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Sulaiman Yusuf
"Recurrent abdominal pain is one of the most common symptoms found in children. Description of abdominal pain is important in determining the etiologic cause. Organic pain must be ruled out first before suspecting psychogenic cause of pain. However; Children and infant are likely having difficulties in describing abdominal pain. Referred pain may lead to misdiagnosis. Alarm symptoms of abdominal pain are important indices and must be recognized. Careful and complete anamnesis and physical examination play critical role in management approach of recurrent abdominal pain in children and determine whether medical therapy only or combination with surgical intervention is considered necessary."
Jakarta: The Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy, 2006
IJGH-7-2-Agt2006-42
Artikel Jurnal  Universitas Indonesia Library
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Harsono
"ABSTRAK
Nyeri pasca bedah abdomen adalah gabungan dari beberapa pengalaman sensori, emosional, dan mental yang tidak menyenangkan akibat trauma bedah. Walaupun nyeri telah dikelola dengan baik, kira-kira 86% pasien mengalami nyeri sedang ke hebat pasca bedah meskipun analgesik ditingkatkan. Penelitian ini bertujuan mendeskripsikan karakteristik responden (exploratory study) dan selanjutnya menjelaskan faktor-faktor yang mempengaruhi intensitas nyeri pasca bedah abdomen (explanatory study). Desain penelitian ini adalah deskriptif analitik dengan pendekatan cross sectional pada 67 orang responden pasca bedah abdomen. Pada penelitian ini digunakan instrumen State Anxiety Inventory (S-AI) Form Y untuk menilai keadaan cemas pasien pasca bedah abdomen, sikap dan keyakinan terhadap nyeri, dan skala nyeri untuk menilai intensitas nyeri pasca bedah menggunakan kombinasi Visual Analog Scale (VAS) dan Numeric Rating Scale (NRS). Hasil penelitian ini menunjukan bahwa faktor-faktor yang mempengaruhi secara signifikan terhadap intensitas nyeri pasca bedah abdomen adalah jenis kelamin (p value = 0,005), letak insisi (p value = 0,0005), dan tingkat kecemasan (p value = 0,0005). Faktor yang paling mempengaruhi intensitas nyeri pasca bedah abdomen adalah tingkat kecemasan (standardized coefficient β 0,501). Hasil penelitian ini bermanfaat bagi praktisi keperawatan sebagai acuan asuhan keperawatan dalam melakukan pengelolaan nyeri pasca bedah abdomen untuk mempertimbangkan faktor tingkat kecemasan, jenis kelamin, dan letak insisi. Rekomendasi hasil penelitian ini perlu adanya penelitian lebih lanjut dengan jumlah sampel yang lebih besar dan faktor-faktor lain yang dapat mempengaruhi nyeri.

ABSTRACT
Abdominal postoperative pain is a combined of several unpleasant sensory, emotional, and mental experience precipitated by the surgical trauma. Pain experience are influenced by many factors and it is difficult to understand and about 86% of patients experience moderate to severe pain following surgery in the hospital. The purpose of this study was to identify the characteristic of respondent (exploratory study) and to explain influencing factors of abdominal postoperative pain intensity (explanatory study). The design was an analytic description using a cross sectional for 67 respondents abdominal postoperative. In the study using State Anxiety Inventory (S-AI) Form Y instrument was used to measure the abdominal postoperative state anxiety, attitudes and beliefs about pain, and pain scale using a combined Visual Analog Scale (VAS) and Numeric Rating Scale (NRS) was used to measure postoperative pain intensity. The finding showed that gender (p value = 0,005), incision site (p value = 0,0005), and anxiety levels (p value = 0,0005) were significantly influencing factors of abdominal postoperative pain intensity. The most influencing factor of abdominal postoperative pain intensity was anxiety levels (standardized coefficient β 0,501). This study information for nursing practitioner as reference in nursing care planning should be considered anxiety levels, gender, and incision site to management of patients with postoperative pain relief. It is recommended to conduct further research using more samples and other factors that also may alter pain reaction.
