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Mutiara Anissa
"Latar Belakang: Komorbiditas depresi pada PPOK dapat memengaruhi kepatuhan pengobatan, hospitalisasi dan kualitas hidup. Salah satu target tatalaksana PPOK adalah meningkatkan kualitas hidup penderitanya. Pasien PPOK dengan gangguan depresi memiliki kualitas hidup yang buruk dibandingkan pasien PPOK tanpa gangguan depresi. Untuk itu perlu diketahui perbedaan rerata skor kualitas hidup pasien PPOK dengan gangguan depresi dan pasien PPOK tanpa gangguan depresi.
Metode: Penelitian potong lintang deskriptif-analitik pada 40 pasien PPOK dengan gangguan depresi dan 40 pasien PPOK tanpa gangguan depresi di klinik Asma/PPOK RSUP Persahabatan menggunakan Mini-International Neuropsychiatric Interview International Classification Of Diseases (MINI ICD 10) dan instrumen World Health Organization Quality Of Life (WHOQOL)-BREF.
Hasil: Terdapat perbedaan median skor kualitas hidup pada pasien PPOK dengan gangguan depresi dan pasien PPOK tanpa gangguan depresi berdasarkan domain kesehatan fisik (p = 0,005), domain relasi sosial (p < 0,001) dan domain lingkungan (p = 0,005). Tidak terdapat perbedaan median skor kualitas hidup berdasarkan domain kesehatan psikologis ( p = 0,421) namun rerata skor domain kesehatan psikologis pasien dengan PPOK lebih rendah dibanding pasien tanpa gangguan depresi.
Simpulan: Pasien PPOK dengan gangguan depresi cenderung memiliki rerata skor kualitas hidup yang lebih rendah pada domain kesehatan fisik, kesehatan psikologis, relasi sosial, dan lingkungan dibandingkan pasien PPOK tanpa gangguan depresi.

Background: Comorbid depression in COPD affects patient’s medical adherence, hospitalization and quality of life. One of the COPD management is improving the patient’s quality of life. COPD patients who have depression disorder have lower quality of life scores compared to COPD patients who do not have depression disorder. We investigated the difference quality of life scores in COPD patients who have depression disorder and COPD patients who do not have depression disorder.
Methods: The study was cross-sectional descriptive-analytic in 40 COPD patients who have depression disorder and 40 COPD patients who do not have a depression disorder in the Asthma and COPD Clinic RSUP Persahabatan using the Mini-International Neuropsychiatric Interview International Classification Of Diseases (MINI ICD 10) and World Health Organization Quality Of Life (WHOQOL)-BREF.
Results: There is a score difference between COPD patients who have depression disorder and COPD patients who do not have depression disorder based on physical health domain (p = 0.005), social relationship domain (p < 0.001) and environment domain (p = 0.005). There is no score difference between COPD patients who have depression disorder and COPD patients based on psychological domain (p = 0,421). COPD patients who have depression disorder have lower mean score compared to COPD patients who do not have depression based on psychological domain.
Conclusion: COPD patients who have depression disorder tend to score lower quality of life in the domains of physical health, psychological health, social relationships, and environment than COPD patients who do not have depression disorder.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tesis Membership  Universitas Indonesia Library
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Nur Nina Rosrita
"ABSTRAK
Latar belakang : Penyakit paru obstruktif kronik (PPOK) merupakan penyebab
utama morbiditas dan mortalitas di dunia. Penyakit ini merupakan salah satu
penyakit tidak menular yang menjadi masalah kesehatan masyarakat di Indonesia.
Penyakit ini mempunyai beberapa komorbid seperti osteoporosis, gagal jantung,
diabetes dan depresi. Depresi merupakan gangguan emosional yang sering terjadi
pada penderita PPOK dan makin menurunkan kualitas hidup penderita namun
sering tidak terdiagnosis di pelayanan kesehatan.
Objektif : Tujuan penelitian ini adalah mendapatkan angka prevalens depresi
pada pasien PPOK stabil di RSUP Persahabatan Jakarta dan hubungannya dengan
kualitas hidup.
Metode : Desain penelitian ini adalah potong lintang. Pasien PPOK stabil
berkunjung ke poliklinik Asma/PPOK RSUP Persahabatan yang memenuhi
kriteria inklusi dan eksklusi. Subjek dilakukan anamnesis, pemeriksaan fisis dan
spirometri untuk memastikan diagnosis PPOK dan pembagian grup dilanjutkan
dengan wawancara menggunakan MINI ICD 10 (Mini International
Neuropsychiatric Interview - International Classification of Disease 10) kemudian
dilakukan analisis statistik.
Hasil : Subjek terbanyak adalah laki-laki (92,9%) dengan kelompok usia > 65
tahun (48,9%). Jumlah depresi adalah 27 orang dari total 141 subjek dengan
prevalens 19,1%. Penelitian ini mendapatkan bahwa nilai CAT sedang berat (≥
10) mempunyai kualitas hidup yang lebih rendah dan berisiko 14 kali terjadi
depresi dibanding CAT ringan (p<0,001). Penelitian ini mendapatkan hubungan
bermakna pada grup PPOK yang dibagi berdasarkan gejala (p<0,001), penderita
PPOK yang depresi dengan status terpajan rokok (p<0,007) dan indeks
Brinkmann (p<0,026) namun tidak pada grup PPOK yang dibagi berdasarkan
risiko (p>0,799) dan hambatan aliran udara yang diukur dengan spirometri.
