Hasil Pencarian  ::  Simpan CSV :: Kembali

"To determine the differences in mean plasma values of von willebrand factor and platelet agregation in type 2 DM patient with or without peripheral artirial disease...."

"ABSTRAK"

"Background: thyroid dysfunction is more likely to occur in diabetes mellitus patients than general population. Until now, no study has been done to find prevalence of hypothyroidism and hyperthyroidism in Indonesian diabetics. This study aimed to find the proportion and characteristics of thyroid dysfunction in Indonesian type 2 diabetes mellitus patients. Methods: a cross-sectional study was conducted in Endocrine and Diabetes Polyclinic, Department of Internal Medicine, Cipto Mangunkusumo Hospital from July to September 2015. This study include type 2 diabetes mellitus patients, age ≥ 18 year-old, willing to undergo thyroid laboratory testing. In this study, hypothyroidism defined as TSH more than 4.0 mIU/L, while hyperthyroidism is defined as TSH less than 0.4 mIU/L with eCLIA. Results: from 364 subjects who were recruited from Endocrine and Diabetes Polyclinic, Cipto Mangunkusumo Hospital, 303 subjects underwent this study until analysis. Two hundred and three (273) subjects (90.1%) were euthyroid, 7 subjects (2.31%) were hyperthyroid, and 23 subjects (7.59%) were hypothyroid. Majority of the patients had subclinical hypothyroidism (56.5% based on Zulewski and Billewicz Score and 65.2% based on fT4 laboratory result), while 42.9% and 71.4% subjects had clinical hyperthyroidism based on clinical appearance and fT4 laboratory result respectively. Conclusion: proportion of hypothyroidism was 7.59% and hyperthyroidism was 2.31%, while the proportion of total thyroid dysfunction was 9.9% among diabetics. It is suggested that screening for thyroid dyscfunction can be done in high risk condition as a part of comprehensive management in type 2 diabetes mellitus patients."

"Penelitian ini bertujuan untuk mengetahui hubungan antara profil lipid darah dengan derajat retinopati diabetik penderita DM tipe-2. Penelitian potong-lintang pada 52 pasien retinopati diabetika dilaksanakan di Poliklinik Mata, Rumah Sakit Cipto Mangunkusumo, Jakarta. Data yang dikumpulkan meliputi data demografi, gaya hidup, lama menderita DM, pemeriksaan fisik dan antropometrik, asupan lemak, asam lemak dan kolesterol data kadar gula darah puasa, A1C, kolesterol total, kolesterol-LDL, kolesterol-HDL and trigliserida, dan pemeriksaan fundus. Analisis statistik yang digunakan adalah uji chi-square untuk mengetahui hubungan antara profil lipid darah dengan derajat retinopati diabetik. Subyek terdiri dari 20 orang laki-laki dan 32 orang perempuan dengan rerata usia 53,8 ± 5,2 tahun. Sebanyak 53,8% telah didiagnosis DM selama >10 tahun, dengan rerata IMT adalah 24,1 ± 3,3 kg/m2 dan 38,5% diklasifikasikan sebagai obes I dan II. Rerata kadar gula darah puasa 157,5 ± 71,8 mg/dL, dan A1C 9,1 ± 2,4 %. Sebanyak 40,4% subyek mempunyai kadar kolesterol total darah tinggi, 34,6% kadar kolesterol-LDL darah sangat tinggi, dan 65,4% dengan kolesterol-HDL dan trigliserida darah normal. Derajat keparahan retinopati diabetika ditunjukkan dengan adanya 61,6% subyek dengan retinopati diabetika non-proliferasi berat (NPDR) and retinopati diabetika proliferasi (PDR). Kesimpulannya, belum dapat dibuktikan adanya hubungan yang bermakna antara profil lipid dengan derajat retinopati diabetika.

---

This study aimed to determine the relationship between plasma lipid profile and the severity of diabetic retinopathy in type 2 diabetes patients. A cross sectional study was done in Ophthalmologic Clinic, Cipto Mangunkusumo General Hospital, Jakarta for 52 diabetic retinopathy (DR) patients. Data collected were demographic, life style, duration of diabetes, physical and antropometric examinations, fat, fatty acid and cholesterol intake, fasting plasma glucose, A1C, total-, LDL-, HDL-cholesterol and triglyceride level, and fundus examination.

