Full Description
| Cataloguing Source | LibUI ind rda |
| Content Type | text (rdacontent) |
| Media Type | computer (rdamedia) |
| Carrier Type | online resource (rdacarrier) |
| Physical Description | xv, 161 pages : illustration ; appendix |
| Concise Text | |
| Holding Institution | Universitas Indonesia |
| Location | Perpustakaan UI |
- Availability
- Digital Files: 1
- Review
- Cover
- Abstract
| Call Number | Barcode Number | Availability |
|---|---|---|
| S-Pdf | 14-21-645288195 | TERSEDIA |
| No review available for this collection: 20466135 |
Abstract
Latar Belakang: Gen Interleukin-1 Receptor Antagonist IL-1RN merupakan gen yang mengkodekan protein IL-1RN dan polimorfisme VNTR 86bp gen tersebut telah dihubungkan dengan terjadinya berbagai kanker, termasuk kanker kepala dan leher KKL. Penelitian ini bertujuan untuk mendeskripsikan polimorfisme gen IL-1RN pada penderita KKL di Indonesia.
Metode: Analisis Polymerase Chain Reaction PCR digunakan pada sampel DNA tersimpan dari 50 subyek kontrol dan 50 subyek penderita KKL untuk melihat polimorfisme gen IL-1RN VNTR.
Hasil: Persentase genotip pembawa alel A2 alel mutan adalah 18 pada sampel kontrol dan 32 pada sampel penderita KKL. Nilai p>0,05 untuk distribusi genotip dan alel pada sampel kontrol dan penderita KKL.
Kesimpulan: Ditemukan polimorfisme gen IL-1RN VNTR pada penderita KKL dan tidak terdapat perbedaan bermakna pada distribusi polimorfisme gen IL-1RN VNTR antara penderita KKL dan individu sehat di Indonesia.
Background: Interleukin 1 Receptor Antagonist IL-1RN gene encodes IL-1RN protein and its 86bp variable number of tandem repeat VNTR polymorphism within intron 2 has been associated with the development of several cancers, including head and neck cancer HNC. This study aimed to describe the IL-1RN polymorphism of HNC patients in Indonesia. Methods: The polymerase chain reaction PCR analysis was conducted on stored blood derived DNA samples from 50 control subjects and 50 HNC subjects for IL-1RN VNTR polymorphism. Results: The percentage of A2 carrier genotype is 18 in control samples and 32 in HNC samples. The p value is 0,05 in the frequencies of genotypes or alleles in both control and cancer groups. Conclusion: There is IL-1RN VNTR gene polymorphism in HNC patients and there is no significant association of IL 1RN VNTR polymorphism between HNC patients and healthy individuals in the studied Indonesian population.
Background: Interleukin 1 Receptor Antagonist IL-1RN gene encodes IL-1RN protein and its 86bp variable number of tandem repeat VNTR polymorphism within intron 2 has been associated with the development of several cancers, including head and neck cancer HNC. This study aimed to describe the IL-1RN polymorphism of HNC patients in Indonesia. Methods: The polymerase chain reaction PCR analysis was conducted on stored blood derived DNA samples from 50 control subjects and 50 HNC subjects for IL-1RN VNTR polymorphism. Results: The percentage of A2 carrier genotype is 18 in control samples and 32 in HNC samples. The p value is 0,05 in the frequencies of genotypes or alleles in both control and cancer groups. Conclusion: There is IL-1RN VNTR gene polymorphism in HNC patients and there is no significant association of IL 1RN VNTR polymorphism between HNC patients and healthy individuals in the studied Indonesian population.