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"PT. Kimia Farma Apotek merupakan anak perusahaan dari PT. Kimia Farma (Tbk). PT. KFA saat ini bertransformasi menjadi healthcare provider company. Dengan keberadaan Apotek Kimia Farma yang tersebar luas di seluruh Indonesia, Apotek Kimia Farma menjadi salah satu tujuan utama masyarakat saat hendak berbelanja Vitamin salah satunya Vitamin D. Apotek Kimia Farma khususnya Apotek Kimia Farma 298 Bendungan Hilir menyediakan berbagai macam kebutuhan suplemen dan starter kit sebagai COVID-19 prevention. Analisis terkait dengan hubungan kasus COVID 19 harian di Jakarta terhadap penjualan Vitamin D di Apotek Kimia Farma 298 Bendungan Hilir penting dilakukan untuk dapat membantu menentukan strategi penjualan Vitamin D di apotek. Tujuan dari penelitian ini yaitu mengetahui hubungan kasus COVID 19 harian di Jakarta terhadap penjualan Vitamin D di Apotek Kimia Farma 298 Bendungan Hilir. Penelitian ini dilakukan untuk menemukan korelasi atau hubungan penjualan Vitamin D dengan peningkatan kasus COVID-19 harian di Jakarta dengan menggunakan analisis korelasi atau uji korelasi. Teknik korelasi yang digunakan dalam penelitian ini adalah Korelasi Pearson Product Moment. Analisis data dalam penelitian ini menggunakan IBM SPSS Statistics 21. Kasus COVID 19 harian di Jakarta dan penjualan Vitamin D di Apotek Kimia Farma 298 Bendungan Hilir menunjukkan adanya korelasi sedang dari kedua variabel. Apabila kasus harian COVID-19 di Jakarta meningkat maka berhubungan dengan peningkatan penjualan Vitamin D di Apotek Kimia Farma 298 Bendungan Hilir dan berlaku sebaliknya karena kedua variable saling mempengaruhi.

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PT. Kimia Farma Apotek is a subsidiary of PT. Kimia Farma (Tbk). PT. KFA is currently transforming into a healthcare provider company. With the existence of Kimia Farma Pharmacies that are widely spread throughout Indonesia, Kimia Farma Pharmacy is one of the main destinations for people when they want to shop for Vitamins, one of which is Vitamin D. Kimia Farma Pharmacy, especially Kimia Farma Pharmacy 298 Bendungan Hilir provides various kinds of supplements and starter kit needs as COVID -19 precautions. Analysis related to the relationship of daily COVID 19 cases in Jakarta to sales of Vitamin D at Kimia Farma 298 Bendungan Hilir Pharmacy is important to be able to help determine the sales strategy of Vitamin D at pharmacies. The purpose of this study is to determine the relationship between daily COVID-19 cases in Jakarta and Vitamin D sales at Kimia Farma 298 Bendungan Hilir Pharmacy. This research was conducted to find a correlation or relationship between Vitamin D sales and an increase in daily COVID-19 cases in Jakarta by using a correlation analysis or correlation test. The correlation technique used in this study is the Pearson Product Moment Correlation. Data analysis in this study used IBM SPSS Statistics 21. Daily COVID-19 cases in Jakarta and sales of Vitamin D at Kimia Farma 298 Bendungan Hilir Pharmacy showed a moderate correlation of the two variables. If the daily cases of COVID- 19 in Jakarta increase, it is related to an increase in Vitamin D sales at the Kimia Farma 298 Bendungan Hilir Pharmacy and vice versa because the two variables influence each other."