Statistical analysis was done using chi-square test to see the associations between plasma lipid profile and DR in type 2 diabetes patients. Subjects comprised of 20 males and 32 females diabetes patients with mean age of 53.8 ± 5.2 years. As much as 53.8% had been diagnosed as DM for >10 years. The mean value of BMI was 24.1 ± 3.3 kg/m2 and 38.5% were classified as obese I and II. The mean value of fasting plasma glucose was 157.5 ± 71.8 mg/dL, and A1C was 9.1 ± 2.4 %.

For lipid profile, 40.4% had high total cholesterol level (>240 mg/dL), 34.6% had high and very high LDL-cholesterol level (≥160 mg/dL), and 65.4% had normal HDL-cholesterol (40-60 mg/dL) and triglyceride level (<150 mg/dL). For the severity of retinopathy, 61.6% had severe non-proliferative diabetic retinopahy (NPDR) and proliferative diabetic retinopahy (PDR). In conclusion, there were no significant associations between plasma lipid profile and the severity of diabetic retinopathy."

"Diabetes mellitus tipe 2 adalah penyakit kronis dimana tubuh tidak bisa menggunakan insulin untuk metabolisme glukosa. Penyakit ini terus menerus bertambah setiap tahun baik pada masyarakat perkotaan maupun pedesaan. Disayangkan, penyakit diabetes mellitus tidak dapat disembuhkan, hanya bisa dikendalikan.Penelitian ini bertujuan mengetahui faktor dominan terhadap kejadian pre DM dan DM tipe 2 pada Staf Kependidikan FKM UI, Depok. Variabel independen yang diteliti adalah umur, jenis kelamin, riwayat keluarga, asupan zat gizi (energi, karbohidrat, lemak, dan serat), aktivitas fisik, status gizi lebih, lingkar pinggang, dan pengetahuan gizi. Desain studi penelitian yaitu cross sectional dengan analisis chi square. Penelitian dilakukan pada 122 responden dan pada bulan April 2014.Hasil penelitian menunjukkan 26,2% penderita pre DMDM (Pre DM (17,2%) dan DM (9%)). Variabel yang memiliki perbedaan proporsi yang bermakna dengan kejadian pre DM-DM adalah umur. Faktor dominan adalah riwayat keluarga dan umur. Staf kependidikan FKM UI diharapkan meningkatkan kesadaran untuk melakukan pola hidup sehat baik makan-makanan seimbang maupun olahraga rutin, dan melakukan pengecekan glukosa darah.

---

Diabetes mellitus type 2 is a chronic disease which the body can not use insulin for glucose metabolism. The disease is constantly increasing every year both in urban and rural communities. Unfortunately, diabetes mellitus can not be cured, only controlled.

This study aims to determine the dominant factor on the incidence of pre-diabetes and type 2 diabetes mellitus in Education Staff at FKM UI, Depok. The independent variables studied were age, sex, family history, the adequacy of nutrients (energy, carbohydrates, fats, and fiber), physical activity, BMI, waist circumference, and nutrition knowledge. The study design is a crosssectional study with a chi-square analysis. The study was conducted on 122 respondents, on April 7 to 25, 2014.

Results showed 26.2% of patients with pre-DM - DM (Pre DM (17.2%) and DM (9%)). Variables that had significant differences in the proportion of the incidence of pre-DM and DM is age. Dominant factor is family history ang age. Education Staff at FKM UI is expected to raise awareness for do healthy lifestyle such as eat balanc meals and exercise regularly, and do a blood sugar check."

"Efikasi diri dan kepatuhan merupakan faktor yang penting dalam meningkatkan kualitas hidup pasien DM tipe 2. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat efikasi diri dan kepatuhan dengan kualitas hidup pasien DM tipe 2 yang menjalani rawat jalan di Rumah Sakit di Jakarta.Desain dalam penelitian ini adalah cross sectional, dengan jumlah sampel 125 pasien DM tipe 2. Alat ukur yang digunakan adalah Diabetes Management Self-Efficacy (DMSES), the Diabetes Activities Questionare (TDAQ), dan Diabetes Quality Of Life (DQOL).Hasil penelitian menunjukkan bahwa efikasi diri (0,0005), dan kepatuhan (0,0005) berhubungan secara signifikan dengan kualitas hidup dengan variabel yang paling dominan adalah kepatuhan.Hasil uji multivariat menunjukkan bahwa variabel efikasi diri, kepatuhan, tingkat pendidikan, dan depresi menentukan kualitas hidup pasien DM. Perlunya dikembangkan pengkajian dan intervensi keperawatan yang berfokus pada efikasi diri dan kepatuhan pasien DM tipe 2.

