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"ABSTRAK Ulkus kaki diabetik mengakibatkan mortalitas yang semakin meningkat terutamapasca amputasi, beban yang signifikan pada pembiayaan kesehatan danmenyebabkan hilangnya produktivitas. Penelitian ini bertujuan untuk mengetahuiefektivitas terapi kombinasi dari laserpunktur dan perawatan luka konvensionaldibandingkan dengan laserpunktur sham dan perawatan luka konvensionalterhadap penyembuhan ulkus kaki diabetik. Uji klinis acak tersamar ganda denganpembanding dilakukan terhadap 36 pasien yang dialokasikan ke dalam kelompokkasus atau kelompok kontrol. Tindakan laserpunktur dilakukan pada titik LI4Hegu, ST36 Zusanli, SP6 Sanyinjiao, dan KI3 Taixi bilateral serta penyinaranpada ulkus dua kali seminggu, selama empat minggu. Rerata ukuran ulkus kakidiabetik sebagai keluaran primer diukur setiap minggu. Hasil penelitianmenunjukkan perbedaan yang bermakna antara penurunan luas luka akhir dikelompok laserpunktur dan perawatan luka konvensional dengan kelompoklaserpunktur sham dan perawatan luka konvensional (p=0,006). Dapatdisimpulkan bahwa terapi kombinasi laserpunktur dan perawatan lukakonvensional efektif mempercepat penyembuhan ulkus kaki diabetik denganfrekuensi terapi dua kali seminggu. ABSTRACT Diabetic foot ulcers result in mortality is increasing, especially after theamputation, a significant burden on health financing and lead to loss ofproductivity. This study aims to determine the effectiveness of the combinationtherapy between laserpuncture and conventional wound care compared withsham laserpuncture and conventional wound treatment for healing diabetic footulcers. Double-blind randomized clinical trial with a control carried out on 36patients allocated to the case group or control group. Laserpuncture actionsperformed on LI4 point Hegu, Zusanli ST36, SP6 Sanyinjiao and Taixi KI3bilateral as well as exposure to ulcers twice a week, for four weeks. The mean sizeof diabetic foot ulcers as the primary output is measured every week. The resultsshowed a significant difference between the reduction in wound area at the end ofthe group laserpuncture and conventional wound care compare withlaserpuncture sham group and conventional wound treatment (p = 0.006). It canbe concluded that the combination therapy laserpuncture and conventional woundcare effectively accelerate the healing of diabetic foot ulcers with frequencytherapy twice a week.;Diabetic foot ulcers result in mortality is increasing, especially after theamputation, a significant burden on health financing and lead to loss ofproductivity. This study aims to determine the effectiveness of the combinationtherapy between laserpuncture and conventional wound care compared withsham laserpuncture and conventional wound treatment for healing diabetic footulcers. Double-blind randomized clinical trial with a control carried out on 36patients allocated to the case group or control group. Laserpuncture actionsperformed on LI4 point Hegu, Zusanli ST36, SP6 Sanyinjiao and Taixi KI3bilateral as well as exposure to ulcers twice a week, for four weeks. The mean sizeof diabetic foot ulcers as the primary output is measured every week. The resultsshowed a significant difference between the reduction in wound area at the end ofthe group laserpuncture and conventional wound care compare withlaserpuncture sham group and conventional wound treatment (p = 0.006). It canbe concluded that the combination therapy laserpuncture and conventional woundcare effectively accelerate the healing of diabetic foot ulcers with frequencytherapy twice a week.;Diabetic foot ulcers result in mortality is increasing, especially after theamputation, a significant burden on health financing and lead to loss ofproductivity. This study aims to determine the effectiveness of the combinationtherapy between laserpuncture and conventional wound care compared withsham laserpuncture and conventional wound treatment for healing diabetic footulcers. Double-blind randomized clinical trial with a control carried out on 36patients allocated to the case group or control group. Laserpuncture actionsperformed on LI4 point Hegu, Zusanli ST36, SP6 Sanyinjiao and Taixi KI3bilateral as well as exposure to ulcers twice a week, for four weeks. The mean sizeof diabetic foot ulcers as the primary output is measured every week. The resultsshowed a significant difference between the reduction in wound area at the end ofthe group laserpuncture and conventional wound care compare withlaserpuncture sham group and conventional wound treatment (p = 0.006). It canbe concluded that the combination therapy laserpuncture and conventional woundcare effectively accelerate the healing of diabetic foot ulcers with frequencytherapy twice a week."

