Hasil Pencarian  ::  Simpan CSV :: Kembali

Hasil Pencarian

Ditemukan 56100 dokumen yang sesuai dengan query
cover
Soehartati Argadikoesoemo Gondhowiardjo
Peran radiasi dalam penangganan adenoma hipofise
"Adenoma hipofise adalah tumor yang walaupun mempunyai gambaran histopatologi jinak, akan tetapi seringkali memberikan penampakan klinis yang tidak ringan. Penampakan klinis ini dapat merupakan efek dari adanya masa tumor, gangguan hormonal, atau keduanya. Disamping itu, tumor ini sering kali mengalami kekambuhan setelah terapi. Penanganan jenis tumor ini banyak mengalami kemajuan dengan adanya perbaikan baik teknik berbagai modalitas terapi yang digunakan yaitu pembedahan dan radiasi, maupun ditemukannya berbagai obat. Penanganan multimodalitas seringkali diperlukan dalam penanganan adenoma hipofise untuk mendapatkan hasil terapi yang optimal. Radiasi merupakan salah satu agen sitotoksik dengan menggunakan sinar pengion yang banyak digunakan dalam pengobatan adenoma hipofise bersama dengan modalitas terapi lainnya. Pemberian radiasi pasca pembedahan terbukti menurunkan angka kekambuhan (22-71% vs 8-23%) secara bermakna. Saat ini telah terjadi perkembangan yang pesat dalam teknik pemberian radiasi pada adenoma hipofise. Perkembangan tersebut didasari baik oleh perbaikan pengetahuan dalam bidang teknologi komputer dan peralatan radiasi, maupun oleh berkembangnya pengetahuan dalam bidang biologi seluler maupun molekuler baik jaringan sehat maupun tumor. Tujuan untuk mengembangkan teknik dan metode radiasi adalah supaya mendapatkan dosis radiasi yang tinggi dan homogen di daerah target radiasi dengan dosis serendah mungkin pada jaringan sehat di sekitarnya. Dengan berbagai perkembangan ilmu pengetahuan maupun teknologi, khususnya sehubungan dengan ilmu komputer, maka terjadi perkembangan dalam metode maupun teknik radiasi. Makalah ini membahas berbagai aspek penggunaan radiasi yang mutakhir dalam penanganan adenoma hipofise.
The Role of Irradiation in Hypophyseal Adenoma. Pituitary adenomas are histopathologically benign, however the clinical presentations are often quite severe. These clinical signs are due to the tumor mass effect, hormonal disturbances or both. Besides that, these tumors often recurred after treatment. The treatment of pituitary tumors have developed greatly with the improvement of techniques of several modalities such as surgery, radiation and medication. Multimodality treatment is often used for optimal results in treating these tumors. Radiotherapy is a cytotoxic agent using ion radiation for the treatment of pituitary tumors in combination with other methods. Post-surgical radiotherapy has shown to decrease the recurrence rate significantly (22-71% vs 8-23%). At present there has been rapid improvements in radiation techniques for pituitary tumors. These developments are not only based upon the increase of know-how in computer technology and radiation instruments, but are also based upon the development of cellular and molecular biology in connection with normal and tumor tissues. The objective in developing radiation methods and techniques is to create a high radiation dose, homogeneous in the target area with low radiation dose in normal tissue. The development in science and technology, in particular concerning computer science, have created the development of radiation techniques and methods. This paper elaborates on several aspects of radiation in the treatment of pituitary tumors."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2004
AJ-Pdf
Artikel Jurnal  Universitas Indonesia Library
cover
Fitri Anugrah
Peran Teknik Bone Marrow Sparing dalam Menurunkan Toksisitas Hematologi Akut Pada Pasien Kanker Serviks yang Menjalani Radiasi Definitif. = The role of Bone Marrow Sparing in Reducing Acute Hematologic Toxicity of Patients with Cervical Cancer Undergoing Definitive Radiation
"Tujuan : Penelitian ini bertujuan untuk mengetahui peran dari teknik bone marrow sparing intensity modulated radiotherapy (BMS-IMRT) dalam menurunkan toksisitas hematologi akut derajat 2 atau lebih. Metode : Dalam studi prospektif ini melibatkan 24 pasien kanker serviks stadium IB2-IVA yang dibagi secara random menjadi kelompok 3D konformal (3DCRT) atau kelompok BMS-IMRT. Toksisitas hematologi akut dinilai berdasarkan Common Terminology Criteria for Adverse Events (versi 5.0). Hasil : Tidak ditemukan perbedaan antar kedua kelompok terkait nilai awal hemoglobin, limfosit absolut, neutrofil absolut dan trombosit. Pada kelompok BMS-IMRT didapatkan kejadian anemia derajat 2 atau lebih yang lebih rendah secara signifikan (50% vs 91.7%, p = 0.025). Tidak didapatkan perbedaan signifikan terkait limfopenia dan trombositopenia. Neutropenia derajat 2 hanya didapatkan pada kelompok 3DCRT (33.3% vs 0%) namun perbedaan ini tidak signifikan secara statistik (p = 0.093). Kesimpulan: Teknik BMS-IMRT dapat menurunkaan kejadian anemia derajat 2 atau lebih pada pasien kanker serviks yang menjalani radiasi definitif.
