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Rahma Anindya Prathitasari
Proportion and factors that associate with incidence of hepatotoxicity in rheumatoid arthritis patients treated with methotrexate in RSCM year 2013-2015
"ABSTRAK
Background Rheumatoid arhtirtis is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase and/or alanine aminotransferase beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients medical records.Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60 percent. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity p>0.05. Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX."
Jakarta: University of Indonesia School of Medicine, 2018
616 IJR 10:1 (2018)
Artikel Jurnal  Universitas Indonesia Library
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Fadhil Naufal Hidayatullah
Pengaruh Faktor Reumatoid terhadap Keberhasilan Terapi Metotreksat pada Pasien Artritis Reumatoid = The Effect of Rheumatoid Factors on the Success of Methotrexate Therapy in Rheumatoid Arthritis Patients
"Artritis Reumatoid merupakan suatu penyakit autoimun sistemik kronis
yang menyerang sendi dan sekitarnya, seperti jaringan ikat, otot, tendon, dan jaringan
fibrosa. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh Faktor Reumatoid
terhadap keberhasilan terapi Metotreksat pada pasien Artritis Reumatoid hingga
mencapai remisi di RS Cipto Mangunkusumo tahun 2020 – 2022 ditinjau dari aktivitas
penyakit pasien setelah ≥ 6 bulan pemakaian terapi tunggal metotreksat menurut kriteria
DAS28.
Metode: Penelitian ini termasuk penelitian jenis obserbasional, pengambilan data secara
kohort retrospektif dengan melihat data rekam medik pasien AR dan dianalisis secara
deskriptif. Pengambilan subjek sebanyak 54 pasien dengan metode Chi Square Test.
Kriteria inklusi dari penelitian ini adalah pasien AR usia ≥18 tahun, pasien terdiagnosa
AR menurut kriteria ACR/EULAR 2010, dan menerima terapi tunggal MTX ≥6 bulan
dengan data rekam medik lengkap. Kriteria ekslusi dari penelitian ini adalah pasien AR
yang memiliki penyakit autoimun lain, pasien AR dengan terapi kombinasi DMARD,
pasien dengan kontraindikasi MTX, pasien yang tidak control rutin, serta data rekam
medik tidak lengkap. Standar acuan evaluasi yang digunakan adalah Perhimpunan
Rheumatologi Indonesia 2021.
Hasil: Hasil penelitian evaluasi keberhasilan terapi MTX pada 54 pasien AR di RS Cipto
Mangunkusumo tahun 2020 – 2022 yaitu 53,6% pasien RF Negatif berhasil terapi MTX,
23,1% pasien RF Positif berhasil terapi MTX, dan sisanya tidak mencapai remisi.
Kesimpulan: Terdapat hubungan yang signifikan antara faktor reumatoid terhadap efek
keberhasilan terapi metotreksat pada pasien artritis reumatoid.
Rheumatoid arthritis is a chronic systemic autoimmune disease that attacks
the joints and surrounding areas, such as connective tissue, muscles, tendons, and fibrous
tissue. The purpose of this study is to determine the effect of Rheumatoid Factors on the
success of Methotrexate therapy in Rheumatoid Arthritis patients to achieve remission at
Cipto Mangunkusumo Hospital in 2020-2022 based on parameters of patient disease
activity after 6 months of using methotrexate single therapy according to DAS28 criteria.
Method: This study is observational research. Data was obtained cohort retrospectively
from medical records of patients with RA. Data was descriptively analyzed 54 patients
were included as sample by Chi Square method The inclusion criteria of this study were
RA patients aged ≥18 years, patients diagnosed with RA according to the 2010
ACR/EULAR criteria, and receiving MTX single therapy ≥6 months with complete
medical record. The exclusion criteria of this study were RA patients who had other
autoimmune diseases, AR patients on DMARD combination therapy, patients with MTX
contraindications, patients who were not routinely controlled, and incomplete medical
record. The standard evaluation used is the Rheumatology Association of Indonesian
2021
Result: The results of the study evaluating the success of MTX therapy in 54 AR patients
at Cipto Mangunkusumo Hospital in 2020-2022 are 53,6% of RF Negative patients
achieved remission, 23,1% of RF Positive patients achieved remission, and the remaining
patients did not achieve remission.