"ABSTRAK Gastroesophageal reflux disease (GERD) merupakan suatu kondisi patologis yang disebabkan oleh refluks kandungan lambung ke dalam esofagus. GERD memiliki dampak yang besar terhadap penderitanya baik secara fisik, psikologik, sosial maupun ekonomi. Penurunan kualitas hidup dan produktifitas kerja sering ditemukan pada penderita GERD. Berbagai terapi farmakologis telah dikembangkan, namun belum memberikan hasil yang optimal. Hal tersebut mendorong pengembangan modalitas terapi lain, salah satunya akupunktur tanam benang. Penelitian ini bertujuan untuk mengetahui efektifitas terapi kombinasi akupunktur tanam benang dan medikamentosa terhadap gejala dan kualitas hidup penderita GERD. Uji klinis acak tersamar ganda dengan pembanding dilakukan terhadap 52 penderita GERD yang dialokasikan secara acak ke dalam kelompok kombinasi akupunktur tanam benang dan medikamentosa (kelompok perlakuan) atau kelompok akupunktur sham dan medikamentosa (kelompok kontrol). Akupunktur tanam benang dilakukan pada titik CV12 Zhongwan, ST36 Zusanli dan BL21 Weishu sebanyak 2 kali dengan interval 15 hari. Skor GERDQ, RQS dan SF-36 digunakan untuk mengukur keluaran terapi. Hasil penelitian menunjukkan bahwa penurunan skor GERDQ pada kelompok perlakan lebih besar dari kelompok kontrol (p<0,001) dan peningkatan skor RQS serta peningkatan skor seluruh komponen SF-36 pada kelompok perlakuan lebih besar dibanding kelompok kontrol (p<0,001). Kesimpulan penelitian adalah terapi kombinasi akupunktur tanam benang dan medikamentosa lebih efektif dalam mengurangi gejala dan meningkatkan kualitas hidup penderita GERD dibandingkan dengan terapi medikamentosa saja ABSTRACT Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients.;Gastroesophageal reflux disease (GERD) is a pathological condition caused by reflux of gastric contents into the esophagus. It has been shown that GERD has significant impact on patients either physically, psychologically, socially or economically. Impaired of quality of life and working productivity are common in GERD patients. Various pharmacological therapies have been developed, but not yet provide optimal results. It encourages the development of other therapeutic modalities, such as acupoint catgut embedment. The aim of this study was to establish the effect of acupoint catgut embedment combine with medical treatment on symptom and quality of life of GERD patients. A double-blind randomized controlled trial involved 52 GERD patients randomly allocated into catgut embedding therapy with medication group (treatment group) or medication only group (control group). Catgut embedding therapy was given 2 times at CV12 Zhongwan, ST36 Zusanli and BL21 Weishu every 15 days. GERDQ, RQS and SF-36 were used to measure the primary outcomes. The result shown, the decreased of GERDQ scores at treatments group significant higher than control groups (p<0,001), the increased of RQS score and all of SF-36 components scores at treatment group significant higher than control group (p<0,001). The result suggested that acupoint-catgut embedment combined with medical treatment is more effective than medical treatment in alleviating symptoms and enhancing the quality of life of GERD patients."

"ABSTRAKLatihan fisik merupakan hal yang penting untuk kesehatan namun dapat pula meningkatkan stres oksidatif yang menyebabkan peningkatan Reactive Oxygen Species ROS . Superoksida dismutase SOD adalah antioksidan endogen yang terdapat dalam tubuh, merupakan enzim yang mengkatalisis dismutasi ion superoksida radikal O2- menjadi hidrogen peroksida H2O2 dan molekul oksogen O2 sebagai perlawanan terhadap stres oksidatif.Akupunktur merupakan salah satu modalitas terapi yang diharapkan dapat mengurangi stress oksidatif yang terjadi akibat latihan fisik. Penelitian ini dilakukan pada tiga puluh pria tidak terlatih yang dibagi secara acak menjadi dua kelompok, kelompok akupunktur manual n = 15 yang dilakukan penusukan pada titik akupunktur ST36 dan SP6 bilateral, dan kelompok plasebo n = 15 yang dilakukan penusukan jarum pada plester tanpa menembus kulit. Terapi akupunktur dilakukan satu kali selama 30 menit segera setelah subyek selesai melakukan latihan fisik akut.. Penilaian kadar SOD darah dinilai sebelum latihan fisik dan satu jam setelah melakukan latihan fisik. Hasil penelitian ini menunjukkan terdapat perbedaan bermakna secara statistik selisih kadar SOD antara sebelum dan sesudah latihan fisik antara kelompok akupunktur manual dan kelompok plasebo p = 0,001.

