Latar belakang: Kanker ovarium menyumbang 152.000 kematian di seluruh duniasetiap tahun. Apendik merupakan organ intraperitoneal yang rentan terhadapmetastasis oleh kanker epitel ovarium. Penentuan keterlibatan apendik merupakansalah satu penentu surgical staging. Surgical staging yang optimal merupakansebuah kunci untuk tatalaksana setelah operasi serta memperoleh prognosis yangbaik, serta peningkatan respon tatalaksana kemoterapi. Oleh karena itu, penelitianini dilakukan untuk melihat keterlibatan apendiks pada pasien-pasien dengankanker epitel ovarium di RSCM yang menjalani pembedahan primer.Tujuan: Mengetahui prevalensi metastasis kanker epitelial ovarium ke apendiksyang dilakukan pembedahan primer di RSCMMetode: Penelitian ini merupakan studi potong lintang menggunakan data rekammedis pasien kanker ovarium epitelial yang menjalani pembedahan primer danapendiktomi pada bulan juli 2009-juli 2019 di RSCM Jakarta yang memenuhikriteria inklusi, dan dilakukan pengambilan data secara acakHasil: Didapatkan 80 subjek penelitian yang memenuhi kriteria inklusi daneksklusi. Dari 80 subjek penelitian, dengan rerata usia 48 tahun. Sebanyak 43subjek (53,8%) sebagai stadium I, 7 subjek (8,8%) sebagai stadium II, 30 subjek(37,5%) stadium III, dan tidak terdapat stadium IV (0%). Dari 80 subjek yangmenjalani apendiktomi, didapatkan 8 subjek (10%) anak sebar ke apendiks, 19subjek (23,8 %) apendisitis kronis, 53 subjek (66,3%) tidak terdapat anak sebar.Dari 8 subjek yang terdapat anak sebar ke apendik dengan temuan histologi 4musinosum, 2 serosum, 2 endometroid. Sebanyak enam dari delapan subjekterdiagnosis pada stadium klinis stadium III dan dua lainnya pada stadium klinissatu. Dua subjek yang terdiagnosis dari stadium klinis satu memiliki temuanhistologi musinosum.Kesimpulan: Terdapat 10 persen pasien kanker epitelial ovarium yang dilakukanpembedahan primer di RSCM memiliki metastasis ke apendiks yang terbagi atasjenis musinosum, serosum, dan endometrioid. Oleh karena itu, apendektomi dapatdipertimbangkan dilakukan pada pembedahan baik stadium awal maupun stadiumlanjut.
Background: Around 152,000 women were death every year because of ovariancancer. Appendix is an intraperitoneal organ which prone to ovarian epithelialcancer metastasis. Appendix involvement is one of surgical staging scoring.Optimal surgical staging is one of key point to determine post operation treatment,accurate prognosis, and better chemotherapy response. This research was done tosee appendix involvement from primary surgery in ovarian epithelial cancer atRSCMAim: To determine prevalence of metastasis to the appendix from primary surgeryin ovarian epithelial cancer at RSCMMethod: This cross sectional study used ovarian epithelial cancer patient medicalrecord which primary surgery and appendectomy were conducted on July 2009-July 2019 at RSCM. Inclusion and exclusion criteria were counted and consecutiverandom sampling were used.Result: Eighty subjects which were taken from inclusion and exclusion criteria hasaverage age on 48 years old. Out of 80, 43 subjects (53.8%) were defined as stadiumI patient, 7 subjects (8.8%) as stadium II, 30 subjects (37.5%) as stadium III, andnone of them as stadium IV. Appendectomy were done and eight subjects (10%)has metastasis to the appendix. On the other hand, 19 subjects (23.8%) have chronicappendicitis and 53 subjects (66.3%) doesnt have metastasis to the appendix. Fromeight subjects which has appendix involvement, four were defined have mucinoushistology, two serous, and two endometrioid. Six out of eight were diagnosed atclinical stadium III and two were diagnosed at stadium I. These two stadium Isubjects has mucinous histology.Conclusion: There are 10 percent appendix metastases from primary surgery inovarian epithelial cancer at RSCM which consist of mucinous, serous, andendometrioid histological types. Based on this research, appendectomy can beconsidered done on surgery whether in early or late stadium. |
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