Kesimpulan : Prevalens depresi pada pasien PPOK stabil di RSUP Persahabatan
Jakarta adalah 19,1%. Terdapat hubungan yang bermakna secara statistik antara
kualitas hidup dengan depresi pada pasien PPOK stabil, grup PPOK yang dibagi
berdasarkan gejala dalam meningkatkan risiko depresi, status merokok dan indeks
Brinkmann, tidak ditemukan hubungan grup PPOK yang dibagi berdasarkan
risiko dan hambatan aliran udara yang dinilai dengan spirometri.ABSTRACT Background : Chronic obstructive pulmonary disease (COPD) is a major cause
of morbidity and mortality in the world. This diesease is one the main diseases
problem in Indonesia. It can cause comorbid such as osteoporosis, heart failure,
diabetes and depression. Depression is a common comorbid affecting COPD
patients that influence quality of life but unfortunatelly this comorbid often mis or
underdiagnosed.
Objective : The purpose of this study is to get the prevalence of depression in
stable COPD patients in Persahabatan Hospital Jakarta and its relation to the
quality of life.
Methods : The study design was cross-sectional. Stable COPD patients who
visited the Asthma/COPD clinic in Persahabatan Hospitals Jakarta who met the
inclusion and exclusion criteria. Subjects were asked for history of disease,
physical examination and spirometry then underwent MINI ICD 10.
Results : Most subjects were male (92,9%), in the age group > 65 years (48,9%).
Prevalence of depression was 19,1%. Subjects with moderate-high CAT (≥ 10)
has lower quality of life compared to subjects with mild CAT (< 10) and 14 times
higher risk in having depression (p<0,001). In this study there was statistically
significant relationship in COPD group that divided by symptomps (p<0,001) in
causing depression, smoking status (p<0.007) and Brinkmann index (p<0,026).
This study also suggests that there is no statistically relationship in COPD group
that divided by risk (p>0,799) and airflow limitation that measured by spirometry
(p>1,000).
Conclusion : The prevalence of depression in stable COPD patients in
Persahabatan Hospital Jakarta is 19.1%. There is statistically significant
relationship between quality of life with depression in stable COPD patients,
COPD group that is divided by symptomps in causing depression, smoking status
and Brinkmann index, there is no statistically significant relationship in COPD
grup that is divided by risk and airflow limitation."
Fakultas Kedokteran Universitas Indonesia, 2016
Sp-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Agung Wiretno Putro
"[ABSTRAK
Latar Belakang: Pasien asma dengan tingkat kontrol yang buruk dan adanya
komorbiditas seperti gangguan depresi dan stres psikososial akan memengaruhi
kualitas hidup pasien asma serta meningkatkan beban dan biaya ekonomi yang
harus ditanggung oleh pasien dan keluarganya. Untuk itu perlu diketahui
hubungan antara gangguan depresi dengan kualitas hidup, stresor psikososial, dan
tingkat kontrol asma pada pasien asma.
Metode: Penelitian cross-sectional deskriptif-analitik pada 37 pasien asma yang
memiliki gangguan depresi dan 37 pasien asma yang tidak memiliki gangguan
depresi di Poliklinik Alergi dan Imunologi RSUPN Dr. Cipto Mangunkusumo
Jakarta menggunakan Structured Clinical Interview for DSM IV Disorder(SCID)1,
instrumen World Health Organization Quality Of Life (WHOQOL)-BREF,
instrumen stresor psikososialHolmes & Rahe, dan kuesioner Ashtma Control Test
(ACT).
Hasil: Terdapat hubungan antara ada tidaknya gangguan depresi pada pasien asma
dengan skor kualitas hidup berdasarkan kesehatan fisik (p < 0,001), skor kualitas
hidup berdasarkan kesehatan psikologis (p < 0,001), skor kualitas hidup
berdasarkan relasi sosial (p = 0,023), skor kualitas hidup berdasarkan lingkungan
(p = 0,022), stresor psikososial (OR 3,85; p = 0,005), dan tingkat kontrol asma (p
= 0,001).
Simpulan: Pasien asma yang memiliki gangguan depresi cenderung memiliki
skor kualitas hidup yang lebih rendah pada domain kesehatan fisik, kesehatan
psikologis, relasi sosial, dan lingkungan dibandingkan pasien asma yang tidak
memiliki gangguan depresi. Pasien asma yang mengalami stresor psikososial yang
tinggi berisiko 3,8 kali untuk memiliki gangguan depresi. Pasien asma yang
memiliki gangguan depresi cenderung memiliki skor tingkat kontrol asma yang lebih rendah dibandingkan pasien asma yang tidak memiliki gangguan depresi. ABSTRACT Background: Asthmatic patients with poor control level and the presence of
comorbid disorders such as depression and psychosocial stress will affect the
quality of life of asthmatic patients and increases the burden and economic costs
for patient and his family. We investigated the correlation between depressive
disorders, quality of life, psychosocial stressors, and level of asthma control in
asthmatic patients.
