; p = 0.48). Conclusions: There was a positive correlationbetween ZIP1 and Caspase-3 expression in prostate adenocarcinoma. |