"Latar Belakang: Penggunaan heparin inhalasi pada beberapa penelitian COVID-19memberikan hasil dalam perbaikan klinis pasien, baik dalam menurunkan lama rawat,perbaikan oksigenasi paru, dan mortalitas. Dosis harian total heparin inhalasi yangbervariasi terutama bila diberikan bersamaan dengan antikoagulan sistemik, memilikiresiko komplikasi perdarahan yang memerlukan kajian terhadap keefektifan dankeamanannya.Tujuan: Meneliti keefektifan dan keamanan inhalasi heparin dosis 150,000 IU/haridengan dosis 100.000 IU/hari dinilai dari AaDO2, aPTT dan d-Dimer dalam 7 haripengamatan pada pasien ICU COVID-19.Metode: Penelitian ini merupakan penelitian observasional dengan studi kohortretrospektif menggunakan data sekunder rekam medis pasien ICU COVID-19 bulanSeptember 2020 – September 2021. Terdapat 300 sampel menggunakan consecutivesampling. Pasien dikelompokkan menjadi kelompok heparin dosis 150.000 IU/hari dan100.000 IU/hari. Pencatatan dilakukan dalam 7 hari pengamatan. Uji Statistikmenggunakan uji Mann Whitney untuk menilai tingkat keparahan, Uji Wilcoxon rank testuntuk melihat perbedaan variabel dependen hari pertama dengan hari ketujuh padamasing-masing dosis.Hasil: Heparin inhalasi baik dosis 150.000 IU/hari dan 100.000 IU /hari bermaknamenurunkan AaDO2 pada 7 hari pengamatan (p 0.001). Nilai aPTT tidak memanjangpada kedua kelompok, dan kedua dosis heparin sama- sama menurunkan nilai d-Dimerpada 7 hari pengamatan (p 0.001).Simpulan: Heparin Inhalasi dosis 150.000 IU/hari sama efektif dinilai dari AaDO2, dansama amannya terhadap aPTT dan d-Dimer dibandingkan heparin inhalasi dosis 100.000IU/hari.

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Rationale: The use of inhaled heparin in several COVID-19 studies has resulted in

clinical improvements in patients, both in reducing length of treatment, improving

pulmonary oxygenation, and reducing mortality. The varying total daily dose of inhaled

heparin, especially when given together with systemic anticoagulants, poses a risk of

bleeding complications that require review of its effectiveness and safety.

Objective: To analyze effectiveness and safety of heparin inhalation dosage 150,000

IU/day compare to 100,000 IU/day assessed from AaDO2, aPTT and d-Dimer from 7

days observation in ICU COVID-19 patients with invasive and non-invasive ventilator

patterns.

Methods: An observational cohort retrospective study used secondary data from medical

records ICU COVID-19 patients with invasive and noninvasive ventilator patterns from

September 2020 – September 2021. There were 300 samples using consecutive sampling.

Patients divided into 2 groups, one received dosage 150,000 IU / day heparin inhalation,

the other received heparin inhalation dosage 100,000 IU / day. Recording of the research

from medical records is carried out at 7 days of ICU treatment. Statistical tests were

carried out using Mann Whitney to assess severity, Wilcoxon rank test to see the

difference in dependent variables day 1 and day 7 to dose.

Measurements and Main Results: Heparin inhalation at dose of 150,000 IU/day and

100,000 IU/day both significantly decreased AaDO2 at 7 days of observation (p 0.001).

The aPTT on both groups at 7 days of observation are within normal limits. Both doses

of heparin inhalation decreased d-dimer at 7 days of observation (p 0.001).

Conclusion: Inhaled heparin doses of 150,000 IU/day as effective and as safe as inhaled

heparin doses of 100,000 IU/day."

"Peningkatan angka kasus COVID-19 yang tidak terkendali mengakibatkan fasilitas kesehatan di Indonesia kurang mampu untuk menampung seluruh pasien yang terinfeksi COVID-19. Sementara itu, pasien COVID-19 harus mendapatkan pengobatan dan perawatan. Salah satu upaya untuk yang dilakukan adalah isolasi mandiri bagi pasien tanpa gejala dan bergejala ringan. Penelitian ini dilakukan dengan tujuan mengeksplorasi akses pasien COVID-19 untuk memperoleh obat saat isolasi mandiri di rumah serta kendala yang dialami saat isolasi. Instrumen penelitian menggunakan kuesioner yang dikembangkan oleh peneliti berdasarkan studi literatur dan telah divalidasi dua tahap. Kuesioner disebarkan secara online dan mendapatkan 115 responden sebagai subjek penelitian. Butir pertanyaan kuesioner memuat tentang data sosiodemografi, gambaran keadaan subjek saat melakukan isolasi mandiri, dan aspek – aspek akses obat (aksesibilitas, ketersediaan, keterjangkauan). Sebagian besar responden melakukan isolasi mandiri pada periode Januari – Maret (53,2%). Persebaran responden paling banyak melakukan isolasi mandiri di Jakarta (45,22%). Ditinjau dari persentase tertinggi setiap aspek, 71,3% mengatakan sangat mudah dalam aspek aksesibilitas, 48,7% mengatakan ketersediaan obat cukup baik, dan 41,7% mengatakan harga obat cukup terjangkau. Adapun kendala yang terjadi selama isolasi mandiri, seperti kemacetan lalu lintas sehingga membutuhkan waktu lebih untuk ke fasilitas kesehatan, informasi obat tidak valid, serta harga antivirus mahal dengan ketersediaan yang minim. Uji komparatif dilakukan untuk mengetahui faktor yang mempengaruhi akses obat dan terdapat perbedaan bermakna pada variabel periode COVID-19 (p=0,003). Dari hasil analisis skor akses obat, disimpulkan bahwa akses obat saat isolasi mandiri mudah (89,6%) bagi pasien COVID-19 di Jabodetabek.

