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"Systemic lupus erythematosus (SLE) as a chronic autoimmune disease with multi-organ involvement often occurs in women of childbearing age. We report a case of active SLE in a-23 year old woman who presented with multi-organ involvement, including pericardia! effusion, severe anemia that caused congestive heart failure, and kidney involvement. ANA and ami ds DNA were positive. The patient was treated with intravenous digoxin followed by a daily dose of oral digoxin, ROmg/day of furosemide, 600 ml packed red cell transfusion, and !.5 mg/kg bodyweight/day of prednisan. The patient was discharged in good condition on the I5'h day of hospitalization."

"LES merupakan penyakit inflamasi autoimun kronis dan banyak terjadi pada  anak remaja dengan rata-rata onset usia 11-12 tahun. Sekitar 10% dari remaja dengan penyakit kronis seperti LES mengalami masalah psikososial, termasuk masalah emosi seperti depresi dan kecemasan. Penelitian ini bertujuan untuk mengetahui apakah pelatihan kecakapan hidup pada anak dengan LES dapat memperbaiki masalah emosi. Penelitian dilakukan dengan 30 subjek remaja perempuan dengan LES yang sudah mendapatkan pengobatan, dan nilai SLEDAI 0-5. Subjek dibagi menjadi 2 kelompok secara acak tanpa penyamaran, perlakuan dan kontrol.  Pelatihan kecakapan hidup diberikan pada kelompok perlakuan sebanyak 1 kali dalam kelas. Perbaikan masalah emosi dinilai dengan membandingkan nilai SDQ sebelum pelatihan dan 4 minggu setelah pelatihan. Penelitian melibatkan 30 remaja perempuan dengan LES dengan usia rerata 14 tahun. Sebanyak 20/30 subjek memiliki nilai SDQ normal, 4/30 dengan SDQ borderline dan 6/30 dengan SDQ abnormal. Terdapat perbedaan bermakna selisih masalah emosi pada kedua kelompok (p: 0,025; effect size: 0,87). Pada kelompok yang mendapatkan pelatihan terdapat perbaikan nilai SDQ total (p: 0,001), nilai masalah emosi (p: 0,002), nilai masalah perilaku (p: 0,027) dan nilai masalah perilaku hiperaktif (p: 0,040) dibandingkan dengan awal studi. Sedangkan pada kelompok kontrol hanya terdapat perubahan nilai masalah dengan teman sebaya (p: 0,011). Selain itu ditemukan pula perbaikan masalah emosi pada kelompok pelatihan yakni keluhan sakit fisik (p: 0,021), rasa khawatir (p: 0,020) dan perasaan gugup (p: 0,020). Studi ini menyimpulkan bahwa pelatihan kecakapan hidup-modul pengelolaan emosi efektif dalam memperbaiki masalah emosi pada remaja perempuan dengan LES secara signifikan, terutama gugup atau sulit berpisah dengan orangtua/pengasuhnya pada situasi baru, mudah kehilangan rasa percaya diri dan banyak kekhawatiran atau sering tampak khawatir.

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SLE is a chronic autoimmune inflammatory disease and many occur in adolescents with an average age of onset of 11-12 years. About 10% of adolescents with chronic diseases such as SLE experience psycho-mental problems, including emotional problems such as depression and anxiety. The aim of this study is to determine whether life skills training in children with SLE can improve emotional problems. The study was conducted with 30 female adolescent with SLE who had received treatment and SLEDAI score 0-5. Subjects were divided into 2 groups randomly, not-blinding, experiment and control. Life skills training is given to the experiment group one time in group. Emotional problem improvement was assessed by comparing SDQ scores before training and 4 weeks after training. The study involves a total of 30 female adolescent with SLE with an average age of 14 years. A total of 20/30 subjects had normal SDQ values, 4/30 with borderline SDQ and 6/30 with abnormal SDQ. There were significant differences in the difference between emotional problems in the two groups (p: 0.025; effect size: 0.87). In the group that received training there was an improvement in the total SDQ value (p: 0.001), the value of emotional problems (p: 0.002), the value of conductive problems (p: 0.027) and the value of hyperactive behavior problems (p: 0.040) compared to the beginning of the study. Whereas in the control group there were only changes in the value of problems with peers (p: 0.011). In addition it also found improvements in emotional problems in the experiment group, they are complaints of physical pain (p: 0.021), anxiety (p: 0.020) and nervous feelings (p: 0.020). This study concludes that life skills training-emotion management module is significantly effective in improving emotional problems in female adolescent with LES, especially nervous or having difficulty separating from parents/caregivers in new situations, easily losing self-confidence and many worries or often seems worried."

