Hasil Pencarian  ::  Simpan CSV :: Kembali

"Background a meta-analysis of randomized control trials (RCTs) on category I pulmonary tuberculosis (PTB) treatments showed that either part-daily (2RHZE/4R3H3) or daily dose (2RHZE/4RH) had the same failure and recurrence rates. However, the World Health Organization (WHO) concluded that the part-daily dose had higher failure and recurrence rates. Therefore, this study was conducted to compare the treatment outcomes between both regimens, whether daily dose regimen has a better treatment outcome than part-daily dose regimen, and the adverse effects between both regimens. Methods this was an analytic cross-sectional study of patients at the Persahabatan General Hospital, over the period of January 2015-June 2018. Data were taken from medical records and supported by telephone interviews, each regimen group had 175 patients.Results there were no significant differences for success rates (p=0.470), lost to follow up rates (p=0.659), failure rates (p=1.000), death rates (p=1.000), and adverse effects in the continuation phase (p=0.324) between the groups. There were, however, significant differences in cure rates (p < 0.001) and complete treatment rates (p<0.001) between the groups. Conclusion the cure rate and complete treatment rate were found to be better for the part-daily than the daily doses. The success rate of both regimens were the same as Indonesia's target (90%). In the continuation phase, there were no significant difference of adverse effects between both regimens."

"Pendahuluan: Tuberkulosis (TB) adalah penyebab utama kematian akibat infeksi di dunia. Sejak tahun 2008 - 2017 terdapat penurunan angka keberhasilan pengobatan TB di Indonesia (< 90%). Rekomendasi pengobatan TB di Indonesia adalah paduan obat antituberkulosis (OAT) dosis berselang sebagian (2RHZE/4R3H3) atau harian (2RHZE/4RH). Menurut WHO, paduan OAT RHZE/R3H3 mempunyai angka kegagalan dan kekambuhan yang lebih tinggi. Namun, penelitian meta-analisis RCT menyatakan bahwa kedua paduan OAT mempunyai angka kegagalan dan kekambuhan yang sama. Oleh karena itu, dilakukan penelitian untuk membandingkan hasil pengobatan dan efek samping antara paduan OAT 2RHZE/2RH dengan 2RHZE/4R3H3.Metode: Penelitian ini merupakan studi analitik observasional dengan desain cross sectional yang membandingkan hasil pengobatan dan efek samping antara paduan OAT 2RHZE/4RH dengan 2RHZE/4R3H3 pada pasien TB paru kategori I di RSUP Persahabatan periode Januari 2015 sampai Juni 2018. Data sekunder diambil dari rekam medik. Hasil pengobatan dinilai sesuai definisi dalam pedoman nasional penanggulangan TB di Indonesia dan WHO. Efek samping dinilai dari seluruh efek samping terkait OAT yang tercatat dalam rekam medik.Hasil: Terdapat 175 pasien pada masing-masing kelompok. Pada kelompok paduan OAT 2RHZE/4RH terdapat 89.1% pasien berhasil, 13.1% sembuh,76.0% pengobatan lengkap, 10.6% putus berobat, 0.6% gagal, dan tidak ada yang meninggal. Pada kelompok paduan OAT 2RHZE/4R3H3 terdapat 91.4% pasien berhasil, 39.4% sembuh, 52.0% lengkap, 8% putus berobat, tidak ada yang gagal, dan 0.6% meninggal. Tidak ada perbedaan bermakna untuk keberhasilan pengobatan (p=0.470, OR=1.299, IK95%;0.637-2.648), putus berobat (p=0.659 ,OR=0.758, IK95%;0.365-1.577), gagal (p=1.000), dan meninggal (p=1.000) di antara kedua kelompok. Namun, terdapat perbedaan bermakna untuk kesembuhan (p=0.003, OR=2.358, IK95%;1.375-5.206) dan pengobatan lengkap (p=<0.001, OR=0.342, IK95%;0.217-0.540). Sebagian besar pasien mengalami efek samping pengobatan (51.1%) terutama di tahap intensif (73.2%). Pada tahap lanjutan tidak ada perbedaan bermakna kejadian efek samping antara kedua kelompok (p= 0.324, OR=1.386, IK95%; 0.723-2.657).Kesimpulan: Kesembuhan kelompok paduan OAT 2RHZE/4R3H3 lebih baik daripada 2RHZE/4RH, sedangkan pengobatan lengkap sebaliknya. Tidak ada perbedaan bermakna untuk keberhasilan pengobatan, putus berobat, kegagalan, meninggal, dan kejadian efek samping pada tahap lanjutan di antara kedua kelompok.