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The number of COVID-19 cases that increased uncontrollably cause the health facilities in Indonesia being unable to accommodate all patients infected with COVID-19. Meanwhile, patients must receive treatment and care. One of the efforts to do is self- isolation for asymptomatic patients and mild symptoms. This study was conducted with the aim of exploring the accessibility of COVID-19 patients to obtain medication during self-isolation at home and the obstacles experienced during isolation. The research instrument used a questionnaire developed by the researcher based on a literature study and was validated in two stages. The questionnaire was distributed online and got 115 respondents as research subjects. Questionnaire items contain sociodemographic data, a description of the subject's condition when doing self-isolation, and aspects of drug access (accessibility, availability, affordability). Most of the respondents self-isolated in the January – March period (53.2%). The distribution of respondents who mostly self- isolated in Jakarta (45.22%). Judging from the highest percentage of each aspect, 71.3% said it was very easy in terms of accessibility, 48.7% said the drug availability was quite good, and 41.7% said the price of the medicine was quite affordable. The Obstacles that occur during self-isolation, such as traffic jams that require more time to go to health facilities, invalid drug information, and expensive antivirus prices with minimal availability. A comparative test was conducted to determine the factors that influence drug access and there was a significant difference in the COVID-19 period variable (p=0.003). From the results of the analysis of drug access scores, it was concluded that access to drugs during self-isolation is easy (89.6%) for COVID-19 patients in Jabodetabek."

"Pandemi Covid-19 menjadi tantangan bagi RS UI dalam mengedepankan pelayanan kepada pasien yang bersifat holistik, demi kepentingan dan keselamatan pasien. Case manager merupakan jabatan baru di RS UI, sehingga dianggap masih memiliki banyak celah dalam penerapannya. Peran case manager dirasakan belum optimal di lapangan, terutama oleh klinisi dan manajemen. Tujuan penelitian adalah untuk merumuskan tugas pokok fungsi case manager dalam pelayanan pasien Covid-19, dan mengidentifikasi peran yang telah dilaksanakan oleh case manager. Penelitian ini merupakan penelitian non eksperimental kualitatif, menggunakan pendekatan fenomenologi dengan desain potong lintang. Peneliti menemukan bahwa case manager RS UI belum menjalankan peran sesuai rumusan tugas pokok fungsi case manager yang ada dalam standar akreditasi RS; rumusan tugas pokok fungsi case manager belum sesuai dengan kebutuhan pelayanan pasien Covid-19 di RS UI, sehingga case manager RS UI belum menjalankan peran sesuai rumusan tugas pokok fungsi case manager untuk kebutuhan pelayanan pasien Covid-19 di RS UI. Secara garis besar, terdapat tiga hambatan peran case manager, yaitu hambatan pengorganisasian, hambatan aktivitas, dan hambatan evaluasi. Peneliti merekomendasikan agar tupoksi case manager tetap memenuhi standar akreditasi, dan disesuaikan dengan karakteristik RS. Selain itu, perlu dilakukan penguatan case manager secara kualitas dan kuantitas, agar dapat berperan lebih optimal.

