Hasil Pencarian  ::  Simpan CSV :: Kembali

"A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment."

"Kanker payudara merupakan salah satu masalah kesehatan terbesar di Indonesia di mana sekitar 42,7% datang pada stadium lanjut lokal. Pemberian kemoterapi neoajuvan pada stadium lanjut lokal bertujuan mengecilkan ukuran tumor sehingga dapat dilakukan operasi dan menurunkan mortalitas. Salah satu prediktor untuk mengetahui keberhasilan kemoterapi neoajuvan adalah Ki-67, yaitu protein non-histone yang ekspresinya tinggi saat proliferasi sementara obat-obatan kemoterapi bekerja efektif pada fase proliferasi. Tujuan penelitian ini adalah untuk mengetahui peran Ki-67 sebagai faktor prediktor terhadap respons kemoterapi neoajuvan pada pasien KPDLL. Metode: Penelitian ini merupakan studi kohort retrospektif dengan kriteria inklusi adalah pasien dengan diagnosis kanker payudara stadium lanjut lokal dan mendapatkan kemoterapi neoajuvan di Rumah Sakit Cipto Mangunkusumo (RSCM) sejak 1 Januari 2014- 31Desember 2019. Cut-off ekspresi Ki-67 adalah 20%. Respons klinis kemoterapi neoajuvan dinilai berdasarkan kriteria WHO yang diukur setelah pemberian kemoterapi ketiga. Respons kemoterapi ini dikelompokkan menjadi respons baik (complete response dan partial response) dan respons buruk (stable disease dan progresive response). Hasil: Pasien kanker payudara lanjut lokal rata-rata berusia 50 tahun, ukuran tumor terbanyak T4 (90,4%), keterlibatan kelenjar getah bening N1 (52,1%), jenis histopatologi NST (71,3%), grade 2 (54,4%), ER positif (78,7%), PR positif (70,2%), HER2negatif (58,5%), Ki67 tinggi (70,2%), dan luminal B (56,4%). Lima puluh dua koma satu persen subjek memiliki respons kemoterapi buruk. Tidak terdapat perbedaan bermakna secara statistik antara ekspresi Ki-67 dengan respons kemoterapi (p= 1). Bila dihitung presentase sisa tumor, pasien dengan ekspresi Ki-67 tinggi memiliki persentase sisa tumor 74,6%, pasien dengan ekspresi Ki-67 rendah rata-rata tidak mengalami penurunan ukuran tumor dengan sisa tumor 103,8% (p= 0,977). Simpulan: Tidak terdapat perbedaan bermakna secara statistik antara ekspresi Ki-67 dan respons kemoterapi neoajuvan pada kanker payudara stadium lanjut lokal di RSCM.

---

Breast cancer is one of the most common health problems in Indonesia where 42.7% of patients have been diagnosed with Locally Advanced Breast Cancer (LABC). Neoadjuvant chemotherapy (NAC) is aimed to decrease the tumor size to be operable and decrease mortality. Ki-67 is highly expressed in the cell proliferation phase, while chemotherapy agents work effectively by targeting this proliferation. This study evaluates the utility of Ki-67 in LABC patients of the Asian-Indonesian population. Methods: This is a retrospective cohort study. Ki-67 data was from the medical record based on the immunohistochemistry staining with >20% cut off point. Clinical response was measured based on the WHO criteria after the third chemotherapy cycle, classified as good response (complete response and partial response) and poor response (stable disease and progresive response). Result: The majority of subjects in this study were 50 years old, with T4 tumor size (90.4%), N1 lymph node involvement (52.1%), NST histopathological type (71.3%), grade 2 (54.4%), ER-positive (78.7%), PR-positive (70.2%), HER2-negative (58.5%), high Ki67 expression (70.2%), and luminal B subtype (56.4%). 52.1% of all subjects showed ‘poor’ clinical responses to NAC. There was no significant association between subjects’ characteristics and the NAC Clinical response. Moreover, there was no significant association between Ki-67 and chemotherapy clinical response (p=1). Residual tumor size was 74.6% in high Ki-67 group and 103.8% in low Ki-67 group (p= 0.977). Conclusion: There is no statistically significant association between Ki-67 expression and NAC clinical response of LABC patients in Indonesia."

