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Gatra Satria
"Pada era pandemi COVID-19, perawatan intensif menjadi krusial bagi pasien dengan sindrom gangguan pernapasan akut (ARDS) yang memerlukan alat bantu napas. Setelah perawatan intensif, penting untuk mengevaluasi kualitas hidup penyintas COVID-19 untuk mengetahui dampak jangka panjang terhadap kesehatan fisik dan mental. Penelitian ini bertujuan untuk menilai kualitas hidup dan karakteristik yang memengaruhinya pada penyintas COVID-19 dengan riwayat ARDS pasca penggunaan alat bantu napas, baik invasif dan non-invasif, di ruang perawatan intensif. Penelitian ini menggunakan pendekatan cross-sectional dan dilaksanakan secara multicenter dengan total 56 responden yang memenuhi kriteria inklusi dari tiga rumah sakit rujukan COVID-19 nasional yang masuk dalam jejaring Academic Health System (AHS) Universitas Indonesia. Instrumen yang digunakan adalah The St. George Respiratory Questionnaire (SGRQ). Pada hasil penelitian ini, ditemukan Tingkat kualitas hidup yang rendah berkaitan dengan sistem pernapasan pada domain Tanda dan Gejala serta Aktivitas. Akan tetapi, domain Dampak mempunyai skor kualitas hidup yang baik. Total skor kualitas hidup pada kelompok invasif tergolong rendah yaitu 12 (0-64,9), dan non-invasif (NIV, HFNC dan NRM) yaitu 14 (0,7-57,8). Selain itu, terdapat hubungan kualitas hidup pada kelompok yang menggunakan alat bantu napas non-invasif terhadap usia, pekerjaan, rentang waktu survivor, dan APACHE II.

In the era of the COVID-19 pandemic, intensive care has become crucial for patients with Acute Respiratory Distress Syndrome (ARDS) who require breathing assistance. After intensive treatment, it is important to evaluate the quality of life of COVID-19 survivors to determine the long-term impact on physical and mental health. This study aims to assess the quality of life and the characteristics that influence it in COVID-19 survivors with ARDS after using ventilatory support, both invasive and non-invasive, in the Intensive Care Unit (ICU). This research used a cross-sectional approach and was carried out in a multicenter manner with a total of 56 respondents who met the inclusion criteria from three national COVID-19 referral hospitals within the University of Indonesia's Academic Health System (AHS) network. The instrument used was The St. George Respiratory Questionnaire (SGRQ). In the results of this study, it was found that a low quality of life was related to the respiratory system in the Signs and Symptoms and Activity domains. However, the Impact domain has a good quality of life score. The total quality of life score in the invasive group was low, namely 12 (0-64.9), and non-invasive (NIV, HFNC and NRM) namely 14 (0.7-57.8). Apart from that, there was a relationship between the quality of life in the group using non-invasive ventilatory support on age, occupation, period of survivors, and APACHE II score."
Fakultas Ilmu Keperawatan Universitas Indonesia, 2024
T-pdf
Unggah3  Universitas Indonesia Library
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Lovia Lova
"Pendahuluan: Dengan ditetapkannya Covid-19 sebagai kondisi kegawatdaruratan kesehatan dunia oleh WHO pada bulan Januari 2020, dan angka kematian yang terlihat lebih tinggi pada pasien dengan ARDS (Acute Respiratory Distress Syndrome), maka kebutuhan akan pelayanan unit intensif (ICU) sangat meningkat. Lonjakan pasien yang terjadi sangat cepat, mengharuskan rumah sakit beradaptasi dan segera mempersiapkan pelayanan khusus ICU Covid-19. Strategi manajemen keperawatan diperlukan untuk mengatasi kebutuhan tenaga keperawatan ICU yang ikut melonjak. Sementara jumlah tenaga keperawatan dengan kualifikasi ICU yang belum memadai kondisi pandemi Covid yang belum pernah dialami sebelumnya, menyebabkan tenaga keperawatan banyak yang menolak untuk melayani pasien Covid-19.