Aims: This study was aimed to evaluate the impact of pelvic bone marrow sparing intensity modulated radiotherapy (BMS-IMRT) in reducing grade 2 or higher hematological toxicity for cervical cancer patients undergoing definitive radiotherapy. Methods: A total of 24 patients with stage IB2-IVA cervical cancer were prospectively enrolled and randomly allocated into the conformal radiotherapy (3DCRT) group or the BMS-IMRT group. Hematologic toxicity was defined by use of Common Terminology Criteria for Adverse Events (version 5.0). Results: No differences were seen in the baseline hemoglobin, absolute lymphocyte, absolute neutrofil, and platelet levels between the two groups. The incidence of grade 2 or higher anemia in the BMS-IMRT group was 50%, significantly lower than the 91.7% incidence in the 3DCRT group (P = 0.025) while the incidence of grade 2 or higher lymphopenia and thrombocytopenia did not differ significantly. The incidence of grade 2 or higher neutropenia was only found in the 3DCRT group (33.3%, vs 0%) but this difference did not reach statistical significance (p = 0.093). Conclusion: This study suggest that BMS-IMRT reduced the incidence of grade 2 or higher anemia in cervical cancer patients undergoing definitive radiation."
Depok: Fakultas Kedokteran Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Primary hyperaldosteronism due to adrenocortical adenoma: a case report
"Primary hyperaldosteronism is an adrenal abnormality in which there is some degree of autonomy of aldosterone secretion. We report a case of thirty three years old Javanese female presented with uncontrolled hypertension, muscular weakness, cramps and progressing shortness of breath during working for 6 years. She had history of hypertension since age 20. Her serum potassium level was always low that associated with inappropriate kaliuresis. Blood gas analysis revealed metabolic alkalosis. Sonography of the adrenal gland showed right hipoechoic architecture; CT scan of the abdomen confirmed an right adrenal tumor measured 4 cm in its greatest dimension. Endocrine evaluation revealed high plasma aldosterone concentration, suppressed plasma renin activity, aldosterone/renin ratio of 112 and confirmed the diagnosis of primary aldosteronism. She underwent unilateral adrenalectomy. Histopathological report from excised adrenal tumor were compatible to benign adrenocortical adenoma. The patient discharge home with well controlled blood pressure and normokalemia. No clinical symptoms was reported in follow-up."