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The Covid-19 pandemic is a challenge for UI Hospital in prioritizing its services to patients that are holistic in nature, for the benefit and safety of patients. Case manager is a new position at UI Hospital, so it is considered that there are still many gaps in its implementation. The role of the case manager is felt to be not optimal in the field, especially by clinicians and management. The purpose of the study was to formulate the main duties and functions of the case manager in the service of Covid-19 patients, as well as to identify the roles that have been carried out by the case manager. This research was a non-experimental qualitative using a phenomenological approach with a cross-sectional design. The researcher found that the case manager of the UI Hospital had not carried out the role according to the formulation of the main duties and functions of the case manager in the hospital accreditation standard; The formulation of the main duties and functions of the case manager was not in accordance with the service needs of Covid-19 patients at the UI Hospital. Therefore, the case manager was considered not to have carried out the roles accordingly for the service needs of Covid-19 patients at the UI Hospital. Thus, in general terms, there are three barriers to the role of the case manager, namely organizational barriers, activity barriers, and evaluation barriers. The researcher recommends that the main duties of the case manager still meet accreditation standards, and are adjusted to the characteristics of the hospital. In addition, it is necessary to strengthen case managers in terms of quality and quantity, so that they can play a more optimal role."

"Latar Belakang. Pandemi COVID-19 yang terjadi sejak akhir tahun 2019 telah menginfeksi puluhan juta orang di di dunia, termasuk di Indonesia. Tes pemeriksaan PCR sebagai tes standar untuk diagnosis merupakan salah satu upaya pencegahan sekunder penting untuk mencegah penyebaran penyakit, mengetahui besar masalah dan pengambilan keputusan segera untuk upaya pencegahan selanjutnya. Adanya jeda waku yang panjang untuk menunda pemeriksaan diagnosis PCR ini berpotensi menimbulkan penyebaran virus yang lebih luas dan kemungkinan kesalahan diagnosis. Tujuan. Mengetahui gambaran jeda waktu diagnosis pasien COVID-19 dan faktor-faktor pasien yang berpengaruh. Metode Penelitian. Penelitian dilakukan dengan Sumber data Rekam Medis pasien rawat inap COVID-19 tahun 2020 di Rumah Sakit Universitas Indonesia dengan pendekatan cross sectional. Total sampling dilakukan dengan menerapkan kriteria inklusi dan eksklusi. Hasil. Dari 254 subjek penelitian, laki-laki lebih banyak (55.1%). Panjang jeda waktu diagnosis di luar fasilitas pelayanan kesehatan median 6 hari, di fasilitas pelayanan kesehatan 1 hari, dan total 7 hari. Jumlah pasien terlambat di luar fasilitas pelayanan ksesehatan lebih banyak dibandingn dengan terlambat di dalam fasilitas pelayanan kesehatan (80.7% vs. 5.7%). Dari uji chi-square, faktor yang berhubungan dengan keterlambatan diagnosis yaitu jenis kelamin (p=0.013), umur (p=<0.01), status perkawinan (p=0.021), pendidikan (p=0.024), riwayat kontak (p=0.031), dan gejala (p=0.003). Kesimpulan. Ada hubungan antara keterlambatan diagnosis COVID-19 dengan beberapa faktor demografi dan faktor penyakit pasien.

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Background. The COVID-19 pandemic that has occurred since the end of 2019 has infected tens of millions of people worldwide, including in Indonesia. PCR test as a standard test for diagnosis is one of the important secondary prevention efforts to prevent the spread of the disease, find out the magnitude of the problem and make immediate decisions for further prevention. This long delay in delaying PCR diagnosis may represent a wider spread of the virus and a possible misdiagnosis. Objective. To find out the description of the time lag in the diagnosis of COVID-19 patients and the factors that influence it Research methods. The study was conducted using Medical Record data sources for COVID-19 inpatients in 2020 at the Universitas Indonesia Hospital with a cross sectional approach. Total sampling was done by applying inclusion and exclusion criteria. Results. Of the 254 research subjects, more men (55.1%). The length of time delay for diagnosis outside health care facilities is a median of 6 days, at a health service facility 1 day, and a total of 7 days. The number of late patients outside health care facilities was higher than those late in health care facilities (80.7% vs. 5.7%). From the chi-square test, factors associated with late diagnosis were gender (p=0.013), age (p=<0.01), marital status (p=0.021), education (p=0.024), contact history (p=0.031), and symptoms (p=0.003). Conclusion. There is a relationship between the delay in the diagnosis of COVID-19 with several demographic factors and patient disease factors."