"Kanker ovarium merupakan kanker paling mematikan ke-8 pada perempuan di dunia. Pasien kanker ovarium umumnya akan mengalami kemoresistensi, kekambuhan dan prognosis buruk setelah operasi sitoreduktif dan kemoterapi berbasis platinum. Hal tersebut berhubungan dengan peningkatan ekspresi Cancer Stem Cells (CSCs) CD44+/CD24-, RAD6, dan penurunan DDB2. Penelitian ini bertujuan untuk menganalisis hubungan ekspresi CSCs, RAD6 dan DDB2 dengan kemoresistensi kanker ovarium di jaringan kanker ovarium dan sirkulasi darah.Penelitian kohort ambispektif ini dilakukan di RSUP Cipto Mangunkusumo, RSUD Tarakan, RSUP Dharmais, dan RSUP Fatmawati pada Februari 2018–Februari 2022. Subjek adalah 64 orang pasien yang dibagi menjadi dua kelompok. Semua subjek menjalani operasi sitoreduktif dan pemeriksaan histopatologi. Kemoterapi diberikan sebanyak enam seri diikuti enam bulan observasi, kemudian ditentukan respons terapi dengan kriteria Response Criteria in Solid Tumors (RECIST). Uji imunohistokimia dilakukan langsung ke jaringan kanker ovarium (retrospektif) dan uji flowsitometri darah (prospektif) untuk menilai Ekspresi CSCs, RAD6 dan DDB2.Terdapat peningkatan Ekspresi CSCs, RAD6 serta penurunan bermakna ekspresi DDB2 (p < 0,05) di jaringan kanker ovarium kemoresisten, dan peningkatan bermakna Ekspresi CSCs, dan RAD6 yang bermakna (p < 0,05) di sirkulasi darah penderita kanker ovarium. Ekspresi DDB2 di uji imunohistokimia adalah protein dengan nilai AUC terbaik sedangkan di uji flowsitometri, CSCs memiliki nilai AUC terbaik. Disusun skor IHC-UNEDO (imunohistokimia) dan skor FCM- UNEDO (flowsitometri) untuk membantu memprediksi respons terapi.Penelitian ini menunjukkan bahwa terdapat peningkatan Ekspresi CSCs, RAD6 dan penurunan DDB2 di jaringan kanker ovarium, serta peningkatan Ekspresi CSCs di sirkulasi darah penderita kanker ovarium dan protein tersebut merupakan prediktor respons terapi kanker ovarium yang baik."