Conclusion: There is a significant relationship between rheumatoid factors and the
success effect of methotrexate therapy in rheumatoid arthritis patients"
Depok: Fakultas Kedokteran Universitas Indonesia, 2022
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Bambang Setyohadi
The use of tocilizumab in combination with methotrexate in Indonesian rheumatoid arthritis patients (PICTURE INA Study)
"ABSTRAK
Background Aim of this research is to assess the efficacy and safety of tocilizumab in combination with methotrexate in Indonesian patients with moderate to severe active rheumatoid arthritis who have an inadequate response to non biologic DMARDs.Methods This was a interventional, prospective, single arm, multicenter, study in Indonesian male or female patients aged > 18 years old, with a diagnosis of RA for > 6 months based on ACR 1987 revised criteria with moderate to severe disease activity DAS28 score > 3.2 after > 12 weeks of non biologic DMARDs treatment. The treatment consisted of tocilizumab, 8 mg/kg, intravenous, every 4 weeks for a total of 6 infusion in combination with oral MTX 10 until 25 mg every week. Efficacy was assessed based on the percentage of patients achieving low disease activity state DAS28 < 3.2, percentage of patients achieving reduction > 1.2 point of DAS28, percentage of patients achieving remission DAS28 < 2.6, and percentage of patients with ACR20, ACR50, and ACR70 responses. Descriptive statistics will be used for presentation of results.Results 100 percent patients reached low disease activity DAS28 < 3.2 at last study visit week 24 and clinically significant improvement reduction at least 1.2 units at every visit in DAS28, both for ITT or PP patients. Remission DAS28 < 2.6 was observed in 82.1 percent ITT patients and 93.1 percent PP patients on last study visit. ACR20, ACR50, and ACR70 were achieved in 20 percent, 34 percent, and 34 percent ITT patients, and 7 percent, 24 percent, and 62 percent PP patients on week 24. There were 3 out of 39 patients 7.69 percent with adverse events and serious adverse events that resulted in discontinuation of TCZ treatment, consisting of 1 patient with SAE of sepsis ec acquired community pneumonia, 1 patient with SAE of pneumonia tuberculosis, and 1 patient with AE of candidiasis. Most common adverse events were hepatic dysfunction 30.7 percent, hypercholesterolemia 23.1 percent, followed by arthralgia 20.5 percent Twelve percent of patients needed dose modification due to elevated liver enzyme elevated ALT/SGPT level. Conclusion Tocilizumab seems to be efficacious and likely to have good safety profile in non biologic DMARD nonresponsive RA patients of PICTURE INA study. "
Jakarta: University of Indonesia School of Medicine, 2018
616 IJR 10:1 (2018)
Artikel Jurnal  Universitas Indonesia Library
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Fita Fitrianti
Pengaruh pemberian terapi metotreksat terhadap fungsi kognitif pada pasien artritis reumatoid = Effect of methotrexate on cognitive function in rheumatoid arthritis patients
"Latar Belakang. Artritis reumatoid merupakan penyakit autoimun yang menyebabkan inflamasi kronik artikular dan non-artikular yang  dapat menimbulkan komplikasi berupa gangguan fungsi kognitif. Beberapa studi menunjukkan pemberian terapi Metotreksat mempengaruhi penurunan fungsi kognitif pada pasien AR. Belum ada studi di Indonesia yang menilai hubungan dosis MTX dengan fungsi kognitif pada pasien AR.
Tujuan. Penelitian ini bertujuan untuk mengetahui perubahan fungsi kognitif sesudah pemberian terapi MTX selama 3 bulan dan mengetahui hubungan antara dosis MTX dengan fungsi kognitif pada pasien dengan AR.
