Hasil Pencarian  ::  Simpan CSV :: Kembali

"[ABSTRAKAkne vulgaris (AV) merupakan kelainan kulit menahun folikel pilosebasea yang banyak dijumpai remaja dan dewasa muda. Beberapa penelitian melaporkan adanya hubungan antara seng dan AV. Penelitian dengan desain kasus kontrol ini bertujuan mencari hubungan kadar seng serum dengan derajat keparahan AV berdasarkan klasifikasi Lehmann dan dengan jumlah lesi inflamasi. Tujuh puluh subyek dengan AV, terdiri atas 35 AV ringan (AVR) [kelompok A] dan 35 AV sedang (AVS) dan AV berat (AVB) [kelompok B] berdasarkan klasifikasi Lehmann diperiksakan kadar seng serum yang diukur menggunakan Atomic absorption spectrophotometry. Hasil kadar seng serum kelompok A median (min-maks) 11,15 (10,23-14,21) μmol/L dan kelompok B median (min-maks) 9,93 (6,72-10,69) μmol/L. Kadar seng serum kelompok A lebih tinggi dibandingkan kelompok B (p<0,001). Terdapat korelasi negatif yang bermakna antara kadar seng serum dengan jumlah lesi inflamasi pada AV(r -0,488). Sebagai tambahan didapatkan korelasi negatif kadar seng serum dengan jumlah lesi non inflamasi (r-0,582) ataupun total lesi AV (r-0,662). Hasil penelitian ini membuktikan bahwa kadar seng serum berhubungan dengan derajat keparahan AV menurut klasifikasi Lehmann, yakni kadar seng serum lebih rendah pada AV derajat berat dan sedang dibandingkan derajat ringan, dan sejalan dengan hubungannya terhadap jumlah lesi, baik inflamasi, non inflamasi, dan total lesi.

---

ABSTRACTAcne vulgaris (AV) is a chronic cutaneous disorder in pilosebaceous follicles affecting many of the adolescents and young adults. Several studies have reported an association between serum zinc level and acne vulgaris. This case-control study aimed to find the relationship between serum zinc level with severity of AV according on Lehmann?s classification and the number of inflamatory lesions. Seventy AV subjects, consisting of 35 subjects with mild AV (Group A) and 35 subjects with moderate and severe AV (Group B) based on Lehmann?s classification are measured their serum zinc levels with Atomic absorption spectrophotometry. In group A serum zinc level median (min-max) was 11,15 (10,23-14,21) μmol/L and in group B, median (min-max) was 9,93 (6,72-10,69) μmol/L. Serum zinc levels in group A were statistically significant higher than group B (𝑃𝑃<0,001). There was a negative correlation between serum zinc levels with the number of inflammatory lesions (r-0,488). Additional result obtained were negative correlation between serum zinc levels with number of non-inflammatory lesions (r-0,582) and total lesion of AV (r-0,662). The results of this study proved that serum zinc levels was associated with the severity of AV according to Lehmann?s classification,i.e. serum zinc levels were lower in severe and moderate acne compared with mild acne, and in line with its correlation to number of lesions, either inflammatory, non-inflammatory, and total lesions.;Acne vulgaris (AV) is a chronic cutaneous disorder in pilosebaceous follicles affecting many of the adolescents and young adults. Several studies have reported an association between serum zinc level and acne vulgaris. This case-control study aimed to find the relationship between serum zinc level with severity of AV according on Lehmann?s classification and the number of inflamatory lesions. Seventy AV subjects, consisting of 35 subjects with mild AV (Group A) and 35 subjects with moderate and severe AV (Group B) based on Lehmann?s classification are measured their serum zinc levels with Atomic absorption spectrophotometry. In group A serum zinc level median (min-max) was 11,15 (10,23-14,21) μmol/L and in group B, median (min-max) was 9,93 (6,72-10,69) μmol/L. Serum zinc levels in group A were statistically significant higher than group B (𝑃𝑃<0,001). There was a negative correlation between serum zinc levels with the number of inflammatory lesions (r-0,488). Additional result obtained were negative correlation between serum zinc levels with number of non-inflammatory lesions (r-0,582) and total lesion of AV (r-0,662). The results of this study proved that serum zinc levels was associated with the severity of AV according to Lehmann?s classification,i.e. serum zinc levels were lower in severe and moderate acne compared with mild acne, and in line with its correlation to number of lesions, either inflammatory, non-inflammatory, and total lesions., Acne vulgaris (AV) is a chronic cutaneous disorder in pilosebaceous follicles affecting many of the adolescents and young adults. Several studies have reported an association between serum zinc level and acne vulgaris. This case-control study aimed to find the relationship between serum zinc level with severity of AV according on Lehmann’s classification and the number of inflamatory lesions. Seventy AV subjects, consisting of 35 subjects with mild AV (Group A) and 35 subjects with moderate and severe AV (Group B) based on Lehmann’s classification are measured their serum zinc levels with Atomic absorption spectrophotometry. In group A serum zinc level median (min-max) was 11,15 (10,23-14,21) μmol/L and in group B, median (min-max) was 9,93 (6,72-10,69) μmol/L. Serum zinc levels in group A were statistically significant higher than group B (𝑃𝑃<0,001). There was a negative correlation between serum zinc levels with the number of inflammatory lesions (r-0,488). Additional result obtained were negative correlation between serum zinc levels with number of non-inflammatory lesions (r-0,582) and total lesion of AV (r-0,662). The results of this study proved that serum zinc levels was associated with the severity of AV according to Lehmann’s classification,i.e. serum zinc levels were lower in severe and moderate acne compared with mild acne, and in line with its correlation to number of lesions, either inflammatory, non-inflammatory, and total lesions.]"