"Sleep disturbances and fatigue are frequently complained by adolescents with cancer. These problems will lead to avariety of changes that may affect adolescents? development. However, there is very limited data concerningadolescents with cancer in Indonesia. The research aimed to explore sleep disturbances and fatigue in adolescents withcancer who are receiving chemotherapy. The research applied a qualitative design with phenomenology approach. Datawere collected using in-depth interviews with seven adolescents with cancer in Jakarta, Bogor, and Bekasi. Theinterviews involved open questions on seven aspects, consisting of level of fatigue, responses to psychological drives,sleep disturbances, sleep disruption due to illness and chemotherapy, disruptions in some aspects of daily life, responsesto problematic situations, and general perspective on life. Participants stated that chemotherapy induced sleepdisturbances and fatigue, and this situation greatly influenced their overall quality of life. These problems areinterrelated to each other and may affect the success of chemotherapy program. In terms of nursing, this research alsoshows the importance of developing a more effective system for managing sleep disturbances and fatigue duringchemotherapy program.Gangguan Tidur dan Kelelahan pada Remaja Pengidap Kanker yang Menjalani Kemoterapi. Gangguan tidur dankelelahan seringkali dikeluhkan oleh para remaja yang mengidap kanker. Keluhan ini mengakibatkan timbulnyaberbagai perubahan yang dapat memengaruhi pertumbuhan remaja. Namun, data tentang remaja penderita kanker diIndonesia masih sangat terbatas. Penelitian ini bertujuan untuk menyelidiki keluhan-keluhan berupa gangguan tidur dankelelahan yang diderita oleh remaja pengidap kanker yang sedang menjalani kemoterapi. Penelitian ini menerapkanrancangan kualitatif dengan pendekatan fenomenologis. Pengumpulan data dilakukan dengan mengadakan wawancaramendalam mengenai tujuh aspek yang terdiri dari tingkat kelelahan, reaksi terhadap dorongan-dorongan psikologis,gangguan tidur, tidur tidak nyenyak karena penyakit dan kemoterapi, gangguan pada sejumlah aspek dalam kehidupansehari-hari, reaksi terhadap keadaan yang menyulitkan, dan pandangan hidup secara umum. Para responden menyatakanbahwa kemoterapi menimbulkan gangguan tidur dan kelelahan. Selain itu, mereka juga menyatakan bahwa situasi inisangat memengaruhi kualitas hidup mereka secara umum. Masalah-masalah ini berkait satu sama lain dan dapatmemengaruhi kesuksesan program kemoterapi yang mereka jalankan. Dari segi keperawatan, penelitian ini jugamenunjukkan pentingnya merancang sebuah sistem yang lebih efektif untuk menghadapi gangguan tidur dan kelelahanselama program kemoterapi."

"Tujuan: Penelitian ini dilakukan untuk mengetahui korelasi perubahan nilai ADC pada DWMRI dengan perubahan ukuran tumor pasca kemoterapi neoajuvan kanker payudara dalam menilai respons kemoterapi neoajuvan. Metode: Penelitian studi deskriptif analitik dari data sekunder MRI pasien kanker payudara yang mendapat kemoterapi neoajuvan serta menjalankan pemeriksaan MRI. Pemeriksaan MRI dilakukan sebelum pasien mendapat kemoterapi neoajuvan, setelah pasien mendapat kemoterapi neoajuvan siklus pertama dan siklus ketiga. Pengukuran ukuran tumor dilakukan sesuai standar RECIST, sedangkan nilai ADC diperoleh pada nilai b800s/mm2. Hasil dan diskusi: Dilakukan analisis bivariat dengan menggunakan korelasi Pearson untuk melihat korelasi perubahan nilai ADC kedua terhadap nilai ADC pertama dengan perubahan ukuran tumor pada pemeriksaan MRI ketiga terhadap pemeriksaan MRI pertama. Sebanyak 17 pasien penelitian dengan usia antara 40 tahun sampai 65 tahun dan ukuran tumor antara 5,41 cm sampai 13,41 cm. Terdapat 16 pasien yang mengalami peningkatan nilai ADC dan 1 pasien yang mengalami penurunan nilai ADC setelah pemberian kemoterapi neoajuvan siklus pertama. Sebanyak 17 pasien mengalami pengurangan ukuran tumor setelah kemoterapi neoajuvan siklus ketiga. Berdasarkan standar RECIST diperoleh sebanyak 7 pasien dengan pengurangan ukuran tumor lebih dari 30% (antara 31,55% sampai 56,25%) dan sebanyak 10 pasien dengan pengurangan ukuran tumor kurang dari 30% (antara 7,47% sampai 29,22%). Nilai korelasi yang diperoleh sebesar -0,499. Kesimpulan: Terdapat korelasi yang bermakna antara perubahan nilai ADC pada DWMRI dengan perubahan ukuran tumor sebagai respons kemoterapi neoajuvan kanker payudara dengan kekuatan korelasi yang sedang dan arah negatif.

---

Objectives: To determine the correlation of changes in ADC values in DWMRI with changes in tumor size after neoadjuvant chemotherapy in breast cancer to assess neoadjuvant chemotherapy response.