---

Introduction: Tuberculosis (TB) is the main cause of death for infectious disease in the world. Since 2008 - 2017, there was a decline of TB success rate (< 90%) in Indonesia. Treatment of TB in Indonesia are using antituberculosis drugs with part daily dose combination (2RHZE/4R3H3) or daily dose combination (2RHZE/4RH). WHO concluded that 2RHZE/4R3H3 combination had higher failure and recurrence rate. However, a meta-analysis study showed that both combinations had same failure and recurrence rate. Therefore, this study is conducted to compare treatment outcomes and adverse effects between 2RHZE/4RH combination and 2RHZE/4R3H3 combination.

Method: This was an observational analytic study with cross sectional design which compared treatment outcomes and adverse effects between 2RHZE/4RH combination and 2RHZE/4R3H3 combination in pulmonary tuberculosis patient at RSUP Persahabatan period January 2015 until June 2018. Secondary data was taken from medical record. Treatment outcomes were assessed using definition in Indonesia National Guideline of TB and WHO. Adverse effects were assessed from all adverse effects that written in medical record.

Result: There are 175 patients in each group. In 2RHZE/4RH combination group, there were 89.1% patients succeed, 13.1% cured, 76.0% completed treatment, 10.6% lost to follow up, 0.6% failed and no one died. In 2RHZE/4R3H3 combination group, there were 91.4% patients succeed, 39.4% cured, 52.0% completed treatment, 8% lost to follow up, no one failed, and 0.6% died. There was no significant difference for success (p=0.470, OR=1.299, IK95%;0.637-2.648), loss to follow up (p=0.659, OR=0.758, IK95%;0.365-1.577), failure (p=1.000), and death rate (p=1.000) between two groups. However, there was a significant difference for cure (p=0.003, OR=2.358, IK95%;1.375-5.206) and complete treatment rate (p=<0.001, OR=0.342, IK95%;0.217-0.540) between two groups. Most patients had adverse effects (51,5%), especially in intensive phase (73,2%). In continuation phase, there was no significant difference of adverse effects event between two groups (p = 0.324, OR= 1.386, IK95%; 0.723-2.657).

Conclusion: Cure rate was better in 2RHZE/4R3H3 group than 2RHZE/4RH group, for completed treatment on the contrary. There was no significant difference for success rate, loss to follow up rate, failure rate, death rate, and adverse effects event in continuation phase between two groups."

"Tuberkulosis paru merupakan salah satu penyakit infeksi penyebab kematian tertinggi di Indonesia. Pengobatannya yang lama dan sulit mengarahkan pada upaya pencegahan yang dimulai dengan identifikasi faktor risiko. Studi crosssectional analitik ini bertujuan untuk membahas hubungan usia terhadap prevalensi TB paru pada pasien DM tipe 2. Berdasarkan hasil penelitian, diketahui bahwa ditemukan hubungan yang bermakna antara usia pasien di atas 40 tahun dengan peningkatan jumlah prevalensi TB paru pada pasien dengan DM tipe 2. Karenanya, disarankan untuk melakukan proses pencegahan DM tipe 2 sebagai faktor resiko infeksi paru yang bersifat modifiable, terutama pada pasien dengan usia di atas 40 tahun.

---

Lung tuberculosis is one of the high cause of mortality infection diseases in Indonesia. Recovering is usually difficult and needs long term of treatment, leading to the trend of preventing by identifying the risk factors. The purpose of this analytic cross-sectional study is to identify the influence of age to the prevalence of lung tuberculosis in patients with DM type 2. From the result of this study, it is known that there is statistically significant result concerning the influence of age older than 40 years old to the increase of prevalence of lung tuberculosis in patients with DM type 2. Therefore, it is suggested to prevent DM type 2 as a modifiable risk factor of lung infection, especially in patients older than 40 years old."

