Ditemukan 13 dokumen yang sesuai dengan query
Arry Yanuar, author
ABSTRACT
Histone Deacetylase (HDAC) enzymes in the human body play an important role in the transcriptional regulation of gene expression. In the last decade, HDAC inhibitors and activators have been explored and have become known as therapeutic agents for many diseases such as osteodystrophy, neurogenerative disorders, cardiomyopathy, cancer, and diabetes. In...
2016
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Artikel Jurnal Universitas Indonesia Library
Arry Yanuar, author
2014
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Artikel Jurnal Universitas Indonesia Library
Arry Yanuar, author
2009
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
ABSTRACT
Cytochrome P450 isoform 2C9 (CYP2C9) is a main enzyme which metabolizes phenytoin [I]. The inhibition of this enzyme will increase plasma level of phenytoin. Cimetidine is known as drug that inhibits this enzyme, resulting an increased plasma level of phenytoin [2]. Recently, the three dimentional molecular basis of interaction between...
2009
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
ABSTRACT
Plasmepsin is a prime enzyme in malarial parasite life cycle. Plasmepsins are worked in the hemoglobin degradation inside the food vacuole during the erythrocytic phase. The structures of this enzyme are available through crystallography and show that these structures have an active site which allows many of probabilities of ligand...
2010
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
ABSTRACT
Malaria is one of problematic infectious diseases worldwide. The absence of an effective vaccine and the spread of drug resistant strains of Plasmodium clearly indicate the necessity for the deveploment of new chemotherapeutic agents. Recent method being developed is searching a new drug of antimalarial using in silica screening, or...
2011
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
Rem GTPase is a member ofRGK subfamily (Rad, Rem, Rem2, Gem and Kir) found recently. Rem is highly expressed at cardiac muscle.[l] Crystal structure of Rem (2NZJ) unveiled disordered structures of switch I (residue 102-110) and switch II (residue 135-145). These both regions have been acknowledged to be involved in...
2010
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
Sik.looksigenase merupakan enzim yang mengkonversi asam arakidonat menjadi prostaglandin Prostaglandin yang dihasilkan berperan penting dalam menimbulkan respons inflamasi. Oleh karena itu obat-obat antiinflamasi baru umumnya dikembangk.an berdasarkan aktivitas inhibisi i.iklooksigenase.
Ku1kumin, senyawa aktif dari Curcuma longa, dan analog alamiahnya memiliki aktivitas inhibii iklooksigenase yang teramati secara in vitro dan m vivo...
2009
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
ABSTRACT
Human Immunodeficiency Virus type 1 (HIV-1) is a retroviral virus that causes deadly disease, AIDS (Acquired Immunodeficiency Syndrome). The virus that mutates so fast, causes no drugs available to cure this disease totally yet. One of enzyme targets that can be inhibited to block the replication of this virus is...
2010
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
Arry Yanuar, author
Cytochrome P450 3A4 (CYP3A4) contributes to the metabolism of 50% of drugs used in therapy [l]. Nowadays, the structures of CYP3A4 are available through crystallography technique and these structures show that CYP3A4 has a flexible active site which allows many probabilities of ligand interaction [2]. Nelfinavir, one of the HIV-Protease...
Depok: Fakultas Farmasi Universitas Indonesia, 2009
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UI - Makalah dan Kertas Kerja Universitas Indonesia Library