"Latar belakang: Coronavirus Disease 2019 (COVID-19) adalah penyakit baru. Infeksi saluran napas akibat virus yang disertai infeksi bakteri akan meningkatkan derajat keparahan dan angka mortalitas. Insidens ventilator associated pneumonia (VAP) pada kelompok COVID-19 yaitu 21-64%. Kasus VAP dapat menjadi penyebab tingginya mortalitas pada pasien COVID-19 terintubasi.Metode penelitian : Penelitian ini adalah penelitian retrospektif di RS Persahabatan. Seluruh sampel yang digunakan adalah kelompok pasien COVID- 19 terintubasi >48 jam dalam periode tahun 2020-2022 yang memenuhi kriteria inklusi dan eksklusi.Hasil penelitian : Penelitian ini meliputi 196 data penelitian yang memenuhi kriteria inklusi. Proporsi laki-laki lebih banyak dibandingkan perempuan dan hanya 29% adalah populasi usia lanjut. Proporsi VAP pada COVID-19 terintubasi pada tahun 2020-2022 mencapai 60% dengan VAP rates 92,56. Terdapat dua faktor bermakna terhadap VAP pada pasien COVID-19 terintubasi yaitu penggunaan azitromisin (OR 2,92; IK95% 1,29-6,65; nilai-p 0,01) dan komorbid penyakit jantung. (OR 0.38; IK95% 0,17-0,87; nilai-p 0,023). Proporsi terbesar biakan mikroorganisme aspirat endotrakeal adalah Acinetobacter baumannii (44%), Klebsiella pneumoniae (23%), Escherichia coli (9%).Kesimpulan : Proporsi VAP pada COVID-19 terintubasi adalah 60%. Terdapat hubungan bermakna pada penggunaan azitromisin dan komorbid penyakit jantung sedangkan usia lanjut dan penggunaan steroid tidak memiliki hubungan bermakna terhadap VAP pada pasien COVID-19 terintubasi.

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Background : Coronavirus Disease 2019 (COVID-19) is a novel disease. Viral respiratory infection following bacterial infection could increase the severity and mortality of the disease. The incidence of Ventilator (VAP) in COVID-19 group is 21-64%. VAP might be the leading cause of high mortality in intubated COVID-19 patient.

Methods : This research is a retrospective study at Persahabatan hospital. The collected samples is a group of COVID-19 patient intubated for >48 hours in the period of 2020 to 2022 that meet the inclusion and exclusion criteria.

Results : This study consist of 196 data fulfilling the inclusion criteria. Male proportion much greater than female and only 29% is an elderly population. The proportion of VAP in the period of 2020-2022 is 60% with the VAP rates 92,56. There are two factors significantly affected VAP in intubated COVID-19 patient which are the usage of azitromisin (OR 2,92; CI95% 1,29-6,65; p-value 0,01) and cardiovascular disease comorbidity(OR 0.38; CI95% 0,17-0,87; p-value 0,023). The most abundance proportion of endotracheal aspirate microorganism culture are Acinetobacter baumannii (44%), Klebsiella pneumoniae (23%), and Eschrichia coli (9%).

Conclusion : The proportion of VAP in intubated COVID-19 is 60%. There are significant association of azitromicin usage and cardiovascular comorbidity while elderly and the usage of steroid are not significantly associated to VAP in intubated COVID-19 patient."