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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2009
T-Pdf
UI - Tesis Open  Universitas Indonesia Library
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Nauli, Cindi Fakta
"Konstipasi merupakan salah satu masalah umum yang dialami oleh lansia karena manifestasi dari perubahan fisiologis pada tubuh mereka. Konstipasi adalah kondisi saat lansia mengalami buang air besar yang jarang dan sulit dengan tinja yang keras serta sensasi buang air besar yang tidak tuntas atau mengejan. Tujuan penulisan ini adalah untuk mengidentifikasi asuhan keperawatan yang sesuai bagi lansia dengan konstipasi dan mengevaluasi intervensi unggulan yang dapat diberikan. Salah satu intervensi keperawatan yang dapat dilakukan untuk mengatasi konstipasi adalah masase abdomen dengan minyak aromaterapi lavender, jahe, dan almond yang dilakukan selama lima hari berturut-turut pada lansia yang mengalami konstipasi. Hasil dari intervensi yang dilakukan menunjukkan bahwa masase abdomen dengan minyak aromaterapi lavender, jahe, dan almond efektif dalam menurunkan gejala ketidaknyamanan seperti kembung, kurangnya frekuensi BAB, tekanan pada rektum, nyeri pada rektum, ukuran feses yang kecil tapi keras dan merasa mulas namun kesulitan buang air besar. Hasil evaluasi juga menunjukkan bahwa intervensi tersebut menurunkan skor Constipation Assessment Scale (CAS) pada lansia dengan konstipasi.

Constipation is a common problem experienced by the elderly because it is a manifestation of physiological changes in their bodies. Constipation is a condition when elderly people experience infrequent and difficult defecation with hard stools and the sensation of incomplete defecation or straining. The aim of this paper is to identify appropriate nursing care for elderly people with constipation and evaluate superior interventions that can be provided. One of the nursing interventions that can be carried out to treat constipation is abdominal massage with lavender, ginger, and almond aromatherapy oil which is carried out for five consecutive days for elderly people who experience constipation. The results of the intervention carried out showed that abdominal massage with lavender, ginger, and almond aromatherapy oil was effective in reducing symptoms of discomfort such as bloating, lack of frequency of defecation, pressure in the rectum, pain in the rectum, small but hard stools and feeling heartburn but having difficulty defecating. The evaluation results also showed that the intervention reduced Constipation Assessment Scale (CAS) scores in elderly people with constipation.
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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2024
PR-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Indra Raymond
"Latar belakang :Tesis ini membahas tentang analisis kasus kematian pada pasien Aneurisma aorta abdominal di RSUP Fatmawwati yang menjalani operasi elektif. Sampel dan Metode : Data pasien diambil periode 2013 sampai April 2018. Semua pasien yang meninggal dari operasi elektif aneurisma aorta abdominal akan di data. Penelitian ini ditampilkan dalam bentuk deskriptif, dengan data kualitatif dan kuantitatif. Data kualitatif didapatkan dengan melakukan wawancara dengan tim operasi, operator, tim anestesi dan paramedis instrumen. Data kuantitatif didapatkan dengan telusur rekam medis. Hasil : Terdapat 27 kasus, selama periode 2013 sampai April 2018. Hanya 15 kasus yang rekam medis lengkap, 5 kasus hidup, 2 kasus meninggal pada operasi emergency dan 8 kasu meninggal pada operasi elektif. Dari 8 kasus ini, 5 kasus disertai anemia dan trombositopenia yang menetap sampai pada tahap postoperasi, 2 kasus dengan gangguan ginjal dan 1 kasus dengan penyebab yang belum jelas. Pada 8 kasus kematian, lama operasi berkisar dari 4 jam 20 menit sampai 8 jam 10 menit. Jumlah perdarahan berkisar dari 750 cc sampai 7.000 cc. Kadar creatinin preoperasi, berkisar dari 1,0 sampai 4,3 mg/dL. Kadar creatinin postoperasi berubah dari 1,0 sampai 4,5 mg/dL. Kadar hemoglobin postoperasi berkisar 5,9 sampai 9,4 g/dL. Kadar trombosit, berkisar 45.000 sampai 108.000/uL. Rata rata jumlah perdarahan adalah 3.156 cc. Kesimpulan : Penelitian ini menyimpulkan bahwa kasus dengan hasil akhir kematian, sebagian besar disertai oleh jumlah perdarahan yang masif. Perbaikan yang dilakukan untuk resusitasi komponen darah tidak mencapai hasil yang optimal.

