Pendahuluan: Pestisida, salah satunya organofosfat masih banyak digunakan untukmeningkatkan hasil produksi pertanian, karena efektif dalam pengendalian hama. Efek pajanankronis organofosfat terhadap manusia belum diketahui secara jelas. Indonesia merupakan negaraagrikultural dan termasuk negara pengguna pestisida terbanyak. Terdapat beberapa bukti, bahwapaparan perstisida dalam jangka panjang, dapat menyebabkan gangguan neurologis, denganpeningkatan kadar b-amyloid plasma, yang dapat meningkatkan risiko risiko terjadinya penyakitAlzheimer.Tujuan: Penelitian ini bertujuan untuk mengidentifikasi kadar b-amyloid plasma pada laki-lakipenyemprot pestisida di perkebunan dan mengetahui apakah terdapat hubungan dengan intensitaspajanan pestisida jangka panjang.Metode: : Studi cross-sectional pada penyemprot pestisida di perkebunan yang sudahmenggunakan pestisida organofosfat dan/atau karbamat selama enam bulan. Pengumpulan datadilakukan pada pagi hari sebelum mulai bekerja, dengan cara mewawancara dan mengambilsampel darah vena dari fossa cubiti, kemudian dianalisis menggunakan metode LC-MS. Jumlahresponden yang memenuhi kriteria inklusi dan masuk dalam penelitian ini yaitu 57 responden.Intensitas pajanan pestisida dinilai dengan metode skoring, yang sudah digunakan sebelumnyadan sudah dimodifikasi Agricultural Health Study di Amerika Serikat dan disesuaikan dengansituasi di Indonesia.Hasil: Sebanyak 91,2% pekerja mengalami peningkatan kadar β-Amyloid plasma. Skor intensitaspajanan pestisida jangka panjang antara 45 sampai 300, dengan nilai median 260. Berdasarkananalisis bivariat secara korelasi antara kadar b-amyloid plasma dengan total skor kumulatifintensitas pajanan didapatkan korelasi rendah (r=0.243) dan memiliki korelasi linier berbandinglurus, di mana peningkatan skor total kumulatif intensitas memberikan peningkatan kadar β-amyloid plasma sebesar 4,6%, tetapi tidak bermakna secara statistik.Kesimpulan: Berdasarkan penelitian ini, tidak ada hubungan antara kadar β-amyloid plasmadengan intensitas pajanan pestisida.
Introduction: The use of pesticides, especially organophosphates are still very often to increaseagricultural production, because it is effective in pest control. Indonesia is an agricultural country,which is among the highest user of pesticides The effect of chronic organophosphate exposure onhumans health is not fully understood yet. There are some evidence that long term exposure topesticides can lead to neurologic diseases, among others by increasing b-amyloid plasmalevels,which can lead to Alzheimer disease..Objective: This study aims to identify b-amyloid plasma levels among male plantation pesticidesprayer and determine if there is an association with the intensity of longterm pesticide exposure.Methods: A Cross-sectional study was conducted among pesticide sprayers on plantations, thathave used organophosphate and / or carbamate pesticides for at least the last six months. Datawas collected in the morning before working, by interviewing and taking venous blood sample.The blood sample was analyzed using the LCMS Method to measure b-amyloid plasma levels.Fifty-seven subjects were included in this study. The intensity of long term exposure to pesticideswas assessed using a scoring method, that has been used before. which is modified from theAgricultural Health Study.and adjusted to the situation in Indonesia.Results: As many as 91.2% workers had plasma β-amyloid levels above normal. While theintensity score for long term pesticide exposure was between 45 to 300 with a median 260. Usingcorrelation analysis, No significant correlation between b-amyloid plasma levels and totalcumulative intensity exposure score was found (r = 0.243, p>0,05),.Conclusion: Based on this study, 91.2% had high levels of b-amyloid plasma and no relationshipbetween intensity of pesticide exposure with plasma β-amyloid levels was found |
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