Methods: The study was cross-sectional descriptive-analytic in 37 asthmatic
patients with depressive disorder and 37 asthmatic patients without depressive
disorder in the Allergy and Immunology Clinic RSUPN Dr. Cipto
Mangunkusumo using the Structured Clinical Interview for DSM-IV Disorder
(SCID)-1, World Health Organization Quality of Life (WHOQOL)-BREF
questionnaire, Holmes & Rahe psychosocial stressors questionnaire, and Ashtma
Control Test (ACT) questionnaire.
Results: There is arelation between the presence of depressive disorders and
lower quality of life scores based on physical health (p <0.001), quality of life
scores based on psychological health (p <0.001), quality of life scores based on
social relations (p = 0.023), quality of life scores based on the environment (p =
0.022), psychosocial stressors (OR 3.85; p = 0.005), and the level of asthma
control (p = 0.001) in asthmatic patients.
Conclusion: Asthmatic patients with depressive disorders tend to have lower
quality of life score in all domains (physical health, psychological health, social
relationships, and environment) than asthmatic patients without depressive
disorders. Asthmaticpatients who have psychosocial stressors have risk 3.8 times
higher to have depressive disorders. Asthmatic patients with depressive disorders tend to have lower level of asthma control scores than asthmatic patients without depressive disorders.;Background: Asthmatic patients with poor control level and the presence of
comorbid disorders such as depression and psychosocial stress will affect the
quality of life of asthmatic patients and increases the burden and economic costs
for patient and his family. We investigated the correlation between depressive
disorders, quality of life, psychosocial stressors, and level of asthma control in
asthmatic patients.
Methods: The study was cross-sectional descriptive-analytic in 37 asthmatic
patients with depressive disorder and 37 asthmatic patients without depressive
disorder in the Allergy and Immunology Clinic RSUPN Dr. Cipto
Mangunkusumo using the Structured Clinical Interview for DSM-IV Disorder
(SCID)-1, World Health Organization Quality of Life (WHOQOL)-BREF
questionnaire, Holmes & Rahe psychosocial stressors questionnaire, and Ashtma
Control Test (ACT) questionnaire.
Results: There is arelation between the presence of depressive disorders and
lower quality of life scores based on physical health (p <0.001), quality of life
scores based on psychological health (p <0.001), quality of life scores based on
social relations (p = 0.023), quality of life scores based on the environment (p =
0.022), psychosocial stressors (OR 3.85; p = 0.005), and the level of asthma
control (p = 0.001) in asthmatic patients.
Conclusion: Asthmatic patients with depressive disorders tend to have lower
quality of life score in all domains (physical health, psychological health, social
relationships, and environment) than asthmatic patients without depressive
disorders. Asthmaticpatients who have psychosocial stressors have risk 3.8 times
higher to have depressive disorders. Asthmatic patients with depressive disorders tend to have lower level of asthma control scores than asthmatic patients without depressive disorders.;Background: Asthmatic patients with poor control level and the presence of
comorbid disorders such as depression and psychosocial stress will affect the
quality of life of asthmatic patients and increases the burden and economic costs
for patient and his family. We investigated the correlation between depressive
disorders, quality of life, psychosocial stressors, and level of asthma control in
asthmatic patients.
Methods: The study was cross-sectional descriptive-analytic in 37 asthmatic
patients with depressive disorder and 37 asthmatic patients without depressive
disorder in the Allergy and Immunology Clinic RSUPN Dr. Cipto
Mangunkusumo using the Structured Clinical Interview for DSM-IV Disorder
(SCID)-1, World Health Organization Quality of Life (WHOQOL)-BREF
questionnaire, Holmes & Rahe psychosocial stressors questionnaire, and Ashtma
Control Test (ACT) questionnaire.
Results: There is arelation between the presence of depressive disorders and
lower quality of life scores based on physical health (p <0.001), quality of life
scores based on psychological health (p <0.001), quality of life scores based on
social relations (p = 0.023), quality of life scores based on the environment (p =
0.022), psychosocial stressors (OR 3.85; p = 0.005), and the level of asthma
control (p = 0.001) in asthmatic patients.
Conclusion: Asthmatic patients with depressive disorders tend to have lower
quality of life score in all domains (physical health, psychological health, social
relationships, and environment) than asthmatic patients without depressive
disorders. Asthmaticpatients who have psychosocial stressors have risk 3.8 times
higher to have depressive disorders. Asthmatic patients with depressive disorders tend to have lower level of asthma control scores than asthmatic patients without depressive disorders., Background: Asthmatic patients with poor control level and the presence of
comorbid disorders such as depression and psychosocial stress will affect the
quality of life of asthmatic patients and increases the burden and economic costs
for patient and his family. We investigated the correlation between depressive
disorders, quality of life, psychosocial stressors, and level of asthma control in
asthmatic patients.
