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"Penatalaksanaan kanker payudara mungkin merupakan suatu hal yang amat kontrovesial dan telah mengalami perubahan luarbiasa dengan berjalannya waktu."

"Penatalaksanaan kanker payudara mungkin merupakan suatu hal yang amat kontroversial dan telah mengalami perubahan luarbiasa dengan berjalannya waktu. MRI dengan kontras muncul sebagai alat diagnostik pencitraan yang paling efisien. Pendekatan yang mutakhir untuk biopsi kanker payudara yang tidak sesuai untuk pembedahan, ditujukan untuk mendapatkan sampel jaringan yang cukup untuk keperluan diagnostik namun meminimalkan penyebaran dan resiko komplikasi. Penanganan regional yang dilakukan Halstead secara ketat, walaupun berhasil mengendali lokal regional secara bermakna, namun tidak berhasil meningkatkan kesintasan (survival) jangka panjang. Dengan berjalannya waktu, orang telah memahami disposisi sistemik penyakit ini dan pentingnya menggabungkan terapi sistemik bahkan sejak tahap dini dan melengkapi teknik ablatif surgikal. Peranan terapi sistemik primer dalam manajemen kanker payudara dengan cepat muncul sebagai suatu pilihan yang vital. Pada pasien dengan ekspresi berlebih gen HER 2/neu, tambahan ?transtuzumab? pada pengobatan sistemik menghasilkan peningkatan yang jelas pada kesintasan secara keseluruhan.

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AbstractThe management of breast cancer is perhaps the most controversial of all and has evolved a sea change over the years. Contrast enhanced MRI imaging is emerging as the most efficient imaging diagnostic tool. Newer approaches for the biopsy of inoperable breast cancer are aimed at obtaining diagnostically adequate tissue samples while minimizing invasiveness and the risk of complications. The regional vigour that Halsted followed rigorously, albeit, achieved significant locoregional control, could not lead to improved long-term survival. With the passage of time, people have understood the systemic nature of the disease and the paramount need to incorporate systemic treatment even in relatively earlier stages and curtain surgical ablative techniques. The role of primary systemic therapy in the management of breast cancer is fast emerging as a vital option. In HER 2/neu gene overexpressed patients, addition of trastuzumab to the systemic treatment is a distinct improvement in overall survival. "

"The book is the first one published exclusively on the field of nutritional epidemiology of breast cancer. It summarizes the currently existing knowledge, with an updated and comprehensive international bibliography (~ 1.000 references). The authors also performed a review on the epidemiological studies on nutrition and breast cancer carried out in Uruguay between 1994 and 2011, which allowed exploring and identifying the main risk and protective factors for the disease in this high-risk country. "

"This book is the one of the few textbooks that summarizes the latest information dated to inflammatory breast cancer. The uniqueness of this book is that it has summarized the latest molecular and mechanistic findings, which may lead to novel diagnostic tool or therapeutic approach to fight this deadly disease."

"Pasien dengan kanker payudara banyak yang mengalami gangguan dan hampir seluruhnya mengalami depresi yang dapat memperberat gejala fisik, meningkatkan gangguan fungsional, dan membuat kepatuhan berobat menjadi rendah. Kami melakukan tinjauan pustaka yang tersedia di PubMed tentang prevalensi, besar gangguan, kemampuan coping, dan metode penatalaksanaan depresi berat pada wanita dengan kanker payudara dari tahun 1978 sampai 2010. Diagnosis dan penatalaksanaan episode depresi pada wanita dengan kanker payudara merupakan tantangan karena gejala yang tumpang tindih dan kondisi penyerta. Depresi berat sering disepelekan dan penatalaksanaan tidak adekuat pada pasien kanker payudara. Tinjauan ini menekankan pada masalah dalam identifikasi dan pengelolaan depresi pada pasien kanker payudara dengan latar klinis.

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AbstractMany of breast-cancer patients experience distress and most of them experience depression which may lead to amplification of physical symptoms, increased functional impairment, and poor treatment adherence. We did a review on available literature from PubMed about prevalence, distress magnitudes, coping styles, and treatment methods of major depression in women with breast cancer from 1978 to 2010. Diagnosis and treatment of depressive episodes in women with breast cancer is challenging because of overlapping symptoms and co-morbid conditions. Major depression is often under-recognized and undertreated among breast cancer patients. This review highlighted the issues on identifying and managing depression in breast cancer patients in clinical settings."

"As a concept, quality of life is quite well known particularly in relation to patient with chronic disease. The number of study focuses on this concept has been increasing since the 90"s. Furthermore, quality of life measurement is considered to be an important factor, which should not be skipped, in order to treat chronic disease patients including breast cancer patient. Having such a good quality of life is sometimes considered to be one of significant predictors of survival life for patients. Unfortunately, theoretical concept of quality of life is still of clarity up to now. Hence, the aim of this article is to describe some basic concepts and theory of quality of life in general situation and also in breast cancer."

"The result of breast cancer therapy is usually evaluated using the five-year survival rate. Besides therapeutical aspects, several factors also determine the five-year survival rate, e.g. the stage of cancer and tumor size. The goal of this study is to determine the probability of 5-year survival among breast cancer patients at Dharmais Cancer Hospital Jakarta, and the relationship between cancer stage, tumor size, and 5-year survival rate.The design was a longitudinal study. Data were collected from the medical records of breast cancer patients admitted to Dharmais Cancer Hospital between 1993 and 1996. The sample was 137 women. Data was collected from the medical record as well as by telephoning or sending post mail to establish how long each breast cancer patient survived.The results show that the 5-year survival rate for breast cancer patients at Dharmais Cancer Hospital was 48%, with a median survival rate of 54 months. The 5-year survival rate of patients of early operable stages was 72%, while that of those from late stages was 12%. By us ing patients from early operable stages for baseline comparison, the risk-ratio of death in the late stage was 6.612 (95% CI: 4.014; 10.78). Moreover, the 5-year survival rate of patients with tumors that were less than 5 cm in size was 81 %, whilst the 5-year survival rate of patients with tumors larger than 5 cm was 24%. If compared to patients with a tumor size < 5 cm, the risk-ratio of death among patients with tumors over 5 cm in size was 6,612 (95% CI: 5.50; 12.48)."