:: Artikel Jurnal :: Kembali

Artikel Jurnal :: Kembali

Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum

Masashi Miguchi, Takao Hinoi, Kohji Tanakaya, Tatsuro Yamaguchi, Yoichi Furukawa, Teruhiko Yoshida, Kazuo Tamura, Kokichi Sugano, Chikashi Ishioka, Nagahide Matsubara, Naohiro Tomita, Masami Arai, Hideki Ishikawa, Keiji Hirata, Yoshihisa Saida, Hideyuki Ishida, Kenichi Sugihara (Springer, 2018)

 Abstrak

ABSTRACT
We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13-5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38-1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS.

 Metadata

No. Panggil : 617 SUT 48:8 (2018)
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Penerbitan : Tokyo: Springer, 2018
Sumber Pengatalogan : LibUI eng rda
ISSN : 09411291
Majalah/Jurnal : Surgery Today Official Journal of The Japan Surgical Society
Volume : Vol. 48 No. 8, August 2018: Hal. 810-814
Tipe Konten : text
Tipe Media : unmediated (rda media)
Tipe Carrier : volume
Akses Elektronik : https://link.springer.com/article/10.1007/s00595-018-1654-7
Institusi Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lt 4, R. Koleksi Jurnal
  • Ketersediaan
  • Ulasan
No. Panggil No. Barkod Ketersediaan
617 SUT 48:8 (2018) 03-19-187482482 TERSEDIA
Ulasan:
Tidak ada ulasan pada koleksi ini: 20496432