Tujuan : Mengetahui bagaimana kesiapan dan hal apa saja yang dilakukan oleh manajemen keperawatan ICU Covid-19 RS Hasanah Graha Afiah dalam menghadapi pandemi Covid-19 ini, sehingga pelayanan ICU Covid-19 dapat tetap berjalan dengan baik.
Metode : Penelitian ini menggunakan desain penelitian studi kasus dengan pendekatan dekriptif kualitatif, menganalisis hasil wawancara dengan informan terpilih.
Hasil : Dalam menghadapi pandemi Covid-19 ini, manajemen keperawatan ICU Covid-19 bekerjasama dengan seluruh unit terkait terutama dengan komite Pengendalian dan Pencegahan Infeksi, melakukan perencanaan dari pemetaan ketenagaan merekrut tenaga perawat secara internal maupun external dan pemberian insentif dari internal maupun external. Perencanaan, pengorganisasian, pengarahan dan pengendalian dari sistem manajemen keperawatan diatur berkesinambungan dengan tujuan untuk menyeimbangkan antara jumlah dan kualifikasi tenaga keperawatan Icu Covid-19 dengan beban kerja perawat dan tetap mengutamakan kesehatan dan keselamatan mereka.
Kesimpulan : Berdasarkan seluruh tindakan yang sudah dilakukan dan penilaian dari daftar tilik kesiapan RS HGA dalam menghadapi pandemi Covid-19 ini komponen Sumber Daya Manusia, Lonjakan Pasien, Komunikasi internal dan Pengendalian dan pencegahan Infeksi dapat dinyatakan bahwa manajemen keperawatan ICU Covid-19 RS HGA siap dalam menghadapi pandemi Covid-19.

Introduction : With the determination of Covid-19 as a world health emergency by WHO in January 2020, and the higher mortality rate in patients with ARDS (Acute Respiratory Distress Syndrome), the need for intensive unit (ICU) services has greatly increased. The surge in patients is happening very quickly, requiring hospitals to adapt and immediately prepare for the Covid-19 intensif care unit. A nursing management strategy is needed to address the increasing need for ICU nursing staff. Meanwhile, the number of nursing staff with ICU qualifications has not been adequate in the conditions of the Covid-19 pandemic, which has never been experienced before, causing many nursing staff to refuse to serve Covid-19 patients.
Aim : knowing how to prepare and what kind of things were done by the nursing management of the Covid-19 ICU at Hasanah Graha Afiah Hospital in the face of the Covid-19 pandemic, so that the Covid-19 ICU service could continue to run well.
Method : This study is a case study research design with a qualitative descriptive approach, analyzing the results of interviews with selected informants.
Results: In dealing with the Covid-19 pandemic, the Covid-19 ICU nursing management collaborated with all related units, especially with the Infection Control and Prevention committee, carried out planning from mapping the workforce to recruit nurses internally and externally and providing incentives from internal and external. Planning, organizing, directing and controlling the nursing management system is regulated continuously with the aim of balancing the number and qualifications of the COVID-19 ICU nursing staff with the workload of nurses and still prioritizing their health and safety.
Conclusion : Based on all the actions that have been taken and the assessment of the HGA Hospital readiness checklist in the face of the Covid-19 pandemic, the components of Human Resources, Patient Surges, Internal Communications and Infection Control and Prevention can be stated that the nursing management of the Covid-19 ICU HGA Hospital is ready to face Covid-19 pandemic.