Metode. Desain studi ini adalah kohort prospektif yang melibatkan 39 pasien baru terdiagnosis Artritis reumatoid berusia <60tahun di Poliklinik Reumatologi RSCM. Karakteristik demografi, parameter klinis dan penilaian kognitif didokumentasikan secara lengkap. Penilaian fungsi kognitif dilakukan dengan tes Montreal Cognitive Assessment versi Indonesia (MoCA-Ina) yang sudah tervalidasi. Studi ini menggunakan analisis statistik uji Wilcoxon, analisis bivariat dan korelasi Spearman untuk menganalisis data dengan menggunakan software Stata 15.1.
Hasil. Terdapat 28% subjek dengan penurunan fungsi kognitif. Tidak ditemukan perbedaan bermakna terhadap fungsi kognitif global sesudah pemberian MTX selama 3 bulan. Analisis korelasi Spearman menunjukkan adanya korelasi negatif antara kadar dosis MTX dengan domain fungsi memori (r=-0,4,  p =0,01).
Kesimpulan. Tidak terdapat perbedaan bermakna terhadap fungsi kognitif global sesudah pemberian MTX selama 3 bulan. Namun, terdapat korelasi negatif antara kadar dosis metotreksat dengan domain fungsi memori
Background. Rheumatoid arthritis is an autoimmune disease causes chronic articular and non-articular inflammation with cognitive impairment as one of its complication. Several studies have shown that Methotrexate affects the decline of cognitive function in RA patients. There are no studies in Indonesia that have assessed the relationship between MTX and cognitive function in Indonesia. Aim. We aimed to know and to investigate the association between cumulative dose of MTX and cognitive function in patient with RA.
Methods. This is a prospective cohort study involving 39 subject with newly diagnosed Rheumatoid arthritis. Demographics characteristics, clinical parameters, and cognitive assessment were documented. Cognitive assessment was assessed based on validated Indonesian version of Montreal Cognitive Assessment (MoCA-Ina) test. This study used Wilcoxon, bivariate analysis and Spearman correlation to analyse the data.
Results. A total of 39 patients with RA, 28% were classified as cognitively impaired. There was no significant difference in global cognitive function after administration of MTX in 3 months. Spearman correlation analysis showed negative correlation between cumulative dose of MTX and memory function domain (r=-0.4, p=0.01).
Conclusion. There was no significant difference in global cognitive function after administration of MTX in 3 months. Cumulative dose of MTX negatively correlated with memory function domain."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Harahap, Alvin Tagor
Proporsi dan gambaran flat foot pada penderita artritis reumatoid dan faktor-faktor yang berhubungan = Proportion, description, and related factors of flat foot on rheumatoid arthritis patients
"Latar Belakang. Flat fool adalah salah satu kelainan kaki yang sering dijumpai pada penderita artritis reumatoid. Selain nyeri yang disebabkan oleh penyakitnya, penderita AR juga dapat mengalami nyeri akibat flat foot. Selama ini kita selalu menganggap nyeri kaki dan gangguan berjalan pada penderita AR selalu disebabkan oleh AR, padahal mungkin juga akibat flat fool. Di Amerika prevalensi flat foot sebesar 50%. Untuk itu ingin diketahui proporsi kelainan ini pada penderita AR yang mengunjungi poliklinik reumatologi RSCM, serta gambaran dan faktor-faktor yang mempengaruhinya.
Tujuan. (1) Mengetahui proporsi flat foot pada penderita AR. (2) Mengetahui rasio odds faktor-faktor lama menderita penyakit (LMP), Disease Activity Score (DAS), dan Indeks Massa Tubuh (IMT) terhadap kejadianflat foot pada penderita AR.
Metodologi. Dilakukan studi potong lintang pada penderita AR dengan keluhan kaki yang berobat ke poliklinik reumatologi RSCM untuk mengamati gambaran cetak kaki, dan kelainan kaki yang diderita, IMT, DAS, dan LMP. Gambaran kelainan kaki pada penderita AR disajikan dalam bentuk statistik deskriptif. Faktor-faktor yang mempengaruhi flat foot dianalisa dengan uji chi square serta perhitungan rasio odds.