---

Self-efficacy and adherence are important factor in improving the quality of life of patients with type 2 diabetes. This study aimed to determine the relationship between self-efficacy and adherence to the quality of life of patients with type 2 diabetes mellitus in an outpatient unit of a Hospital in Jakarta.

This study was a cross-sectional, with sample of 125 patients with type 2 diabetes mellitus. The Diabetes Management Self- Efficacy (DMSES), the Diabetes Activities Questionare (TDAQ), and the Diabetes Quality of Life (DQOL) were employed as instruments.

The results showed that selfefficacy (0.0005), and adherence (0.0005) were significantly associated with quality of life and the most dominant variable is adherence.

Multivariate test results indicate that the variable self-efficacy, adherence, education level, and depression determines quality of life of diabetic patients. This study suggestsis the need fornursing assessment and interventions that focus on the self-efficacy and adherence diabetes mellitus patient."

"Latar Belakang: Prevalensi Diabetes Melitus (DM) tipe 2 cenderung meningkat di seluruh dunia dan keteraturan pengobatan masih menjadi masalah hingga saat ini. Penelitian terdahulu menemukan bahwa terdapat hubungan antara temperamen dengan kontrol glukosa namun belum banyak penelitian yang membahas hal ini. Penelitian ini bertujuan mengetahui hubungan antara temperamen dengan terkontrol atau tidak terkontrolnya DM tipe 2.Metode: Penelitian ini adalah penelitian analitik potong lintang. Pengambilan sampel dilakukan dengan consecutive sampling pada 110 penyandang DM tipe 2 di Poliklinik Metabolik Endokrin RSCM selama bulan Agustus-Desember 2015. Responden dikelompokkan menjadi penyandang DM terkontrol atau DM tidak terkontrol berdasarkan hasil laboratorium HbA1c terakhir. Responden mengisi kuesioner Modified-Temperament and Character Inventory versi bahasa Indonesia.Hasil: Hasil penelitian ini menunjukkan bahwa skor temperamen harm avoidance, novelty seeking, dan reward dependence tidak berhubungan bermakna dengan terkontrol atau tidak terkontrolnya DM tipe 2.Simpulan: Tidak ada hubungan bermakna antara temperamen dengan pengendalian kadar HbA1c pada penyandang DM tipe 2.

---

Background: Prevalence on type 2 Diabetes Mellitus (DM) tend to increase across the world and regulating treatment still being one of the matters to be discussed until recently. Previous research had found that there are correlations between temperament with glucose control but with limited study on that area. This research aim to qualify the relationship between temperament to controllable or uncontrollable type 2 DM.

Method: This research is a cross sectional sampling method. Sampling conducted with consecutive sampling on 110 respondents with type 2 DM in RSCM Metabolism Endocrine Polyclinic, sampling was done between August to December 2015. Respondents are grouped to two different groups which is controllable DM and uncontrollable DM based on last HbA1c laboratory results. Respondents were requested to fill up Modified-Temperament and Character Inventory questionnaire in Bahasa Indonesia.

Results: Result on this research indicates that temperament score in harm avoidance, novelty seeking, and reward dependence are unrelated with whether Type 2 DM being controllable or uncontrollable.

Conclusion: Absent of significant relation between temperament and HbA1c level control in type 2 DM patients."

"Kriteria utama obesitas menurut WHO adalah IMT namun obesitas sentral lebih berhubungan dengan risiko kesehatan dibanding obesitas umum Tujuan penelitian untuk mendapatkan cut off point dari ketiga indikator dalam mendeteksi terjadinya DMT2. Juga untuk mengetahui hubungan obesitas dengan indikator IMT, LP dan rasio LP-TB dengan terjadinya DMT2 dan menentukan indikator mana yang lebih baik dari ketiganya. Desain Cross Sectional. menggunakan data sekunder. Analisis menggunakan regresi logistic dan metode ROC. Hasil : prevalensi DMT2 9,1% dan prevalensi obesitas berkisar 38,37 % - 41,98 % Nilai cut off obesitas umum IMT ≥ 25,72 kg/m2, LP laki-laki ≥ 80,65 cm perempuan ≥ 80,85 cm dan LP-TB laki-laki ≥ 0,51 perempuan ≥ 0,55. Kesimpulan : orang dengan obesitas meningkatkan risiko terjadinya DMT2 setelah dikontrol faktor umur. Karena hasil ketiga indikator tidak jauh berbeda, maka penggunaanya tergantung keputusan praktisi kesehatan itu sendiri.