Jakarta: University of Indonesia. Faculty of Medicine, 2017
610 UI-IJIM 49: 3 (2017)
Artikel Jurnal  Universitas Indonesia Library
cover
Farida Falaivi
Perbedaan ekspresi annexin A10 pada polip hiperplastik, polip sessile serrated adenoma dan adenoma konvensional = Annexin A10 expression in hyperplastic polyp sessile serrated adenoma polyp and conventional adenoma
"ABSTRAK
Latar belakang: Salah satu lesi prekursor terjadinya kanker kolorektal KKR adalah polip kolon. Polip hiperplastik PH masuk dalam kategori non neoplastik bersama polip inflamasi dan hamartoma. Sedangkan polip serrated PS dan adenoma konvensional masuk kedalam golongan polip neoplastik. World Health Organization WHO pada tahun 2010 memasukkan PH kedalam subtipe PS bersama dengan Sessile serrated adenoma SSA/P dan Traditional serrated adenoma TSA . Ketiga polip diatas harus dapat dibedakan secara morfologik, karena prognosis, terapi, serta survelain endoskopi yang berbeda. Beberapa penelitian terakhir mengemukakan Annexin A10 ANXA 10 dapat digunakan sebagai penanda SSA/P, untuk membedakannya dengan polip lainnya. Tujuan penelitian ini untuk mengetahui perbedaan ekspresi ANXA 10 pada PH, SSA/P dan Adenoma. Bahan dan cara kerja: Penelitian ini merupakan penelitian deskriptif analitik menggunakan desain potong lintang. Sampel terdiri dari 16 kasus PH, 16 kasus SSA/P dan 16 kasus adenoma konvensional. Dilakukan pulasan ANXA 10 dan penilaian dilakukan menggunakan H score. Hasil: Titik potong H score pada ekspresi ANXA 10 didapatkan pada 215,05 71,6 dengan sensitivitas 81,3 dan spesifisitas 81,2 . Ekspresi ANXA 10 tinggi didapatkan pada 13 kasus SSA/P dan 3 kasus PH, sedangkan pada 16 kasus adenoma konvensional umumnya memiliki ekspresi ANXA 10 yang rendah p < 0,001 . Kesimpulan: Terdapat perbedaan ekspresi ANXA 10 pada PH, SSA/P dan adenoma konvensional. Pulasan ANXA 10 berpotensi digunakan sebagai penanda untuk membantu mendiagnosis SSA/P.
ABSTRACT Background One of precursor lesion of colorectal cancer CRC is colon polyps. Hyperplastic polyp HP is one of non neoplastic polyps category along with inflammatory polyp and hamartomas. While serrated polyps SP and conventional adenomas categorized as neoplastic polyp. World Health Organization WHO in 2010 divided SP into hyperplastic polyps HP , Sessile Serrated adenomas SSA P and Traditional Serrated adenomas TSA . We must be able to distinguish this polyps, because they have different prognosis, therapy and endoscopic surveillance. Several recent studies have suggested that Annexin A10 ANXA 10 can be used as a marker of SSA P, to distinguish it from other polyps. The aim of this study is to know the difference of expression of ANXA 10 on HP, SSA P and conventional adenoma.Materials and methods This was a cross sectional study with 16 cases of HP, 16 cases of SSA P and 16 cases of Adenoma. All cases stained by ANXA 10 antibody and evaluated using H score. Results The cut off point H score on ANXA 10 expression was obtained at 215.05 71.6 with 81.3 sensitivity and 81.2 specificity. High ANXA 10 expression was obtained in 13 cases of SSA P and 3 cases of PH, while in 16 cases of conventional adenomas were generally have low expression of ANXA 10 p "
Fakultas Kedokteran Universitas Indonesia, 2017
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
cover
M Adi Soedarso
Cushings syndrome: a large adenoma of adrenal grand
"ABSTRACT
A 20-year old man was admitted for evaluation of Cushings syndrome. He presented with a history of headache, fatique, mood disorder, hypertension (Blood Pressure 170/120 mmHg), moon face, buffalo hump, striae rubrae. Cortisol serum laboratory increased 33.53 µgr/dl (Normal range: 3.09 -16.6ugr/dl). Abdominal CT Scan showed a right adrenal mass diameter 10.53 x 6.83 cm, with calcified and necrotized area. Levels of ACTH < 5 pg/ml (Normal range : 6 - 50 pg/ml), absence hypothalamus pituitary defect in brain MRI angiography lead the primary site on adrenal. Patient was given ketoconazole 600 mg daily to treat hypercortisolemia. The patient underwent laparoscopic right adrenalectomy. Preparation of hydrocortisone 100 mg during anesthesia-surgery to prevent occurrence of adrenal crisis. Patient position was LLD, 11mm trocar port with 0, 30 degree optic, 2 port 5mm was used