"[ABSTRAKLatar belakang. Rekomendasi Global Alliance dalam penanganan AVS meliput antibiotik, asam retinoat, dengan atau tanpa BPO. Resistensi obat menjadi perhatian utama pada penggunaan antibiotik jangka panjang dalam terapi akne vulgaris sedang. Kombinasi antibiotik dan BPO direkomendasikan untuk mengatasi masalah tersebut. Pada tipe kulit IV-V hiperpigmentasi pasca akne merupakan masalah yang sering dikeluhkan. Tujuan. Membandingkan efektivitas, efek samping dan kejadian hiperpigmentasi pasca inflamasi penggunaan BPO sebagai paduan terapi lini pertama AVS pada tipe kulit IV-V Fitzpatrick. Metode. Penelitian analitik dengan desaain uji klinis acak tersamar ganda membandingkan dua sisi wajah. Subyek diberikan paduan terapi lini pertama. Sisi wajah perlakuan diberikan gel BPO 2,5% sedangkan kelompok kontrol gel plasebo. Hasil. Pada minggu ke-2,4,6,8 didapatkan penurunan persentase total lesi sebesar 51,47%, 71%, 75%, 82,84% pada kelompok BPO dan 30%, 53,75%, 62,28, 71% pada kelompok plasebo (p<0,001 .) Efek samping dan kejadian HPI pada minggu ke 2,4,6 dan 8 tidak berbeda bermakna. Kesimpulan. Penggunaan BPO sebagai bagian dari paduan terapi lini pertama AVS lebih efektif, tidak meningkatkan efek samping ataupun kejadian HPI.Kata kunci. akne vulgaris, gel BPO 2,5%,

---

ABSTRACTBackground. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo., Background. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo.]"