---

The WHO's major obesity criteria is BMI but central obesity is more associated to health risks than general obesity. The objective of the research is to define the cut off points of the three measurements in detecting the occurrence of T2DM. It is also aimed to examine the relationship of obesity indicators (BMI, WC, and WHtR) with T2DM and determine the best indicator of them. Design of Cross Sectional employs secondary data. Analysis apply logistic model and ROC method.

The result: prevalence of type 2 DM is about 9.1%, and obesity prevalence is about 38.37 % to 41.98 %. The cut off values of BMI general obesity, male WC, female WC, male WHtR, and female WHtR are ≥ 25.72 kg/m2, ≥ 80.65 cm, ≥ 80.85 cm, ≥ 0.5, and ≥ 0,55 respectively.

Conclusion: adjusted by age, obesity increases the risk of type 2 DM occurrence. Since there is no significantly different result, the use of obesity indicators depends on the health practitioner decisions."

"Diabetes Melitus tipe 2 merupakan sekumpulan gangguan metabolik dengan karakteristik hiperglikemia. Komplikasi klinis akibat DM berkolerasi dengan status glikemik, sehingga diperlukan upaya pengontrolan status glikemik pasien DM, baik jangka pendek, jangka menengah maupun jangka panjang untuk mencegah atau mengurangi komplikasi progresif akibat penyakit tersebut. Parameter laboratorium untuk pemantauan status glikemik meliputi kadar glukosa darah harian, HbA1c, dan albumin glikat (AG). Penelitian ini bertujuan untuk mendapatkan gambaran kadar HbA1c dan kadar AG pada pasien DM tipe 2 tidak terkontrol, mendapatkan korelasi antara kadar HbA1c dan kadar AG, juga melihat penurunan kadar HbA1c dan AG sesudah terapi 1 dan 3 bulan. Penelitian dilakukan dengan desain studi diagnostik, yang melibatkan 32 subyek penelitian yang diikuti selama 3 bulan mulai bulan Februari hingga Mei 2014. Diagnosis DM tipe 2 ditegakkan oleh dokter Spesialis Penyakit Dalam dan diagnosis DM tipe 2 tidak terkontrol didapatkan dari hasil pemeriksaan HbA1c > 7 %. Hasil penelitian mendapatkan rerata (SD) kadar glukosa darah puasa bulan ke-0, ke-1, dan ke-3 berturut-turut sebesar 170,5(51,6) mg/dL; 162,7(54,6) mg/dL, dan 147,3(45,9) mg/dL. Median (rentang) kadar glukosa darah 2 jam postprandial l(G2PP) bulan ke-0 dan ke-1 sebesar 220 mg/dL (90-544) mg/dL dan 191,5 mg/dL (114-468) mg/dL; rerata(SD) kadar G2PP bulan ke-3 sebesar 201(65,98) mg/dL. Korelasi antara kadar HbA1c dan kadar AG adalah : pada bulan ke-0, r=0,79, p<0,001, bulan ke-1 r=0,74, p<0,001 dan bulan ke-3 r=0,78, p<0,001. Penurunan kadar HbA1c dari baseline (delta-1) dan pada bulan ke-3 (delta-3) adalah median (rentang) delta-1 sebesar 0,43% (0,35-0,74)%, p<0,001 dan median (rentang) delta-3 sebesar 0,89% (0,64-2,30)%, p<0,001. Penurunan kadar AG bulan ke-1 dari baseline (delta-1) dan pada bulan ke-3 (delta-3): median (rentang) delta-1 sebesar 0,94% (0,48-1,64)%, p<0,001, dan median (rentang) delta-3 sebesar 1,79% (0,33-1,40)%, p<0,001. Kami menyimpulkan bahwa terdapat korelasi positif bermakna antara kadar HbA1c dan kadar AG pada bulan ke-0, ke-1, dan ke-3, dengan kekuatan korelasi kuat (r = 0.7-0.8), selain itu terdapat penurunan kadar HbA1c dan AG yang bermakna sesudah terapi 1 dan 3 bulan.