Background : The aim of this study is to confirm the factors that affect the mortality following open elective abdominal aortic aneurysm repair. Subject and Methode : This study was a retrospective study. Qualitative and quantitave data were collected from interviewing the team in charge and from the hospital database medical record. The data were collected for five years, from 2013 until April 2018. Data will be displayed in descriptive. Result : Twentyseven cases were hospitalized during the periode of 2016 until April 2018. Ten cases were not availlable to analyze, medical record were missing. Out of two case from these fivteen cases, was an emergency case. Five cases were alive when they discharge from the hospital. The other eight were elective cases and were able to analyze. Five cases, out of this eight, were accompanied by anemia and thrombositopenia, which last until they all move from the surgery room to the ICU. Two cases with renal disfunction, and one case with unclear cause of death. Duration of surgery in all this elective cases, ranged from 4 hours 20 minutes until 8 hours 10 minutes. Bood loss during surgery, estimated from 750 cc to 7.000 cc. Preoperative creatinin level, ranged from 1,0 to 4,3 mg/dL. Postoperative cretainin level, ranged from 1,0 to 4,5 mg/dL. Postoperative hemoglobin level, ranged from 5,9 to 9,4 g/dL. Postoperative platelet count , ranged from 45.000 to 108.000/uL. Mean blood loss during surgery was 3.156 cc. Conclusion : This study concluded that most of the death case was accompanied by massive bleeding. And all those attempt to improve by blood rescusitation, was not promptly worked."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
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UI - Tugas Akhir  Universitas Indonesia Library
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Andrew Renato Nafarin
"ABSTRAK
Latar belakang: Sakit perut berulang SPB merupakan penyebab terbanyak dari sakit kronis pada anak. Irritable bowel syndrome IBS merupakan salah satu penyebab terbanyak dari SPB, ditandai oleh nyeri/ rasa tidak nyaman pada perut dan perubahan fungsi saluran cerna. Patofisiologi IBS saat ini banyak dihubungkan dengan gangguan pada mikroflora usus. Belum ada data tentang mikroflora usus pada anak dengan IBS di Indonesia.Tujuan: Mengetahui pola mikroflora saluran cerna pada anak penderita IBS dan anak sehat berusia 13-18 tahun di Indonesia.Metode: Penelitian kasus-kontrol dilakukan pada 22 anak penderita IBS dan 28 kontrol pada anak usia 13-18 tahun di SMP dan SMA di Jakarta Pusat. Diagnosis IBS menggunakan kriteria Rome III. Usia, jenis kelamin, pendidikan dicatat saat awal penelitian. Spesimen feses dikumpulkan lalu diperiksa jumlah Bifidobacterium dan Enterobacteriaceae.Hasil: Penderita IBS terbanyak dari perempuan 17/22 dengan median usia 16 tahun. Nilai median Bifidobacterium spp sebesar 138,95 rentang 0,2 ndash;22.735,8 pada kelompok IBS dan 232,5 rentang 1,9 ndash;38.985,6 CFU/gram pada kelompok kontrol. Tidak ada perbedaan bermakna Bifidobacterium antara kedua kelompok p=0,493 . Nilai median Enterobacteriaceae sebesar 58,9 rentang 2,5 ndash;9.577,8 CFU/gram pada kelompok IBS dan 85 rentang 12,1 ndash;3.139,4 CFU/gram pada kelompok kontrol. Tidak ada perbedaan bermakna Enterobacteriaceae antara kedua kelompok p=0,938 .Simpulan: Tidak didapatkan perbedaan bermakna antara jumlah Bifidobacterium dan Enterobacteriaceae pada kelompok IBS maupun kontrol. Terdapat kecenderungan peningkatan jumlah Enterobacteriaceae pada kelompok IBS dan peningkatan jumlah Bifidobacterium pada kelompok kontrol.Kata kunci: irritable bowel syndrome, mikroflora usus, Bifidobacterium, Enterobacteriaceae
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"ABSTRACT