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ABSTRACTPhysical exercise is important for health but can also increase oxidative stress that induce Reactive Oxygen Species ROS . Superoxide dismutase SOD is endogenous antioxidants found in the body, an enzyme that catalyzes the dismutation of radical superoxide ions O2 into hydrogen peroxide H2O2 and oxygen molecules O2 against oxidative stress Acupuncture is one of the therapeutic modalities that is expected to reduce oxidative stress that occurs due to physical exercise. The study was conducted on thirty untrained men who were randomly divided into two groups, the manual acupuncture group n 15 performed acupuncture therapy at bilateral ST36 and SP6 acupuncture points, and the placebo group n 15 performed the needle stitching on the plaster without penetrating the skin. Acupuncture therapy is performed once for 30 minutes immediately after the subjects have finished acute physical exercise. Assessment of the blood SOD level was assessed before physical exercise and one hour after physical exercise. The results of this study showed a statistically significant difference in the difference between the level of SOD before and after physical exercise between the manual acupuncture group and placebo group p 0.001. "

"Latar belakang dan tujuanNyeri biasanya dianggap sebagai suatu fenomena patologis. Tetapi nyeri yang berhubungan dengan persalinan mempunyai makna berbeda pada wanita dan sangat bergantung pada pengalaman nyeri serta konstribusi ibu pada pengendalian nyeri tersebut. Ketika seorang wanita merasa bahwa suatu persalinan, terdiri dari lsquo;nyeri dan kerja keras rsquo;, dan rasa nyeri yang lama dan tak tertahankan dapat mengganggu ibu serta bayi, maka saat itulah diperlukan intervensi pengendalian rasa nyeri pada persalinan. Telah banyak metode yang dipergunakan dalam penanggulangan nyeri pada persalinan salah satunya adalah akupunktur. Penelitian ini ditujukan untuk melihat efek terapi akupunktur terhadap pengurangan nyeri ibu bersalin normalMetodePenelitian ini memakai metode Randomized Clinical Trial With Control. Penelitian ini dilakukan terhadap 50 wanita bersalin normal. Terdiri dari 25 orang kelompok kasus dan 25 orang kelompok kontrol. Kedua kelompok mendapat perlakuan sama sesuai protokol kebidanan wanita akan melahirkan. Pada kelompok kasus diberikan terapi akupunktur pada saat kala 1 aktif atau dimana rasa nyeri mulai mengganggu, sedangkan pada kelompok kontrol tidak. Dilakukan penilaian terhadap NAS nyeri persalinan, dihitung jumlah dan lama his. Lama kala 2 dan membandingkan APGAR Score bayiHasilTerapi akupunktur mempunyai efek terhadap pengurangan nyeri persalinan dengan dilihat pada kelompok kasus secara bermakna.

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Back Ground and PurposePain is usually regarded as a pathological phenomenon. But the pain associated with childbirth have different meanings in women and relies heavily on the experience of pain as well as the mother 39 s contribution is on controlling the pain. When a woman feels that a labor, consists of 39 pain and hard work 39 , and the prolonged pain and unbearable can interfere with the mother and the baby, that 39 s when the necessary interventions for controlling pain in childbirth. Many methods have been used in pain relief in childbirth one is acupuncture. This study aimed to look at the effect of acupuncture therapy against a reduction of the normal maternity mother pain researchMethodThis method of wear of Randomized Clinical Trial With Control. Research. This research was conducted against 50 women maternity normally. Consists of 25 people groups of case and control groups of 25 people. Both groups received the same treatment protocol accordingly obstetrics women will give birth. In the case group was given acupuncture therapy at the time of the fase 1 active or where the pain starts to interrupt, whereas in the control group did not. Conducted assessment of the NAS calculated the amount of labor pain, and long and intensity of the uterus contraction . Long fase 2 and compare the APGAR Score baby.Results of acupuncture Therapy has an effect against the reduction of labor pain with views on this group of cases significantly p 0.05 Acupuncture Therapy Conclusion have the effect of a reduction of labor pain. Strengthen uterus contraction, speed up fase 2 and has no side effects on the mother and baby. "