"ABSTRAKPenelitian yang membahas hubungan antara seng dan derajat keparahan akne masih terbatas dengan hasil yang tidak konsisten antara satu penelitian dengan penelitian yang lain. Penelitian ini merupakan penelitian potong lintang komparasi untuk menilai hubungan asupan seng dan konsentrasi seng serum dengan derajat keparahan akne vulgaris berdasarkan kriteria Indonesian Acne Expert Meeting. Dilakukan penilaian asupan seng dan pemeriksaan konsentrasi seng serum terhadap 60 pasien akne vulgaris di Rumah Sakit Cipto Mangunkusumo. Analisis data asupan seng terhadap derajat keparahan akne menggunakan uji T tidak berpasangan sedangkan analisis data konsentrasi seng serum terhadap derajat keparahan akne menggunakan uji Mann-Whitney. Pada penelitian ini, asupan seng pada seluruh subjek berada dibawah nilai Angka Kecukupan Gizi Indonesia dan rerata asupan seng pada kelompok akne ringan lebih tinggi dibandingkan kelompok akne derajat sedang berat. Konsentrasi seng serum pada kelompok akne ringan lebih tinggi dibandingkan kelompok akne derajat sedang berat. Ditemukan perbedaan yang bermakna antara asupan seng pada kelompok akne derajat ringan dengan kelompok akne derajat sedang berat, dan konsentrasi seng serum antara kelompok akne derajat ringan dengan kelompok akne derajat sedang berat.

---

ABSTRACTZinc recently known to have an effect on reducing the severity of acne, but this finding was still inconsistent between one study to another. A comparation cross sectional study was conducted to assess the association of zinc intake and serum zinc level with the severity of acne based on Indonesian Acne Expert Meeting criteria. A total of 60 acne patients in Cipto Mangunkusumo Hospital were selected. Data analysis on zinc intake on acne severity using unpaired T test while zinc serum concentration on acne severity with Mann Whitney test. In this study, zinc intake in all subjects was below the Indonesian Recommended Daily Allowance and mean of zinc intake in mild acne group was higher compare to the moderate severe acne group. Zinc serum level in mild acne group was higher compare to the moderate severe acne group. There was a significant difference between zinc intake in mild and moderate severe acne group, and zinc serum level between mild and moderate severe acne group."

"Latar belakang dan tujuan: Akne vulgaris AV merupakan inflamasi kronik pada unit pilosebasea. Beberapa penelitian telah meneliti kadar 25-hydroxyvitamin D [25 OH D] serum pada pasien AV dengan hasil bervariasi, namun umumnya rendah. Kadar vitamin D diduga terpengaruh oleh pajanan sinar matahari, letak geografis, ras/tipe kulit, dan asupan makanan, sehingga mungkin temuan di Indonesia akan berbeda daripada penelitian terdahulu di luar negeri. Penelitian ini bertujuan untuk mengetahui kadar 25 OH D serum dan hubungan dengan derajat keparahan, lesi inflamasi, noninflamasi, dan total lesi AV. Metode: Penelitian potong lintang ini melibatkan 30 subjek penelitian SP, direkrut secara consecutive sampling, terbagi rata ke dalam kelompok AV ringan AVR, AV sedang AVS, dan AV berat AVB berdasarkan klasifikasi Lehmann. Faktor risiko AV yang berkaitan dengan vitamin D pajanan sinar matahari, penggunaan tabir surya, suplementasi, jumlah lesi, dan kadar 25 OH D serum dinilai pada seluruh SP. Hasil : Median kadar 25 OH D serum pada kelompok AVR, AVS, dan AVB yaitu 16,3 9,1- 17,8 ng/mL, 12,7 9,6-15,6 ng/mL, dan 9,35 4,9-10,9 ng/mL Median pada kelompok AVR dan AVS lebih tinggi dibandingkan AVB.

---

Background and objective: Acne vulgaris AV is chronic inflammation of pilosebaceous units. Several studies have investigated the levels of serum 25 hydroxyvitamin D 25 OH D in AV patients with varying outcomes, but mostly decreased. Vitamin D levels are thought to be affected by sun exposure, geographical location, race skin type, and food intake, that research in Indonesia may yield different results. This study aimed to determine the level of serum 25 OH D and its association with the severity and the number of inflammatory, noninflammatory, and total AV lesions.