for working element. Harmonic ultrasoundshear was used for dissection, hemoLock clip to control vascular. Right subcostal incision make to remove adrenal gland. EBL 1000 cc, close monitoring in ICU ward. Hydrocortison was continued 5 days after surgery. Ventilatory support removed in 2 day after surgery. On the fifth day condition stable without signs of adrenal crisis, and the patient sent to elective ward. The pathology report revealed a cushing adenoma of adrenal gland. On the fifth day after surgical intervention, postoperative cortisol levels at 12 µgr/dl. On seventh day, surgical wound healing was well with minimum dose NSAID orally. Striae thining, ginecomastia, buffalo neck, moon face was reduced. The patient was regularly followed up at Endocrine division, Department of Internal medicine. Moon face have been eliminated, no striae and good mood condition. Blood pressure was 130/ 70 mmHg (without antihypertensive drugs) and cortisol serum was 4.52 µgr/dL and independent from steroid medication. Multidisciplinary approach including endocrine treatment, prevention adrenal crisis and laparoscopic adrenalectomy procedure have good result for Cushings syndrome due to adenoma of adrenal gland."
Jakarta: University of Indonesia. Faculty of Medicine, 2019
610 UI-IJIM 51:1 (2019)
Artikel Jurnal  Universitas Indonesia Library
cover
Soehartati Argadikoesoemo Gondhowiardjo
Onkologi radiasi dalam penanganan kanker fakta dan harapan
Jakarta: UI-Press, 2005
PGB 0210
UI - Pidato  Universitas Indonesia Library
cover
Proses radiasi dalam industri, sterilisasi radiasi, dan aplikasi teknik nuklir dalam hidrologi / penyunting, Widjang Herry Sisworo... [et.al.]
Jakarta : Pusat Aplikasi Isotop dan Radiasi-Batan , 1989
623.04 RIS p
Buku Teks  Universitas Indonesia Library
cover
Andreas Ronald Barata Sebastian
Peran Radiasi Adaptif Pada Kasus Radiasi Definitif Kanker Nasofaring,Tinjauan Aspek Dosimetri = The role of adaptive radiation in definitive radiation cases for nasopharyngeal cancer, a review of dosimetry aspect
"Tujuan : untuk mengetahui waktu terbaik dilakukan adaptasi perencanaan radiasi terhadap kasus kanker nasofaring yang menjalani radiasi di RSCM serta mencari tahu hubungan penurunan berat badan dan pengecilan ukuran tumor terhadap perubahan dosimetri pasien kanker nasofaring serta batasan perubahan separasi leher yang memerlukan tindakan adaptasi perencanaan radiasi. Metode : Dilakukan studi kohort prospektif pada 11 pasien kanker Nasofaring. Dilakukan pengukuran berat badan dengan timbangan dan separasi pada tip mastoid , kelenjar getah bening terlebar menggunakan alat ukur di TPS pada data set CT Simulator dan pada CBCT fraksi 1,6,11,16,21,26,dan 31. Data set hasil CBCT dilakukan fusi terhadap data set CT simulator kemudian dilakukan delineasi dan dilanjutkan rekalkulasi dosis dengan parameter yang sama seperti perencanaan radiasi awal kemudian dilakukan evaluasi dosimetri. Jika terdapat deviasi pada minimal 1 organ normal berisiko atau target volume maka masuk ke kriteria untuk dilakukan adaptasi perencanaan radiasi. Batasan waktu dalam menilai hubungan adaptasi perencanaan radiasi dengan parameter klinis dilakukan menggunakan kurva ROC (Receiving Operator Characteristic) Hasil : Dari 11 pasien yang diteliti,terdapat 10 pasien yang memerlukan adaptasi perencanaan radiasi dikarenakan melewati batas toleransi. Perubahan dosimetri yang menyebabkan adaptasi perencanaan radiasi, terjadi pada fraksi dan struktur organ yang berbeda. Hubungan antara waktu fraksinasi dengan indikasi tindakan adaptasi perencanaan radiasi signifikan mulai fraksi ke 6 sedangkan perubahan relative risk terbesar terdapat pada fraksi 11 ke fraksi 16. Indikasi adaptasi perencanaan radiasi dengan parameter klinis; Δ separasi KGB terlebar (AUC 0.951, 95% CI 0.905-0.996), Δ separasi Tip mastoid (AUC) 0.741, 95% CI 0.631-0.852, Δ persentase berat badan ((AUC) 0.911, 95% CI 0.844-0.978). dengan batas tengah kurva ROC pada Δ separasi KGB terlebar 1,21 cm dan Δ persentase berat badan 4,49 %. Kesimpulan : dari penelitian ini, pasien kanker nasofaring membutuhkan radiasi adaptif untuk memberikan terapeutik ratio yang baik dan didapatkan adanya hubungan antara perubahan separasi dan penurunan berat badan dengan adaptasi perencanaan radiasi.