Methods: The study was cross-sectional descriptive-analytic in 37 asthmatic
patients with depressive disorder and 37 asthmatic patients without depressive
disorder in the Allergy and Immunology Clinic RSUPN Dr. Cipto
Mangunkusumo using the Structured Clinical Interview for DSM-IV Disorder
(SCID)-1, World Health Organization Quality of Life (WHOQOL)-BREF
questionnaire, Holmes & Rahe psychosocial stressors questionnaire, and Ashtma
Control Test (ACT) questionnaire.
Results: There is arelation between the presence of depressive disorders and
lower quality of life scores based on physical health (p <0.001), quality of life
scores based on psychological health (p <0.001), quality of life scores based on
social relations (p = 0.023), quality of life scores based on the environment (p =
0.022), psychosocial stressors (OR 3.85; p = 0.005), and the level of asthma
control (p = 0.001) in asthmatic patients.
Conclusion: Asthmatic patients with depressive disorders tend to have lower
quality of life score in all domains (physical health, psychological health, social
relationships, and environment) than asthmatic patients without depressive
disorders. Asthmaticpatients who have psychosocial stressors have risk 3.8 times
higher to have depressive disorders. Asthmatic patients with depressive disorders tend to have lower level of asthma control scores than asthmatic patients without depressive disorders.]"
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Erry Prasetyo
"Latar belakang: Inflamasi pada Penyakit Paru Obstruktif Kronik (PPOK) dominan disebabkan oleh neutrofil namun inflamasi dikarenakan eosinofil juga dapat terjadi pada PPOK. PPOK eosinofilik jika ditemukan eosinofil di sputum ≥3%. Peningkatan eosinofil dapat dideteksi di darah dan sputum.
Metode: penelitian ini menggunakan potong lintang dengan menggunakan data primer di poli asma dan PPOK RS Rujukan Respirasi Nasional dari Juni 2019 sampai September 2019. Pemilihan subjek dilakukkan secara consecutive sampling dan dilakukan wawancara, pemeriksaan uji faal paru, pemeriksaan sputum dan darah eosinofil.
Hasil: total 74 sampel yang datang ke poli asma dan PPOK RS Rujukan Respirasi Nasional Persahabatan terdapat 7 sampel sputum yang tidak terdapat leukosit dan hanya epitel sehingga didapatkan 67 sampel yang dianalisis (61 laki-laki dan 6 perempuan). Pasien dalam penelitian ini memiliki  rata-rata  usia 66,7±8,6 tahun. Pasien didominasi oleh pasien perokok dan bekas perokok sebesar 62 pasien (92,5%). Indeks Brinkman terbanyak adalah IB sedang dan berat sebanyak 48 pasien (71,6%). Derajat hambatan aliran jalan napas paling banyak pada GOLD III dan IV (68,7%). Median eosinofil darah pasien pada penelitian ini sebesar 280 sel/μL dengan rentang 0-1300 dan median eosinofil sputum 4% dengan rentang 0-47. Korelasi darah dan sputum pada penelitian ini sebesar 0,43
Kesimpulan: penelitian ini menggambarkan korelasi positif dengan kekuatan lemah antara eosinofil darah dan sputum pada pasien PPOK stabil

Background: Dominant Chronic Obstructive Pulmonary Disease (COPD) inflamation is neutrofil but eosinofilic inflammation for COPD can be occurred. Eosinopilic COPD is defined by increament of eosinophils in sputum ≥3%. Increament of eoshinophils can be shown in blood and sputum
Method: this study use cross sectional method from primary data at asma and PPOK clinic in National Referal Rspuratory Persahabatan Hospital. Subject were taken to participate in study in consecutive sampling basis and all patients were interviewed, lung function test and blood and sputum eoshinophils
Results: Total 74 patient have been recruited who came to asma and PPOK klinik in National Referal Respiratory Persahabatan Hospital. Seven sputum sample is not have the leukocyt but ephitel only. Total patients are 67 (61 male dan 6 female). The mean of age from this study is 66,7±8,6 years old. Most of pasien is smokers and former smoker about 62 patients (92,5%). Brinkman index from this study dominating moderate and severe about 48 patients (71,6%). Airflow limitations from this study are GOLD III and IV (68,7%). Median of blood eoshinophils of this study is 280 cells/μL (0-1300). Median of sputum eoshinophils in this study is 4% (0-47). Correlations of blood and sputum eoshinophils from this study is 0,43
Conclusion: this study shown positive correlations with weak power between blood and sputum eoshinophils.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2019
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Sri Sulistiowati
"Prakktik residensi merupakan bagiam dari pendidikan profesi yang bertujuan untuk memebentuk perawat spesialis. Beberapa kompensasi yang harus dicapai dalam praktik residensi keperawatan medikal ebdah adalah manajemen kasus   menggunakan teori model keperawatan, penerapan model keperawatan berbasis bukti, dan proyek inovasi. Model adaptasi Roy digunakan dalam asuhan keperawatan dengan pasien dengan gangguan system pernapasan. Pendekatan model adaptasi Roy bertujuan untuk mempertahankan integritas adaptasi manusia. Model adaptasi Roy berperan dalam membantu mengembangkan mekanisme koping yang adaptif terhadap stimulusdari lingkungan. Pada target kompetensi penerapan asuhan berbasis bukti dengan penerapan Aroma Hand Massage untuk mengurangi nyeri, tingkat kecemasan dan depresi pada pasien dengan kanker paru terminal.