Methods: This cross sectional study included 30 patients. Subjects were recruited by consecutive sampling, grouped equally into mild, moderate, and severe AV based on Lehmann's classification. The risk factors for inadequate vitamin D such as sun exposures, sunscreen, and suplements, the number of lesions, and serum 25 OH D levels were assessed on all subjects.

Results: The median concentrations of serum 25 OH D in the three groups were respectively 16.3 9.1 17.8 ng mL, 12.7 9.6 15.6 ng mL, and 9.35 4.9 10.9 ng mL p."

"Latar Belakang: Akne vulgaris AV adalah peradangan kronis pilosebasea yang terutama dijumpai pada remaja dan dewasa muda. Peranan diet pada patogenesis AV terus menjadi perdebatan. Salah satu mikronutrien yang diduga berperan dalam patogenesis AV adalah vitamin A atau retinol. Tujuan: Mengetahui kadar retinol serum dan korelasinya dengan derajat keparahan AV, serta asupan vitamin A pasien AV. Metode: Studi potong lintang dengan 20 subjek penelitian SP yang direkrut secara consecutive sampling. Kadar retinol serum diukur menggunakan high performance liquid chromatography HPLC, sedangkan asupan vitamin A dinilai dengan metode food frequency questionnaire FFQ semikuantitatif. Hasil: Rerata kadar retinol serum kelompok AVR, AVS, dan AVB yaitu 0,962 SB 0,145 mol/L, 0,695 SB 0,054 mol/L, dan 0,613 SB 0,125 mol/L. Terdapat korelasi bermakna antara kadar retinol serum dengan derajat keparahan AV r = -0,798, p = 0,000. Rerata asupan vitamin A per hari pada kelompok AVR, AVS, dan AVB sebesar 476,21 SB 221,32 g, 823,71 SB 221,32 g, dan 780,99 SB 530,45 g. Simpulan: Kadar retinol serum ditemukan rendah pada kelompok AVS dan AVB. Hasil penelitian ini membuktikan semakin rendah kadar retinol serum, semakin berat derajat keparahan AV. Tidak terdapat perbedaan asupan vitamin A di antara ketiga kelompok.

---

Background: Acne vulgaris AV is a chronic inflammation of pilosebaceus that is primarily found in adolescents and young adults. The role of diet in the pathogenesis of AV continues to be a debate. One of micronutrients alleged in the pathogenesis of AV is vitamin A or retinol.

Objective: This study aims to know the levels of serum retinol and its correlation with the degree of severity of the AV, as well as the patient 39 s intake of vitamin A.

Method: This cross sectional study included 20 subjects divided into mild, moderate, and severe groups based on Lehman rsquo s classification. Serum retinol levels measured using high performance liquid chromatography, whereas the intake of vitamin A was assessed by semiquantitative food frequency questionnaire method.

Results: The mean serum retinol levels of mild, moderate, and severe groups were respectively 0.962 SD 0.145 mol L, 0.695 SD 0.054 mol L, and 0.613 SD 0.125 mol L. There was significant correlation between serum retinol levels with the degree of severity of the AV r 0.798, p 0.000. The mean intake of vitamin A per day of mild, moderate, and severe groups were respectively 476.21 SD 221.32 g, 823.71 SD 221.32 g, and 780.99 SD 530.45 g.

Conclusion: Levels of serum retinol found lower on the moderate and severe groups. The results has proven that the lower the levels of serum retinol, the more severe the degree of severity of the AV. There was no difference in vitamin A intake among the three groups."

