Full Description
| Cataloguing Source : | LibUI eng rda |
| ISSN : | 09411291 |
| Magazine/Journal : | Surgery Today Official Journal of the Japan Surgical Society |
| Volume : | Vol.45 No.10, Maret 2017: hal.1283-1286 |
| Content Type : | text (rdacontent) |
| Media Type : | unmediated (rdamedia) |
| Carrier Type : | volume (rdacarrier) |
| Electronic Access : | |
| Holding Company : | Universitas Indonesia |
| Location : | Perpustakaan UI, Lantai 4, R. Koleksi Jurnal |
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- Digital Files: 0
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- Abstract
| Call Number | Barcode Number | Availability |
|---|---|---|
| AJ-Pdf | 03-18-705409030 | TERSEDIA |
| No review available for this collection: 20472175 |
Abstract
PURPOSE: A proposed etiopathogenesis of biliary atresia (BA) involves T-cell-mediated inflammatory bile duct damage and progressive hepatic fibrosis. Pediatric surgeons often observe swelling of the hepatic hilar lymph nodes during the Kasai procedure. Given the importance of regulatory mechanisms in immune responses, the present study was designed to analyze the quantitative changes of regulatory T cells (T reg cells) in the hepatic hilar lymph nodes (hepatic hilar LNs) and peripheral blood (PB) in BA.
METHODS: The hepatic hilar LNs and PB obtained during the Kasai procedure were analyzed by flow cytometry. The ratios of total and active Tregs to the total CD4+ cells in the PB and the hepatic hilar LNs were compared.
RESULTS: In patients with BA, the ratios of both the total and active T reg cells in the hepatic hilar LNs were higher than those in the PB (total T reg cells: PB vs. LN; P?
CONCLUSION: The present study showed that the ratios of both total T reg cells and active T reg cells were higher in the hepatic hilar lymph nodes of BA patients. This finding could shed light on the pathogenesis of BA.
METHODS: The hepatic hilar LNs and PB obtained during the Kasai procedure were analyzed by flow cytometry. The ratios of total and active Tregs to the total CD4+ cells in the PB and the hepatic hilar LNs were compared.
RESULTS: In patients with BA, the ratios of both the total and active T reg cells in the hepatic hilar LNs were higher than those in the PB (total T reg cells: PB vs. LN; P?
CONCLUSION: The present study showed that the ratios of both total T reg cells and active T reg cells were higher in the hepatic hilar lymph nodes of BA patients. This finding could shed light on the pathogenesis of BA.