---

Type 2 diabetes mellitus (T2DM) is a group of metabolic disorders with hyperglycemic characteristic. Clinical complications of DM correlate with glycemic state, therefore it is necessary to make an effort to control DM glycemic state, in short-, medium-, and long-term to prevent or minimize progressive complications due to the disease. Laboratory parameters to monitor glycemic state include daily blood glucose, HbA1c, and glycated albumin (GA).

This study aimed to obtain HbA1c and GA levels in uncontrolled type 2 DM patients, the correlations between HbA1c and GA levels, and also the decrease in HbA1c and GA levels after 1 month and 3 months treatment. This was a diagnostic study involving 32 subjects that were followed for 3 months from February to May 2014. Type 2 DM was diagnosed by the internist in the Department of Internal Medicine and the uncontrolled type 2 DM was confirmed by HbA1c measurement of > 7%.

The results showed that mean (SD) fasting blood glucose levels at baseline, 1 month and 3 months were 170.5 (51.6) mg/dL; 162.7 (54.6) mg/dL, and 147.3(45.9) mg/dL, respectively. Median (range) 2 hours postprandial blood glucose levels at baseline and 1 month respectively, were 220 mg/dL (90-544) mg/dL and 191.5 mg/dL, respectively, and mean (SD) at 3 months was 201,7 (65,98) mg/dL. Correlations between HbA1c and GA levels : at baseline r =0.79, p<0.001, at 1 month r=0.74, p<0.001 and at 3 months r=0.78, p<0.001.

Decreases of HbA1c level from baseline, at 1 month (delta-1) and at 3 months (delta-3) : median (range) delta-1was 0.43% (0.35-0.74)%, p<0.001 and median (range) delta-3 was 0.89% (0.64-2.30)%, p<0.001. Decreases of GA level from baseline, at 1 month (delta-1) and at 3 months (delta-3) : median (range) delta-1 was 0.94%(0.48-1.64)%, p<0.001, and median (range) delta-3 was 1.79%(0.33-1.40)%, p<0.001.

We concluded that there were significant positive correlations between HbA1c and GA levels at baseline,1 month and 3 months, with strong correlations (r=0.7-0.8). In addition, there were also significant decreases in HbA1c and GA levels from baseline at 1 month and 3 months therapy."

"Indonesia merupakan negara terbanyak keempat kematian akibat diabetes Mellitus dan penyakit jantung diantara negara-negara Asia Tenggara. Penelitian dengan desain studi cross sectional ini bertujuan untuk mengetahui gambaran biaya akibat sakit serta kualitas hidup pasien diabetes mellitus tipe 2 dengan penyakit jantung dengan sampel 110 orang di RSUD Dr.M.Yunus Bengkulu. Rata-rata biaya pasien akibat sakit diabetes mellitus tipe 2 dengan penyakit jantung selama setahun adalah Rp. 6.081.572 dimana komposisi biaya langsung adalah (81,54%) dan biaya tidak langsung (18,46%). Proporsi terbesar adalah biaya obat (37,05%). Faktor-faktor yang mempengaruhi biaya akibat penyakit tersebut adalah Lama Hari Rawat (LHR) dan jenis pekerjaan sedangkan faktor yang mempengaruhi kualitas hidup pasien adalah Lama/durasi sakit. Disarankan agar RSUD.dr.M.Yunus Bengkulu menyusun clinical pathway dan formularium rumah sakit. Pemerintah perlu merevisi formularium nasional dengan memperhatikan kondisi lokal dan mengembangkan program peningkatan kualitas hidup pasien.

---

Indonesia is the fourth most deaths due diabetes mellitus and heart disease among south Asia countries. This study with cross-sectional design is aiming to describing the cost of illness and quality of life of patients with type 2 diabetes mellitus with heart disease in dr.M.Yunus public hospital. Number of samples was110 patients. The annual cost of illness due to type 2 diabetes mellitus with heart disease perpatient was Rp. 6,081,572, with direct cost is reached (81.54%) and indirect cost (18.46%). The largest proportion of the cost was drug (37.05%). Factors that affect COI were Length of Stay (LOS) and the type of work, and factor affect quality of life was duration of illness. It is recommended that dr.M.Yunus Public Hospital Bengkulu should prepare clinical pathways and hospital formulary. The central government needs to revise national formulary with considering variability of country situation and develop program to improve quality of DM patient."