Methods: Analytical descriptive study using secondary data from MRI of breast cancer patients receiving neoadjuvant chemotherapy as well as running an MRI. MRI examination performed before neoadjuvant chemotherapy, after received first cycle neoadjuvant chemotherapy and third cycle. Tumor size measurements carried out according to standard RECIST, whereas the ADC values obtained in the b800s/mm2. Bivariate analysis using Pearson correlation was conducted to determine the correlation of changes in the value of the second ADC to first ADC and changes of the tumor size on the third MRI to the first MRI examination.

Result and discussion: A total of 17 study patients, 40 years to 65 years old, tumor size between 5.41 cm to 13.41 cm. 16 patients experienced an increase in ADC values while 1 patient had decreased ADC values after the first cycle of neoadjuvant chemotherapy. Tumor size in all patients decreased after three cycles of neoadjuvant chemotherapy. Based on RECIST standards, 7 patients showed tumor size reduction of more than 30% (between 31.55% to 56.25%) and tumor size in 10 patients was reduced less than 30% (between 7.47% to 29.22% ). Correlation value of -0.499 obtained.

Conclusions: There is a significant moderate and negative correlation between in ADC value changes in DWMRI with tumor size changes in response to neoadjuvant chemotherapy."

"[ABSTRAK Latar belakang : Kanker payudara lanjut lokal (KPLL) adalah kanker payudara stadium III.Modalitas terapi KPLL adalah pembedahan, kemoterapi, radioterapi, hormonal terapi dan terapi target. Respon kemoterapi neoadjuvan terdiri dari respon klinis dan respon patologi. Penilaian respon kemoterapi neoadjuvan penting untuk memprediksi angka ketahanan hidup dan dapat menjadi pedoman kemoterapi selanjutnya. Penilaian respon patologi selama ini bersifat kuantitatif dan sering tidak selaras dengan respon klinis. Perubahan jumlah selularitas dapat terlihat, tetapi kualitas sel tumor tersebut tidak dapat diketahui dengan pulasan Haematoxylin-eosin (HE) pada fase awal fragmentasi DNA, sehingga penilaian respon patologi perlu dilakukan secara kuantitatif dan kualitatif yaitu menilai selularitas sel tumor dan persentase apoptosis. Bahan dan cara : Dilakukan penelitian retrospektif analitik secara potong lintang pada kanker payudara lanjut lokal tahun 2010-2014 di Departemen Patologi Anatomi FKUI/RSCM dan divisi bedah onkologi RSCM. Sampel biopsi dan reseksi dibandingkan untuk mengevaluasi penurunan selularitas, kemudian diklasifikasikan ke derajat Miller- Payne (MP). Sampel reseksi dipulas dengan TUNEL dan dihitung persentase apoptosis. Penurunan selularitas antara biopsi dan mastektomi dengan TUNEL merupakan Modifikasi MP. Hasil : Perubahan respon patologi dengan Modifikasi MP menimbulkan peningkatan derajat pada 24 kasus. Tidak terdapat hubungan antara respon klinis dengan persentase apoptotis (p=0,108), respon klinis dengan MP (p=1,000) dan Modifikasi MP (p=0,655). Tidak didapatkan hubungan dan adanya korelasi yang lemah antara penyusutan massa tumor secara klinis dengan jumlah sel tumor yang mati dengan MP (p=0,177; r =0,212) dan Modifikasi MP (p=0,609; r = 0,081). Terdapat perbedaan signifikan antara jumlah sel mati yang dinilai dengan MP dan Modifikasi MP (p =0,000). Kesimpulan : Persentase apoptosis tidak berhubungan dengan respon klinis. Modifikasi MP meningkatkan nilai derajat respon patologik, tetapi penilaian Modifikasi MP tetap tidak menunjukkan korelasi dengan respon klinik.ABSTRACT Background: Locally advanced breast cancer (LABC) is a stage III breast cancer. The management of LABC includes surgery, chemotherapy, radiotherapy, hormonal and targeted therapy. Responses to neoadjuvant (before surgery) chemotherapy consist of clinical and pathological responses. Evaluating chemotherapy response is essential to predict survival rate and it may become guidelines for the next chemotherapy in the future. Until now, the evaluation of pathological response only involves quantitative assessment and the clinical responses are often inconsistent with the pathological responses. Morphological changes of apoptotic cells can still be seen. However, the quality of the tumor cells is vague when the cells are stained with Hematoxylin-eosin (HE) during the first stage of DNA fragmentation. The evaluation of pathological responses; therefore, need to be performed by quantitative and qualitative methods, i.e. by evaluating the cellularity of tumor cells and the percentage of apoptosis.