"Pendahuluan: Laser akupunktur adalah pemanfaatan laser berenergi rendah untuk menstimulasi titik akupunktur diketahui memiliki efek dalam menurunkan kadar gula darah. Tujuan penelitian ini adalah untuk melihat pengaruh laser akupunktur pada titik EX-B3 Weiwanxiashu terhadap gambaran histologi pankreas dan kadar gula darah pada model tikus diabetes tipe 2.Bahan dan Metode: Desain studi ini adalah studi eksperimental dengan randomized control group pretest and posttest. Sebanyak 18 tikus Sprague-Dawley jantan usia 8 s.d 10 minggu dengan berat badan 200-250 gram dibagi menjadi 3 kelompok masing-masing 6 ekor tikus, yaitu: (1) kelompok tikus normal; (2) kelompok tikus DM; (3) kelompok tikus laser. Dilakukan induksi STZ 50 mg/kgBB untuk menjadikan tikus diabetes. Laser akupunktur dilakukan sebanyak 3 kali seminggu dengan total 6 sesi terapi di titik akupunktur EX-B3 Weiwanxiashu. Pengukuran gula darah dilakukan pada sebelum, setelah 3 sesi dan setelah 6 sesi yang diambil dari ujung ekor tikus. Pemeriksaan gambaran histologi berdasarkan kepadatan sel dan persentase luas pulau Langerhans dengan software ImageJ.Hasil: Rerata kepadatan sel pulau Langerhans kelompok tikus DM lebih rendah secara bermakna dibandingkan dengan kelompok tikus normal (p=0,010) dan kelompok tikus laser (p=0,002). Rerata persentase luas pulau Langerhans kelompok tikus normal lebih tinggi dibandingkan dengan kelomok tikus DM (p=0,028) dan kelompok tikus laser (p=0,152). Rerata kadar GDP kelompok laser lebih rendah secara bermakna dibandingkan kelompok tikus DM (p=0,015).Kesimpulan: Laser akupunktur dapat memperbaiki gambaran histologi pankreas melalui penilaian kepadatan sel dan persentase luas pulau Langerhans, dan menurunkan kadar gula darah tikus diabetes

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Introduction: Laser acupuncture is the use of a low-energy laser to stimulate acupuncture points known to have an effect on lowering blood sugar levels. The purpose of this study was to determine the effect of laser acupuncture at the EX-B3 Weiwanxiashu point on the histology of the pancreas and blood sugar levels in a type 2 diabetes rats model.

Materials and Methods: This study design was an experimental study with a pretest and posttest randomized control group. Eighteen male Sprague-Dawley rats aged 8 to 10 weeks, weighing 200-250 gram, were divided into 3 groups of 6 rats each: (1) a normal rats group; (2) a DM rats group; and (3) a laser rats group. STZ 50 mg / kgBW induction was performed to make diabetic rats. Laser acupuncture was performed 3 times a week for a total of 6 therapy sessions at the Weiwanxiashu EX-B3 acupuncture point. Blood sugar measurements were carried out before, after 3 sessions and after 6 sessions taken from the tail of the rats. Histological examination based on cell density and the percentage area of Langerhans islands using ImageJ software.

Results: The mean cell density of Langerhans islets in the DM rat group were significantly lower than the normal mice group (p = 0.010) and the laser mouse group (p = 0.002). The mean percentage of Langerhans island area in the normal rat group was higher than the DM mouse group (p = 0.028) and the laser mouse group (p = 0.152). The mean levels of GDP in the laser group were significantly lower than those in the DM group (p = 0.015).

Conclusion: Laser acupuncture can improve pancreatic histology by assessing the cell density and percentage of Langerhans islets, and reducing blood sugar levels in diabetic rats."