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Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2022
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Angela Nathania
"Diketahui bahwa insidensi infeksi sekunder bakterial cukup tinggi pada pasien ICU COVID-19 yang diduga dapat memengaruhi kondisi kesehatan pasien. Penelitian ini meneliti hubungan antara infeksi sekunder bakterial terhadap lama rawat serta outcome mortalitas pasien ICU COVID-19. Penelitian dilakukan terhadap data rekam medis pasien ICU COVID-19 di RSCM menggunakan desain penelitian cohort retrospektif. Data yang dihimpun berupa data demografis (usia dan jenis kelamin), status infeksi sekunder bakterial, lama rawat, dan outcome mortalitas. Analisis hubungan infeksi sekunder bakterial dengan lama rawat dilakukan dengan analisis regresi linear, sedangkan hubungan infeksi sekunder bakterial dengan mortalitas dilakukan dengan analisis regresi logistik biner. Dari 173 pasien ICU COVID-19 yang memenuhi kriteria inklusi, hampir separuhnya (47,98%; n=83) mengalami infeksi sekunder bakterial. Median usia pasien secara keseluruhan adalah 20 (1–80) tahun, dengan 54,9% pasien berjenis kelamin laki-laki. Adanya infeksi sekunder bakterial dinilai memperpanjang lama rawat pasien selama 12,5 hari (R=0,911; B coefficient=12,486; p=0,000). Selain itu, infeksi sekunder bakterial juga meningkatkan risiko kematian sebesar 3,993 kali lipat (OR=3,993; CI=95%; p=0,020). Sehingga dapat disimpulkan bahwa terdapat hubungan yang signifikan antara infeksi sekunder bakterial dengan lama rawat dan outcome mortalitas pasien.

It is known that the incidence of secondary bacterial infections is quite high among COVID-19 patients in the ICU, which is suspected to affect the patients' health conditions. This study examines the relationship between secondary bacterial infections and the length of stay as well as the mortality outcome of COVID-19 ICU patients. The research was conducted on the medical records of COVID-19 ICU patients at RSCM using a retrospective cohort study design. Data collected included demographic information (age and gender), the status of secondary bacterial infections, length of stay, and mortality outcome. The relationship between secondary bacterial infections and the length of stay was analyzed through linear regression, while the association between secondary bacterial infections and mortality was examined using binary logistic regression. Out of 173 COVID-19 ICU patients who met the inclusion criteria, almost half (47.98%, n=83) experienced secondary bacterial infections. The overall median age of the patients was 20 years (range: 1–80 years), with 54.9% of patients being male. The presence of secondary bacterial infections was found to significantly extend the length of stay for patients by 12.5 days (R=0.911; B coefficient=12.486; p=0.000). Additionally, secondary bacterial infections increased the risk of mortality by 3.993 times (OR=3.993; CI=95%; p=0.020). Hence, it can be concluded that there is a significant relationship between secondary bacterial infections, the length of stay, and the mortality outcome of patients."
Jakarta: Fakultas Kedokteran Universitas ndonesia, 2023
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UI - Skripsi Membership  Universitas Indonesia Library
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Pierce, Lynelle N.B.
Philadelphia: W.B. Saunders , 1995
615.836 PIE g
Buku Teks SO  Universitas Indonesia Library
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Tri Octavianti
"ABSTRAK
Latar Belakang : O3 udara ambien berisiko menyebabkan penyakit pernapasan seperti asma, dan PPOK. 300 juta orang dari berbagai usia di dunia memiliki asma. Selanjutnya, 210 juta orang di dunia terkena PPOK (WHO, 2007). Di Indonesia, prevalensi asma sebesar 4,5% sedangkan prevalensi PPOK sebesar 3,7%. Di wilayah Jagakarsa, trend rata-rata tahunan konsentrasi O3 udara ambien pada tahun 2011 – 2013 menunjukan angka di atas baku mutu ambien rata-rata tahunan yang tercantum dalam PP Nomor 41 Tahun 1999. Pada tahun tersebut, jumlah kasus penyakit pernapasan di sana cenderung meningkat.