"ABSTRAKBackground: Systemic lupus erythematosus (SLE) is an autoimmune disease that more commonly affects women of childbearing age. It is a multi-organ disease and can involve virtually any organ in the body. Pleural effusion can occurred in 30% of patients with SLE, which may be a result of SLE itself, pulmonary emboli, or end-organ damage such as heart or renal failure. The management of pleural effusions in SLE patient can be challenging because the numerous of potential underlying cause and sometimes effusion recur despite appropriate treatment of primary process. Case Report: We reported 33 years old woman patient admitted to our ED with chief complaint of shortness of breath for last 1 week. Chest X-ray result showed bilateral pleural effusion. Serial pleural fluid analysis consistent with conclusion of transudate fluid. Echochardiograpy showed dilatation of left atrium and ventricle and reduced LVEF 34%. These data suggest congestive heart failure as the cause of pleura effusion. A few days after initial thoracocentesis, the patient become dyspnea again because of reccurent pleural effusion. To relieve the symptom, we did insertion of pigtail catheter connected with mini WSD (Water seal drainage). Conclusion: Pleural effusion is a relatively common clinical presentation of a patient with SLE. Pleural effusions may be a result of SLE itself, pulmonary emboli, or end-organ damage such as heart or renal failure. The management of pleural effusions are mainly to relieve the symptoms and treatment of underlying cause."

"Systemic lupus erythematosus (SLE) is a chronic excacerbative autoimmune disease with wide clinical spectrum. Gastrointestinal manifestasion is a frequent clinical manifestasion seen in SLE. Management with glucocorticoid and non-steroid anti-inflammatory drugs (NSAID) can mask the gastrointestinal symptoms in patient with SLE. One of the etiologies of gastrointestinal manifestations in SLE is acute appendicitis. Patients with acute appendicitis usually have abdominal pain as its chief complaint. The pathophysiology of acute appendicitis can occur primarily from SLE and secondary from other causes eg: infection, inflammation, etc. When a SLE patient has acute appendicitis as its initial assessment, determining its etiology is pivotal to give comprehensive management and preventing life-threatening complications.

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Lupus eritematosus sistemik (LES) adalah suatu penyakit autoimun kronis eksaserbatif dengan manifestasi klinis yang sangat beragam. Manifestasi gastrointestinal merupakan manifestasi yang sering dijumpai namun dapat terjadi efek masking oleh karena penggunaan obat-obatan untuk mengontrol penyakitnya seperti obat anti-inflamasi non-steroid (OAINS) dan kortikosteroid. Appendisitis akut merupakan salah satu penyebab nyeri abdomen pada penderita LES. Patofisiologi appendisitis akut dapat terjadi primer oleh aktivitas penyakitnya maupun sekunder oleh sebab lain. Membedakan etiologi appendisitis akut perlu dilakukan untuk memberikan tatalaksana yang komprehensif pada penderita dengan LES."

"Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with various clinical disorders and frequent exacerbations. Psoriasis vulgaris is a common skin disorder which affect 1-3% of general populations. The pathophysiology regarding the coexistence of these diseases is not fully understood. Therapeutic challenges arise since the treatment one of these diseases may aggravate the other. We reported two cases of SLE with psoriasis vulgaris with clinical manifestations as recurrent erythroderma with photosensitivity. Improvement in clinical condition was observed after treating the patients with methylprednisolone combined with methotrexate. The coexistence SLE and psoriasis are considered very rare. The presence of this overlap syndrome may precede one another or occur simultaneously and is closely related with the presence of anti-Ro/SSA. Thus, it raises new challenge regarding its relationships, diagnosis, therapeutic, and management.

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Lupus eritematosus sistemik (LES) adalah penyakit autoimun kronik eksaserbatif dengan manifestasi klinis yang beragam. Psoriasis vulgaris adalah penyakit kulit yang menyerang 1-3% dari populasi. Patofisiologi mengenai tumpang tindihnya penyakit tersebut belum sepenuhnya tersendiri dalam tatalaksana kedua penyakit tersebut. Dua orang laki-laki dengan LES dan psoriasis vulgaris dilaporkan dengan manifestasi klinis eritroderma berulang dengan fotosensitif. Perbaikan klinis dicapai setelah terapi kombinasi metilprednisolon dengan metotrexat. Adanya LES yang tumpang tindih psoriasis vulgaris merupakan suatu fenomena klinis yang langka. Hubungan kedua penyakit tersebut dapat berupa saling mendahului atau tumpang tindih pada suatu waktu yang sama dan memiliki hubungan dengan adanya anti-Ro/SSA. Adanya tumpang tindih dari dua penyakit tersebut memberikan paradigma baru dalam patofisiologi, diagnosis, dan tatalaksana di masa mendatang."