"ABSTRAKKerutan nasolabial merupakan salah satu tanda penuaan wajah yang menonjol. Upaya mengurangi tanda penuaan wajah dengan metode invasif minimal belakangan semakin marak. Akupunktur tanam benang Polydioxanone (PDO) sering dipraktekkan untuk mengurangi kerutan, namun penelitian yang menilai efek obyektif akupunktur tanam benang terhadap perbaikan kerutan masih sedikit. Uji klinis open-label prospektif lengan tunggal dilakukan terhadap wanita usia 30-49 tahun, dengan Skala Glogau II-III. 13 subyek menerima 1 sesi akupunktur tanam benang dengan penjabaran sesuai Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA). Penilaian utama yaitu perbedaan jarak kerutan nasolabial dilakukan 4 kali pada sebelum, tepat sesudah, 2 minggu dan 4 minggu sesudah tindakan. Penilaian sekunder adalah skor Modified Fitzpatrick Wrinkle Score (MFWS) dan skor kepuasan subyek. Tidak ada subyek yang dinyatakan gugur. Penilaian utama menunjukkan penurunan jarak rerata kerutan nasolabial kanan yang signifikan pada tepat sesudah (6.43 ± 7.15), 2 minggu (6.53 ± 6.07), dan 4 minggu (15.32 ± 6.21) dibandingkan dengan nilai awal (p<0.05), serta penurunan jarak rerata kerutan nasolabial kiri pada tepat sesudah (7.05 ± 5.23), 2 minggu (7.52 ± 4.29), dan 4 minggu (15.65 ± 6.25) dibandingkan dengan nilai awal (p<0.05). Didapatkan penurunan signifikan rerata skor MWFS pada 4 minggu dibandingan nilai awal baik pada kerutan nasolabial kanan maupun kiri. Sebelas subyek (84.62%) merasa sangat puas dengan tindakan akupunktur tanam benang PDO, sementara 2 subyek lainnya merasa cukup puas. Efek samping yang ditemui berupa eritema, hematoma, edema, gatal, dan nyeri, bersifat sementara dan menghilang tanpa intervensi. Akupunktur tanam benang PDO terbukti mengurangi jarak kerutan nasolabial kiri dan kanan, dimana pengurangan jarak kerutan lebih besar setelah 2 Minggu.

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ABSTRACTNasolabial folds are one of the most prominent facial aging signs. There is a growing trend on minimally invasive procedures to correct facial aging signs. While Polydioxanone (PDO) thread embedding acupuncture are often practiced in wrinkle treatment, the clinical trials with objective measurements are scarce. A single arm, prospective, open-label clinical trial was done to women aged 30-49 years, with Glogau scale II-III. Thirteen participants each receive a single thread embedding acupuncture reported according the Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA). The primary outcome, length of nasolabial fold, were oberved 4 times; before, right after, 2 weeks, and 4 weeks after procedure. The secondary outcomes are Modified Fitzpatrick Wrinkle Score (MFWS) and patient satisfaction score. There was no dropout. Primary outcome analisis shows significant improvement in every mean difference of dextra nasolabial folds right after (6.43 ± 7.15), 2 weeks (6.53 ± 6.07), and 4 weeks (15.32 ± 6.21), as well on sinistra nasolabial folds right after (7.05 ± 5.23), 2 weeks (7.52 ± 4.29), and 4 weeks (15.65 ± 6.25) compared to baseline (p<0.05). Significant improvement in MWFS score was also observed in 4 week for both right and left nasolabial folds compared to baseline. Eleven participants (84.62%) scored very satisfied, while the rest scored quite satisfied. Side effects found were erythema, bruising, edema, itchiness, and pain were all brief and self limiting. PDO thread emnbedding acupuncture are effective in reducing both right and left nasolabial length, with higher decrease 2 weeks after post treatment."

"ABSTRAKSampai saat ini, walaupun terapi akupunktur telah diakui, namun pertanyaantentang bagaimana rangsang pada titik akupunktur dapat menimbulkan efek terapimasih belum dapat dijawab secara lengkap dan memuaskan. Para ahli di duniaberbeda pendapat mengenai hal tersebut. Kim Bong Han adalah yang pertama kalimelaporkan telah menemukan bahwa ada struktur khusus yang terlibat dalammenghantarkan rangsang akupunktur, dan struktur yang dimaksud bukanlahpembuluh arteri, vena, limf, maupun saraf, namun merupakan struktur anatomibaru, yang diyakini sebagai jejaring meridian. Struktur tersebut kemudian diberinama Sistem Bong Han. Empat puluh tahun setelah Kim Bong Han menghilang,Kwang Sup Soh dkk. berhasil melakukan penelitian untuk menemukan kembaliapa yang telah ditemukan Kim Bong Han dan memberi nama baru menjadi SistemPrimo-Vaskular SPV .Penelitian ini dilakukan untuk membuktikan bahwa benar ada struktur SPV padapermukaan organ interna tikus. Berbeda dengan berbagai-penelitian terdahulu,penelitian ini mengambil sampel dari tikus yang sudah dibunuh. Penelitian inimerupakan penelitian desktiptif menggunakan hewan coba 3 ekor tikus Wistar.Keberadaan SPV dideteksi secara makroskopis dengan menyemprotkan TrypanBlue pada permukaan organ interna tikus. Struktur seperti benangterwarna biruyang merupakan ciri khas SPV ditemukan pada permukaan hati dan lambung.Setelah dibuat sediaan histologi dan diwarnai dengan H E terlihat strukturpembuluh berlumen, yang berisi struktur seperti serat/ pembuluh kecil dan unsursel. Gambaran histologi seperti ini berbeda dengan pembuluh arteri, vena, limf,maupun serat saraf, sehingga dapat disimpulkan bahwa struktur khusus yangberbeda itu memang ada. Karena itu, diperlukan penelitian lanjutan yang lebihdetil untuk mengeksplorasi berbagai unsur penyusun maupun fungsi strukturtersebut."