Hasil penerapan menunjukkan bahwa terapi aroma hand massage menurunkan skor nyeri dan depresi pada pasien dengan kanker paru terminal. Proyek inovasi adalah penerapan mobile phone application untuk pengkajian dan manajemen keperawatan mandiri pada pasien dengan kanker paru. Hasil penerapan aplikasi tersebut  menunjukkan bahwa kemanfaatan, mudah dalam penggunaan dan kepuasan responden dalam mengaplikasikannya.

The residency practice is a part of professional education to build specialist nurses. Some of the competencies must be achieved in residency practice of medical surgical are case management using nursing model theory, the application of  evidence-based nursing practice, and innovation projects. Roys adaptation mode is used in nursing care in patients with impaired respiratory function. Roys adaptation model aimed to develop adaptive coping mechanism from environment stimuli.
The implementation of evidence based nursing used Aroma Hand Massage was effective and useful significantly to reduce score pain and depression on patient with terminal lung cancer. Innovation project was the use of mobile phone application for assessment and management nursing intervention  on patient with lung cancer it was  useful, easy and fun to be applied.
"
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2019
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Alyanisa Ulfathinah
"Penyakit paru obstruktif kronik dapat menyebabkan seseorang mengalami keluhan pernapasan seperti sesak napas, batuk, sputum berlebih. Keluhan pernapasan dan berbagai faktor dapat mempengaruhi kualitas tidur. Penelitian ini bertujuan untuk mengetahui gambaran kualitas tidur pada pasien PPOK. Desain penelitian menggunakan cross sectional dengan purposive sampling. Sebanyak 200 sampel diambil di tiga rumah sakit daerah jakarta pada Mei-Juni 2018. Kuesioner menggunakan COPD Assesment Test dan Pittsburgh Sleep Quality Index.
Hasil penelitan menunjukkan 66 pasien PPOK memiliki kualitas tidur buruk dengan masalah tertinggi yaitu durasi tidur. Kualitas tidur buruk ditemukan rata-rata pada usia 62 tahun, berjenis kelamin laki-laki, tingkat pendidikan SD/SMP, pendapatan kurang lebih Rp.2.000.000, menikah, IMT normal, memiliki >1 penyakit penyerta, terdiagnosis PPOK 12 bulan. Pasien PPOK yang mengalami kualitas tidur buruk mayoritas memiliki keluhan pernapasan sedang-berat. Tingkat keluhan pernapasan memiliki hubungan dengan kualitas tidur p = 0,016;OR:2,28. Perawat sebagai pemberi asuhan keperawatan diharapkan dapat memperbaiki atau meningkatkan kualitas tidur pasien PPOK.

Chronic obstructive pulmonary disease can cause someone experience respiratory complaints such as shortness breath, coughing, excessive sputum. Respiratory complaints and many factors can influence sleep quality. This study purpose to describe sleep quality in COPD. Design used cross sectional purposive sampling in May June 2018. Respondents was 200 at three hospitals in Jakarta. Questionnaire used COPD Assesment Test and the PSQI.
Results showed that 66 COPD had poor sleep quality, the highest problems was sleep duration. Poor sleep quality was found average at 62 years old, male, education level in elementary junior high school, income Rp.2.000.000, married, had normal BMI and 1 comorbidities, diagnosed COPD for 12 months. Most of COPD who experience poor sleep had moderate severe respiratory complaints. There was relationship between respiratory complaints and poor sleep quality in COPD p 0.016 OR 2,28 . Nurses as caregivers is expected to correct or improve sleep quality in COPD.
"
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2018
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Rania Imaniar
"Latar belakang: Asma dan PPOK merupakan dua penyakit berbeda. Beberapa kelompok pasien, terutama perokok dan usia tua seringkali memiliki gambaran klinis yang mirip dengan asma dan PPOK sehingga diagnosis sulit ditegakkan. Hal ini telah memunculkan suatu entitas klinis baru yang disebut STAP.
Tujuan: Mengetahui prevalens dan karakteristik STAP pada pasien asma dan PPOK di RSUP Persahabatan.
Metode: Penelitian menggunakan studi potong lintang, dilakukan di Poli Asma-PPOK RSUP Persahabatan Jakarta pada Maret-Agustus 2018. Kriteria GINA/GOLD 2017 yang dimodifikasi digunakan untuk mendiagnosis STAP.Pasien didiagnosis STAP apabila memiliki minimal tiga karakteristik klinis yang mendukung asma dan PPOK.
