Latar belakang: Melasma merupakan kelainan hiperpigmentasi didapat yangdisebabkan disfungsi melanogenesis, berupa makula coklat kehitaman simetris,terutama mengenai area wajah. Patogenesis melasma belum diketahui dengan jelas,beberapa faktor yang diduga berperan, di antaranya disfungsi tiroid dan defisiensi seng.Tujuan: Mengetahui kadar seng serum pada pasien melasma dan nonmelasma dengandan tanpa disfungsi tiroid.Metode: Sebuah penelitian dengan desain potong lintang dilakukan di Jakarta padaSeptember-Desember 2019. Terdapat 60 pasien melasma dan 60 pasien nonmelasma.Kedua kelompok dilakukan matching usia dan jenis kelamin. Atomic absorptionspectrophotometry digunakan untuk mengukur kadar seng serum. Laboratorium darahuntuk memeriksa fungsi tiroid (TSH dan FT4). Analisis statistik menggunakan softwareSPSS.Hasil: Rerata kadar seng serum pada kelompok melasma 10,25±1,89 μmol/L dannonmelasma adalah 10,29±1,46 μmol/L (p <0,901). Rerata kadar seng serum padapasien melasma dengan disfungsi tiroid 8,77±0,69, melasma tanpa disfungsi tiroid10,33±1,89, nonmelasma dengan disfungsi tiroid 10,48±2,4, dan nonmelasma tanpadisfungsi tiroid 10,27±1,4 (p <0,184).Kesimpulan: Tidak didapatkan perbedaan bermakna antara kadar seng serum padakelompok melasma dan nonmelasma dengan dan tanpa disfungsi tiroid.
Background: Melasma is an acquired hyperpigmentation disorder, clinically asasymmetrical blackish brown macules, especially on the facial area. Several factors arethought to play a role, including thyroid dysfunction and zinc deficiency.Objective: To determine serum zinc levels in melasma and non-melasma patients withand without thyroid dysfunction.Methods: A cross-sectional study was conducted in Jakarta in September-December2019. There were 60 melasma patients and 60 non-melasma patients. The two groupswere matched for age and sex. Atomic absorption spectrophotometry was used tomeasure serum zinc levels. Blood laboratory was used to check thyroid function (TSHand FT4). Statistical analysis was done by SPSS software.Results: The mean serum zinc level in the melasma group was 10.25 ± 1.89 μmol / Land non-melasma was 10.29 ± 1.46 μmol / L (p <0.901). The mean serum zinc level inmelasma patients with thyroid dysfunction was 8.77 ± 0.69, melasma without thyroiddysfunction 10.33 ± 1.89, non-melasma with thyroid dysfunction 10.48 ± 2.4, and nonmelasmawithout thyroid dysfunction 10.27 ± 1.4 (p <0.184).Conclusions: There was no significant difference between serum zinc levels in themelasma and non-melasma groups with and without thyroid dysfunction. |
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