Patogenesis terjadinya aterosklerosis pada penyakit jantung koroner telah meluas dari suatu pandangan yang semula etiologi utama karena lemak yang abnormal menjadio proses inflamasi termasuk periodontitis. Tannerella forsythia adalah bakteri negatif Gram, anaerob, berbentuk batang fusiform yang diduga berperan pada kedua penyakit tersebut. Tujuan: Menganalisis perbedaan kuantitatif T.forsythia pada plak gigi dengan status periodontal pada penderita PJK dan non PJK. Metode: 66 pasien PJK dan 40 kontrol diperiksa status periodontal dan diambil sampel plak subgingiva dan kuantitatif T.forsythia dihitung dengan menggunakan metode real time polymerase chain reaction. Hasil: Kuantitatif T.forsythia PJK tidak berbeda dengan non PJK. Tidak terdapat hubungan antara T.denticola dengan perdarahan gingival, kedalaman poket, dan kehilangan perlekatan klinis pada penderita PJK dan non PJK. Kesimpulan: Kuantitatif T.forsythia penderita PJK tidak berbeda dengan penderita non PJK. Kuantitatif T.forsythia tidak berhubungan dengan status periodontal. The pathogenesis of the development of atherosclerosis in subjects with coronary heart disease has evolved to the extent where abnormal fat accumulation was no longer the culprit, but rather a certain inflammatory process, including periodontitis. Tannerella forsythia is a Gram-negative anaerobic bacteria, with fusiform rod shape, that has played a role in inducing the development of both diseases. Objective : The aim of this study was to analyze the difference in quantitative measurement of Tannerella forsythia accumulated in the plaque and the periodontal status of subjects with and without coronary heart disease. Tannerella forsythia was counted by utilizing the Real-Time Polymerase Chain Reaction (RT-PCR). Methods: Periodontal status of 66 CHD patients and 40 controls was obtained. Subgingival plaque was isolated. Tannerella forsythia level were measured using real-time PCR. Result: Tannerella forsythia level of CHD patients (-6,29 log10 CFU/ml) was significantly different from control (-19,63 log10 CFU/ml). Tannerella forsythia was not significntly associated with any periodontal status (p<0.05). Conclusion: Tannerella forsythia levels of CHD patients were higher than control. Tannerella forsythia was not associated with any periodontal status. |