ABSTRAK Latar Belakang:Kadar hsCRP berhubungan dengan mayor adverse cardiac events. Pada PJK stabil,hubungan antara kadar hsCRP dengan skor SYNTAX sebagai gambaran derajataterosklerosis koroner belum jelas.Tujuan :Mengetahui hubungan antara kadar hsCRP dengan skor SYNTAX pada penderitaPJK stabil, dan mengetahui titik-potong kadar hsCRP yang dapat membedakanantara kelompok skor SYNTAX rendah dengan yang tinggi.Metode:Observasional potong-lintang pada consecutive 93 subjek penderita PJK stabildewasa yang menjalani angiografi koroner di RSUPNCM pada bulan Mei sampaiSeptember 2018, untuk memperoleh skor SYNTAX. Diambil darah dari arteriperifer sebelum tindakan angiografi untuk pemeriksaan hsCRP dan laboratoriumdasar. Dieksklusi penderita infeksi berat, trauma, PGK, sirosis hati, keganasan,pengobatan steroid. Selanjutnya data dikumpulkan dan dianalisis. Skor SYNTAXdikelompokkan tinggi bila > 27, dan rendah bila nilai < 27. Untuk menilai titikpotongkadar hsCRP dipakai uji Sperman karena distribusi data tidak normal.Hasil:Ditemukan rerata umur 60,23 tahun (SB 8,984), IMT 26,30 Kg/m2 (SB 3,903), kol-LDL117,74 mg/dL (SB 36,31). Kadar hsCRP dan skor SYNTAX tidak dipengaruhi olehIMT atau kol-LDL (hsCRP-IMT: r:0,032; p:0,772; skor SYNTAX-IMT: r:-0,021;p:0,849; hsCRP-kol LDL: r:-0,149; p:0,266; skor SYNTAX-kol LDL: r:0,159;p:0,234). Ditemukan korelasi positif lemah hsCRP dengan skorSYNTAX (r:0,270;p:0,009) dan Titik-potong pada kadar hsCRP 2,35 mg/L (sensitifitas 0,69;spesifisitas 0,53). Nilai AUC 0,554, IK 95%, p: 0,472, merupakan diskriminasiyang kurang baik.Simpulan:Pada penderita PJK stabil, kadar hsCRP berkorelasi positif lemah dengan skor SYNTAXsebagai gambaran derajat aterosklerosis. Kadar hsCRP dengan titik-potong > 2,35 mg/Ldapat membedakan kelompok yang mempunyai skor SYNTAX rendah dengan kelompokskor SYNTAX tinggi, namun nilai prediksinya relatif rendah. ABSTRACT ackground:High sensitivity C-reactive protein levels are associated with mayor adverse cardiac events.In stable CAD, the association of baseline hcCRP level with coronary atherosclerosisseverity assessed by SYNTAX score were not clear.Objective:To investigate the association between hsCRP level and SYNTAX score in patients withstable CAD, and to know cut-off point of hsCRP level which can differentiated betweenthe group of low SYNTAX score and of high SYNTAX score.Methods:Cross-sectional observation to the consecutive 93 subject adult patients of stable CAD,undergoing coronary angiography in Cipto Mangunkusumo General Hospital on May toSeptember 2018 to obtain SYNTAX score. The blood tests were taking from pheripheralartery prior to carrying out of coronary angiography to obtain level of hsCRP and laboratorydata base. The exclusion were severe infection, trauma, CKD, cirrhosis hepatis,malignancy, and steroid therapy. The SYNTAX score will be differentiated between thegroup of high if the value > 27, and the group of low if the value < 27. Sperman analysiswill be used to evaluate hsCRP cut-off point.Results:Average age was 60,23 year (SD 8,984), BMI 26,30 Kg/m2 (SD 3,903), and LDL-chol117,74 (SD 36,31). The Level of hsCRP and SYNTAX score were not influenced by BMIor LDL-chol (hsCRP - BMI: r:0,032; p:0,772; SYNTAX score - BMI: r:-0,021; p:0,849;hsCRP- LDL-chol: r:-0,149; p:0,266; SYNTAX score - LDL-chol: r:0,159; p:0,234). Wefound positif corelation (weak) between hsCRP and SYNTAX Score (r:0,270; p:0,009).Cut-off point was found in the hsCRP level 2,35 mg/L (sensitivity 0,69; spesivisity 0,53).AUC 0,554, CI 95%, p: 0,472, were the poor discrimination.Conclusions:There were positif (weak) correlation between hsCRP level and SYNTAX score instable CAD patients. Cut-off point in the hsCRP level > 2,35 mg/L candifferentiated between the group of low SYNTAX score and of high SYNTAXscore, but the prediction value is low-grade |