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"This book describes how systems biology, pharmacogenomic and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. Authors review and discuss approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. This book presents cross-cutting research tools and animal models, along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity; the developmental basis of adolescent or adult onset of disease; risk assessment of methyl mercury and its effects on neurodevelopment; challenges in the field to identify environmental factors of relevance to autism; and the strategy and progress of epilepsy research."

"Leading authorities on percutaneous tumor ablation come together in this volume to provide a complete overview of everything physicians and other health professionals need to know to successfully implement and administer an image-guided ablation service. After an introduction to the protocols and attendant physics of ablation technology, concise organ-based chapters focus on a wide range of both straightforward and atypical cases to teach readers how to handle the unique clinical and technical challenges associated with percutaneous tumor ablation in different areas of the body. Succinct, step-by-step descriptions complement high-resolution images throughout to illustrate the nuances of each procedure. This must-have clinical reference will develop the technical and clinical tumor ablation skills of every fellow and practicing physician in interventional radiology, oncology, and surgical oncology."

""While most of the focus in "omics" science over the past decade has been on sequencing the human genome [1] or annotating the human proteome [2], there is another equally important component of the human body that has, until recently, been largely overlooked: the human metabolome. The human metabolome can be thought of as the complete collection of small molecule metabolites found in our bodies. These small molecules include such chemical entities as peptides, amino acids, nucleic acids, carbohydrates, organic acids, vitamins, minerals, food additives, drugs and just about any other chemical (with a molecular weight 1500 Da) that can be used, ingested or synthesized by humans. Metabolites act as the bricks and mortar of our cells. They serve as the building blocks for all of our macromolecules including proteins, RNA, DNA, carbohydrates, membranes and all other biopolymers that give our cells their structure and integrity. Metabolites also act as the fuel for all cellular processes, the buffers to help tolerate environmental insults and the messengers for most intra- and intercellular events. Together with the genome and the proteome, the human metabolome essentially defines who and what we are."-- Provided by publisher"