Hasil:Penelitian melibatkan 60 subjek. Prevalens STAP didapatkan 58,3%. Sebanyak 51,4% pasien STAP memiliki jenis kelamin perempuan, 65,7% tidak bekerja, 65,7% berpendidikan tinggi, 54,3% memiliki riwayat merokok dengan median indeks Brinkman 0,5 (0-1536) dan memiliki rerata IMT 24,9±3,8 kg/m2. Satu tahun terakhir, median eksaserbasi kelompok STAP adalah 1 (0-10) kali dan median rawat inap di RS adalah 0 (0-1) kali.Uji provokasi bronkus positif ditemukan pada 97,1% pasien STAP.
Kesimpulan: Prevalens STAP pada penelitian ini sebesar 58,3%. Kebanyakan pasien STAP adalah perempuan, tidak bekerja, berpendidikan tinggi, memiliki riwayat merokok, indeks Brinkmann yang rendah, IMT normaldan memiliki uji bronkodilator yang positif.

Asthma and COPD are two different diseases. Some patients, in particular smokers and elderly patients, often have overlapping clinical features of asthma and COPD so that the diagnosis is difficult to establish. This has led to a new clinical entity called ACOS.
Objectives: To determine the prevalence and characteristics of ACOS in patients with asthma and COPD.
Methods: This study was a cross sectional study conducted at Asthma-COPD Polyclinic of Persahabatan Hospital, Jakarta in March-August 2018. ACOS diagnosis was made using the modified 2017 GINA / GOLD criteria. Patients are diagnosed with ACOS if they have at least three clinical characteristics that support asthma and COPD.
Results: The study involved 60 subjects. ACOS prevalence was 58.3%.51.4% of ACOS patients were female, 65,7% did not work, 65,7% were highly educated, 54,3% had a history of smoking with  median Brinkman index 0.5 (0-1536) and had mean BMI of 24,9±3.8 kg/m2.In the past year, median exacerbation of the ACOS group was 1 (0-10) time and median hospitalization was 0 (0-1) times. Positive bronchial challenge test found in 97,1% ACOS patients.
Conclusion: ACOS prevalence in this study was 58,3%. Most of ACOS patients are female, unemployed, highly educated, had history of smoking, low Brinkmann index, normal BMI, had complaint of shortness of breath and had positive bronchial challenge test.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Astari Pranindya Sari
"Pendahuluan: Neutrofil merupakan sel inflamasi yang diyakini berperan pada patogenesis Penyakit Paru Obstruktif Kronik (PPOK). Telah terdapat bukti korelasi antara hambatan aliran udara pada pasien PPOK dengan kadar neutrofil sputum. Penelitian beberapa tahun terakhir membuktikan nilai rasio neutrofillimfosit (RNL) dan protein C-reaktif (CRP) dari darah perifer berpotensi menjadi petanda inflamasi sistemik, tidak terkecuali PPOK. Beberapa penelitian membuktikan nilai RNL dan CRP lebih tinggi pada pasien dengan PPOK dibanding orang normal. Begitu pula saat kondisi eksaserbasi, nilai RNL dan CRP lebih tinggi daripada kondisi stabil. Selain itu terdapat bukti korelasi antara hasil spirometri dengan nilai RNL dan CRP. Hasil beberapa penelitian yang telah dilakukan sejauh ini menunjukkan bahwa nilai RNL dan CRP dapat menjadi suatu penilaian yang layak diperhatikan dalam PPOK.
Tujuan: Memperoleh data mengenai nilai RNL dan CRP pada pasien PPOK eksaserbasi dan stabil di Rumah Sakit Umum Pusat Persahabatan.
Metode: Analisis observasional kohort prospektif di RS Persahabatan, Jakarta Indonesia sebanyak 31 sampel dari Juli 2018 hingga Desember 2018. Kami mengikutsertakan 31 pasien PPOK eksaserbasi untuk dilakukan pemeriksaan spirometri dan pemeriksaan darah dan membandingkan hasil pemeriksaan pasien yang sama pada kondisi stabil.
Hasil: Petanda inflamasi yang diperiksa pada penelitian ini RNL dan CRP keduanya menunjukkan penurunan kadar pada kondisi stabil, bertutut-turut dari 7,95 ± 6,8 menjadi 4,6 ± 5,5 dan 43,4 ± 71 menjadi 12,2 ± 18,5 dengan nilai p < 0,01. Didapatkan pula korelasi negatif yang bermakna antara RNL dan nilai VEP1/KVP pada kondisi eksaserbasi. Nilai CRP menunjukkan korelasi negatif hanya dengan VEP1 pada saat eksaserbasi. Di samping itu, terdapat pula subjek penelitian dengan nilai CRP yang sangat tinggi pada saat eksaserbasi, meninggal dunia dalam kurun waktu dua bulan setelah eksaserbasi.
Kesimpulan: Nilai RNL dan CRP pada subjek dengan PPOK lebih tinggi pada kondisi eksaserbasi dan mungkin dapat menggambarkan status eksaserbasi pada pasien PPOK.

Introductions: Although COPD has been believed to be characterized by respiratory disease, currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive method. We observed the COPD severity, future exacerbation by using peripheral blood test. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status.