Hasil. Selama periode Juli - September 2005 terkumpul sebanyak 52 orang penderita AR di Poliklinik Reumatologi Rumah Sakit Dr. Cipto Mangunkusumo, Jakarta. Dua orang tidak sesuai dengan kriteria inklusi, sehingga hanya 50 orang yang dapat dianalisa. Ditemukan proporsi kelainan ini sebesar 40% (11(95% 26% - 53%). Pengujian bivariat menggunakan uji chi square menemukan faktor-faktor yang mempengaruhi kejadian flat foot ialah IMT (P = 0,03; 012 = 3,7; IK95% 1,1 - 12,2) dan DAS (P = 0,047; OR = 0,2; IK 95% 0,03 - 0,9). Untuk mengetahui faktor-faktor yang paling berperan, dilakukan uji multivariat terhadap faktor-faktor dengan P < 0,25 (LMP, DAS, dan IMT). Ditemukan faktor yang paling berperan ialah IMT (P = 0,05; OR = 3,5;IK95% 0,99 - 12,2).
Kesimpulan. Proporsi kelainan flat foot pada penderita AR yang berobat di Poliklinik Reumatologi RSCM tidak berbeda dengan penelitian di Amerika. Faktor risiko yang berhubungan ialah IMT. Penelitian ini tidak menemukan hubungan LMP dan DAS terhadap kejadian. Flat foot pada penderita AR.
Background. Flat foot, as one of the deformities found on Rheumatoid Arthritis (RA) patients, also causes pain. In the case of RA patients, we often thought foot pain or gait disturbances were caused by pain from RA, on the other hand they might be caused by flat foot. Study in United States of America (USA) revealed the prevalence of flat foot were 50%. For this reason we would like to know the proportion of these deformities among RA patients visiting the rheumatology outpatient unit in dr. Cipto Mangunkusumo hospital, and factors which influenced it.
Objectives. To find : (1) the proportion of flat foot on RA patient, (2) the odds ratios of Body Mass Index, disease duration, and Disease Activity Score on the prevalence of flat foot in RA patients.
Methods. A cross sectional study was done on RA patients with lower extremity complaints who came to Rheumatology outpatient unit at Cipto Mangunkusumo General Hospital, Jakarta. The study was done by observing foot print, foot deformities, Body Mass Index (BMI), Disease Activity Score (DAS), and disease duration. The description of flat foot was presented in the form of descriptive statistics. Factors which influenced flat foot were analyzed using chi square method and odds ratios measurements.
Results. We observed 52 patients with RA during July - September 2005 in rheumatology outpatient unit Dr. Cipto Mangunkusumo Hospital, Jakarta. Two patients did not conform inclusion criteria, thus excluded from this study. We found the proportion of flat foot in those patients was 40% (95% CI = 26% to 53%). Bivariate analysis using chi square method revealed BMI (P = 0.03, OR = 3.7 95% CI = 1.1 to 12.2) and DAS (P = 0.047, OR = 0.2, 95% CI = 0.03 to 0.9) as factors related to flat foot in RA patients. Further analysis on variables which had P value <0.25 (BMI, DAS, and disease duration) using multivariate method revealed BMI as the factor related to flat foot in RA patients.
