Penilaian efektivitas dan dermatofarmakokinetik krim pelembap minyak kelapa untuk pencegahan sekunder dermatitis-tangan akibat kerja pada perajin batik = Effectiveness and dermatopharmacokinetic of moisturizer containing cocos nucifera L. and glycerin for secondary prevention of hand dermatitis among batik workers
Windy Keumala Budianti;
Rustarti Retno Widowati Soebaryo, promotor; Muchtaruddin Mansyur, co-promotor; Joshita Djajadisastra, co-promotor; Suhendro, examiner; Franciscus D. Suyatna, examiner; Siagian, Minarma, examiner; Cita Rosita Sigit Prakoeswa, examiner
(Fakultas Kedokteran Universitas Indonesia, 2019)
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ABSTRAK Batik workers are a group at highest risk of acquiring occupational contactdermatitis, especially hand dermatitis. Prevention of using personal protectiveequipment (PPE) does not provide optimal protection therefore other interventionsare needed for secondary prevention. The development of topical agents thatimprove skin barrier function is a promising approach for the management ofhand dermatitis. Topically applied lipids and humectants may interfere with skinbarrier function, and facilitate skin barrier repair. The aim of this study is toevaluate the effectiveness of Cocos nucifera and glycerine for secondaryprevention of hand dermatitis among batik workers.In a double-blind, cross-over randomized study, the effect of glycerine coconutoil-containing cream vs. glycerine alone on skin barrier functions was determinedby assessment after repeated application of moisturizers over a 2-week period inbatik workers with occupational hand dermatitis. As much as 32 batik dyeingand/or rinsing process workers were enrolled in this study for a minimum of 6months with mild to moderate occupational hand dermatitis. Assessment oftransepidermal water loss (TEWL), skin capacitance and the Hand EczemaSeverity Index (HECSI) were made at baseline and day 14.The research showed that the type of hand dermatitis among subjects that occurswere 56 palmar hyperkeratosis, 15.6 interdigital eczema, 12.5 nummularhand eczema, 9.4 pulpitis and 6.3 recurrent vesicular hand eczema. As muchas 96.97 of the subjcts have nail discoloration. 40.6 of the subjects always usePPE were at risk of developing hand dermatitis.After applying 14 days, both moisturizers showed clinical improvement by 20decreased of HECSI and TEWL and 20 increased of skin capacitance. Therewas no statistically significant treatment effect between both moisturizers. Skinstripping result was analyzed using chromatography method showed penetrationat 3rd hour (uptake) and still detected at 12th hour (clearance).The findings of the study support the skin health program for batik workers androutine usage of moisturizers are recommended for a minimal of 12 hours per dayto prevent hand dermatitis. |
 D-Windy Keumala Budianti.pdf :: Unduh
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| No. Panggil : | D-Pdf |
| Entri utama-Nama orang : | |
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| Penerbitan : | Depok: Fakultas Kedokteran Universitas Indonesia, 2019 |
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| Bahasa : | ind |
| Sumber Pengatalogan : | |
| Tipe Konten : | text |
| Tipe Media : | computer |
| Tipe Carrier : | online resource |
| Deskripsi Fisik : | xxix, 160 pages : illustration; 30 cm + appendix |
| Naskah Ringkas : | |
| Lembaga Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 3 |
| No. Panggil | No. Barkod | Ketersediaan |
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| D-Pdf | 07-19-605444183 | TERSEDIA |
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| Tidak ada ulasan pada koleksi ini: 20485970 |