Aims: To study the value of NLR and CRP of COPD patients during exacerbation and stable in Persahabatan Hospital, Jakarta.
Methods: Starting from July to December 2019, a prospective cohort study was performed with blood and pulmonary function test in 31 COPD patients in two different conditions: during exacerbation and stable. The mean of both inflammation markers was compared and correlated them with pulmonary function test.
Results: Both inflammation markers NLR and CRP value decreased during stable condition (from 7,95 ± 6,8 to 4,6 ± 5,5 and 43,4 ± 71 to 12,2 ± 18,5) with p < 0,01 respectively. In addition, we also found a significant inverse correlation between NLR and FEV1/FVC during exacerbation but not during the stable condition, and CRP showed inverse correlation only with FEV1 during exacerbation. Another interesting finding was subject with very high CRP whose value remained above nomal limit during stable, died within 2 month after exacerbation.
Conclusions: NLR and CRP in COPD patients increased during exacerbation and may reflect lung function and exacerbation status in COPD patient.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
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Putu Eka Pujanta Putra
"Pendahuluan: Pasien penyakit paru obstruktif kronik (PPOK) yang mengalami eksaserbasi akan meningkatan angka morbiditas dan mortalitas. Berdasarkan Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD), PPOK derajat sedang dan berat dapat diberikan antibiotik sebagai tata laksananya. Salah satu cara menilai ketepatan pemberian antibiotik adalah dengan menggunakan alur Gyssens. Penelitian ini bertujuan melihat proporsi ketepatan pemberian antibiotik berdasarkan alur Gyssens dan hubungannya dengan mortalitas, perbaikan klinis, kebutuhan ventilasi mekanis invasif dan perawatan berulang dalam satu tahun. Metode: Penelitian ini merupakan studi observasional dengan menggunakan desain penelitian kohort restrospektif. Sebanyak 161 pasien PPOK derajat sedang dan berat yang dirawat di RS Persahabatan Pusat Respirasi Nasional pada Januari 2022 hingga Desember 2023 mendapatkan terapi antibiotik. Pasien yang mendapatkan antibiotik selama perawatan dinilai ketepatannya sesuai alur Gyssens. Hasil: Berdasarkan ketepatan pemberian antibiotik sesuai alur Gyssens, sebanyak 93 subjek (62,8%) laki-laki dan lima subjek (38,5%) perempuan dengan rerata usia 64,34 (±9,62) tahun. Sebagian besar memiliki status merokok indeks Brinkman berat dengan kelompok PPOK grup E dan derajat esksaserbasi sedang. Hipertensi merupakan komorbiditas yang paling sering ditemukan. Terdapat hubungan bermakna antara ketepatan pembrian antibiotik dengan rerata lama rawat (p=<0,001). Proporsi ketepatan pemberian antibiotik sesuai alur Gyssens sebesar 60,9%. Antibiotik yang paling seering digunakan adalah levofloxacin. Hasil analisis bivariat menunjukkan tidak terdapat hubungan yang bermakna antara ketepatan pemberian antibiotik berdasarkan alur Gyssens dengan mortalitas, lama perbaikan klinis, penggunaan ventilasi mekanis invasif dan perawatan berulang dalam satu tahun. Kesimpulan: Proporsi pemberian antibiotik sesuai alur Gyssens pada pasien PPOK eksaserbasi derajat sedang dan berat sebesar 60,9%. Tidak terdapat hubungan yang bermakna secara statistik antara ketepatan pemberian antibiotik sesuai alur Gyssens dengan mortalitas, lama perbaikan klinis, penggunaan ventilasi mekanis invasif dan perawatan berulang dalam satu tahun.

Introduction: Patients with chronic obstructive pulmonary disease (COPD) experiencing exacerbations will increase morbidity and mortality rates. According to the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD), moderate and severe COPD can be treated with antibiotics. One way to assess the appropriateness of antibiotic administration is by using the Gyssens flowchart. This study aims to examine the proportion of appropriateness of antibiotic administration based on the Gyssens flowchart and its relationship with mortality, clinical improvement, need for mechanical ventilation and readmission within one year. Method: This study is an observational study using a retrospective cohort design. A total of 161 moderate and severe COPD patients treated at Persahabatan Hospital National Respiratory Center from January 2022 to December 2023 received antibiotic therapy. The appropriateness of antibiotic administration during treatment was assessed according to the Gyssens flowchart.. Results: Based on the appropriateness of antibiotic administration according to the Gyssens flowchart, there were 93 male subjects (62.8%) and five female subjects (38.5%) with a mean age of 64.34 (±9.62) years. Most of them had a heavy Brinkman smoking index with COPD group E and moderate exacerbation. Hypertension was the most commonly found comorbidity. There is a significant relationship between the appropriateness of antibiotic administration and length of stay (p=<0.001). The proportion of appropriateness of antibiotic administration according to the Gyssens flowchart was 60.9%. Levofloxacin was the most frequently used antibiotic. Bivariate analysis results showed no significant relationship between the appropriateness of antibiotic administration based on the Gyssens flowchart with mortality, duration of clinical improvement, use of invasive mechanical ventilation and readmission within one year. Conclusion: The proportion of antibiotic administration according to the Gyssens flowchart in patients with moderate and severe exacerbations of COPD is 60.9%. There is no statistically significant relationship between the appropriateness of antibiotic administration according to the Gyssens flowchart and mortality, duration of clinical improvement, use of invasive mechanical ventilation and readmission within one year"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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Rina Amtarina
"[ABSTRAK
Latar Belakang: Psoriasis adalah salah satu penyakit inflamasi kronis pada kulit yang dapat mengganggu penampilan. Pasien psoriasis seringkali komorbid dengan gangguan psikiatri seperti depresi, gangguan cemas, gejala psikotik, distimia dan gangguan tidur. Aspek psikiatri tersebut dapat memengaruhi kualitas hidup pasien psoriasis. Belum terdapat penelitian tentang perbedaan rerata kualitas hidup antara pasien psoriasis dengan psikopatologi dibandingkan dengan pasien psoriasis tanpa psikopatologi.
