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"This book summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems.An extensive Part I deals with recent experimental and theoretical findings on radiation induced damage at the molecular level. It includes many contributions on electron and positron collisions with biologically relevant molecules. X-ray and ion interactions are also covered. Part II addresses different approaches to radiation damage modelling. In Part III biomedical aspects of radiation effects are treated on different scales. After the physics-oriented focus of the previous parts, there is a gradual transition to biology and medicine with the increasing size of the object studied. Finally, Part IV is dedicated to current trends and novel techniques in radiation reserach and the applications hence arising. It includes new developments in radiotherapy and related cancer therapies, as well as technical optimizations of accelerators and totally new equipment designs, giving a glimpse of the near future of radiation-based medical treatments. "

"This book provides readers with invaluable overviews and updates of the most important topics in the radiation-effects field, enabling them to face significant challenges in the quest for the insertion of ever-higher density and higher performance electronic components in satellite systems. Readers will benefit from the up-to-date coverage of the various primary (classical) sub-areas of radiation effects, including the space and terrestrial radiation environments, basic mechanisms of total ionizing dose, digital and analog single-event transients, basic mechanisms of single-event effects, system-level SEE analysis, device-level, circuit-level and system-level hardening approaches, and radiation hardness assurance. Additionally, this book includes in-depth discussions of several newer areas of investigation, and current challenges to the radiation effects community, such as radiation hardening by design, the use of Commercial-Off-The-Shelf (COTS) components in space missions, CubeSats and SmallSats, the use of recent generation FPGAs in space, and new approaches for radiation testing and validation. The authors provide essential background and fundamentals, in addition to information on the most recent advances and challenges in the sub-areas of radiation effects.- Provides a concise introduction to the fundamentals of radiation effects, latest research results, and new test methods and procedures;- Discusses the radiation effects and mitigation solutions for advanced integrated circuits and systems designed to operate in harsh radiation environments;- Includes coverage of the impact of Small Satellites in the space industry."

"The Fukushima accident resulted in the melting of the reactor core due to loss of supply of coolant when the reactor stopped from operating conditions. The earthquake and tsunami caused loss of electricity due to the flooding that occurred in the reactor. The absence of the coolant supply after reactor shutdown resulted in heat accumulation, causing the temperature of the fuel to rise beyond its melting point. In the early stages of the accident, operator could not determine the severity of the accident and the percentage of the reactor core damaged. The available data was based on the radiation exposure in the environment that was reported by the authorities. The aim of this paper is to determine the severity of the conditions in the reactor core based on the radiation doses measured in the environment. The method is performed by backward counting based on the measuring radiation exposure and radionuclides releases source term. The calculation was performed by using the PC-COSYMA code. The results showed that the core damage fraction at Dai-ichi Unit 1 was 70%, and the resulting individual effective dose in the exclusion area is 401 mSv, while the core damage fraction at Unit 2 was 30%, and the resulting individual effective dose was 99.1 mSv, while for Unit 3, the core damage fraction was 25% for an individual effective dose of 92.2 mSv. The differences between the results of the calculation for estimation of core damage proposed in this paper with the previously reported results is probably caused by the applied model for assessment, differences in postulations and assumptions, and the incompleteness of the input data. This difference could be reduced by performing calculations and simulations for more varied assumptions and postulations."

"This book will focus on recent developments in isotope labeling methods for structural studies of small molecules, peptides, proteins and nucleic acids. The aim of the book is to serve as a compendium of isotope labeling for the biomolecular NMR community providing comprehensive coverage of the existing methods and latest developments along with protocols and practical hints on the various experimental aspects. The book will cover a wide range of topics in isotope labeling under one title including emerging areas of metabolonomics and solid state NMR."

"Over the past 40 years the field of molecular simulations has evolved from picosecond studies of isolated macromolecules in vacuum to studies of complex, chemically heterogeneous biological systems consisting of millions of atoms, with the simulation time scales spanning up to milliseconds. In Biomolecular Simulations: Methods and Protocols, expert researchers illustrate many of the methods commonly used in molecular modelling of biological systems, including methods for electronic structure calculations, classical molecular dynamics simulations and coarse-grained techniques. A selection of advanced techniques and recent methodological developments, which rarely find coverage in traditional textbooks, is also introduced. Written in the highly successful Methods in Molecular Biology series format, chapters include general introductions to well-established computational methodologies, applications to real-world biological systems, as well as practical tips and general protocols on carrying out biomolecular simulations. Special emphasis is placed on simulations of proteins, lipids, nucleic acids, and carbohydrates. Authoritative and practical, Biomolecular Simulations: Methods and Protocols seeks to aid scientists in further simulation studies of biological systems."

"Abstract:Describes the fundamentals, practices, and applications of protein crystallography. This textbook also describes mathematical and physical concepts. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures"

"The book focuses on a vital area of biophysical research that has been—in the author’s view—substantively overlooked if not relegated, an area from within many of the needed breakthroughs are likely to sprout: the physics of biomolecular interfaces. The book advocates its paramount relevance to tackle some of the core problems in molecular biophysics in a unified systematic manner. To this effect, the book introduces powerful theoretical and computational resources and is set to inspire scientists at any level in their careers determined to address the major challenges in the field."