Pengaruh Rejimen RCHOP pada Aktivitas dan Sistem Koagulasi Pasien Limfoma Non Hodgkin = Effects of R-CHOP Regimens on the Activity and Coagulation System of non-Hodgkin's lymphoma patients
Maya Hestiningtyas Arini Djohansjah;
Tubagus Djumhana Atmakusuma, supervisor; Noorwati Sutandyo, supervisor; Soekamto Koesnoe, supervisor; Santosa, examiner; Pradana Soewondo, examiner; Andhika Rachman, examiner; Aulia Rizka, examiner; Suhardjono, examiner; Hamzah Shatri, examiner
(Fakultas Kedokteran Universitas Indonesia, 2020)
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Latar Belakang : Kemoterapi sitostatika dilaporkan meningkatkanaktivitas koagulasi (D-dimer meningkat) dan mengubah hypercoagulable statemenjadi hiperkoagulasi. Hypercoagulable state adalah suatu kondisi yangberpotensi untuk terjadinya trombosis (misal pada pasien kanker) yang ditandaidengan perubahan aktivitas koagulasi pra trombin (peningkatan fragmenprotrombin 1-2 atau kompleks TAT) dengan D-dimer yang normal.Hiperkoagulasi ditandai dengan PT dan aPTT memendek sementara fibrinogendan D-dimer meningkat. Insidens kemoterapi menimbulkan trombus pertahunsekitar 11 %. Insidens tromboemboli vena pada pasien yang dirawat inap yangmendapat kemoterapi pada populasi Thailand ttinggi, terutama pada pemberianterapi. Sampai saat ini belum ada laporan mengenai insidens TEV pada pasienkanker limfoma yang menjalani kemoterapi di Indonesia.Tujuan Penelitian : Menilai aktivitas koagulasi (D-dimer) dan sistemkoagulasi (PT,aPTT, fibrinogen) pada pasien limfoma non Hodgkin yangmendapatkan kemoterapi R-CHOPMetode Penelitian : Penelitian pre dan post prospektif pada pasienlimfoma non Hodgkin yang menjalani kemoterapi dengan rejimen R-CHOPsecara consecutive sampling di Ruang Rawat Inap Gedung A RSCM dan RuangRawat Inap RS Kanker Dharmais. Penelitian dilakukan pada April-Juni 2019.Pasien diambil darah dengan parameter aktivitas koagulasi (D-dimer) dan systemkoagulasi (PT, aPTT, fibrinogen). Analisis data untuk melihat perubahan reratapre dan post kemoterapi dilakukan uji t berpasangan (distribusi normal) dan ujiWilcoxon (tidak terdistribusi normal).Hasil Penelitian : Sebanyak 33 pasien dilibatkan dalam penelitian ini.Terdapat peningkatan D-dimer secara bermakna (p : 0.046), pemendekkan PT(0.048) dan aPTT ( <0.001) secara bermakna, disertai penurunan kadar fibrinogennamun tidak signifikan secara statistikaKesimpulan : Peningkatan D dimer secara bermakna, disertaipemendekkan PT dan aPTT secara bermakna, sedangkan fibrinogen mengalamipenurunan walaupun tidak signifikan secara statistik. Hal ini menunjukkankecenderungan pasien mengalami status hiperkoagulasi Background : Cytostatic chemotherapy is reported to increasecoagulation activity (increased D-dimer) and change the hypercoagulable stateinto hypercoagulation. Hypercoagulable state is a condition that has the potentialfor thrombosis (for example in cancer patients) characterized by changes in prethrombincoagulation activity (increase in prothrombin fragments 1-2 or TATcomplex) with normal D-dimers. Hypercoagulation is characterized by PT andaPTT shortening while fibrinogen and D-dimer are increasing. The incidence ofchemotherapy causes thrombus annually about 11%. The incidence of venousthromboembolism in hospitalized patients receiving chemotherapy in the highThai population, especially in the administration of therapy. To date there havebeen no reports of TEV incidence in lymphoma cancer patients undergoingchemotherapy in Indonesia.Objectives : Assess the activity of coagulation (D-dimers) andcoagulation systems (PT, aPTT, fibrinogen) in non-Hodgkins lymphoma patientsreceiving R-CHOP chemotherapyMethods : Pre and post prospective studies in non-Hodgkinslymphoma patients undergoing chemotherapy with the R-CHOP regimen byconsecutive sampling in the Inpatient Room of Building A RSCM and theInpatient Room of Dharmais Cancer Hospital. The study was conducted in April-June 2019. Patients were taken blood with parameters of coagulation activity (Ddimer)and coagulation system (PT, aPTT, fibrinogen). Data analysis to seechanges in mean pre and post chemotherapy was performed paired t test (normaldistribution) and Wilcoxon test (not normally distributed).Results: A total of 33 patients were included in this study. There was a significantincrease in D-dimer (p: 0.046), PT shortening (0.048) and aPTT (<0.001)significantly, accompanied by a decrease in fibrinogen levels but not statistically significantConclusion : D significantly increased dimer, accompanied bysignificant shortening of PT and aPTT, whereas fibrinogen decreased even thoughit was not statistically significant. This shows the tendency of patients toexperience hypercoagulable state |
 SP-Maya Hestiningtyas Arini Djohansjah.pdf :: Unduh
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| No. Panggil : | SP-pdf |
| Entri utama-Nama orang : | |
| Entri tambahan-Nama orang : | |
| Entri tambahan-Nama badan : | |
| Subjek : | |
| Penerbitan : | Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020 |
| Program Studi : |
| Bahasa : | ind |
| Sumber Pengatalogan : | LibUI ind rda |
| Tipe Konten : | text |
| Tipe Media : | computer |
| Tipe Carrier : | online resource |
| Deskripsi Fisik : | ix, 62 pages : illustration ; 28 cm + appendix |
| Naskah Ringkas : | |
| Lembaga Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 3 |
| No. Panggil | No. Barkod | Ketersediaan |
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| SP-pdf | 16-21-163987579 | TERSEDIA |
| Ulasan: |
| Tidak ada ulasan pada koleksi ini: 20501751 |
