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Role of allogeneic mesenchymal stem cells in the reconstruction of bone defect in rabbits

Hadisoebroto D. Ismail, Phedy, Erica Kholinne, Achmad A. Jusuf, Nyimas D. Yulisa (Faculty of Medicine Universitas Indonesia, 2014)

 Abstrak

Abstrak
Despite the advancement of bone reconstruction in the past decade, large bone defect remains a challenge for orthopedic surgery. As mesenchymal stem cells (MSCs) emerges as one of the possible treatment of these defects, we evaluate the effect of its transplantation, particularly in combination with hydroxyapatite-calcium sulphate pellets. Methods: Twenty eight rabbits were randomly assigned into four different treatment groups. Each group received a different type of grafts (Autograft, hydroxyapatite-calcium sulphate [HA-CaSO4], HA-CaSO4 combined with marrow aspirate, or HA-CaSO4 combined with 2x106 MSCs). One centimeter long bone defects were created then immediately fixated with mini plate-screw and two cerclage wires. It was followed by the graft transplantation. Callus thickness was measured from the x-rays taken at 4, 8, 12 week after transplantation by two authors working independently. At the end of the study, histological staining along with osteocyte index were obtained by sacrificing the rabbits. These data were analyzed by one-way ANOVA test.Results: At the fourth week, callus thickness showed significant difference (p = 0.018). Although statistically insignificant, callus in MSCs group at the eighth week seemed to be thicker than any other groups of intervention (p = 0.546). The MSCs group also tend to have a higher osteocyte index at the follow-up weeks.Conclusion: MSC transplantation on bone defect results in faster callus formation and tends to generate a thicker callus.

 Metadata

No. Panggil : 610 UI- MJI 23:1 (2014) (2)
Entri utama-Nama orang :
Entri tambahan-Nama orang :
Subjek :
Penerbitan : Jakarta: Faculty of Medicine Universitas Indonesia, 2014
Sumber Pengatalogan : LibUI eng rda
ISSN : 08531773
Majalah/Jurnal : Medical Journal of Indonesia
Volume : Vol. 23, No.1 February 2014: Hal: 9-14
Tipe Konten : text
Tipe Media : unmediated
Tipe Carrier : volume
Akses Elektronik :
Institusi Pemilik : Universitas Indonesia
Lokasi : Perpustakaan UI, Lantai 4, R. Koleksi Jurnal
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No. Panggil No. Barkod Ketersediaan
610 UI- MJI 23:1 (2014) (2) 03-19-877615853 TERSEDIA
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