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""ABSTRACT"Until recently when acupuncture has already been used widely, the questionsabout how does acupuncture produce therapeutic effect cannot be answeredclearly. There are still dissenting opinions about it. Kim Bong Han was the first todeclare the existence of special new anatomical structures that were differentfrom arteries, veins, lymphs, and nerve fibers, which corresponded to theacupuncture meridian system. The structure was then called the Bong HanSystem. Forty years after the disappearance of Kim Bong Han, Kwang Sup Soh etall began the research to rediscover the Bong Han System. They succeeded tofind the structures and changed the name into Primo Vascular System PVS .This research was conducted to discover and prove the existence of PVS oninternal organ surface of rats. Different from previous reports, this research used3 scarificed Wistar rats. The existence of PVS in rats was detected by sprayingTrypan Blue on internal organ surface. Thread like structures in blue colorappeared on the organ surface of liver and stomach of two rats. The thread likestructures showed specific macroscopic characteristics of PVS. After beingprocessed into histological specimen and stained with H E, we could observethe histological appearance of vessels with fibers or small ducts and cells insidethe lumen. These appearances were different from arteries, veins, lymph vessels,and nerve fibers. In conclusion, the PVS does exist and needs further researchwith a specific design to identify the composition and function of the PVS."

"Latar belakang: Ulkus kaki diabetik adalah komplikasi umum yang terjadi pada penderita diabetes mellitus (DM). Penurunan aliran darah berkontribusi terhadap kronisitas ulkus kaki diabetik. Vibrasi diduga berdampak pada perbaikan aliran darah. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas vibrasi terhadap percepatan penyembuhan ulkus kaki diabetik. Metode: Penelitian ini merupakan penelitian eksperimen dengan desain penelitian yang digunakan adalah randomized clinical trial (RCT) non blinding. Subyek penelitian merupakan pasien dengan ulkus kaki diabetik derajat 0-2 yang dibagi menjadi 2 kelompok yaitu kelompok kontrol dan kelompok intervensi. Pada kelompok intervensi, vibrasi diberikan dengan dosis 3 kali sehari dengan lama pemberian 15 menit sampai luka dinyatakan sembuh. Hasil: Penelitian ini menunjukkan perbedaan bermakna (p<0,05) pada laju kesembuhan, rerata skor penyembuhan luka khususnya pengamatan minggu pertama dan kedua serta rerata penutupan area luka. Laju kesembuhan dan penutupan luka pada kelompok intervensi lebih cepat dibandingkan kontrol. Vibrasi juga meningkatkan kadar nitric oxide (NO) setelah intervensi diberikan dan menunjukkan perbedaan bermakna antara kedua kelompok. Sebagai luaran sekunder didapatkan hubungan antara kadar NO dengan laju kesembuhan dan penutupan area luka. Kesimpulan: Pemberian vibrasi efektif mempercepat penyembuhan ulkus kaki diabetik diukur dari laju kesembuhan, skor penyembuhan, penutupan area luka dan kadar NO.

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Background: Diabetic foot ulcer is a common complication in patient with diabetes mellitus. The decreased blood flow has a role in the chronicity of diabetic foot ulcer. Vibration therapy was supposed to be able to improve the blood flow. The aim of this study was to evaluate the effect of vibration on the acceleration of healing of diabetic foot ulcer.