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Background Recurrent abdominal pain RAP is the most frequent cause of chronic pain in children. Irritable bowel syndrome IBS is one of the most occuring type of RAP, marked with abdominal pain discomfort and changes in bowel movement. The current pathophysiology of IBS is associated with alterations of gut microflora. Currently, there is no data about gut microflora in children with IBS in Indonesia.Aim To evaluate gut microflora in healthy children and children with IBS aged 13 18 years old in Indonesia.Methods A case control study was conducted to 22 IBS children and 28 healthy subjects aged 13 18 years old at junior high school and senior high school in Central Jakarta. Irritable bowel syndrome diagnosed using Rome III criteria. Age, sex, and level of education were recorded. Stool samples were collected and investigated for Bifidobacterium and Enterobacteriaceae.Result Most of the IBS subjects were females 17 22 with a median age 16 years old. The median value of Bifidobacterium spp was 138.95 range 0.2 ndash 22,735.8 for the IBS subjects and 232.5 range 1.9 ndash 38,985.6 CFU gram on healthy subjects with no statistical difference p 0,493 . The median value of Enterobacteriaceae was 58.9 range 2.5 ndash 9,577.8 on IBS subjects and 85 range 12.1 ndash 3,139.4 CFU gram on healthy subjects with no statistical difference p 0,938 .Conclusion There was no statistical difference for Bifidobacterium and Enterobacteriaceae on either IBS or healthy subjects. There was an increasing tendency of Enterobacteriaceae on IBS subjects and increasing tendency of Bifidobacterium on healthy subjects.Keywords irritable bowel syndrome, gut microflora, Bifidobacterium, Enterobacteriaceae"
2017
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Agnes Minarni
"Latar Belakang: Sebagian besar pasien pasca pembedahan abdominal yang masuk ICU menggunakan alat bantu berupa ventilasi mekanik. Kecemasan akibat penggunaan ventilasi mekanik dapat meningkatkan respon stres pasca pembedahan yang bila dibiarkan dapat menghasilkan hal-hal yang tidak diinginkan. Sedasi dibutuhkan untuk meniminalkan respon stres yang terjadi akibat penggunaan ventilasi mekanik. Deksmedetomidin dan midazolam merupakan agen sedasi yang banyak digunakan di ICU.
Metode: Penelitian uji klinis acak tersamar ganda ini mengelompokkan 22 pasien dewasa pascabedah abdominal yang mendapat layanan sedasi di ruang ICU RSCM menjadi 2 kelompok. Grup deksmedetomidin menerima 0,5 μg/kgbb intravena. Grup midazolam menerima 0,05 mg/kgbb intravena. Pemberian ke dua obat tanpa loading dose dan mulai diberikan setelah pasien tiba di ICU pada skala RASS nol (0). Kriteria inklusi adalah pasien dengan rentang usia 18-65 tahun, ASA I sampai III yang membutuhkan ventilasi mekanik pascabedah abdominal.
Hasil: Deksmedetomidin dan midazolam tidak mampu menurunkan respon stres karena hanya satu dari tiga parameter yang signifikan secara statistik. Penurunan gula darah terjadi pada grup midzolam setelah 6 jam pasca pembedahan abdominal (p<0,05), sedangkan untuk kadar IL-6 dan kortisol tidak ada perbedaan yang signifikan (p>0,05). Skala RAAS pada grup deksmedetomidin menunjukkan perbedaan yang signifikan dibandingkan grup midazolam (p<0,05) sedangkan FAS tidak ada perbedaan yang signifikan (p>0.05).
Simpulan: Sebagai agen sedasi, deksmedetomidin dan midazolam tidak mampu menurunkan respon stres pada pasien yang menggunakan ventilasi mekanik pasca bedah abdominal. Tingkat sedasi pada grup deksmedetomidin lebih baik daripada grup midazolam, tetapi deksmedetomidin dan midazolam sama-sama mampu meminimalkan kecemasan.

Background: Post-operative mechanical ventilation were often needed in patients after abdominal surgeries. Sedation was often given to minimize anxiety and stress response to mechanical ventilation. Both dexmedetomidine and midazolam are commonly used as sedatives in ICU. This study was aimed to compare the ability of dexmedetomidine and midazolam in reducing anxiety and stress response.
Methods: Twenty two patients aged 18-65 years, ASA physical status I to III, underwent abdominal surgery and requiring postoperative ventilation were included. Subjects were randomly divided into equal groups. Subjects in group D received dexmedetomidine 0.5 µg/kg iv, while in group M received midazolam 0,05 mg/kg iv. Vital signs, Face Anxiety Scale, RASS score, cortisol, blood glucose and IL-6 level were taken at baseline when subjects were admitted to the ICU and followed up until 6 hours.
Results: Both of dexmedetomidine and midazolam can not decreased stress response, in group M only decreased blood glucose level after 6 hours post-operative achieved statistical significance (p<0.05). Only RASS scale was significantly differed between group D and group M(p<0.05), while there was no statistically significant difference in other measured parameters.