"Latar belakang: Akne vulgaris (AV) merupakan kelainan kulit akibat peradangan kronik folikel pilosebasea yang sering dijumpai pada remaja dan dewasa muda. Pada pasien perempuan didapatkan prevalensi AV yang lebih tinggi dan dampak psikososial yang lebih berat. Beberapa studi meneliti terdapat hubungan antara peningkatan kadar homosistein dengan derajat keparahan AV, namun peran homosistein dalam patogenesis AV masih belum jelas. Kadar homosistein ditentukan oleh multifaktor sehingga temuan di Indonesia dapat berbeda dibandingkan penelitian terdahulu. Secara fisiologis, kadar homosistein pada perempuan lebih rendah dari laki-laki.Tujuan: Mendapatkan data kadar homosistein plasma pada pasien perempuan dengan AV ringan (AVR), AV sedang (AVS), dan AV berat (AVB) serta mengetahui korelasi kadar homosistein plasma dengan berbagai derajat keparahan AV.Metode: Studi potong lintang dilakukan terhadap 46 subjek penelitian (SP), direkrut secara consecutive sampling, yang terdiagnosis AV berdasarkan kriteria Lehmann pada bulan April-Juni 2019. Setiap SP akan diambil darahnya untuk dilakukan pemeriksaan kadar homosistein plasma dengan metode chemiluminescent microparticle immuno assay (CMIA).Hasil: Pada pasien perempuan dengan AV didapatkan rerata kadar homosistein plasma kelompok AVR, AVS, dan AVB yaitu 7,39 (1,84) μmol/L, 7,14 (1,73) μmol/L, dan 6,95 (1,14) μmol/L. Terdapat korelasi negatif lemah yang tidak bermakna antara kadar homosistein plasma dengan derajat keparahan AV (r=-0,0964, p=0,524).Kesimpulan: Kadar homosistein plasma ditemukan lebih rendah pada kelompok AVS dan AVB. Dari hasil penelitian didapatkan bahwa semakin rendah kadar homosistein plasma, maka semakin berat derajat keparahan AV.

---

Background: Acne vulgaris (AV) is a skin disorder caused by chronic inflammation of pilosebaceus that is primarily found in adolescents and young adults. In female patient, there is a higher prevalence of AV and more severe psychosocial impact. Several studies have investigated association between the levels of serum homocysteine and severity of AV, but the role of homocysteine in AV is not clearly understood. Homocysteine levels are thought to be affected by varying factors, so it is assumed that homocysteine levels in Indonesian people will yield a different results. Physiologically, female has a lower homocysteine levels.

Objective: This study aims to know the levels of homocysteine plasma in female patients suffering from mild, moderate, and severe AV, also its correlation with the degree of AV severity.

Methods: This cross-sectional study included 46 subjects, recruited by consecutive sampling, who have been diagnosed with AV based on Lehmann criteria on April-June

2019. Blood sample will be taken from each subject to measure homocycsteine plasma levels by using chemiluminescent microparticle immuno assay method (CMIA).

Results: In female patients, the mean plasma homocycteine levels of mild, moderate, and severe groups were respectively 7,39 (1,84) μmol/L, 7,14 (1,73) μmol/L, and 6,95 (1,14) μmol/L. There was no significant corelation between plasma homocysteine levels and the degree of acne severity (r=-0,0964, p=0,524).

Conclusion: Levels of plasma homocysteine was found lower on moderate and severe AV groups. The lower the levels of plasma homocysteine, the more severe the the degree of acne severity.

"

"Latar belakang: Akne vulgaris AV adalah penyakit kulit yang ditandai dengan terjadinya sumbatan dan peradangan kronik pada unit pilosebasea. Penelitian sebelumnya tentang kadar lipid darah pada pasien AV menunjukkan hasil yang bervariasi. Lipid darah diduga memengaruhi aktivitas kelenjar sebasea. Tujuan: Mengetahui korelasi antara kadar lipid darah dan kadar sebum dengan derajat keparahan AV, serta mengetahui korelasi kadar lipid darah dengan kadar sebum kulit wajah. Metode: Studi potong lintang ini dilakukan terhadap 30 pasien AV non-obesitas, yang terbagi berdasarkan tiga derajat keparahan AV. Dilakukan pemeriksaan kolesterol total, trigliserida, LDL, HDL darah dan kadar sebum kulit wajah pada SP. Hasil: Terdapat korelasi yang bermakna antara kadar sebum dengan derajat keparahan AV r = 0,6689, p = 0,0001 . Tidak terdapat korelasi antara kadar kolesterol total, trigliserida, LDL, HDL darah dengan derajat keparahan AV. Tidak terdapat korelasi antara sebum kulit wajah dengan kadar kolesterol total, trigliserida, LDL, HDL darah. Kesimpulan: Hasil penelitian ini menunjukkan bahwa kadar lipid darah tidak memengaruhi keparahan AV dan kadar sebum, sedangkan peningkatan kadar sebum kulit wajah dapat meningkatkan keparahan AV.