Tujuan : Penelitian ini bertujuan untuk mengetahui risiko gangguan pernapasan dan pajanan O3 udara ambien. Selain itu, peneliti juga melihat risiko dari faktor-faktor lainnya seperti iklim (suhu ambien dan kelembaban ambien), karakteristik pekerjaan (masa kerja dan lama kerja), serta karakteristik individu (tempat tinggal, jenis kelamin, umur, perilaku merokok, dan riwayat penyakit pernapasan).
Metode : Penelitian ini menggunakan desain studi cross-sectional. Sampel dalam penelitian sebanyak 76 PKL dengan teknik quota sampling sedangkan pengukuran O3 udara ambien dilakukan pada dua titik sampling.
Hasil : Rata-rata konsentrasi O3 udara ambien di wilayah Kecamatan Jagakarsa sebesar 217,7 µg/m3. Hasil tersebut melebihi baku mutu udara ambien DKI Jakarta dalam Keputusan Gubernur Provinsi DKI Jakarta Nomor 551 Tahun 2001 (200 µg/m3). Hasil bivariat menunjukan gangguan pernapasan dan O3 udara ambien memiliki p value = 0,05 dan OR = 2,9; gangguan pernapasan dan lama kerja memiliki p value = 0,89 dan OR = 1,2; gangguan pernapasan dan jenis kelamin memiliki p value = 0,78 dan OR = 1,3; gangguan pernapasan dan umur memiliki p value = 0,85 dan OR = 1,2; serta gangguan pernapasan dan riwayat penyakit pernapasan memiliki p value = 1,00 dan OR = 1,1.
Kesimpulan : Rata-rata hasil pengukuran konsentrasi O3 udara ambien di wilayah Kecamatan Jagakarsa sebesar 217,7 µg/m3. Konsentrasi tersebut melebihi baku mutu udara ambien DKI Jakarta. O3 udara ambien dapat menyebabkan gangguan pernapasan pada konsentrasi ≥ 150 µg/m3. Maka, konsentrasi O3 udara ambien di wilayah Kecamatan Jagakarsa berisiko menyebabkan gangguan pernapasan terhadap para PKL.

ABSTRACT
Background : Ground level O3 has potential risk to induce respiratory disorder such as asthma and COPD. 300 millions people all ages worldwide have asthma. Then, 210 millions people worldwide are also affected by COPD (WHO, 2007). In Indonesia, asthma prevalence is 4,5% and COPD prevalence is 3,7%. At Jagakarsa Sub District, trend of mean per year of ground level O3 concentration in 2011 – 2013 shows the value that overs the ambient threshold limit value in PP Nomor 41 Tahun 1999. At the same period, amount case of respiratory disorder at Jagakarsa also tends to increase.
Objective : Determining the risk for the respiratory disorder exposed by ground level O3 also other risk factors such as climate factor (ambient temperature and ambient humidity), occupational characteristic (work duration and work hour), and personal characteristic (house living, sex, age, smoking behaviour, and respiratory disease history).
Method : This study uses cross-sectional study among 76 street vendors as sample with quota sampling technique. Hence, ground level O3 is measured in two sampling points.
Result : Mean of ground level O3 concentration at Jagakarsa Sub District is 217,7 µg/m3. This value over the ambient TLV of DKI Jakarta based on Keputusan Gubernur Provinsi DKI Jakarta Nomor 551 Tahun 2001 (200 µg/m3). Result of bivariate analysis shows between respiratory disorder and ground level O3 have p value = 0,05 and OR = 2,9; respiratory disorder and work hours have p value = 0,89 and OR = 1,2; respiratory disorder and sex have p value = 0,78 and OR = 1,3; respiratory disorder and age have p value = 0,85 and OR = 1,2; respiratory disorder and respiratory disease history have p value = 1,00 and OR = 1,1.
Conclusion : Mean of ground level O3 concentration at Jagakarsa Sub District is 217,7 µg/m3 which already over the ambient TLV of DKI Jakarta. Concentration of ground level O3 which can be potential to induce respiratory disorder is ≥ 150 µg/m3. Therefore, concentration of ground level O3 at Jagakarsa Sub District risks to induce respiratory disorder to street vendors."
