Effect of uric acid on blood glucose levels
Wardhana, Achmad Rudijanto (University of Indonesia. Faculty of Medicine, 2018)
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ABSTRACT Uric acid as the final result of purine bases metabolism. In high level condition, uric acid enters the cell and act as oxidant, and acts as independent risk factor and predicts the incident of type 2 diabetes mellitus (T2DM). It may directly inactivate or through oxidative reaction that lower the nitric oxide (NO) level. Lower NO level will reduce insulin uptake in tissues and reduce in GLUT4 translocation in cell that will effect the blood glucose level. The High level of uric acid or hyperuricemia makes oxidative stress by inducing the production of reactive oxygen species (ROS) which interferes the insulin signalling pathway,creates inflammatory state that reduced the insulin sensitivity,blood glucose uptake and metabolism, also reducing the insulin production from pancreatic islet cells. |
| No. Panggil : | 610 UI-IJIM 50:3 (2018) |
| Entri utama-Nama orang : | |
| Entri tambahan-Nama orang : | |
| Penerbitan : | Jakarta: University of Indonesia. Faculty of Medicine, 2018 |
| Sumber Pengatalogan : | LibUI eng rda |
| ISSN : | 01259326 |
| Majalah/Jurnal : | The Indonesian Journal of Internal Medicine |
| Volume : | Vol. 50, No. 3 July 2018: Hal. 253-256 |
| Tipe Konten : | text |
| Tipe Media : | unmediated (rda media) |
| Tipe Carrier : | volume |
| Akses Elektronik : | |
| Institusi Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 4, R. Koleksi Jurnal |
| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| 610 UI-IJIM 50:3 (2018) | 03-19-074591057 | TERSEDIA |
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| Tidak ada ulasan pada koleksi ini: 20497880 |