---

Background: Acne vulgaris is a common chronic skin disease involving blockage and inflammation of pilosebaceous units. Previous studies about blood lipids in acne patients revealed variable results. Blood lipids were considered affecting sebum production.

Objective: To identify the correlation between blood lipids, sebum excretion rate and acne severity. This study also determines the correlation between blood lipids and sebum excretion rate.

Methods: This study was conducted at Dr. Cipto Mangunkusumo Hospital in Jakarta. This was a cross sectional study with total of 30 non obese AV patients. The patients were divided into 3 groups based on the severity of AV. Total cholesterol, triglycerides, LDL, HDL serum and sebum excretion rate were measured.

Results: The results revealed significant correlation between sebum excretion rate and severity of acne vulgaris r 0,6689, p 0,0001 . There were no correlation between total cholesterol, LDL, triglycerides, HDL and acne severity. Blood lipids had no correlation with sebum excretion rate.

Conclusion: The results of this study has proven that blood lipids does not affect the severity of acne and sebum excretion rate. While increased sebum secretion would increase acne severity."

"Latar belakang: Dampak Dermatitis Atopik DA terhadap kualitas hidup seorang anak di Amerika dan Negara-negara eropa relatif telah dikenal dengan baik, namun belum pernah di evaluasi di Indonesia. Terlebih lagi hubungan antara derajat dermatitis atopik dan biaya obat belum pernah diteliti, walaupun beberapa penelitian mendeteksi perburukan dan biaya pengobatan yang lebih tinggi pada bayi/anak yang lebih muda dengan DA.Tujuan: Mengetahui kualitas hidup dan biaya pengobatan pada bayi/anak dermatitis atopik DA .Metode: Penelitian ini adalah penelitian cross sectional pada 60 bayi/anak berusia 0 ndash; 4 tahun menjalani pemeriksaan objective SCORAD dan orang tua mereka diwawancara dengan kuesioner kualitas hidup dermatologis bayi dan biaya pengobatan.Hasil: Terdapat korelasi sedang antara keparahan SCORAD obyektif dengan IDQOL r = 0,431, p = 0,001 , sedangkan korelasi sedang juga terjadi antara SCORAD obyektif dan biaya pengobatan r = 0,367, P = 0,004 . Setelah diklasifikasikan menjadi dermatitis ringan, sedang, dan berat , hubungan antara beratnya DA dan rendahnya kualitas hidup serta tingginya biaya obat juga berkorelasi sedang r = 0,545, P = 0,01 .Kesimpulan: Terdapat korelasi sedang antara keparahan DA dengan gangguan kualitas hidup, sesuai dengan yang ditampakkan oleh banyak literatur internasional dan terdapat korelasi sedang antara derajat dermatitis dengan biaya pengobatan dalam manajemen DA."