2014
S56058
UI - Skripsi Membership  Universitas Indonesia Library
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Syifatul Muizzati
"Pandemi COVID-19 memberikan dampak pada peningkatan kejadian Long COVID, terutama pada rentang usia produktif. Penelitian ini dilakukan sebagai respon tingginya riwayat peningkatan jumlah kasus COVID-19 di wilayah Jabodetabek dan sebagai upaya untuk menggambarkan risiko gejala Long COVID. Penelitian ini bertujuan untuk memberikan gambaran mengenai kualitas hidup penyintas COVID-19 terutama pada penyintas yang memiliki risiko gejala Long COVID pada usia produktif di wilayah Jabodetabek. Metode penelitian yang digunakan adalah cross-sectional. Sampel terdiri dari individu yang pernah terinfeksi COVID-19 pada tahun 2021-2022, usia 15-64 tahun, dan berdomisili di wilayah Jabodetabek. Jumlah sampel terkumpul sebanyak 430 berdasarkan teknik cluster sampling. Metode pengumpulan data menggunakan kuesioner yang terdiri dari karakteristik demografi dan klinis responden, serta instrument kualitas hidup Short Form Health Survey (SF-36) yang telah diuji validitas dan reliabilitasnya. Analisis data dilakukan dengan pendekatan statistik deskriptif kuantitatif. Hasil penelitian didapatkan bahwa Hasil penelitian didapatkan bahwa sebagian besar responden memiliki kualitas hidup baik (76,3%). Diikuti kualitas hidup sedang (17%), dan lemah (6,7%). Responden dengan risiko gejala Long COVID memiliki proposi kualitas hidup yang lebih rendah dibandingkan dengan responden tanpa risiko gejala Long COVID. Domain fungsi sosial adalah domain kualitas hidup baik terbanyak, sedangkan domain energi adalah domain dengan kategori baik terendah. Penemuan ini diharapkan dapat memberikan wawasan dan pemahaman untuk pengembangan intervensi dalam meningkatkan kualitas hidup penyintas COVID-19 dan mengurangi dampak jangka panjang yang dialami.

The COVID-19 pandemic has had an impact on the increased occurrence of Long COVID, especially among the productive age group. This research was conducted in response to the high history of increasing COVID-19 cases in the Jabodetabek area and as an effort to describe the risk of Long COVID. This research was also conducted an overview of the quality of life of COVID-19 survivors, especially those at risk of Long COVID symptoms in the productive age group in the Jabodetabek area. The method that is used is cross-sectional. The sample consists of individuals who had been infected by COVID-19 in 2021-2022, aged 15-64 years, and living in Jabodetabek area. The total collected samples was 430 based on cluster sampling technique. Data was collected through a questionnaire which included respondents' demographic and clinical characteristics, as well as the Short Form Health Survey (SF-36) quality of life instrument which has been tested for validity and reliability. A quantitative descriptive statistical approach is used to analyze the data. The research findings showed that the majority of respondents had good quality of life (76.3%), followed by moderate quality of life (17%), and weak quality of life (6.7%). Respondents at risk of Long COVID symptoms had a lower proportion of quality of life compared to those without the risk of Long COVID symptoms. The social function domain had the highest proportion of good quality of life, while the energy domain had the lowest proportion of good quality of life. These findings are expected to provide insight and understanding for the development of interventions to improve the quality of life of COVID-19 survivors and reduce the long-term impacts they experience."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2023
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UI - Skripsi Membership  Universitas Indonesia Library
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Rosdiana Lukitasari