Conclusion. The flat foot proportion on RA patients visiting Rheumatology outpatient Unit RSCM did not differ from that in USA. Factor related to this deformity was BMI. This study did not find relations of disease duration and DAS to flat foot in RA patients."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2006
T21422
UI - Tesis Membership  Universitas Indonesia Library
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Rheumatoid arthritis
Philadelphia: Mosby Elsevier, 2009
616.722 7 RHE
Buku Teks SO  Universitas Indonesia Library
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Ryannuur Hafizmatta
Pengaruh Nilai Laju Endap Darah Terhadap Keberhasilan Terapi Metotreksat pada Pasien Artritis reumatoid di Rumah Sakit Cipto Mangunkusumo = Relationship between Erythrocyte Sedimentation Rate Level and the Efficacy of Methotrexate Therapy in Rheumatoid Arthritis Patients at Cipto Mangunkusumo Hospital
"Latar belakang: Artritis Reumatoid (AR) merupakan penyakit yang menyerang persendian dan merupakan penyakit autoimun. Pada tahun 2020, estimasi penderita AR di Indonesia mencapai 1,3 juta jiwa, dengan menghitung estimasi dari prevalensi AR di dunia yang mencapai 0,5% hingga 1%. Penelitian dari Majorczyk, et al (2022) menunjukkan adanya pengaruh dari Laju Endap Darah (LED) terhadap keberhasilan terapi metotreksat pada pasien AR. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara LED terhadap keberhasilan terapi Metotreksat pada pasien AR di Rumah Sakit Cipto Mangunkusumo (RSCM).
Metode: Penelitian ini menggunakan desain kohort retrospektif. Penelitian ini menggunakan data dari rekam medis pasien di RSCM. Data pasien yang digunakan dalam penelitian ini merupakan data yang ter-input sejak tahun 2020 hingga 2022. Data yang telah didapat dianalisis menggunakan JASP versi 0.18.3.0. Dilakukan uji normalitas dengan Shapiro-Wilk, dan kemudian dilakukan uji Mann-Whitney untuk mengetahui hubungan dari LED terhadap keberhasilan terapi Metotreksat pada pasien AR.
Hasil: Hasil uji normalitas menunjukkan bahwa data LED dengan keberhasilan terapi Metotreksat tidak terdistribusi normal (p > 0,05). Uji Mann-Whitney menunjukkan tidak ada perbedaan yang signifikan antara kelompok berhasil terapi dengan tidak berhasil terapi (p > 0,05).
Kesimpulan: Tidak terdapat hubungan yang signifikan antara LED dengan keberhasilan terapi metotreksat pada pasien AR di RSCM.
Introduction: Rheumatoid Arthritis (RA) is a disease that attacks the joints and is an autoimmune disease. In 2020, the estimate for RA sufferers in Indonesia reached 1.3 million people, counted from the estimate global prevalence of 0.5% to 1% of global population. Research from Majorczyk, et al (2022) shows that Erythrocyte Sedimentation Rate (ESR) influences the success of methotrexate therapy in RA patients. This study aims to determine whether if there is influence between ESR and the success of Methotrexate therapy in AR patients at Cipto Mangunkusumo Hospital (RSCM).
Method: This study used a retrospective cohort design. This research uses data from patient medical records at RSCM. Patient data used in this research was data inputted from 2020 to 2022. The data obtained was analyzed using JASP version 0.18.3.0. The Shapiro-Wilk normality test was carried out, and then the Mann-Whitney test was carried out to determine the connection between ESR and the success of Methotrexate therapy in AR patients.
Result: The results of the normality test showed that the ESR data with successful Methotrexate therapy were not normally distributed (p > 0.05). The Mann-Whitney test showed there was no significant difference between the successful therapy and unsuccessful therapy groups (p > 0.05).
Conclusion: There was no significant connection between ESR and the success of methotrexate therapy in AR patients at RSCM."
Depok: Fakultas Kedokteran Universitas Indonesia, 2021
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Fara Fauzia
Pengaruh Obesitas Terhadap Tidak Tercapainya Target Terapi Metotreksat Pada Pasien Artritis Reumatoid Di RSUPN Cipto Mangunkusumo Pada Periode Maret 2017-Desember 2021 = Obesity as a Risk Factor of Failure Therapy of Methotrexate in Rheumatoid Arthritis Patients
"Pendahuluan. Artritis Reumatoid (AR) adalah suatu penyakit autoimun yang bersifat sistemik dan kronik yang manifestasi utamanya melibatkan persendian. Tatalaksana AR membutuhkan terapi medikamentosa dan pendekatan gaya hidup. Salah satu tatalaksana AR adalah medikamentosa dengan metotreksat (MTX). Ada banyak faktor yang memengaruhi keberhasilan terapi AR namun di Indonesia belum ditemukan studi yang meneliti obesitas terhadap keberhasilan terapi MTX pada pasien AR di Indonesia. Peneliti ingin mengetahui pengaruh obesitas terhadap ketidakberhasilan terapi MTX monoterapi pada pasien dengan AR.
