Frequency of acute kidney injury in patient receiving piperacillin-tazobactam: A hospital-based study from Qatar
Fahmi Y. Khan, Ahmad M. Abdalhadi, Dalal S. Mudawi, A, sir Sulaiman, Hammad Shabir Chaudhry, Rohit Sharma, Ahmed Elballat, Awni Alshurafa, Fateen Ata (University of Indonesia. Faculty of Medicine, 2021)
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| Background: several studies have been reported piperacillin-tazobactam (TAZ / PIPC)-associated AKI with various frequencies. The aim of this study was to determine the frequency of TAZ/PIPC- associated AKI among our patients and to identify the risk factors for this clinical entity. Methods: this retrospective cross-sectional study was conducted at Hamad General Hospital; it involved adult patients who were admitted from January 2017 to December 2017. Results: we involved 917 patients, of whom 635 (69.25%) were males and 282 (30.75%) were females. The mean age of the patients was 52 (SD 19) years, and 98 (10.7%) patients were diagnosed with AKI. The patients with AKI were significantly older than without AKI [59.71 (SD 19.79) versus 51.06 (SD 18.67); P <0.001]. After TAZ/PIPC initiation, the mean creatinine level in the AKI group was higher than the mean creatinine level in the non-AKI group, [158.91 (SD 81.93) versus 66.78 (SD 21.42); P<001]. The mean time of onset of AKI after PIPC/TAZ initiation was 4.46 (SD 3.20) (1-12 days). AKI was significantly associated with low mean serum albumin (P<0.001), high mean fasting blood glucose (P<0.001), coronary artery diseases (P<0.001), heart failure (P<0.001), liver diseases (P=0.047), diabetes mellitus (P=0.021) and hypertension (P<0.001). The in-hospital mortality was significantly higher in the AKI group [38.78% versus 5.13% in the non-AKI group; P<0.001], and only advanced age and heart failure were found as independent risk factors for TAZ/PIPC-associated AKI. Conclusion: TAZ/PIPC was significantly associated with AKI. Advanced age and heart failure were identified as independent risk factors for TAZ/PIPC-associated AKI |
| No. Panggil : | 610 UI-IJIM 53:2 (2021) |
| Entri utama-Nama orang : | |
| Subjek : | |
| Penerbitan : | Jakarta: University of Indonesia. Faculty of Medicine, 2021 |
| Sumber Pengatalogan : | LibUI eng rda |
| ISSN : | 01259326 |
| Majalah/Jurnal : | The Indonesian Journal of Internal Medicine |
| Volume : | Vol. 53, No. 2, April 2021: Hal. 156-163 |
| Tipe Konten : | text |
| Tipe Media : | unmediated |
| Tipe Carrier : | volume ; online resource |
| Akses Elektronik : | |
| Institusi Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 4 R. Koleksi Jurnal |
| No. Panggil | No. Barkod | Ketersediaan |
|---|---|---|
| 610 UI-IJIM 53:2 (2021) | 08-21-850202322 | TERSEDIA |
| Ulasan: |
| Tidak ada ulasan pada koleksi ini: 20513100 |
