ABSTRAK
Latar belakang: Seminoma testis yang gagal sembuh dengan penatalaksanaan konvensional memiliki prognosis buruk. Beberapa kejadian rekuren setelah dilakukan kemoterapi juga ditemukan. Programmed Death Ligand-1 (PD-L1) terekspresi pada berbagai keganasan dan tumor infiltrating lymphocytes(TILs) serta telah diketahui perannya sebagai faktor prognostik. Penelitian ini dilakukan untuk mengetahui peran ekspresi PD-L1 pada seminoma testisdalam menentukanoverall survival(OS) danprogression free survival(PFS).Bahan dan cara: Penelitian ini merupakan penelitiankohort retrospektif dengan desain analisis kesintasan. Data klinis diambil dari rekam medis RSUPN Cipto Mangunkusumo sejak Januari 2011-Desember 2016 yang diobservasi selama 2 tahun. Data histopatologik diambil dari Departemen Patologi Anatomik RSUPN Cipto Mangunkusumoyang kemudian dilakukan pulasan imunohistokimia PD-L1.Hasil: Terdapat hubungan yang bermakna antara ekspresi PD-L1 pada sel tumor dengan 2-yearOS (p=0,023) dan PFS (p=0,002) padaseminoma testis.Tidak terdapat hubungan yang bermakna antara ekspresi PD-L1 pada TILs dengan 2-year OS (p=0,235) dan PFS (p=0,111). Terdapat hubungan bermakna antara ekspresi PD-L1 pada sel tumor dan ekspresi PD-L1 pada TILs dengan PFS (p=0,019). Terdapat hubungan yang bermakna antara stadiumdengan 2-yearOS (p=0,010)dan PFS (p=0,000)serta metastasis kelenjar getah beningpada 2-yearOS (p=0,010)dan PFS (p=0,000).Kesimpulan: Ekspresi PD-L1 pada sel tumor seminoma testis berhubungan dengan OS dan PFS, tetapi hubungan tersebut tidak ditemukan pada TILs.
ABSTRACT
Background: The prognosis of testicular seminoma who failed to be cured with conventional therapy is poor. Several recurrent events after chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infiltrating lymphocytes (TILs) and its role is known as a prognostic factor. This study was conducted to determine the role of PD-L1 expressionseminomain determining overall survival (OS) and progression free survival(PFS).Materials and Methods: Thisis aretrospective cohort study with survival analysis. Clinical datawere obtained from medical record in RSUPN Cipto Mangunkusumo since January 2011-December 2016 and observed for 2 years. Histopathological datawere obtained from Anatomical Pathology Department and PD-L1 immunohistochemistry staining were performed.Results: Asignificant correlation between PD-L1 expression in tumor cells with 2-year OS (p=0,023) and PFS(p=0,002) intesticular seminoma was found. Nosignificant correlation between PD-L1 expression in TILs with 2-year OS (p=0,235)and PFS (p=0,111).We also found significant correlations between PD-L1 expression in tumor cells and TILs with PFS (p=0,019). A significant correlation between stage with 2-year OS (p=0,010)and PFS (p=0,000) and lymph node metastases with 2-year OS (p=0,010) and PFS (p=0,000) Conclusion: PD-L1 expression in tumor cells testicular seminoma were significantly correlated with OS and PFS. There were no statistically significant associations between PD-L1 expression in TILs with OS and PFS. |
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