Objectives: to determine appropriate timing for adaptive radiation therapy for nasopharyngeal cancer cases undergoing radiation at the RSCM and to find out the relationship between weight loss and tumor size reduction on dosimetry changes in nasopharyngeal cancer patients and the cut off of changes in neck separation that require adaptive radiation therapy. Methods: A prospective cohort study was conducted on 11 nasopharyngeal cancer patients. Separation measurements were made on the tip mastoid, the widest neck lymph node using a measuring instrument at the treatment planning system (TPS) on the CT Simulator data set and the CBCT data set fractions 1,6,11,16,21,26, and 31. The CBCT data set was fused to the CT data set. The CBCT data set was then delineated and continued with dose recalculation using the same parameters as the initial radiation plan, then dosimetry evaluation was carried out. If there is deviation in at least 1 normal organ at risk or target volume, then it is included in the criteria for adaptive radiation therapy. The time limit in assessing the relationship between adaptive radiation planning adaptive and clinical parameters was carried out using the ROC (Receiving Operator Characteristic) curve. Results: there were 10 out of 11 patients who required adaptive radiation planning due to exceeding the tolerance limit. Dosimetry changes that cause adaptive radiation planning occur in different fractions and organ structures. The relationship between fractionation time and indications of radiation planning adaptative measures is significant starting from the 6th fraction, while the largest relative risk changes are found in fractions 11 to 16. Indications of adaptive radiation planning with clinical parameters; widest lymph node separation (AUC 0.951, 95% CI 0.905-0.996), tip mastoid separation (AUC) 0.741, 95% CI 0.631-0.852, weight percentage ((AUC) 0.911, 95% CI 0.844-0.978). with the middle limit of the ROC curve at the widest KGB separation 1.21 cm and body weight percentage 4.49%. Conclusion: Nasopharyngeal cancer patients require adaptive radiation to provide a good therapeutic ratio and there is relationship between changes in separation and weight loss with adaptive radiation planning"
Depok: Fakultas Kedokteran Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
cover
Sigit Supartono
Phleomorphic adenoma (benign mixed tumor) pada palatum molle (laporan kasus)
"Phleomorphic adenoma is the most commonly found tumor of the salivary glands. This tumor is usually found in the postero-lateral region of the hard palate. In this case, a phleomorphic adenoma tumor situated in the oropharynx region was reported. The CT-Scan results showed an expansive and infiltrative appearance, suspected to be a malignancy, where wide excision was previously planned to be carried out. During surgery, the mass was found pedunculated in the soft palate. It was then decided to perform an excision as the choice of therapy."