Metode. Studi kohort retrospektif menggunakan data rekam medis Poli Reumatologi Penyakit Dalam, Rumah Sakit Cipto Mangunkusumo (RSCM) pada kurun waktu Maret 2017-Desember 2021. Dilakukan analisis deskriptif untuk melihat karakteristik sampel berdasarkan tiap variabel dan analisis regresi Cox yang dimodifikasi untuk melihat hubungan antara obesitas terhadap ketidakberhasilan terapi MTX.
Hasil. Dari 72 subyek, proporsi ketidakberhasilan terapi pada pasien obesitas adalah 57.1% (20/35), sementara pada pasien yang tidak obesitas adalah 37.8% (14/37). Risiko ketidakberhasilan terapi MTX pada pasien dengan obesitas adalah 1,45 kali dibandingkan pasien yang tidak obesitas (RR 1,45; 95% CI 0,76-2,78). Faktor jumlah sendi yang terlibat, faktor RF, faktor C-reactive protein, usia, laju endap darah, jenis kelamin, dan onset awal sakit bukan merupakan faktor perancu pada studi ini.
Kesimpulan. Pada studi ini, pasien AR dengan obesitas meningkatkan risiko untuk mengalami ketidakberhasilan terapi MTX dibandingkan pasien AR tanpa obesitas, namun diperlukan studi lebih lanjut menggunakan sampel yang lebih besar untuk meningkatkan kekuatan statistik.
Introduction. Rheumatoid arthritis (RA)) is a systemic and chronic autoimmune disease which main manifestations involve the joints. AR management requires medical therapy and a lifestyle approach. One of the AR treatments is medication with methotrexate (MTX). There are many factors that influence the success of AR therapy but in Indonesia there has not been found a study that examines obesity on the success of MTX therapy in AR patients in Indonesia. Researchers wanted to know the effect of obesity on the failure of MTX monotherapy in patients with AR
Methods. A retrospective cohort study using medical records from the Rheumatology Internal Medicine Polyclinic, Cipto Mangunkusumo Hospital (RSCM) from March 2017 to December 2021. A descriptive analysis was performed to see the sample characteristics based on each variable and a modified Cox regression analysis to see the relationship between obesity and failure of MTX therapy.
Results. Of the 72 subjects, the proportion of treatment failure in obese patients was 57.1% (20/35), while in patients who were not obese it was 37.8% (14/37). The risk of MTX treatment failure in obese subjects was 1.45 times that of non-obese patients (RR 1.45; 95% CI 0.76-2.78). Number of joints involved, RF factor, C-reactive protein factor, age, erythrocyte sedimentation rate, gender, and early onset of illness were not confounding factors in this study.
Conclusion. In this study, RA patients with obesity have an increased risk of MTX treatment failure MTX compared to RA patients without obesity, but further studies using larger samples are needed to increase statistical power."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2023
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Joko Rilo Pambudi
Faktor faktor prediktor adanya aterosklerosis dan plak aterosklerosis pada pasien artritis reumatoid = Predictors factors of atherosclerosis and plaque atherosclerosis in rheumatoid arthritis patients
"Latar Belakang: Aterosklerosis dan penyakit kardiovaskular merupakan penyebab utama meningkatnya morbiditas dan mortalitas penderita artritis reumatoid (AR) Pemeriksaan ketebalan intima media (KIM) arteri karotis dengan ultrasonografi B-mode merupakan surrogate marker aterosklerosis dan penyakit kardiovaskular.