Conclusions: Both dexmedetomidine and midazolam as sedative can not decreased stress response on abdominal surgery patients who required mechanical ventilation. Sedation level of dexmedetomidine was better than midazolam, but both of them can minimize anxiety.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Perwira Widianto
"Aneurisma aorta abdominal merupakan kasus yang relatif sering dijumpai, namun hingga saat ini belum ada analisis karakteristik serta evaluasi klinik yang memadai. Dilakukan penelitian dengan desain retrospektif analitik untuk mendapatkan karakteristik serta evaluasi klinik melalui data rekam medis. Dilakukan analisis pada faktor risiko pasien untuk melihat hubungan dengan tipe aneurisma, letak aneurisma, serta komplikasi pasca bedah. Selama Januari 2009 - Desember 2012 terdapat 32 pasien aneurisma aorta abdominal. didapatkan beberapa faktor risiko pasien 15 orang dengan diabetes, 22 orang dengan hipertensi, 24 orang dengan perokok serta 11 orang dengan riwayat aneurisma dalam keluarga. Didapatkan perbedaan signifikan pada kategori usia dengan tipe aneurisma (p=0,012). Demikian dengan jenis kelamin dengan tipe aneurisma (p=0,012). Pada uji statistik juga didapatkan kemaknaan fraksi ejeksi jantung (p=0,047) dan ukuran aneurisma (p= 0,009) terhadap tipe aneurisma. Juga terdapat kemaknaan faktor sistolik preoperatif terhadap komplikasi pasca bedah (p=0,025).

Abdominal aortic aneurysm (AAA) is relatively common in Indonesia, however until the present, there is no sufficient data on the characteristics and clinical evaluation of AAA. This study utilized an analytic retrospective design to obtain data on the characteristics and clinical evaluation of AAA. Analysis was done to evaluate the association between risk faktors and the type of aneurysm, location of the aneurysm, and postoperative complications.Between January 2009 and December 2012, 32 patients with abdominal aortic aneurysm treated in RS Dr. Cipto Mangunkusumo. Risk faktors were identified, 15 patients had diabetes, 22 patients had hypertension, 24 patients were smokers, and 11 patients had a family history. Significant association was found between age category (above and below 45 years) and the type of aneurysm (p=0,012). Significant association was also found between gender and the type of aneurysm (p=0,012). It also was done to evaluate the association between cardiac ejection fraction (p=0,047) and the aneurysm diameter (p= 0,009) as risk faktors for the type of aneurysm. Significant association was also found between postoperative complications and preoperatif systolic blood pressure (p=0,025).
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T59165
UI - Tesis Membership  Universitas Indonesia Library
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Silitonga, Freddy Guntur Mangapul
"Latar belakang : Pembedahan abdomen secara laparotomi menyebabkan penurunan kadar albumin. Kadar albumin di bawah 3,00 g/dL berperan dalam terjadinya mortalitas dan morbiditas pasca-operasi.
Tujuan: Mengetahui hubungan antara kadar albumin pre-operasi dan pasca-operasi terhadap luaran klinis pasca-operasi laparotomi.
Metode : Penelitian ini dengan desain kohort retrospektif menggunakan data rekam medis Departemen Ilmu Kesehatan Anak tahun 2015-2017. Total sampling pada pasien pasca-laparotomi di PICU dengan rentang usia 1 bulan hingga 18 tahun, dikelompokan ke dalam dua kategori, yaitu: albumin ≤ 3,0 g/dL dan > 3,00 g/dL. Subyek diambil data luaran klinis pasca-operasi seperti sepsis pasca-operasi, infeksi luka operasi, dehisens, relaparotomi, dan lama rawat di PICU.
Hasil : Dua ratus satu subyek pasca-laparotomi diikutsertakan dalam penelitian ini. Kadar albumin pre-operasi ≤ 3,0 g/dL meningkatkan risiko terjadinya sepsis pasca-operasi (RR 3,40(95%IK: 1,54-7,51), relaparotomi (RR 3,84(95%IK: 1,28-11,49), dan lama rawat PICU 2 kali lebih lama daripada normoalbuminemia. Kadar albumin pasca-operasi ≤ 3,0 g/dL meningkatkan risiko terjadinya sepsis pasca-operasi (RR 2,55(95%IK: 1,40-4,63) dan lama rawat PICU 1 hari lebih lama daripada normoalbuminemia. Mortalitas pada kelompok hipoalbuminemia sebesar 19,2% dengan RR 3,44(95%IK: 1,07-11,07).
