ABSTRACT Nothopanax scutellarium is one of plant that has several biological activities such asobstetrics, kidney disease, inflammatory disease, and promotion of hair growth. Ethosomes arethe ethanolic phospholipid vesicles which are used mainly for transdermal drug delivery ofdrugs. Ethosomes have higher penetration rate through skin. It contains soft vesicle, composedof hydroalcoholic or hydroglycolic phospholipid in which concentration of alcohol is relativelyhigh. Ethosomes are a novel carrier for enhanced skin delivery. The aims of this research wereto formulate and obtain ethosome which formed by thin layer hydration method and to knowthe safety of gel ethosome which contain ethyl acetate fraction. Safety test measured by scoringand categorizing within chorioallantoins membran. (HET CAM). The formulation of ethosomethat using 20% ethanol and the ratio of phosphatidylcholine and ethyl acetate fraction were 1:2.The characterization from the ethosome suspension indicated that the entrapment efficiencyvalue of 52.79% with particle size distribution value (Z-Average) 110.5 nm, polydispersityindex (PdI) 0.393 and zeta potential value -11.0 mV. The result of safety test showed that 0.5%and 1% gel ethosome contain ethyl acetate fraction of scutellarium leaves have mild irritationeffect. |