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Two flavonoid compounds, 5,7,3?,4?-tetrahydroxy-6-geranylflavonol (1) and kaempferol 7-O-β-glucose (2) have beenisolated from the leaves of Macaranga hispida (Blume), Mull.Arg. Isolation and purification were conducted bychromatography methods and chemical structure characterization was carried out by spectroscopic methods. The5,7,3?,4?-tetrahydrxyi-6-geranyl flavonol (1) and kaempferol 7-O-glucose (2) had moderate cytotoxic activity againstmurine leukemia P-388 cell lines with IC50 value of 0.22 and 101.5 μg/mL, respectively. The IC50 for antioxidantactivities of (1) and (2) were 2.83 and 13.95 μg/mL, respectively. The LC50 of (1) and (2) from BSLT were 350 and>1000 μg/mL, respectively.Identifikasi dan Studi Bioaktifitas Senyawa Flavonoid dari Macaranga hispida (Blume) Mull.Arg. Dua senyawaflavonoid, 5,7,3?,4?-tetrahidroksi-6-geranilflavonol (1) dan kaemferol 7-O-β-glukosa (2) telah diisolasi dari daunMacaranga hispida (Blume) Mull. Arg. Isolasi dan pemurnian dilakukan dengan metode kromatografi dan karakterisasistruktur kimia dilakukan dengan metode spektroskopi. 5,7,3', 4'-tetrahidroksi-6-geranil flavonol (1) kaemferol 7-Oglukosa(2) memiliki aktivitas sitotoksik sel murine leukemia P-388 dengan nilai IC50 masing-masing 0,22 dan 101,5μg/mL. Aktivitas antioksidan (1) dan (2) dinyatakan dengan nilai IC50 masing-masing sebesar 2,83 dan 13,95 μg/mL.Nilai LC50 dengan uji BSLT (1) dan (2) masing-masing 350 dan >1000 μg/mL. |
