Abstrak
Latar belakang: Melasma merupakan kelainan hiperpigmentasi didapat yang
disebabkan disfungsi melanogenesis, berupa makula coklat kehitaman simetris,
terutama mengenai area wajah. Patogenesis melasma belum diketahui dengan jelas,
beberapa faktor yang diduga berperan, di antaranya disfungsi tiroid dan defisiensi seng.
Tujuan: Mengetahui kadar seng serum pada pasien melasma dan nonmelasma dengan
dan tanpa disfungsi tiroid.
Metode: Sebuah penelitian dengan desain potong lintang dilakukan di Jakarta pada
September-Desember 2019. Terdapat 60 pasien melasma dan 60 pasien nonmelasma.
Kedua kelompok dilakukan matching usia dan jenis kelamin. Atomic absorption
spectrophotometry digunakan untuk mengukur kadar seng serum. Laboratorium darah
untuk memeriksa fungsi tiroid (TSH dan FT4). Analisis statistik menggunakan software
SPSS.
Hasil: Rerata kadar seng serum pada kelompok melasma 10,25±1,89 ?mol/L dan
nonmelasma adalah 10,29±1,46 ?mol/L (p <0,901). Rerata kadar seng serum pada
pasien melasma dengan disfungsi tiroid 8,77±0,69, melasma tanpa disfungsi tiroid
10,33±1,89, nonmelasma dengan disfungsi tiroid 10,48±2,4, dan nonmelasma tanpa
disfungsi tiroid 10,27±1,4 (p <0,184).
Kesimpulan: Tidak didapatkan perbedaan bermakna antara kadar seng serum pada
kelompok melasma dan nonmelasma dengan dan tanpa disfungsi tiroid.
......Background: Melasma is an acquired hyperpigmentation disorder, clinically as
asymmetrical blackish brown macules, especially on the facial area. Several factors are
thought to play a role, including thyroid dysfunction and zinc deficiency.
Objective: To determine serum zinc levels in melasma and non-melasma patients with
and without thyroid dysfunction.
Methods: A cross-sectional study was conducted in Jakarta in September-December
2019. There were 60 melasma patients and 60 non-melasma patients. The two groups
were matched for age and sex. Atomic absorption spectrophotometry was used to
measure serum zinc levels. Blood laboratory was used to check thyroid function (TSH
and FT4). Statistical analysis was done by SPSS software.
Results: The mean serum zinc level in the melasma group was 10.25 ± 1.89 ?mol / L
and non-melasma was 10.29 ± 1.46 ?mol / L (p <0.901). The mean serum zinc level in
melasma patients with thyroid dysfunction was 8.77 ± 0.69, melasma without thyroid
dysfunction 10.33 ± 1.89, non-melasma with thyroid dysfunction 10.48 ± 2.4, and nonmelasma
without thyroid dysfunction 10.27 ± 1.4 (p <0.184).
Conclusions: There was no significant difference between serum zinc levels in the
melasma and non-melasma groups with and without thyroid dysfunction.
