Pengaruh pemberian kurkumin dan vitamin E terhadap aktivitas angiogenesis plasenta preeklampsia = The effect of curcumin and vitamin E supplementation on angiogenesis activity in preeclamptic placenta
Candra Wijaya;
Sri Bekti Subakir, supervisor; Oentoeng Soeradi, supervisor
(Fakultas Kedokteran Universitas Indonesia, 2006)
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Tujuan: Membandingkan aktivitas angiogenik plasenta preeklampsia dengan dan tanpa pemberian kurkumin dan vitamin E.Rancangan Penelitian: Penelitian ini merupakan studi eksperimental in vitro. Plasenta dari ibu hamil preeklampsia (n=11) dibagi dalam 3 kelompok: kelompok kontrol, kelompok pemberian kurkumin dosis 0,01 mM, dan kelompok pemberian vitamin E dosis 20 mg/L Aktivitas angiogenesis ditentukan dengan menilai skor migrasi sel-sel endotel menuju plasenta. Analisis perbedaan aktivitas angiogenesis antar kelompok digunakan tes wilcoxon.Hasil: Aktivitas angiogenik kelompok pemberian kurkumin dosis 0,01 mM tidak berbeda bermakna dibandingkan kelompok kontrol (p>0,05). Sedangkan, aktivitas angiogenik kelompok pemberian vitamin E dosis 20 mg/L berbeda secara bermakna dibandingkan kelompok kontrol (p< 0,05).Kesimpulan: Pemberian vitamin E meningkatkan aktivitas angiogenik pada plasenta dari ibu hamil preeklampsia. Objective: To compare angiogenic activity in preeclamptic placenta with and without supplementation of curcumin and vitamin E.Study design: The study was an in vitro experimental study. Placentae were obtained from woman with preeclampsia (n=11) divided into three groups. The first was control, to the second group 0,01 mM curcumin was added and the third with 20 mg/I, vitamin E. Angiogenic activity was assayed using an endothelial cell migration assay. Differences in placental angiogenic activity between three groups were analysed using the Wilcoxon test.Results: The angiogenic activity in the 0,01 mM curcumin supplementation group was not significantly different than in the control group (p>0,05). While, angiogenic activity in the 20 mg/I, vitamin E group was significantly different than in the control group (p< 0,05).Conclusion: Vitamin E supplementation increased angiogenic activity in the placenta from women with preeclampsia. |
 Pengaruh pemberian - Full text ( T 17686 ) pdf.pdf :: Unduh
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| No. Panggil : | T 17686 |
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| Penerbitan : | Jakarta: Fakultas Kedokteran Universitas Indonesia, 2006 |
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| Bahasa : | ind |
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| Lembaga Pemilik : | Universitas Indonesia |
| Lokasi : | Perpustakaan UI, Lantai 3 |
| No. Panggil | No. Barkod | Ketersediaan |
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| T 17686 | 15-17-182904467 | TERSEDIA |
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| Tidak ada ulasan pada koleksi ini: 98508 |
