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The purpose of this research was to develop anti-cytokine-based treatment using extract of Plectranthus amboinicusapplied to gout arthritis (GA) patients. The research was quasi experimental, with a pretest-posttest randomized controlgroup design. The samples were GA patients in the Outpatient Installation of Internal Medicine in General HospitalHaji, Surabaya. The sample was comprised of 30 respondents. The respondents were divided into a treatment group anda control group. The treatment group was asked to take medicine from the hospital, coupled with P. amboinicus extractcapsules, for 7 days, during which time patients’ joint inflammation was observed. The control group was provided withonly medication from the hospital, and their joint inflammation was likewise observed. Blood samples were takenbefore and after treatment, to measure the levels of blood urea nitrogen (BUN) and creatinine, as well as theconcentrations of TNF-α and IL-1β. There was a decrease in BUN and creatinine levels in the control group, but it wasnot significant, decreasing by 3% and 8%, respectively. The treatment group also showed elevated levels of BUN andcreatinine, which also was not significant at 3% and 7%, respectively. There was a decrease in the concentration ofTNF-α in the control group by 9% and 22%. The concentration of IL-1β in the control group increased by 18%,whereas,in the treatment group, it decreased by 3%; however, the decreases in both groups were not significant.Pengaruh Ekstrak Daun Jintan (Plectranthus amboinicus) terhadap Kadar BUN dan Kreatinin serta ResponSeluler Faktor Proinflamasi TNF-α dan IL-1β Pasien Gout Artritis. Pengobatan gout artritis (GA) saat inidikembangkan berbasis anti sitokin yaitu blokade kemokin, penghambatan pelepasan IL-1β dan TNF-α. Tujuanpenelitian ini adalah mengembangkan pengobatan berbasis anti sitokin dengan menggunakan ekstrak daun jintan yangdiaplikasikan pada penderita GA. Penelitian ini adalah penelitian eksperimental semu dengan desain penelitianrandomized pretest-posttest control group design. Pengambilan sampel pasien GA di Instalasi Rawat Jalan PoliPenyakit Dalam RSU Haji Surabaya yang memenuhi kriteria inklusi dan eksklusi. Jumlah sampel sebanyak 30responden terbagi menjadi kelompok perlakuan dan kelompok kontrol masing-masing 15 responden. Pada kelompokperlakuan diminta untuk minum obat dari Rumah Sakit ditambah dengan kapsul ekstrak daun jintan selama 7 hari,dengan dilakukan pengamatan keradangan sendi. Pada kelompok kontrol minum obat dari Rumah Sakit dan dilakukanpengamatan keradangan sendi. Sampel darah diambil sebelum dan sesudah perlakuan untuk mengukur kadar BUN,kreatinin, konsentrasi TNF-α dan IL-1β. Terdapat penurunan kadar BUN dan kreatinin pada kelompok kontrol namuntidak signifikan yaitu menurun sebesar 3% dan 8%. Sementara pada kelompok perlakuan terdapat peningkatan kadarBUN dan Kreatinin namun juga tidak signifikan sebesar 3% dan 7%. Terdapat penurunan konsentrasi TNF-α padakelompok kontrol sebesar 9% dan kelompok perlakuan sebesar 22%, keduanya tidak signifikan. Sementara konsentrasiIL-1β terjadi peningkatan pada kelompok kontrol sebesar 18%, sementara pada kelompok perlakuan terjadi penurunansebesar 3%, keduanya tidak signifikan. |
