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Sintesis senyawa turunan pirimidin dengan nanokatalis CuFe2O4 = Synthesis of pyrimidine derivatives compound with CuFe2O4 nanocatalyst

Suci Permata Sari; Antonius Herry Cahyana, supervisor; Emil Budianto, examiner; Rika Tri Yunarti, examiner; Widajanti Wibowo; Munawar Khalil, examiner ([Publisher not identified] , 2018)

 Abstrak

ABSTRAK
Senyawa turunan pirimidin telah berhasil disintesis dengan mereaksikan benzaldehida,
etil asetoasetat, dan urea melalui reaksi kondensasi Biginelli. Produk yang terbentuk
dikarakterisasi menggunakan alat FTIR, UV-Vis, dan GC-MS. Pada sintesis senyawa
ini digunakan nanokatalis CuFe2O4 yang berhasil disintesis dengan metode kopresipitasi
dan dikonfirmasi dengan FTIR, XRD, TEM dan PSA. Berdasarkan optimasi (senyawa
1) dengan nama IUPAC 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin2(1-)one
diperoleh kondisi optimum dengan waktu 4 jam reaksi, suhu 70°C, dan 7,5%
berat katalis dengan yield sebesar 71,57%, untuk (senyawa 2) 5-(ethoxy carbonyl)-4-
(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione diperoleh kondisi optimum selama
waktu 4 jam reaksi, suhu 50°C, dan 7,5% berat katalis dihasilkan yield sebesar 76,84%
sedangkan untuk (senyawa 3) pada waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat
katalis dengan yield sebesar 73,69% belum berhasil membentuk senyawa
5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine dari reaktan
benzaldehida, etil asetoasetat dan guanidin.

ABSTRACT
Pyrimidine derivatives have been synthesized by reacting benzaldehyde, ethyl
acetoacetate, urea through Biginelli condensation reaction using CuFe2O4 nanocatalyst .
Characterization of the three of product were performed by using FTIR, UV-Vis and
GC-MS. In the synthesis of these compounds using CuFe2O4 nanocatalyst were
successfully synthesized by coprecipitation method and characterized by FTIR, XRD,
PSA, TEM. Optimum conditions for producing (compound 1) 5-(ethoxy carbonyl)-4-
(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)one were 4 hours reaction, temperature
70° C and 7.5% weight catalyst with yield 71.57% , (compound 2) 5-(ethoxy carbonyl)-
4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione was at 4 hours reaction, 50° C
and 7.5% weight catalyst with yield 76.84% and compound 3 were 4 hours reaction,
temperature 70° C and 7.5% weight catalyst with yield 73.69% has not succeeded in
forming a 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine.

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 Metadata

No. Panggil : T49427
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Entri tambahan-Nama badan :
Subjek :
Penerbitan : [Place of publication not identified]: [Publisher not identified], 2018
Program Studi :
Bahasa : ind
Sumber Pengatalogan : LibUI ind rda
Tipe Konten : text
Tipe Media : unmediated ; computer
Tipe Carrier : volume ; online resource
Deskripsi Fisik : xiv, 45 pages : illustration ; 30 cm + appendix
Naskah Ringkas :
Lembaga Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 3
  • Ketersediaan
  • Ulasan
No. Panggil No. Barkod Ketersediaan
T49427 15-18-266097170 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 20467566