Method: This experimental study used a randomized clinical trial non blinding design. Patients with diabetic foot ulcers grade 0-2 were divided into control group and intervention group. Patients in intervention group received vibration as an adjuvant to standard therapy, three times a day, each for 15 minutes, until the wound were healed.

Results: There were significant differences (p<0.05) in terms of healing rate, wound healing score (especially at the end of week 1 and week 2), and the wound closure area. The rate of wound healing and wound closure were significantly higher in the intervention group. The level of nitric oxide (NO) was also significantly higher in the intervention group. As an additional outcome, there was a positive association between the level of NO and the rate of healing and wound closure.

Conclusion: Vibration therapy accelerated the healing of diabetic foot ulcer in terms of healing rate, healing score, wound closure area, and elevated the level of NO."

"Diabetes sering menyebabkan komplikasi ulkus kaki diabetik (UKD) yang penyembuhannya terhambat pada fase inflamasi dan terjadi gangguan pada pembentukan jaringan granulasi. LL-37 memiliki aktivitas antimikrobial, memicu angiogenesis, serta migrasi dan proliferasi keratinosit. Penelitian ini menganalisis pengaruh krim LL-37 terhadap kecepatan penyembuhan UKD derajat ringan dengan mengkaji IL-1a, TNF-a, serta pola dan jumlah kolonisasi bakteri aerob.Penelitian ini adalah uji klinis buta ganda acak yang dilaksanakan Januari 2020–Juni 2021 di RSUPN dr. Cipto Mangunkusumo dan RSUP Persahabatan, Jakarta. Subjek adalah penyandang UKD tanpa infeksi atau infeksi derajat ringan, berusia 18–60 tahun, ABI 0,9–1,3, luas luka ≥ 2 cm2, kedalaman luka sampai dengan subkutis, dan tanpa infeksi sistemik. Subjek dibagi menjadi kelompok krim LL-37 dan plasebo yang dioles dua kali seminggu selama 4 minggu. Dilakukan pengamatan luka pada akhir minggu dengan metode planimetri dan fotografi digital lalu diolah dengan ImageJ. Subjek diperiksa kadar IL-1a dan TNF-a cairan luka dengan metode ELISA dan kultur bakteri aerob dari apusan luka pada setiap akhir minggu.Kadar LL-37 cairan luka pada kelompok LL-37 adalah 1,07 (0,37–4,96) ng/mg protein dan plasebo sebesar 1,11 (0,24–2,09) ng/mg protein (p = 0,44). Penurunan luas luka pada hari ke-14, ke-21, dan ke-28 dibandingkan hari ke-1 pada kelompok LL-37 lebih besar daripada plasebo, walaupun tidak bermakna. Pada kelompok LL-37 terjadi peningkatan luas jaringan granulasi yang lebih besar daripada plasebo pada semua hari, walaupun hanya bermakna pada hari ke-14 yaitu 0,95 (±1,34) cm2 pada kelompok LL-37 dibandingkan -0,24 (±1,01) cm2 pada kelompok plasebo (p = 0,020). Terjadi peningkatan indeks granulasi yang secara konsisten lebih besar dan bermakna (p < 0,05) pada kelompok LL-37 dibandingkan plasebo pada semua hari. Tidak terjadi penurunan kadar IL-1a dan TNF-a yang lebih besar pada kelompok LL-37. Pada hari ke-1, frekuensi bakteri aerob terbanyak adalah S. aureus yaitu 37,1% pada kelompok LL-37 dan 45% pada kelompok plasebo. Penurunan jumlah koloni bakteri pada kelompok plasebo lebih besar dibandingkan dengan kelompok LL-37 pada hari ke-28 dibandingkan dengan hari ke-1, walaupun tidak bermakna (p = 0,98).Simpulan: Kadar LL-37 pada UKD kedua kelompok rendah. Pemberian LL-37 mempercepat penyembuhan UKD tanpa infeksi maupun derajat ringan dengan meningkatkan indeks granulasi. Pemberian LL-37 tidak menurunkan kadar IL-1a dan TNF-a pada UKD. Pemberian LL-37 tidak memengaruhi pola dan jumlah kolonisasi bakteri aerob pada UKD.

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Diabetes often causes DFU (diabetic foot ulcer). Wound healing in DFU has prolonged inflammation phase and defective granulation tissue formation. LL-37 has antimicrobial property, induces angiogenesis, and keratinocyte migration and proliferation. This study analyzes the efficacy of LL-37 cream on wound healing rate in DFU with mild infection by examining IL-1a, TNF-a, and aerobic bacteria colonization.