Metode: Dilakukan penelitian potong lintang pada 86 subyek penderita AR yang memenuhi kriteria EULAR/ACR 2010 yang berobat di Poliklinik Reumatologi Penyakit Dalam FKUI/RSCM. Aterosklerosis didefinisikan jika ditemukan pada pemeriksaan ultrasonografi KIM ≥ 1,0 mm pada salah satu : a. karotis komunis, a. karotis interna atau bulbus karotis sisi kanan atau kiri. Plak aterosklerosis didefinisikan jika didapatkan abnormalitas pada tebal KIM, bentuk dan atau tekstur dinding arteri.
Hasil: Aterosklerosis dan plak aterosklerosis masing-masing didapatkan pada 47 subyek (47,7%) dan 25 subyek (29,0%).Usia ≥ 40 tahun, adanya hipertensi, lama sakit ≥ 24 bulan pada analisis multivariat mempergunakan regresi logistik didapatkan berhubungan bermakna dengan aterosklerosis dengan RO (95%KI) masing-masing 10,70 (2,93-39,10), 4,99 (1,15-21,61) dan 3,66 (1,11-11,99). Adanya hipertensi, adanya anti-CCP dan usia ≥40 tahun berhubungan bermakna dengan plak aterosklerosis dengan RO (95%KI) masing-masing 3,96 (1,15-13,57), 3,20 (1,11-9,24) dan 3,61 (1,03-12,63).
Kesimpulan: Proporsi aterosklerosis dan plak aterosklerosis masing-masing didapatkan 47,7 % dan 29 %. Usia ≥ 40 tahun, adanya hipertensi dan lama sakit ≥ 24 bulan berturut-urut merupakan prediktor adanya aterosklerosis sementara adanya hipertensi, antibodi anti-CCP dan usia ≥ 40 tahun merupakan prediktor adanya plak aterosklerosis.
Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by B-mode ultrasound have been used as surrogate marker of atherosclerosis and cardiovascular disease.
Method: A cross sectional study involving 86 RA patients fulfill EULAR/ACR 2010 critera was conducted at Rheumatology Clinic FMUI/Cipto Mangunkusumo Hospital. CIMT examinations were perform at right and left side of carotid artery. Atherosclerosis was define if we found CIMT ≥ 1,0 mm at one of CCA, or ICA or carotid sinus. Plaque atherosclerosis presence if 1 of the following 3 criteria were met: abnormal wall thickness, abnormal shape, and abnormal wall texture.
Result: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 years old, hypertension and duration of illness ≥ 24 months were associated with atherosclerosis in multivariate logistic regression analysis with OR (95%CI) 10.70 (2.93-39.10), 4.99 (1.15-21.61) and 3.66 (1.11-11.99) respectively. Whereas hypertension, presence of anti-CCP antibody and age ≥ 40 years old, were associated with plaque formation with OR (95%CI) 3.96 (1.15-13.57), 3.20 (1.11-9.24) and 3.61 (1.03-12.63) respectively.
Conclusion: Proportion of atherosclerosis and plaque atherosclerosis were 47.7% and 29%. Age ≥ 40 years old, hypertension and duration of illness ≥ 24 months was the predictors of atherosclerosis, while hypertension, presence of anti-CCP antibody and age ≥ 40 years old was the predictors of plaque atherosclerosis."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
T58701
UI - Tesis Membership  Universitas Indonesia Library
cover
Ebringer, Alan
Rheumatoid arthritis and proteus
"Rheumatoid arthritis and proteus explores the idea that Rheumatoid arthritis is caused by a urinary tract infection as a result of Proteus bacteria. Rheumatoid arthritis is a severe, painful and crippling disease affecting millions of people throughout the world, especially women. Genetic studies over the last 30 years have shown that individuals who possess the white cell blood groups HLA-DR1/4 carry a susceptibility sequence and are more likely to develop the disease. This book uses the methods of Sir Karl Popper, the philosopher of science, to present 12 “Popper sequences” which have been identified to indicate that proteus is the causative agent of rheumatoid arthritis. Rheumatoid arthritis and proteus proposes that Anti-Proteus therapies should be followed as early as possible to prevent the crippling and irreversible joint deformities that occur in rheumatoid arthritis."
London : Springer, 2012
e20426019
eBooks  Universitas Indonesia Library
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