Metode: Penelitian potong lintang deskriptif-analitik pada 25 pasien psoriasis yang memiliki psikopatologi dan 25 pasien psoriasis yang tidak memiliki psikopatologi di Poliklinik Ilmu Kesehatan Kulit dan Kelamin RSCM Jakarta menggunakan Symptom Checklist 90 (SCL 90) dan instrumen World Health Organization Quality Of Life (WHOQOL)-BREF.
Hasil: Lima gejala psikiatri terbanyak yang dijumpai pada pasien psoriasis adalah sensitivitas interpersonal, obsesif kompulsif, gejala gangguan jiwa tambahan, gejala depresi dan ide paranoid. Terdapat perbedaan rerata kualitas kualitas hidup antara pasien psoriasis dengan psikopatologi dengan tanpa psikopatologi berdasarkan ranah kesehatan fisik (p < 0,05) dan ranah kesehatan psikologis (p < 0,05)
Simpulan: Pasien psoriasis dengan psikopatologi cenderung memiliki rerata kualitas hidup yang lebih rendah bila dibandingkan dengan pasien psoriasis tanpa psikopatologi pada ranah kesehatan fisik dan kesehatan psikologis. Pengenalan dini dan tata laksana gejala klinis psikiatri dapat memperbaiki kualitas hidup pasien.

ABSTRACT
Background: Psoriasis has been known as one of chronic inflammatory skin disease which represent the leading causes of morbidity and bad performance. Psoriasis can have psychiatric comorbidity like depression, anxiety, psychotic symptom, distimia and sleep disorder. This psychiatric aspect can impact quality of life psoriasis patients. In this study, we evaluated the mean difference of quality of life psoriatic patients with psychiatric symptoms and without psychiatric symptoms.
Methods: Cross sectional study included 25 psoriatic pasients with psychiatric symptoms and 25 psoriatic patients without psychiatric symptoms. The patient in this study were subjected to quality of life assessment by World Health Organization Quality Of Life (WHOQOL)-BREF and psychiatric evaluation using Symptom Checklist 90 (SCL 90)
Result: the most frequent psychiatric symptoms experienced by psoriatic patients were interpersonal sensitivity, obsessive compulsive, additional psychiatric symptom, depression and paranoid ideation. There is a difference quality of life in physical domain (p < 0,05) and psychological domain (p < 0,05) between psoriatic patients with psychiatric symptoms and without psychiatric symptoms.
Conclusion: psoriasis with psychiatric symptoms can have a profound impact on patient's quality of life especially in physical domain and psychological domain. Early detection and treatment of psychiatric symptoms can improve quality of life of psoriatic patients., Background: Psoriasis has been known as one of chronic inflammatory skin
disease which represent the leading causes of morbidity and bad performance.
Psoriasis can have psychiatric comorbidity like depression, anxiety, psychotic
symptom, distimia and sleep disorder. This psychiatric aspect can impact quality
of life psoriasis patients. In this study, we evaluated the mean difference of quality
of life psoriatic patients with psychiatric symptoms and without psychiatric
symptoms.
Methods: Cross sectional study included 25 psoriatic pasients with psychiatric
symptoms and 25 psoriatic patients without psychiatric symptoms. The patient in
this study were subjected to quality of life assessment by World Health
Organization Quality Of Life (WHOQOL)-BREF and psychiatric evaluation using
Symptom Checklist 90 (SCL 90)
Result: the most frequent psychiatric symptoms experienced by psoriatic patients
were interpersonal sensitivity, obsessive compulsive, additional psychiatric
symptom, depression and paranoid ideation. There is a difference quality of life in
physical domain (p < 0,05) and psychological domain (p < 0,05) between psoriatic
patients with psychiatric symptoms and without psychiatric symptoms.
Conclusion: psoriasis with psychiatric symptoms can have a profound impact on
patient’s quality of life especially in physical domain and psychological domain. Early detection and treatment of psychiatric symptoms can improve quality of life of psoriatic patients.]"
Fakultas Kedokteran Universitas Indonesia, 2015
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UI - Tugas Akhir  Universitas Indonesia Library
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