This study was a randomized double-blind controlled trial conducted from January 2020–June 2021 at RSUPN dr. Cipto Mangunkusumo and RSUP Persahabatan, Jakarta. Subjects were patients with uninfected DFU or DFU with mild infection according to IDSA, aged 18–60 years old, ABI 0.9–1.3, wound area ≥ 2 cm2, wound no deeper than subcutaneous layer, and without systemic infection. Subjects were divided into the LL-37 cream and placebo cream group which were applied twice a week for 4 weeks. Wounds were measured at the end of every week using planimetric method and digital photography and subsequently processed with ImageJ. The levels of IL-1a and TNF-a from wound fluid were measured using the ELISA method and aerobic bacteria culture was performed using wound swabs.

The level of LL-37 from wound fluid in the LL-37 group was 1.07 (0.37–4.96) ng/mg protein and in the placebo group was 1.11 (0.24–2.09) ng/mg protein (p = 0.44). The decrease in wound area on day 14, 21, and 28 compared to day 1 in the LL-37 group was greater than in the placebo group, although the difference was not significant. In the LL-37 group, there was a greater increase in granulation tissue area than in the placebo group on each day, although the difference was only significant on day 14 which was 0.95 (±1.34) cm2 in the LL-37 group compared to -0.24 (± 1.01) cm2 in the placebo group (p = 0.020). There was a consistently and significantly greater increase in granulation index (p < 0.05) in the LL-37 group compared to placebo group on each day. There was no greater decrease in IL-1a and TNF-a levels in the LL-37 group. On day 1, the highest frequency of aerobic bacteria was S. aureus which was 37.1% in the LL-37 group and 45% in the placebo group. The decrease in the number of bacterial colonies in the placebo group was greater than in the LL-37 group on day 28 compared to day 1, although the difference was not significant (p = 0.98).

Conclusion: The level of LL-37 in DFU was low in both groups. Administration of LL-37 accelerated the healing of uninfected DFU or DFU with mild infection by increasing the granulation index. Administration of LL-37 did not reduce the levels of IL-1a and TNF-a in DFU. Administration of LL-37 did not affect the pattern and number of colonization of aerobic bacteria in DFU."

"Telehealth nursing adalah layanan berbasis teknologi informasi yang diharapkan dapat menjadi sarana untuk mempermudah komunikasi antara pasien dan perawat dalam merawat luka terutama pada saat kondisi pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui efektifitas telehealth nursing terhadap penyembuhan ulkus kaki diabetik. Desain penelitian menggunakan quasi eksperimen dengan pre-post test with control group. Jumlah responden dalam penelitian ini sebanyak 46 orang diperoleh melalui teknik consecutive sampling. Kelompok eksperimen diberikan telehealth nursing yang berisi kombinasi edukasi dan monitoring perawatan luka mandiri dan kelompok kontrol diberikan edukasi dan perawatan luka secara langsung di klinik luka. Penyembuhan luka diukur dengan menggunakan Bates Jensen Wound Assessment Tool (BWAT). Hasil penelitian menunjukkan bahwa telehealth nursing memiliki efektifitas yang signifikan yaitu sebesar p=0,873 (α>0.05) pada proses penyembuhan luka. telehealth nursing adalah pilihan terbaik dalam merawat ulkus kaki diabetik pada pasien yang mengalami kesulitan atau dengan kondisi yang tidak memungkinkan untuk perawatan luka secara langsung ke layanan kesehatan.

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Telehealth nursing as an information technology-based service is expected to be a means to facilitate communication between patients and nurses in caring for wounds, especially during the COVID-19 pandemic. This study aims to identify the effectiveness of telehealth nursing in healing diabetic foot ulcers.This study was a quasi-experimental with a pre-post test with a control group. The study was conducted on 46 people using consecutive sampling. The intervention group was given telehealth nursing which contained a combination of education and self manage wound care monitoring and the control group was given education and wound care at the wound clinic. Wound healing was measured using the Bates Jensen Wound Assessment Tool (BWAT). The results showed that telehealth nursing had significant effectiveness of p=0.873 (α>0.05) in the wound healing process. telehealth nursing is the best choice in treating diabetic foot ulcers in patients who have difficulty or with conditions that do not allow direct wound care to health services."