"Pendahuluan : Kerusakan paru yang luas dan riwayat pemakaian antibakteri jangka panjang merupakan faktor risiko yang meningkatkan angka kejadian kolonisasi jamur. Kedua hal ini terjadi pada pasien TB paru MDR. Meningkatnya kasus TB MDR di Indonesia akan meningkatkan risiko terjadinya kolonisasi jamur di paru. Penelitian ini untuk mengetahui profil kolonisasi jamur pada pasien bekas TB paru MDR.Metode : Penelitian potong lintang terhadap pasien yang telah dinyatakan sembuh dari TB paru MDR dari tahun 2009-2015, yang kontrol ke Poli TB MDR RSUP Persahabatan selama bulan November-Desember 2015. Dengan menggunakan teknik consecutive sampling maka ditentukan sebanyak 61 subjek yang kemudian dilakukan induksi sputum. Hasil sputum induksi kemudian dilakukan pemeriksaan sputum jamur langsung dan biakan jamur dalam media Saboraud Dextrose Agar.Hasil : Subjek berusia antara 19-76 tahun. Dari 61 pasien , kelompok usia terbanyak antara usia 35-50 tahun sebnayak 28 orang (45,9%) diikuti usia kurang dari 35 tahun 23 orang (37,7%) dan usia lebih dari 50 tahun sebanyak 10 orang (16,01%). Sebanyak 28 orang (45,95) IMT normal, 17 orang IMT berlebih dan 16 orang (26%) IMT kurang. Sebanyak 28 subjek (45,9%) mempunyai riwayat merokok. Spektrum kolonisasi jamur pada pasien bekas TB paru MDR adalah 42 orang (68,9%) kolonisasi jamur positif dengan 29 orang (47,5) spesies C. albicans, 6 (9,8%) kombinasi C. albicans dan C. tropicalis, 2 orang (3,3%) masing-masing As flavus dan kombinasi C. albicans dan C. krusei serta masing-masing 1 orang (1,6%) spesies C. tropicalis, C. parapsilosis dan kombinasi C. albicans+C. parapsilosis.Kesimpulan: Kolonisasi jamur pada pasien bekas TB paru MDR tinggi dan harus diawasi dan harus dievaluasi untuk membedakan antara kolonisasi atau penyakit serta diobati untuk meningkatkan kualitas hidup pasca pengobatan TB MDR.

---

Introduction : Extensive lung damage and long term history of using antibacterial drugs are a risk factor that increase the incidence of fungal colonization. Both of these occurred in patients with pulmonary MDR TB. The increasing cases of MDR TB in Indonesia will increase the risk of fungal colonization in the lung. This study is to determine the profile of fungal colonization in post MDR TB patients.

Methods: This cross sectional study included patients who had been cured by the doctor in 2009-2015 and came to MDR Clinic from November-Desember 2015 in Persahabatan Hospital to check up. Sixty one patients were decided by consecutive sampling. From each patient, sputum induction for sputum fungal smear and fungal culture using Sabaraud Dextrose Agar.

Results: The age range of patients are between 19 to 76 years old. Out of 61 patients, among those group 45,9% are between the age of 35-50 years , 37,7% below the age 35 years old and 16,4% above age 50 years old. Twenty eight patients have normal body mass index, 17 patients are overweight and 16 patients are underweight. Number of patients who have smoking history are 45,9%. The spectrum of positive fungal colonization in post pulmonary MDR TB patients were 42 subjects (68.9%) consist of 29 subjects (47.5%)were Candida albicans, 6 subjects (9.8%) were combination of C. albicans and C. tropicalis, 2 subjects (3.3%) respectively were Aspergillus flavus and combinations of C. albicans and C. krusei. The others were C. tropicalis, C. parapsilosis and C. albicans + C. parapsilosis combination were 1 subject (1.6%) respectively.

Conclusion: Fungal colonization in post pulmonary MDR TB patients is high and should be monitored and must be evaluated to distinguish between colonization and disease and treated to improve quality of life post-treatment of MDR TB."