"Pandemi COVID-19 yang berasal dari Kota Wuhan, Provinsi Hubei, China saat ini turut melanda Indonesia dengan angka kasus yang meningkat secara signifikan. COVID-19 diketahui menimbulkan komplikasi terhadap fungsi pernafasan. Salah satu di antara komplikasi yang disebabkan oleh COVID-19 adalah Acute Respiratory Distress Syndrome (ARDS). ARDS menimbulkan masalah keperawatan utama, yaitu gangguan pertukaran gas. Sehingga, pasien dengan masalah gangguan pertukaran gas membutuhkan intervensi keperawatan yang dapat membantu ventilasi-perfusi yang adekuat, salah satunya dengan penerapan pemberian posisi yang sesuai, seperti high-fowler. Tujuan penelitian adalah mengidentifikasi efektivitas penerapan pemberian posisi high-fowler pada pasien COVID-19 dengan ARDS. Pemberian posisi high-fowler dilakukan selama tiga hari dengan durasi 8 jam per hari pada pasien COVID-19 dengan ARDS di setting ruang high-care. Hasil menunjukkan perbaikan difusi alveolar paru yang adekuat berdasarkan indikator laju respirasi, saturasi oksigen, tidak adanya penggunaan otot bantu nafas dapat dipertahankan dalam batas normal. Penelitian ini diharapkan bermanfaat dalam memberikan intervensi keperawatan yang efektif untuk mengatasi gangguan pertukaran gas pada pasien COVID-19 dengan ARDS.

The COVID-19 pandemic, which was obtained from Wuhan City, Hubei Province, China, is currently experiencing a significant increase in Indonesia. COVID-19 is known caused complication for respiratory function. One of complications that caused by COVID-19 is Acute Respiratory Distress Syndrome (ARDS). ARDS poses a major nursing problem, namely impaired gas exchange. Thus, patient with impared gas exchange problem require nursing interventions that can help reach adequate ventilation-perfusion, one of which is by applying appropriate positioning, such as high-fowler. The aim of the study is to identify the effectiveness of applying high-fowler positioning in COVID-19 patient with ARDS. The implementation of high-fowler positioning was carried out for three days with a duration 8-hours per day in COVID-19 patient with ARDS in high-care unit setting. The results show an adequate improvement in pulmonary alveolars diffusion based on indicator, such as respiration rate, oxygen saturation, absence the use of breath-assisted muscles can be maintained within normal limits. This research is expected to be useful in providing effective nursing interventions to overcome impaired gas exchange in COVID-19 patient with ARDS.
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Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2020
PR-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Irene Yuniar
"Anak yang dirawat di ICU cenderung mengalami malnutrisi sejak masuk atau selama perawatan yang dapat memperberat penyakit dasar, memperpanjang lama rawat serta meningkatkan mortalitas. Baik underfeeding atapun overfeeding dapat terjadi di ICU Anak selama perawatan. Penelitian ini merupakan penelitian potong lintang, menggunakan data rekam medis. Selama 3 bulan penelitian. didapatkan 45 subjek penelitian. Dari 45 data pasien didapatkan 127 peresepan untuk menilai keseuaian peresepan dengan pemberian nutrisi pada pasien. Pemberian nutrisi pada pasien yang dirawat di ICU Anak merupakan hal yang sangat penting. Perlu perhitungan kebutuhan nutrisi yang cermat, pemberian nutrisi tepat yang sesuai kebutuhan pasien agar tidak terjadi malnutrisi yang lebih berat lagi.

Children admitted to the Pediatric Intensive Care Unit (PICU) are at risk for poor and potentially worsening nutritional status, a factor that further increases comorbidities and complications, prolongs the hospital stay, increases cost and increases mortality. Both underfeeding and overfeeding are prevalent in PICU and may result in large energy imbalance. This was cross sectional study design, with 3 month consecutive sampling in PICU which met 45 patients as the subject and 127 prescription of nutrition. Nutrition support therapies in PICU is very important .Adequate nutrition therapy is essential to improve nutrition outcomes in critically ill children."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014
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UI - Tesis Membership  Universitas Indonesia Library
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Marilaeta Cindryani Ra R.