Simpulan : Hipoalbuminemia pre-operatif atau pasca-operatif meningkatkan risiko kejadian sepsis pasca-operatif. Hipoalbuminemia pre-operatif atau pasca-operatif tidak berhubungan dengan infeksi luka operasi. Hipoalbuminemia pre-operatif atau pasca-operatif tidak berhubungan dengan risiko kejadian dehisens. Hipoalbuminemia pre-operatif meningkatkan risiko untuk menjalani relaparotomi. Hipoalbuminemia pre-operatif atau pasca-operatif memperpanjang lama rawat di PICU. Hipoalbuminemia pre-operatif meningkatkan angka mortalitas.

Backgrounds : Laparotomy abdominal surgery decreasing serum albumin. Serum albumin concentration below 3,00 g/dL associated with postoperative morbidity and mortality.
Aim: To determine the relationship between serum albumin (preoperative and postoperative) and postoperative clinical course.
Methods : Retrospesctive observational study in pediatric patients undergoing laparotomy and hospitalized in Pediatric Intensive Care Unit during January 2015- December 2017. Post-laparotomy patients over the age range 1 month to 18 years, classified according to serum albumin concentration: ≤ 3,0 g/dL and > 3,00 g/dL. Postoperative outcome measured by postoperative sepsis, surgical site infection, dehiscence, relaparotomy, PICU length of stay, and mortality.
Results : Two hundred and one subjects undergone laparotomy participated. Preoperative serum albumin ≤ 3,0 g/dL increase risk of postoperative sepsis (RR 3,40 (95%CI: 1,54-7,51)), relaparotomy (RR 3,84 (95%CI: 1,28-11,49)), and twice longer in Pediatric Intensive Care Unit length of stay. Postoperative albumin ≤ 3,0 g/dL increase risk of postoperative sepsis (RR 2,55(95%CI: 1,40-4,63)) and Pediatric Intensive Care Unit length of stay. Mortality rate in hypoalbuminemic group is 19,2% with RR 3,44(95%CI: 1,07-11,07).
Conclusions : Preoperative and postoperative hypoalbuminemia increase risk of postoperative sepsis. Preoperative and postoperative hypoalbuminemia not associated with risk of surgical site infection and wound dehiscense. Preoperative hypoalbuminemia increase risk of relaparotomy. Preoperative and postoperative albumin concentration inversely related with Pediatric Intensive Care Unit length of stay. Preoperative hypoalbuminemia increase mortality rate.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
T58705
UI - Tesis Membership  Universitas Indonesia Library
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Nyityasmono Tri Nugroho
"Latar Belakang: Penyakit AAA sebagian besar berlokasi pada infrarenal. Mortalitas meningkat dengan ruptur. Faktor risiko utama ruptur adalah diameter aneurisma dan hipertensi. Analisis computational fluid dynamic (CFD) pada aliran darah memungkinkan untuk mengetahui predileksi area tempat terjadinya ruptur. Wall shear stress (WSS) dan tekanan dinding merupakan parameter yang bisa dianalisis melalui CFD untuk melihat potensi ruptur pada AAA. Tujuan: Mengetahui morfologi aneurisma AAA infrarenal beserta sebaran nilai WSS dan tekanan dinding aneurisma berdasarkan CFD untuk memprediksi ruptur aneurisma. Metode: Studi cross-sectional dengan analisis CT angiogram pasien AAA infrarenal di Divisi Vaskular dan Endovaskular-Departemen Bedah dan Departemen Radiologi RSUPN Dr. Cipto Mangunkusumo pada bulan Juli–Desember 2022. Data CT angiografi diolah dengan Radiant Viewer untuk dijadikan model 3D. Dari keseluruhan sampel, dikelompokkan menjadi 5 tipe aneurisma. Kemudian masing-masing model dilakukan proses pembuatan solid vessel dengan Meshmixer. Proses selanjutnya adalah geometri, meshing, setup parameter CFD, dan solution untuk menghasilkan kontur WSS dan tekanan dinding pada berbagai kecepatan dan tekanan darah dengan program ANSYS 2022 R2 Academic Student. Hasil visual pada tiap tipe dianalisis dan dibandingkan. Uji statistik non-parametrik WSS dan tekanan dinding pada tiap tipe dan antar grup menggunakan SPSS 25.0 dengan nilai p dianggap bermakna jika p<0,05. Hasil: Dari 93 CT angiogram, setelah eksklusi didapatkan 40 sampel. Median usia 67 (47-76 th), dengan 90% adalah laki-laki. Sebanyak 25% sampel memiliki komponen sakular. Hasil analisis visual, terdapat korelasi area antara WSS terendah dengan tekanan dinding tertinggi. Perubahan kecepatan dan tekanan darah inisial juga mengubah nilai dan luas area pada kontur WSS dan tekanan dinding aorta, meskipun pusat perubahan kontur masih berada pada area yang relatif sama. Terdapat perbedaan bermakna pada WSS dan tekanan dinding (p=0,038 dan p<0,001). Kesimpulan: Area WSS terendah berkaitan dengan lokasi tekanan dinding tertinggi. Berubahnya kecepatan dan tekanan darah, mempengaruhi luas dan nilai dari WSS dan tekanan dinding.