"Tuberculosis paru berdampak pada masalah fisiologis terutama masalah respirasi. Masalah keperawatan yang umum pada klien dengan TB paru adalah pola napas tidak efektif yang disebabkan oleh deformitas dinding thorak dan kondisi penyakit. Bentuk tindakan keperawatan yang sederhana dan mudah dilakukan adalah pemberian posisi semi fowler. Posisi semi fowler akan membuat paru dapat memaksimalkan ekspansinya dan menurunkan penggunaan otot bantu napas. Karya Ilmiah Akhir ini memberikan gambaran tentang keefektifan pemberian posisi semi fowler terhadap penurunan sesak napas pada Tn. S dengan TB Paru. Hasil evaluasi yang dilakukan selama lima hari menunjukkan penurunan sesak napas dan penurunan penggunaan otot bantu pernapasan pada Tn. S setelah diberikan posisi semi fowler. Berdasarkan penelitian yang sudah dilakukan, posisi semi fowler mampu memaksimalkan ekspansi paru dan menurunkan upaya penggunaan otot bantu napas. Pemberian posisi semi fowler dapat diaplikasikan sebagai salah satu intervensi non-farmakologi utama dalam mengatasi pola napas tidak efektif.

---

Pulmonary tuberculosis has an impact on physiological problems, especially respiratory problems. A common nursing problem in clients with pulmonary TB is an ineffective breathing pattern caused by thoracic wall deformities and disease conditions. One of the nursing actions that is simple and easy to perform is the provision of a semi-Fowler's position. The semi-Fowler's position will allow the lungs to maximize their expansion and reduce the use of accessory muscles for breathing. This final scientific work provides an overview of the effectiveness of giving the semi-fowler position to reduce shortness of breath in Mr. S with pulmonary TB. The results of the evaluation carried out for five days showed a decrease in shortness of breath and a decrease in the use of accessory muscles of respiration in Mr. S after being given a semi-Fowler's position. Based on the research that has been done, the semi-Fowler position is able to maximize lung expansion and reduce the effort to use the accessory muscles of breathing. Provision of a semi-Fowler's position can be applied as one of the main non-pharmacological interventions in overcoming ineffective breathing patterns."

" ABSTRAKTuberkulosis TB ekstra paru merupakan penyakit infeksi yang banyak terjadi di Indonesia. Penelitian TB ekstra paru di Indonesia masih sedikit, tatalaksana TB ekstra paru, termasuk obat yang digunakan serta hasil pengobatannya juga masih jarang diteliti. Penelitian ini bertujuan mengetahui angka kejadian, karakteristik dan mengevaluasi pengobatan TB ekstra paru di Rumah Sakit dr. Esnawan Antariksa Halim Perdana Kusuma periode 1 Januari 2014 - 31 Desember 2017. Penelitian potong lintang ini menggunakan data sekunder dari data register DOTS TB dan data rekam medis di Rumah Sakit dr. Esnawan Antariksa Halim Perdana Kusuma periode 1 Januari 2014-31 Desember 2017. Dari 456 pasien TB, didapat 153 pasien TB ekstra paru 33,5 , dari jumlah tersebut ada 136 pasien TB ekstra paru dengan data yang lengkap dan di evaluasi. Sebagian besar pasien berusia muda 91,9 , usia rata-rata 36.6 tahun, jenis kelamin terbanyak adalah perempuan 62.5 . Jenis TB ekstra paru terbanyak adalah limfadenitis TB 55,9 . Sebanyak 85,3 pasien pengobatannya lengkap, 11 putus obat, 1,5 gagal, dan 2,2 pindah pelayanan pengobatan. Tidak didapatkan hubungan bermakna antara keberhasilan terapi dengan usia p = 0,58; PR 0,9, 95 CI : 0,763-1,14 , komorbiditas p = 0.25; PR = 0.9, 95 CI : 0.802 ndash; 1.049 , IMT < 18,5 p = 0,613; PR =0,6, 95 CI : 0,15-3,05 . Penambahan etambutol fase lanjutan kategori I, dan pemberian ofloksasin pada terapi kategori II, meskipun tidak sesuai dengan panduan terapi meningkatkan keberhasilan terapi p = 0.039; PR = 1.1, 95 CI : 1.037 ndash; 1.318 . Keberhasilan terapi dengan lama pengobatan ge; 9 bulan lebih baik dibandingkan dengan < 9 bulan, p = 0,001; PR=1,8 95 CI : 1,403-2,533 .Kesimpulan : Penambahan etambutol pada fase lanjutan kategori I meningkatkan keberhasilan terapi TB ekstra paru. Sebagian besar TB ekstra paru membutuhkan lama pengobatan lebih dari 9 bulan.

