The role of epigenetic changes in the development of diabetes mellitus
Wardhana Wardhana, Djoko Wahono Soeatmadji
(University of Indonesia. Faculty of Medicine, 2019)
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ABSTRACT Diabetes mellitus (DM) is one of the most abundant diseases in the 21st century and believed as result of interaction between genes and environment exposure. There is a hypotesis of epigenetic mechanisms, using molecular basis to explain about the mechanism of DM. Because of the enviromental exposure including nutrition status and hyperglycemia state, the risk of DM has started since pre-conception, last until adulthood and will be inhireted trans-generational . Mainly, there are 3 epigenetic mechanisms that have role in DM. Epigenetic mechanisms are also have role in the metabolic memory that the DM complications may still developed although the blood glucose level is already normal. The restriction of calory intake may help delaying the development and onset of degerative diseases including DM by stabilizing genome through epigenetic mechanisms. |
No. Panggil : | 610 UI-IJIM 51:1 (2019) |
Entri utama-Nama orang : | |
Entri tambahan-Nama orang : | |
Penerbitan : | Jakarta: University of Indonesia. Faculty of Medicine, 2019 |
Sumber Pengatalogan : | LibUI eng rda |
ISSN : | 01259326 |
Majalah/Jurnal : | The Indonesian Journal of Internal Medicine |
Volume : | Vol. 51, No. 1 January 2019: Hal. 68-74 |
Tipe Konten : | text |
Tipe Media : | unmediated (rda media) |
Tipe Carrier : | volume |
Akses Elektronik : | |
Institusi Pemilik : | Universitas Indonesia |
Lokasi : | Perpustakaan UI, Lantai 4, R. Koleksi Jurnal |
No. Panggil | No. Barkod | Ketersediaan |
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610 UI-IJIM 51:1 (2019) | 03-19-541347914 | TERSEDIA |
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Tidak ada ulasan pada koleksi ini: 20497946 |