"Latar Belakang: Coronavirus Disease 2019 (COVID-19) merupakan penyakit saluran pernafasan yang menjadi pandemi dasawarsa terakhir dan dapat menyebabkan disfungsi jantung. Galectin-3 diduga terkait dengan proses inflamasi yang berlanjut pada remodelling dan akhirnya fibrosis organ. Diharapkan penilaian terhadap Galectin-3 akan memperoleh gambaran perburukan jantung pasien COVID-19 sehingga diperoleh data faktor-faktor yang berpengaruh terhadap peningkatan Left Ventricular End Diastolic Volume (LVEDV) yang nantinya menjadi gagal jantung pada pasien COVID-19.
Metode: Rancangan penelitian ini adalah observasional prospektif analitik di ICU COVID-19 RSUP Sanglah. Penelitian dilakukan sejak bulan Juni sampai Oktober 2021. Semua subjek penelitian diperiksa kadar Galectin-3 menggunakan pemeriksaan Enzyme-Linked Immunosorbent Assay (ELISA). Subjek juga dilakukan evaluasi Left Ventricular End Diastolic Volume (LVEDV) dengan ekokardiografi, diidentifikasi menggunakan skor SOFA saat di ICU COVID-19, serta pemeriksaan terhadap kadar Troponin I. Subjek penelitian tetap akan mendapat terapi COVID-19 sesuai dengan protokol standar Kementerian Kesehatan RI. Setelah 72 jam pasca admisi ICU COVID-19, subjek penelitian akan dilakukan pemeriksaan ulangan terhadap kadar Galectin-3 dan LVEDV. Data yang didapatkan dianalisis dengan uji statistik menggunakanSTATATM.
Hasil: Didapatkan total 45 subjek penelitian. Dari hasil analisis bivariat terhadap selisih Galectin-3 dengan LVEDV didapatkan tidak signifikan (r=0,08), uji korelasi antara Galectin-3 dan LVEDV saat masuk ruang rawat ICU ternyata tidak signifikan (r=0,191), dan korelasi antara Galectin-3 dan LVEDV pasca rawat 72 jam juga tidak signifikan (r=0,197). Dari hasil multivariat variabel bebas yakni selisih Galectin-3, usia, jenis kelamin, troponin I, skor SOFA dan CHARLSON terhadap variabel LVEDV ternyata tidak ada satu pun variabel yang memiliki hasil yang bermakna secara statistik (p<0,05) terhadap LVEDV.
Simpulan: Tidak ada korelasi antara Galectin-3 dengan peningkatan LVEDV dalam penelitian ini

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Background: Coronavirus Disease 2019 (COVID-19) is a respiratory disease that has become the largest pandemic and also could put heart at risk of dysfunction. Galectin-3 is thought to be related to the inflammatory process that continues with remodeling and eventually fibrosis. By using Galectin-3 assesment, we could overview the possible worsening of the heart and evaluate data on influencing factors in increased Left Ventricular End Diastolic Volume (LVEDV) which could later become heart failure.
Methods: This is an observational prospective analytic study in the COVID-19 ICU of Sanglah Hospital. The study was started from June to October 2021. All research subjects will have their blood samples taken for Galectin-3 levels using Enzyme-Linked Immunosorbent Assay (ELISA). Subjects were also evaluated for Left Ventricular End Diastolic Volume (LVEDV) with echocardiography, identified using SOFA scores, and also examined their Troponin I levels. Subjects were treated with COVID-19 standard protocol from the Health Ministry. After 72 hours post-admission, subjects were re-examined for Galectin-3 levels and LVEDV. The data were analyzed by statistical tests using STATATM.
Results: A total of 45 research subjects were analysed. Bivariate analysis of the difference of Galectin-3 and LVEDV shown to be insignificant (r=0.08), no correlation was found between Galectin-3 level and LVEDV while admitted to the ICU (r=0.191), and no correlation found between Galectin-3 level and LVEDV after 72 hours of hospitalization (r=0.197). Multivariate analysis also showed that none of variables namely difference of Galectin-3 level, age, gender, troponin I, SOFA and CHARLSON had statistically significant results (p<0.05) on LVEDV.