Background: AAA disease is mostly located in infrarenal. Mortality increases with rupture. The main risk factors for rupture are diameter sac and hypertension. Computational fluid dynamic (CFD) analysis of blood flow allows for a detection where rupture area will occur. Wall shear stress (WSS) and wall pressure are parameters that can be analyzed through CFD to see the potential location for rupture in AAA. Objective: Knowing the morphology of infrarenal AAA along with the distribution of WSS values ​​and aneurysmal wall pressure based on CFD to predict aneurysm rupture. Method: Cross-sectional study with CT angiogram analysis of infrarenal AAA patients in the Vascular and Endovascular Division-Department of Surgery and the Department of Radiology RSUPN Dr. Cipto Mangunkusumo in July–December 2022. CT angiography data was processed with Radiant Viewer to be used as a 3D model. From the whole sample, grouped into 5 types of aneurysms. Then for each model the process of making a solid vessel is carried out with the Meshmixer. The next process is geometry, meshing, CFD parameter setup, and solutions to produce WSS and wall pressure contours at various speeds and blood pressures with the ANSYS 2022 R2 Academic Student program. Visual results for each type were analyzed and compared. WSS and wall pressure non-parametric statistical test were performed for each type and between groups using SPSS 25.0 with a p-value considered significant if p <0.05. Results: Of the 93 CT angiograms, after exclusion, 40 samples were obtained. Median age 67 (47-76 years), with 90% were men. As much as 25% of the sample had a saccular component. The results of the visual analysis showed that there was an area correlation between the lowest WSS and the highest wall pressure. Changes in velocity and initial blood pressure also changed the value and area of ​​the WSS and the aortic wall pressure contours, although the center of the contour change was still in the relatively same area. There was a significant difference in WSS and wall pressure (p=0.038 and p<0.001). Conclusion: The area of ​​lowest WSS corresponds to the location of the highest wall pressure. Changes in blood velocity and pressure affect the area and value of WSS and wall pressure."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Badriul Hegar
"Recurrent abdominal pain (RAP) is a very common presenting complaint in pediatric population. There is still a debate regarding the role of Helicobacter pylori (H. pylori) infection as an etiology of RAR Typically the inflammatory process in the gastric mucosa of infected individuals is chronic gastritis. Serologic and histologic examination are widely used for the diagnosis. This study was aimed to determine the role of H.pylori infection in Indonesian children with RAR The presence of serum IgG antibody to H. pylori and upper gastrointestinal endoscopy were performed on the 101 children with RAR Mztcosal biopsies were obtained for histologic analysis. The prevalence of H. pylori infection indicated by serology was 32.7% and by histology was 27. 7%. Histologic evidence of gastritis was present in 94.1 % children and 45% of them had chronic atrophic and active gastritis. Seventy percent children with H. pylori positive were found abnormal through endoscopy and all of the infected children were revealed abnormal through histological examination. Forty eight percent of seropositive children were found H. pylori positive and 80% of seronegatives children were found to be H pylori negative through histologic examination. Conclusion: H. pylori infection can be a cause of RAP in children. Work up for H. pylori infection should be performed when symptoms are suggestive of organic disease. Larger prospective studies are needed to be perforated for a longer time of period to clarify this issue."
Jakarta: The Indonesian Journal of Gastroenterology Hepatology and Digestive Endoscopy, 2001
IJGH-2-2-Agt2001-1
Artikel Jurnal  Universitas Indonesia Library
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