"Kerusakan intrarenal pada pasien Systemic Lupus Erythematosus (SLE) dengan komplikasi Acute Kidney Injury (AKI) menyebabkan zat sisa metabolisme tidak dapat terbuang melalui urin serta terjadi kelebihan cairan. Terapi farmakologi seperti kortikosteroid dan imunosupresan turut memperparah overload cairan. Studi ini bertujuan untuk menganalisis intervensi manajemen cairan pada pasien SLE dengan komplikasi AKI terhadap masalah overload cairan. Manajemen cairan yang dilakukan pada pasien meliputi restriksi cairan; pemantauan asupan dan keluaran cairan; tekanan darah, edema dan asites, nilai laboratorium: ureum, kreatinin dan albumin; edukasi manajemen cairan serta kolaborasi pemberian diuretic dan albumin. Hasil intervensi menunjukkan balans cairan mencapai target (-) 1000 cc, asites berkurang dengan penurunan lingkar abdomen dari 105 menjadi 84 cm, adanya perbaikan fungsi ginjal dengan penurunan ureum kreatinin, pengetahuan pasien terkait pentingnya restriksi cairan meningkat dan pasien menunjukkan penerimaan terhadap perawatan. Hasil ini menunjukkan bahwa terapi kortikosteroid dan imunosupresan pada pasien SLE harus disertai dengan intervensi manajemen cairan. Oleh karena itu, penulis merekomendasikan intervensi manajemen cairan untuk dilakukan pada pasien SLE dengan komplikasi acute kidney injury.

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Intrarenal damage in patients with Systemic Lupus Erythematosus (SLE) with complicated Kidney Injury (AKI) causes metabolic waste substances to not be wasted through urine and excess fluid occurs. Pharmacological therapies such as corticosteroids and immunosuppressants also contribute to fluid overload. This study aims to analyze fluid management in SLE patients with complications of AKI to overcome fluid overload. Fluid management performed on patients includes fluid restriction; monitoring fluid intake and output; blood pressure, edema and ascites, laboratory values: urea, creatinine and albumin; fluid management education and collaboration in the administration of diuretics and albumin. The results of the intervention showed that the fluid balance reached the target (-) 1000 cc, ascites decreased with a decrease in the abdominal circumference of 105 to 84 cm, an improvement in kidney function with a decrease in creatinine ureum, the patient's knowledge regarding the importance of fluid restriction increased and the patient showed acceptance of treatment. These results indicate that corticosteroid therapy and immunosuppressants in SLE patients must be accompanied by fluid management interventions. Therefore, the authors recommend fluid management interventions to be performed in SLE patients with complications of acute kidney injury."

"Seorang wanita usia 22 tahun datang dengan keluhan utama timbul bercak kemerahan dan rasa gatal pada wajah sejak 5 hari sebelum masuk rumah sakit. Keluhan lainnya adalah timbul bengkak pada kedua tungkai, nyeri tenggorokan, dan batuk. Pasien sedang dalam pengobatan untuk lupus eritematosus sistemik dan tuberkulosis paru (sejak 12 hari yang lalu). Pada pemeriksaan fisik, pasien kompos mentis, hemodinamik stabil, dengan edema anasarka, lesi multipel makulo purpura yang tersebar pada tubuhnya, konjungtivis pada kedua mata, lesi multipel ulserasi di rongga mulut, dan tampak eritema pada mukosa genitalia. Hasil laboratorium menunjukkan anemia, lekopenia, hipoalbuminemia, proteinuria. Kami mencurigai pasien ini menderita sindrom Stevens Johnson akibat obat antituberkulosis. Selama perawatan, kami menghentikan pemberian obat antituberkulosis, dan memberikan metilprednisolon parenteral, serta terapi suportif lainnya. Pasien diizinkan untuk rawat jalan setelah terjadi perbaikan klinis dan dapat mobilisasi sendiri.