Conclusions: No correlation was found between Galectin-3 level and an increase in LVEDV.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Andri Susanto
"Tesis ini bertujuan untuk mengetahui korelasi antara derajat sesak napas dan kualitas hidup terkait kesehatan pada lanjut usia pasca COVID-19. Penelitian ini merupakan studi potong lintang pada pasien lanjut usia pasca perawatan COVID-19 di RSUP Persahabatan. Pengambilan data dilakukan menggunakan aplikasi audio-video Whatsapp dan Zoom. Penilaian sesak napas dilakukan dengan skala sesak Borg (modified Borg dyspnea scale) dan skala sesak modified Medical Research Council (mMRC). Penilaian kualitas hidup terkait kesehatan dilakukan dengan instrumen EQ-5D-5L versi bahasa Indonesia. Pada penelitian ini didapatkan 44 subjek lanjut usia pasca COVID-19. Dari hasil penilaian skala sesak Borg didapatkan adanya sesak napas ringan pada 15,9% pasien dan sesak napas sedikit berat pada 6,8% subjek. Dari hasil penilaian skala sesak mMRC didapatkan nilai mMRC > 1 pada 20,4% subjek. Terdapat korelasi antara skala sesak Borg dengan EQ-5D-5L pada komponen kemampuan berjalan (r=0,42; p<0,01), perawatan diri (r=0,51; p<0,01), rasa cemas/depresi (r=0,52; p<0,01), dan EQ-VAS (p=-0,53; p<0,01). Terdapat korelasi antara skala sesak mMRC dengan EQ-5D-5L pada komponen kemampuan berjalan (r=0,65; p<0,01), perawatan diri (r=0,62; p<0,01), kegiatan yang biasa dilakukan (r=0,69; p<0,01), dan EQ VAS (r=-0,58; p<0,01). Kesimpulan penelitian ini adalah adanya hubungan korelasi positif sedang antara derajat sesak napas dengan komponen perawatan diri dan rasa cemas/depresi. Didapatkan adanya korelasi negatif sedang antara derajat sesak napas dengan nilai EQ VAS.

This study aims to determine the correlation between the severity of shortness of breath and health-related quality of life in the elderly after COVID-19. This is a cross-sectional study on elderly patients after COVID-19 inpatient treatment at Persahabatan Hospital, Jakarta. Data collection was carried out using the Whatsapp and Zoom audio-video application. Dyspnea severity was assessed using the modified Borg dyspnea scale and the modified Medical Research Council (mMRC) dyspnea scale. Health-related quality of life assessment was carried out with the Indonesian version of the EQ-5D-5L instrument. A total of 44 elderly subjects post COVID-19 were included in this study. From the results of the modified Borg dyspnea scale assessment, it was found that there was mild dyspnea in 15.9% of subjects and somewhat severe dyspnea in 6.8% of subjects. From the results of the mMRC dyspnea scale assessment, the mMRC value more than 1 is found in 20.4% of the subjects. There was a correlation between the modified Borg dyspnea scale and EQ-5D-5L on the components of mobility (r=0.42; p<0.01), self-care (r=0.51; p<0.01), anxiety/depression (r=0.52; p<0.01), and EQ-VAS (p=-0.53; p<0.01). There is a correlation between the mMRC shortness scale and EQ-5D-5L on the components of mobility (r=0.65; p<0.01), self-care (r=0.62; p<0.01), usual activities (r=0.69; p<0.01), and EQ VAS (r=-0.58; p<0.01). There is a moderate positive correlation between the severity of dyspnea with components of self-care and anxiety/depression. There was a moderate negative correlation between the degree of dyspnea and the EQ VAS value."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
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UI - Tugas Akhir  Universitas Indonesia Library
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