"Latar Belakang: Pandemi COVID-19 telah menjadi tantangan besar bagi dunia kesehatan. Tenaga kesehatan merupakan populasi yang sangat rentan tertular dikarenakan tingginya intensitas dan frekuensi pajanan SARS-CoV-2. Risiko penularan meningkat apabila tenaga medis melakukan tindakan yang memicu aerosilisasi, salah satunya adalah intubasi endotrakeal karena tingginya viral load pada saluran napas. Sebanyak 3,2% pasien COVID-19 memerlukan tindakan intubasi endotrakeal dan ventilasi mekanis. Intubasi endotrakeal yang efektif pada pasien COVID-19 penting dilakukan untuk menurunkan mortalitas dan risiko penularan. Penelitian ini bertujuan intuk mengetahui faktor-faktor yang memengaruhi efektivitas intubasi endotrakeal pada pasien terkonfirmasi COVID- 19 di RSUP Persahabatan.Metode: Penelitian ini merupakan penelitian observasional yang menggunakan desain potong lintang yang dilakukan di IGD, ICU Rasmin Rasjid dan ICU PINERE RSUP Persahabatan pada bulan Juni 2021 – Juni 2022. Subjek peneltian ini adalah pasien terkonfirmasi COVID-19 yang dilakukan tindakan intubasi endotrakeal yang memenuhi kriteria inklusi dan eksklusi. Tindakan intubasi endotrakeal dinilai dari observasi rekaman CCTV. Selanjutnya karakteristik subjek, karakteristik intubasi endotrakeal dan faktor-faktor yang memengaruhi intubasi endotrakeal dievaluasi.Hasil: Pada penelitian ini didapatkan 59 subjek penelitian. Proporsi intubasi endotrakeal efektif pada pasien COVID-19 sebesar 20,34%. Median lama waktu tindakan intubasi endotrakeal adalah 38 (19-189) detik. Sebanyak 32 (54,24%) tindakan intubasi endotrakeal dilakukan oleh spesialis anestesi dan 27 (45,76%) oleh PPDS Pulmonologi dan Kedokteran Respirasi. Hasil analisis bivariat didapatkan hasil bermakna secara statistik pada variabel penyakit kardiovaskular+DM (OR 0,24 (IK 95% 0,06-0,91), p=0,028) dan variabel operator (OR 0,07 (IK 95% 0,01-0,62), p=0,004). Hasil analisis multivariat menunjukkan hasil bermakna secara statistik hanya pada variabel operator (adjusted OR 0,06 (IK 95% 0,01-0,60), p=0,016).Kesimpulan: Terdapat hubungan penyakit kardiovaskular+DM dan operator terhadap intubasi endotrakeal efektif pada pasien COVID-19 di RSUP Persahabatan.

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Background: The COVID-19 pandemic has become a major challenge for the healthcare system. Healthcare workers are vulnerable population of COVID-19 transmission due to high intensity and frequency of exposure to SARS-CoV-2. The risk of transmission increases in aerosolization procedure such as endotracheal intubation because of the high viral load in the airways. Approximately 3.2% of COVID-19 patients require endotracheal intubation and mechanical ventilation. Effective endotracheal intubation in COVID-19 patients is important parameter to reduce mortality and the risk of transmission to healthcare workers. This study aims to determine the factors that influence the effectiveness of endotracheal intubation in patients with COVID-19 in National Respiratory Center, Persahabatan Hospital.

Methods: This study is an observational study using a cross-sectional design which was carried out in the emergency department, ICU Rasmin Rasjid and ICU PINERE of National Respiratory Center, Persahabatan Hospital in June 2021 – June 2022. The subjects of this study were COVID-19 patients who underwent endotracheal intubation who met the criteria inclusion and exclusion. The endotracheal intubation procedure was assessed from the observation of CCTV recordings. The characteristics of the subject, the characteristics of endotracheal intubation and the factors that influence endotracheal intubation were evaluated.

Results: In this study, there were 59 subjects. The proportion of effective endotracheal intubation in COVID-19 patients was 20.34%. The median length of time for endotracheal intubation was 38 (19-189) seconds. Among the subjects, 32 (54.24%) endotracheal intubation were performed by anesthesiologists and 27 (45.76%) were performed by Pulmonology and Respiratory Medicine residents. The results of the bivariate analysis showed statistically significant results on the cardiovascular disease + DM comorbid (OR 0.24 (95% CI 0.06-0.91), p=0.028) and operator (OR 0.07 (95% CI 0.01-0.62), p=0.04). The results of the multivariate analysis showed statistically significant results only for operator (adjusted OR 0.06 (95% CI 0.01-0.60), p=0.016).

Conclusion: There is relationship of cardiovascular disease + DM comorbid and operator with effective endotracheal intubation in COVID-19 patients at National Respiratory Center, Persahabatan Hospital."