---

---

ABSTRACTTuberculosis TB extra pulmonary is a common infectious disease in Indonesia. Extra pulmonary TB research in Indonesia is still small, the management of extra pulmonary TB, including the medicine used and the result of treatment are also rarely studied. This study aims to determine the prevalence, characteristics and evaluate the treatment of extra pulmonary TB in dr. Esnawan Antariksa Halim Perdana Kusuma Hospital period January 1, 2014 - December 31, 2017. This cross-sectional study used secondary data from DOTS TB register data and medical record data in dr. Esnawan Antariksa Halim Perdana Kusuma Hospital period from 1 January 2014-31 through December 2017. Of the 456 TB patients, which of 153 extra pulmonary TB patients 33,5 were found, out of which there were 136 extra pulmonary TB patients with complete data and evaluation. Most of the patients were young 91,9 , the average age was 36,6 years, the majority of patient were female 62,5 . The most common types of TB were TB lymphadenitis 55,9 . Some 85,3 of patients was complete treatment, 11 loss to follow-up, 1,5 failed, and 2,2 transfer out. Significantly, there was no correlation between the success of therapy with age p= 0.58, PR = 0.9;95 CI: 0.763-1.14 , comorbidity p = 0.25; PR = 0.9, 95 CI : 0.802-1.049 , IMT "

"Salah satu indikator program pengendalian TB secara Nasional strategi DOTS adalah angka keberhasilan pengobatan TB. Fokus utama pengendalian TB strategi DOTS adalah memutus mata rantai penularan TB oleh penderita TB paru sputum BTA positif. Berdasarkan penelitian penderita TB paru sputum BTA negatif dapat menularkan 13-20% (Tostmann A, et al, 2008). BBKPM Bandung sebagai salah satu UPK strategi DOTS pencapaian angka keberhasilan pengobatan masih dibawah target Nasional. Tujuan: mempelajari faktor yang mempengaruhi keberhasilan pengobatan pasien TB paru sputum BTA negatif dan pasien TB paru sputum BTA positif. Faktor yang mempengaruhi keberhasilan pengobatan TB antara lain faktor individu (umur, jenis kelamin, pekerjaan, kepatuhan berobat) dan obat dan penyakit (rejimen, dosis, lama pengobatan, komorbid HIV dan DM). Indikator keberhasilan pengobatan: pemeriksaan ulang sputum BTA menjadi/tetap negatif dan kenaikan berat badan. Desain penelitian: kohort retrospektif. Sampel: data pasien TB Paru yang tercatat di TB 01 tahun 2009-2011dijadikan 2 sub populasi, Pasien TB paru dengan sputum BTA negatif 292 kasus dan pasien TB paru dengan sputum BTA positif 461 kasus. Analisis: multivariabel regresi logistik. Hasil: OR keberhasilan pengobatan pasien TB paru sputum BTA negatif patuh berobat 1,4 dibandingkan tidak patuh (CI : 0,7-3,0) dan pasien TB paru sputum BTA positif patuh berobat 1,1 di bandingkan tidak patuh (CI : 0,6-2,2) setelah dikontrol umur, jenis kelamin dan pekerjaan. Saran: Meningkatkan peran PMO, dan memperhatikan faktor komorbid dalam tatalaksana pengobatan pasien TB paru.

---

Succes rate of TB treatment is an important indicator of the Natinal TB control program.The main focus of TB control program DOTS strategy is to break the chain of TB transmission. Tostmann A, et al (2008) showed that through 13-20% sputum smear negative pulmonary tuberculosis patients can spread TB the bacteria. BBKPM Bandung as one of CGU DOTS strategy has lower treatment succes rate of the national targets.

Purpose: To study factors that influence the treatment succes rate of compare with both smear positve and negative pulmonary tuberculosis patients. Those are age, gender, occupation, treatment compliance (factor individu) and regimen, dose, duration of treatment, comorbid HIV and DM (drug and disease). Indicator of treatment succes are the conversion of sputum result examination and the gain weight.