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AbstractA 22-year-old woman was admitted to the hospital because of 5-days history of redness and itch on her face. Additional complains were swelling on her feet, sore throat, and cough. Patient was on treatment for systemic lupus erythematosus and pulmonary tuberculosis (since 12 days). On physical examination, patient was alert, stable hemodynamic, anasarca edema, multiple purpuric macules lesion spread on her body, conjunctivitis of both eyes, multiple oral ulcers, erythema on genital mucosa. Laboratory results were anemia, leucopenia, hypoalbuminemia, proteinuria. We suspected this patient as Stevens Johnson syndrome due to tuberculostatic drugs. During treatment, we stopped the tuberculostatic drugs, and gave her parenteral methylprednisolone, with other supportive treatments. The patient was discharge after improvement of clinical condition and capable of self mobilization."

"Background: systemic lupus erythematosus (SLE) is still a challenging autoimmune disease, especially in pregnancy setting. An early risk factors awareness of poor pregnancy outcome is important to optimize the outcome of pregnancy in SLE patients. This study was conducted to describe pregnancy outcome and determine the risk factors associated with poor pregnancy outcome in SLE patients.Methods: a retrospective case-control study of SLE patients with poor and normal pregnancy outcome was performed. Pregnancy histories were reviewed from Dr. Hasan Sadikin General Hospital lupus registry study. The case group was pregnancy with poor outcome, defined as abortion, premature birth, stillbirth, intrauterine growth restriction (IUGR) and neonatal death. The control group was pregnancy with good outcome, defined as live birth and full term.Results: a total of 84 SLE patients were enrolled in this study with 109 pregnancies after SLE diagnosis. The median age of subjects at the time of pregnancy was 28 (25-32) years old. Poor pregnancy outcome comprising 22.9% abortion, 14.7% premature birth, 5.5% stillbirth, 1.8% IUGR and 4.6% neonatal death. There was a significant difference in the number of planned pregnancy (P=0.011) between groups with poor and good outcome. Clinical variables significantly associated with poor pregnancy outcome were lupus nephritis (OR = 4.813, 95% CI 1.709 - 13.557, P = 0.003) and neuropsychiatric SLE (OR = 5.045, 95% CI 1.278 - 19.920, P = 0.021).Conclusion: the pregnancy in SLE patient should be planned to have better outcome. Lupus nephritis and neuropsychiatric (NP) SLE were risk factors for poor pregnancy outcome in SLE patient.

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Latar belakang: lupus eritematosus sistemik (LES) merupakan penyakit autoimun kompleks yang membutuhkan penanganan khusus, terutama saat kehamilan. Kesadaran akan faktor-faktor yang menyebabkan luaran kehamilan yang buruk penting untuk optimalisasi luaran kehamilan pada pasien LES. Penelitian ini bertujuan memberikan gambaran mengenai luaran kehamilan dan faktor risiko yang berhubungan dengan buruknya luaran kehamilan pada pasien LES.

Metode: penelitian kasus-kontrol retrospektif dilakukan pada pasien LES dengan berbagai luaran kehamilan. Riwayat dan komplikasi kehamilan diketahui dari data registri lupus di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung. Kelompok kasus berupa kehamilan dengan luaran yang buruk; yaitu aborsi, kelahiran prematur, lahir mati, pertumbuhan janin terhambat (PJT), dan kematian neonatal. Kelompok kontrol berupa kehamilan dengan luaran yang baik yakni lahir hidup dan cukup bulan.

Hasil: Total 84 pasien LES terlibat di dalam penelitian ini dengan 109 data kehamilan setelah diagnosis LES. Median usia subjek pada saat kehamilan adalah 28 (25-32) tahun. Luaran kehamilan yang buruk terdiri dari 22,9% abortus, 14,7% kelahiran prematur, 5,5% lahir mati, 1,8% PJT, dan 4,6% kematian neonatal. Kelompok kasus dan kontrol memiliki perbedaan yang bermakna dalam hal jumlah kehamilan terencana (P=0,011). Luaran kehamilan yang buruk dalam penelitian ini berhubungan dengan lupus nefritis (OR = 4,813, 95% CI 1,709 – 13,557, P = 0,003) dan SLE neuropsikiatri (OR = 5,045, 95% CI 1,278 – 19,920, P = 0,021). Kesimpulan: perencanaan kehamilan diperlukan untuk mendapatkan luaran kehamilan yang lebih baik. Nefritis dan neuropsikiatri lupus merupakan faktor risiko bagi terjadinya luaran kehamilan yang buruk"