Jurnal Kedokteran Gigi Universitas Indonesia, 2003
AJ-Pdf
Artikel Jurnal  Universitas Indonesia Library
cover
Pillipus Resar Andreano
Penilaian ekspresi Mucin-6 (MUC6) pada serrated adenoma dan adenoma konvensional displasia keras sebagai lesi prekursor karsinoma kolorektal = Expression aberrant of Mucin-6 (MUC6) assessment in serrated adenoma and conventional adenoma with severe dysplasia as precursor lesions of colorectal cancer
"Latar belakang. Berdasarkan WHO, lesi-lesi prekursor dapat berkembang menjadi karsinoma kolorektal melalui 2 jalur yaitu adenoma - carcinoma sequence dan serrated pathways. Adenoma carcinoma sequence diawali sel atipik - adenoma displasia ringan - adenoma displasia keras -karsinoma kolorektal, sedangkan serrated pathways dimulai dari aberrant crypt foci (ACF) - polip hiperplastik - serrated adenoma (SA) - karsinoma kolorektal. Salah satu komponen penting pada lesi tersebut adalah musin yang berfungsi untuk melindungi lapisan mukosa saluran pencernaan. Musin dapat mengalami perubahan pada tumor ganas yang berperan dalam proses diferensiasi, proliferasi dan invasi sel tumor. Kepustakaan mengatakan bahwa pulasan IHK Mucin-6 (MUC6) dapat digunakan sebagai penanda bagi serrated adenoma dan adenoma konvensional displasia keras.
Tujuan. Untuk mengetahui ekspresi MUC6 aberrant di sitoplasma sel epitel kripta mukosa kolorektal pada serrated adenoma (SA) dan adenoma konvensional displasia keras.
Bahan dan cara. Penelitian ini dilakukan secara retrospektif, menggunakan studi analitik deskriptif potong lintang, dengan mengumpulkan kasus serrated adenoma (SA) dan pembanding menggunakan kasus adenoma konvensional displasia keras masing-masing 20 kasus. Dilakukan pulasan immunohistokimia (IHK) Mucin-6 (MUC6) terhadap semua kasus.
Hasil. Indeks ekspresi MUC6 aberrant kelompok serrated adenoma menunjukkan hasil sedang-kuat pada sebagian besar kasus, sedangkan kelompok adenoma konvensional displasia keras menunjukkan hasil negatif dan positif lemah pada sebagian besar kasus. Maka dapat disimpulkan terdapat hubungan bermakna antara ekspresi MUC6 aberrant pada kelompok serrated adenoma (SA) dan adenoma konvensional displasia keras, dengan nilai p=0,005.
Kesimpulan. Terdapat hubungan bermakna antara ekspresi MUC6 aberrant kelompok kasus serrated adenoma (SA) dan adenoma konvensional displasia keras.
Background. Based on WHO, precursor lesions can develop into colorectal carcinoma through two pathways, namely adenoma - carcinoma sequence pathways and serrated pathways. Adenoma carcinoma sequence begins atypical cells - adenoma with mild dysplasia - adenoma with severe dysplasia - colorectal carcinoma, whereas serrated pathways begins aberrant crypt foci (ACF) - hyperplastic polyps - serrated adenoma (SA) - colorectal carcinoma. One of the important components of the lesion is the mucin layer which serves to protect the gastrointestinal mucosa. Mucin may experience changes in malignant tumors which play a role in the differentiation, proliferation and invasion of tumor cells. The literature says that the outward appearance of IHC Mucin-6 (MUC6) can be used as a marker for serrated adenoma and conventional adenoma with severe dysplasia.
Objective: To find expression aberrant of MUC6 in the cytoplasm of epithelial cells in the colorectal mucosal crypts serrated adenoma (SA) and conventional adenoma with severe dysplasia.
Materials and method. This study was conducted retrospectively, using a crosssectional descriptive analytic study, by collecting case serrated adenoma (SA) and a comparison using conventional adenoma with severe dysplasia case each of the 20 cases. Do outward MUC6 immunohistochemistry staining in all cases.
Results. Index aberrant expression of Mucin-6 (MUC6) serrated adenoma group showed moderate to strong results in most cases, while the conventional adenoma with severe dysplasia was negative and weakly positive in most cases. So we can conclude there is a relationship between the aberrant expression of Mucin-6 (MUC6) in the serrated adenoma (SA) group and conventional adenoma with severe dysplasia, with p= 0.005.
Conclusion. There is a relationship between the aberrant expression of Mucin-6 (MUC6) serrated adenoma (SA) group and conventional adenoma with severe dysplasia."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T58694
UI - Tesis Membership  Universitas Indonesia Library
<<   1 2 3 4 5 6 7 8 9 10   >>