Study design: a retrospective cohort study.

Samples: the pulmonary TB patient data recorded at TB 01 yeras 2009-2011. The number of TB patients with sputum smear positive are 461 and negative are 292.

Analysis: Multivariable logistic regression.

Result: OR treatment succes among sputum smear-negative pulmonary TB patients 1,4 (CI: 0,7-3,0) and among sputum smear positive pulmonary Tb patients who adhere to treatment is 1,1 (CI:0,6-2,2) after controlling for age, sex, and occupation.

Suggestion: Enhancing the role of the PMO to increase the treatment adherence rate, treat the TB patients with HIV and DM co-infection."

"ABSTRAKLatar belakang : Penyebab kematian pada TB paru seringkali tidaktergambarkan dengan jelas disebabkan sebagian besar studi mengandalkan padaregistrasi TB berdasarkan sertifikat kematian. Hanya sedikit studi penyebabkematian berdasarkan otopsi ataupun audit kematian untuk mengetahui penyebabkematian sebenarnya. Audit kematian diperlukan untuk meningkatkan mutupelayanan Rumah Sakit.Tujuan : Penelitian ini dilakukan untuk mengetahui penyebab kematian pada TBparu bakteriologis terkonfirmasi apakah berkaitan dengan TB secara langsungatau tidak langsung (berkaitan dengan komorbid) berdasarkan audit kematian,guna identifikasi intervensi yang efektif untuk mencegah kematian TB.Metoda : Penelitian potong lintang ini dilakukan di RSUP Persahabatan dengansubjek penelitian adalah semua pasien TB paru bakteriologis terkonfirmasi yangmeninggal di RS Persahabatan tahun 2014 yang memenuhi kriteria inklusi daneksklusi. Data diambil dari rekam medis, dilakukan audit kematian dan dinilaikesesuaian penyebab kematian langsung maupun tidak langsung antara sertifikatkematian dengan audit kematian.Hasil : Terdapat 51 subyek dengan laki-laki sebanyak 35 orang (68,6%) danperempuan 16 orang (31,4%). Penyebab kematian langsung terkait TBberdasarkan audit kematian sebanyak 15 subyek (29,4 %) yaitu disebabkan olehgagal napas (17,6 %) dan meningitis TB (11,8%). Penyebab kematian langsungtidak terkait TB berdasarkan audit kematian adalah 36 subyek (70,6%) yaitusepsis infeksi bakteri (41,2%) menjadi penyebab terbanyak, diikuti AIDS (3,9%),penyakit kardiovaskular (3,9 %), penyebab lain (5,9 %) dan tidak diketahui(15,7%). Diagnosis TB paru bakteriologis terkonfirmasi yang sesuai padasertifikat kematian berdasarkan audit adalah 25 subyek (49%) dan penyebabkematian langsung TB paru bakteriologis terkonfirmasi pada sertifikat kematianyang sesuai berdasarkan audit kematian adalah 27 subyek (52,9%).Kesimpulan : Penyebab kematian langsung pada TB paru bakteriologisterkonfirmasi terkait TB yang terbanyak disebabkan oleh gagal napas sedangkanyang tidak terkait TB yang terbanyak disebabkan oleh sepsis infeksi bakteri.Diperlukan intervensi lebih lanjut untuk mencegah kematian TB.