Materials and method: A cross-sectional analytical retrospective study was conducted on the issue of locally advanced breast cancer between 2010 and 2014 at the Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital and Division of Surgical Oncology, Cipto Mangunkusumo Hospital. Specimens of biopsy and resection were compared to evaluate reduction in cellularity, which were subsequently categorized into stages of Miller-Payne (MP) classification. The specimens of resection were stained with TUNEL and the percentage of apoptosis was calculated. Reduction in cellularity between biopsy and mastectomy specimens with TUNEL staining is a modified MP methods.

Results: The evaluation of pathological responses using the modified MP method has increased the value of MP grading in 24 cases. We found no association between clinical responses with percentage of apoptosis (p=0,108), MP pathological responses (p=1,000) and modified MP (p=0,655). There is no association and weak correlation between decreasing tumor mass with MP (p=0,177; r=0,212) and modified MP (p=0,609; r=0,081). There was a correlation between the dead cell evaluated by MP and by modified MP. (p=0.000)

Conclusion: Apoptosis percentage does not correlate with clinical responses. Modified MP increases the degree or grading of pathological responses, but it does not improve the correlation with clinical responses., Background: Locally advanced breast cancer (LABC) is a stage III breast cancer. The management of LABC includes surgery, chemotherapy, radiotherapy, hormonal and targeted therapy. Responses to neoadjuvant (before surgery) chemotherapy consist of clinical and pathological responses. Evaluating chemotherapy response is essential to predict survival rate and it may become guidelines for the next chemotherapy in the future. Until now, the evaluation of pathological response only involves quantitative assessment and the clinical responses are often inconsistent with the pathological responses. Morphological changes of apoptotic cells can still be seen. However, the quality of the tumor cells is vague when the cells are stained with Hematoxylin-eosin (HE) during the first stage of DNA fragmentation. The evaluation of pathological responses; therefore, need to be performed by quantitative and qualitative methods, i.e. by evaluating the cellularity of tumor cells and the percentage of apoptosis.

Materials and method: A cross-sectional analytical retrospective study was conducted on the issue of locally advanced breast cancer between 2010 and 2014 at the Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital and Division of Surgical Oncology, Cipto Mangunkusumo Hospital. Specimens of biopsy and resection were compared to evaluate reduction in cellularity, which were subsequently categorized into stages of Miller-Payne (MP) classification. The specimens of resection were stained with TUNEL and the percentage of apoptosis was calculated. Reduction in cellularity between biopsy and mastectomy specimens with TUNEL staining is a modified MP methods.

Results: The evaluation of pathological responses using the modified MP method has increased the value of MP grading in 24 cases. We found no association between clinical responses with percentage of apoptosis (p=0,108), MP pathological responses (p=1,000) and modified MP (p=0,655). There is no association and weak correlation between decreasing tumor mass with MP (p=0,177; r=0,212) and modified MP (p=0,609; r=0,081). There was a correlation between the dead cell evaluated by MP and by modified MP. (p=0.000)

Conclusion: Apoptosis percentage does not correlate with clinical responses. Modified MP increases the degree or grading of pathological responses, but it does not improve the correlation with clinical responses.]"