"ABSTRAKPrevalensi kasus jerawat (acne vulgaris) 75-85% pada orang dewasa, terutama pada usia remaja, dan sering menjadi kronis. Etiopatologis jerawat multi-faktorial, antara lain disebabkan oleh stres oksidatif dan pengaruh hormon serta pola makan. Tujuan dari penelitian adalah untuk membuktikan bahwa ekstrak etanol kulit buah manggis (Garcinia mangostana L) yang mengandung senyawa aktif xanthones dengan aktivitas anti-oksidan, anti-bakteria dan anti-inflamasi, dapat menunjang terapi medis untuk jerawat. Uji klinis dilakukan secara acak, berpembanding dan tersamar ganda selama 3 minggu pada 94 subyek berjerawat ringan dan sedang, berumur 18-30 tahun yang tinggal di asrama agar relatif homogen. Parameter penelitian adalah derajat keparahan jerawat menurut kriteria Lehman dan kadar malondialdehid (MDA) di dalam darah subyek. Perlakuan dengan pemberian 400 mg ekstrak 3 kali sehari, bersamaan terapi standar dengan krim topikal asam retinoat 0,025% pada lesi jerawat di wajah pada malam hari. Keparahan jerawat berkurang tidak bermakna (p > 0.2) dan penurunan kadar MDA dalam plasma darah tidak bermakna (p = 0.49).

---

ABSTRACTThe prevalence of acne (acne vulgaris) is 75-85% in adults, especially in adolescence, and often becomes chronic. Etiopatology of acne is multi-factorial, partly due to the oxidative stress and the influence of hormones and diet. The purpose of this study is to prove that the ethanol extract of mangosteen rind (Garcinia mangostana L) containing xanthones with properties of anti-oxidant, anti-bacterial and anti-inflammatory, can support medical therapy for acne. A randomized, double-blind and controlled clinical trial done for 3 weeks in 94 subjects with mild and moderate acne, aged 18-30 years living in a dorm which is relatively homogeneous. Parameters of the study are the degree of severity of acne according to Lehman criteria and the levels of malondialdehyde (MDA) in the blood of the subjects. Intervention by administering 400 mg extract 3 times a day, along with standard therapy with topical cream of 0.025% retinoic acid applied in acne lesions on the face at night. Improvement of acne severity was not significant (p > 0.2) and decreased levels of MDA in blood plasma was not significant (p = 0.49)."

"Gupta dkk (2000) melakukan uji in vitro suseptibilitas spesies Malassezia terhadap obat antijamur ketokonazol, itrakonazol, vorikonazol dan terbinafin. Hasil uji memperlihatkan adanya varfasi suseptibiilitas spesies Malassezia terhadap antijamur tersebut. Walaupun masih harus dibuktikan lebih lanjut dengan pengamatan in vivo, data ini mungkin dapat menjelaskan perbedaan rata-rata kesembuhan mikofogis pada pasien PV dengan terapi antijamur. Savin di New york dan Budimulja di Jakarta melakukan penelitian efektivitas pengobatan solusio terbinafin 1% yang digunakan 2 kali sehari seiama 1 minggu pada pasien PV. Budimulja dkk melaporkan angka kesembuhan sebesar 65%, sedangkan Savin 70-80%. Belum diketahui secara pasti apakah perbedaan ini semata-mata terkait dengan faktor geografik atau melibatkan faktor-faktor lain.Selain menggunakan metode biomolekular, identifikasi spesies Malassezia dapat dilakukan dengan teknik biokimia. Guillot memperkenalkan metode biokimia praktis dengan memanfaatkan perbedaan morfologi, toleransi terhadap suhu tinggi, kemampuan aktivitas katalase, serta kemampuan tumbuh pada berbagai media Tweenn. Faergemann melakukan modifikasi metoda Guillot dengan cara menghilangkan tahapan biakan pada media Tween®, dan menggantikannya dengan pemeriksaan difusi Cremophor EL® dan pengamatan aktivitas 13 - g l u kos idase.Sejauh pengetahuan peneliti, di Indonesia belum pernah dilakukan identifikasi spesies Malassezia pada pasien PV. Hal tersebut menjadikan dorongan bagi peneliti untuk melakukan penelitianRUMUSAN MASALAHDi antara tujuh spesies Malassezia, spesies manakah yang ditemukan pada Iesi PV di Poliklinik Divisi Dermatomikologi 1KKK FKUI 1 RSCM ?TUJUAN PENELITIANIdentifikasi spesies Malassezia pada pasien PV yang berobat di Poliklinik Divisi Dermatomikologi 1KKK FKUI 1 RSCM."