---

ABSTRACTBackground : The causes of death in pulmonary TB are often not representedclearly caused most studies rely on the registration of TB based on deathcertificates. Only a few studies based on autopsy or death audits. Medical audit isnecessary to improve the quality of service in the hospital.Objective : The aim of the study is to know the cause of death in pulmonary TBbacterically proven whether related directly or undirecly with TB (regardingcomorbid) based on audit of death to identify effective intervention to preventmortality in TB.Method : This is cross sectional study in RSUP Persahabatan with subject ofstudy all of pulmonary TB patients bacterically proven died in RSUPPersahabatan in 2014 according to inclution and exclusion criteria. The data weretaken from medical record, with audit of death asses the cause of death direct ornot direct between certificate of death and audit of death.Result : There are 51 subjects. Male are 35 subjects (68,6%) and female are 16subject (31,4%).The causes of death directly related with TB based on audit ofdeath are 15 (29,4%) caused by respiratory failure (17,6 %) and meningitis TB(11,8 %). The causes of death are not directly related with TB based on audit ofdeath are 36 subjects (70,6 %) caused by sepsis with bacterial infection (41,2 %),AIDS are (3,9 %), cardiovascular diseases (3,9 %), other causes are (5,9 %) andunknown are (15,7 %). The diagnosis of pulmonary TB in a death certificate inaccordance with the results of the audit are 25 subjects (49%) and pulmonarytuberculosis cause of death on death certificates in accordance with the results ofthe audit are 27 subjects (52.9%).Conclusion : The causes of death are pulmonary tuberculosis bacteriology mostdirectly caused by respiratory failure while the causes of death are notimmediately TB that most caused by sepsis with bacterial infection as the cause.Required further interventions to reduce mortality of TB."

"Perbedaan antara tes untuk infeksi tuberkulosis (TB) yang resistan terhadap obat menjadi lebih umum karena alat diagnostik menjadi lebih bervariasi. Hal tersebut membingungkan dokter karena belum ada tes TB diagnostik cepat dengan sensitivitas dan spesifisitas yang baik. Kasus suspek-TB di RSUPP, pusat primer dan tersier untuk kasus TB paru Indonesia, disaring dengan GeneXpert MTB / RIF dan dikonfirmasikan dengan uji kepekaan obat anti-tuberkulosis.Discrepancies between tests for drug-resistant tuberculosis (TB) infections are becoming more common as diagnostic tools become more varied. These discrepancies confuse clinicians because there is not yet a rapid diagnostic TB test with good sensitivity and specificity. Suspected-TB cases at Rumah Sakit Umum Pusat Perhasabatan (RSUPP), a primary and tertiary center for Indonesia’s pulmonary TB cases, are screened with GeneXpert MTB/RIF and confirmed with conventional drug- susceptibility testing (DST)."

"Tuberkulosis paru merupakan sebuah penyakit yang menular sehingga mengakibatkan kesehatan buruk dan juga salah satu dari sepuluh penyebab kematian paling atas di dunia. Penyebab penyakit tuberkulosis paru yakni Mycobacterium tuberculosis. Penyakit tuberkulosis paru masih menjadi salah satu masalah Kesehatan di kota bogor dari tahun 2020-2022. Tujuan: Menganalisis hubungan cakupan rumah sehat, cakupan rumah tangga ber PHBS, fasilitas kesehatan dan kepadatan penduduk terhadap kasus tuberkulosis paru di Kota Bogor pada tahun 2020-2022. Metode: Penelitian ini merupakan penelitian kuantitatif dengan desain studi ekologi berbasis waktu. Hasil: Hasil analisis korelasi menunjukkan bahwa Rumah sehat (p=0,256), Rumah ber-phbs (p=-0,257), Fasilitas Kesehatan (p=0,338), Kepadatan penduduk (p=-0,943) terhadap kejadian tuberkulosis paru. Kesimpulan: Terdapat hubungan signifikan antara fasilitas Kesehatan dan kepadatan penduduk terhadap kejadian tuberkulosis. Dan terdapat hubungan yang tidak signifikan antara rumah sehat dan rumah tangga ber-phbs terhadap kejadian tuberkulosis paru.

---

Pulmonary tuberculosis is an infectious disease that causes poor health and is also one of the top ten causes of death in the world. The cause of pulmonary tuberculosis is Mycobacterium tuberculosis. Pulmonary tuberculosis is still one of the health problems in Bogor City from 2020-2022. Objective: To analyze the relationship between healthy home coverage, PHBS household coverage, health facilities and population density with pulmonary tuberculosis cases in Bogor City in 2020-2022. Method: This study is a quantitative study with a time-based ecological study design. Results: The results of the correlation analysis showed that Healthy houses (p = 0.256), PHBS houses (p = -0.257), Health facilities (p = 0.338), Population density (p = -0.943) on the incidence of pulmonary tuberculosis. Conclusion: There is a significant relationship between health facilities and population density on the incidence of tuberculosis. And there is an insignificant relationship between healthy houses and PHBS households on the incidence of pulmonary tuberculosis.

"