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"This book presents methods of mathematical modeling from two points of view. Splines provide a general approach while compartment models serve as examples for context related to modeling. The preconditions and characteristics of the developed mathematical models as well as the conditions surrounding data collection and model fit are taken into account. The substantial statements of this book are mathematically proven. The results are ready for application with examples and related program codes given.In this book, splines are algebraically developed such that the reader or user can easily understand and vary the numerical construction of the different kinds of spline functions. The classical compartment models of the pharmacokinetics are systematically analyzed and connected with lifetime distributions. As such, parameter estimation and model fit can be treated statistically with a varied minimum chi-square method. This method is applicable for single kinetics and also allows the calculation of average kinetics.--"

"ABSTRAKPenaksiran parameter dalam model regresi memiliki dua pendekatan yaitu pendekatan regresi parametrik dan pendekatan regresi nonparametrik. Dalam regresi parametrik bentuk dari kurva hubungan antara variabel respon dan variabel prediktor sudah ditentukan berdasarkan plot data, sedangkan dalam regresi nonparametrik bentuk dari kurva tidak diketahui. Salah satu regresi nonparametrik yang dapat digunakan adalah regresi spline. Regresi spline adalah suatu piecewise polynomial yang dihubungkan oleh titik-titik bersama yang disebut dengan knot. Regresi spline yang menggunakan fungsi basis B Spline disebut dengan regresi B Spline. Pada umumnya estimasi parameter regresi B Spline dilakukan dengan menggunakan metode OLS Ordinary Least Square. Namun, dengan metode OLS akan menyebabkan plot taksiran kurva regresi menjadi fluktuatif apabila pemilihan jumlah knot terlalu banyak. Untuk itu diperlukan suatu tambahan kendala berupa penalty yang didalamnya mengandung smoothing parameter sehingga diperoleh taksiran ideal. Metode estimasi parameter ini dikenal dengan metode PLS Penalized Least Square . Metode PLS dengan penalty yang merupakan integral kuadrat derivatif kedua dari taksiran kurva disebut juga dengan metode o rsquo;sullivan penalized spline. Pada penerapan contoh data, didapat 23 buah knot dan smoothing parameter sebesar 0.68.

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ABSTRACTParameter estimation of regression model has two approaches, that is parametric and nonparametric regression approach. In parametric regression, the shape of regression curve is determined based on scatterplot of dependent variable vs independent variable, whereas in the nonparametric regression, the shape of the curve is unknown. One of the nonparametric regression is spline regression. Spline regression is piecewise polynomials that connected by the knots. Spline regression using B Spline basis function is B Spline regression. In B spline regression, parameter estimation were fitted by OLS Ordinary Least Square method. However, the OLS method will lead the plot of estimated regression curve be fluctuative when using too much knots. Therefore, it needs additional constraint of penalty that contain smoothing parameter to obtain ideal fit result. This parameter estimation method known as PLS Penalized Least Square method. The estimate PLS method used penalty which is the integral of the square of second derivative of the estimate curve that called o 39 sullivan penalized spline method. In the application of sample data, 23 is used knots and the smoothing parameters is 0.68. "

"Interest in the temporal fluctuations of biological populations can be traced to the dawn of civilization. How can mathematics be used to gain an understanding of population dynamics? This monograph introduces the theory of structured population dynamics and its applications, focusing on the asymptotic dynamics of deterministic models. This theory bridges the gap between the characteristics of individual organisms in a population and the dynamics of the total population as a whole. In this monograph, many applications that illustrate both the theory and a wide variety of biological issues are given, along with an interdisciplinary case study that illustrates the connection of models with the data and the experimental documentation of model predictions. The author also discusses the use of discrete and continuous models and presents a general modeling theory for structured population dynamics. Cushing begins with an obvious point: individuals in biological populations differ with regard to their physical and behavioral characteristics and therefore in the way they interact with their environment. Studying this point effectively requires the use of structured models. Specific examples cited throughout support the valuable use of structured models. Included among these are important applications chosen to illustrate both the mathematical theories and biological problems that have received attention in recent literature."

"Detailed hints for the implementation of the various algorithms enable readers to write their own flow simulation program from scratch. The variety of applications is shown in several simulation results, including 93 black-and-white and 17 color illustrations. Moreover, after reading this book, readers should be able to understand more enhanced algorithms of computational fluid dynamics and to apply their new knowledge of modeling, discretization, parallelization, and visualization to other scientific fields, where numerical simulation has established itself, in addition to theoretical investigations and practical experiments, as a new path for uncovering the laws of nature. Among these fields are the examination of elastic solids, combustion, melting and coating processes, and crystal growth, as well as weather prediction."

"ABSTRAKTugas akhir ini membahas penerapan sistem antrian yang terdapat pada sistem pelayanan kesehatan di Unit Gawat Darurat R.S.U.P Dr. M. Jamil dengan berlandaskan analisa teori Antrian Model Saluran Pelayanan Kesehatan Tunggal. Atas dasar penelitian ini dapat diketahui bahwa sistem pelayanan kesehatan di Unit Gawat Darurat ini tidak memadai lagi untuk Model Saluran Pelayanan Kesehatan Tunggal."