Detection of helicobacter pylori CagA gene and its association with endoscopic appearance in Balinese dyspepsia patients / Mariadi, I Ketut, Wibawa, I Dewa Nyoman, Wibawa, Ida Bagus Nyoman
Mariadi;
I Ketut; Wibawa; I Dewa Nyoman; Wibawa; Ida Bagus Nyoman
(Interna Publishing (Pusat Penerbitan Ilmu Penyakit Dalam), 2016)
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ABSTRAK Helicobacter pylori (H. pylori) infection causes various abnormalities in the stomach. Only particular strain can cause severe problems in the stomach. CagA is a microbial virulent factor which is associated with more severe stomach problems, such as: peptic ulcer and stomach cancer. We would like to know the prevalence of CagA in Balinese population, and the association of H. Pylori CagA status with the severity of endoscopic appearance in dyspepsia patients.Method: Study design being used was analytic cross sectional study, involving 71 dyspepsia patients who underwent upper gastrointestinal endoscopic examination in Surya Husada Hospital and Balimed Hospital in June-December 2013. Sample was chosen in consecutive manner. Later, polymerase chain reaction (PCR) examinations of the stomach mucous biopsy tissue to determine H. pylori infection status and CagA status were performed. Further, Chi square test was used to identify the difference in proportion of H. pylori and CagA between mild and severe endoscopic appearance.Results: In this study, we found that the prevalence of H. pylori infection was 22.5% using PCR examination. Prevalence of CagA positive in H. pylori positive was 62.5%. There was significant association between status of H. Pylori infection and severity of endoscopic appearance (p = 0.038; OR= 2.67; 95% CI = 1.18-6.05). Status of CagA in H. pylori infected patients was not associated with the severity of endoscopic appearance. Additionally, there was significant association between patients’ age and severity of endoscopic appearance.Conclusion: The prevalence of CagA in H. pylori positive was 62.5%. H. pylori infection was associated with severity of endoscopic appearance and CagA status in H. pylori infected patients was not associated with severity of endoscopic appearance. |
| No. Panggil : | 611 UI-IJGHE 17:2 (2016) |
| Entri utama-Nama orang : | |
| Entri tambahan-Nama orang : | |
| Subjek : | |
| Penerbitan : | Jakarta: Interna Publishing (Pusat Penerbitan Ilmu Penyakit Dalam), 2016 |
| Sumber Pengatalogan : | LibUI eng rda |
| ISSN : | 02161419 |
| Majalah/Jurnal : | The Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy |
| Volume : | Vol.17, No. 2, August 2016, Hal 99-105 |
| Tipe Konten : | text |
| Tipe Media : | unmediated (rda media) |
| Tipe Carrier : | volume |
| Akses Elektronik : | |
| Institusi Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lt 4, R. Koleksi Jurnal |
| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| 611 UI-IJGHE 17:2 (2016) | 03-19-916092910 | TERSEDIA |
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| Tidak ada ulasan pada koleksi ini: 20488951 |
