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"ABSTRACTThe effects of dietary food fortified with orotic acid (1.0%)on liver function were studied in rats. The rats fed with orotic acid promoted liver triglyceride content markedly, that was 5-fold higher than that of the control. The liver malondialdehyde (MDA) content increased by 10%, but the gluthation peroxidase (GSH-Px) activity decreased by 50%. The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities increased by 25% and 30%,respectively. Therefore, the decreased GSH-Px activity was associated with the promotions of AST, ALT, and the liver MDA levels. In conclusion: dietary orotic acid promotes lipid peroxidation but reduces the rate of the antioxidant enzyme. Therefore, dietary food fortified with orotic acid attenuates the liver function. "

"The effects of dietary food fortified with vitamin B4 on lipid profiles in serum and liver tissue were studied. Rats were paired-fed a 0.25% vitamin B4 diet or a diet without vitamin B4 for 10 days. Serum lipid levels were measured using enzyme assay kits. Lipids of liver tissues were extracted and the lipid contents were determined. A piece of liver was prepared to determine the activities of fatty acid synthase (FAS) and fatty acid β-oxidation. The results showed that animals fed a food fortified with vitamin B4 had higher level of serum TG, PL, total cholesterol, and high density lipoprotein. Their increases were approximately by 74%, 20%, 27%, and 27%, respectively. The significant changes in liver lipid were only found in PL component. This treatment promoted FAS activity, but impaired the fatty acid β-oxidation. In conclusion: Dietary food fortified with vitamin B4 induces hypertriglyceridemia and liver PL level."