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"Latar Belakang: Apendisitis masih merupakan salah satu masalah kesehatan di Indonesia dengan insidensi yang cukup tinggi. Salah satu parameter yang dapat dinilai dari apendisitis adalah reaktivitas dari folikel limfoid. Penelitian ini bertujuan mencari hubungan antara reaktivitas folikel limfoid dengan tipe radang apendiks pada pasien yang didiagnosis apendisitis secara histopatologis di RSUPNCM antara tahun 2005 hingga 2007. Metode: Penelitian dilakukan pada 50 sediaan apendisitis akut dan 50 sediaan apendisitis kronik yang dipilih secara acak. Penelitian dilakukan dengan metode analitik desain potong lintang yaitu dengan memperoleh data sekunder dari departemen Patologi Anatomi FKUI-RSUPNCM, mengamati sediaan dengan mikroskop, serta menganalisis data yang diperoleh dengan uji statistik.Hasil: Pada apendisitis akut, ditemukan hiperplasia folikel limfoid sebanyak 32%, sedangkan pada apendisitis kronik ditemukan hiperplasia folikel limfoid sebanyak 42%.Kesimpulan: Berdasarkan uji non-parametrik Chi square, didapatkan kesimpulan bahwa tidak terdapat perbedaan proporsi yang bermakna antara hiperplasia folikel limfoid pada apendisitis akut maupun kronik pada pasien yang didiagnosis apendisitis secara histopatologis di RSUPNCM tahun 2005 hingga 2007.

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Background: Appendicitis is still causing health problem in Indonesia with high incidency. One of the parameter that can be studied in appendicitis is lymphoid follicle hyperplasia. Objective of this study is to know whether there is relationship between lymphoid follicle reactivity and type of inflammation in patients who are diagnosed histopathologically suffering appendicitis in Cipto Mangunkusumo National General Hospital in 2005-2007.

Method: This study evaluated 50 speciments of acuteappendicitis and 50 speciments of chronic appendicitis selected by random sampling. This study is a cross sectional analitic study done by analizing secondary data and observing preparates of appendix.

Result: In this study, 32% of acute appendicitis have lymphoid follicle hyperplasia, and 42% of chronic appendicitis have lymphoid follicle hyperplasia.

Conclusion: Based on Chi square non-parametric test, it is concluded that there are no significant difference of lymphoid follicle hyperplasia between acute and chronic appendicitis in patients who are diagnosed histopathologically suffering appendicitis in Cipto Mangunkusumo National General Hospital in 2005-2007."

"Latar Belakang: Pemeriksaan histopatologi pada apendisitis akut dianggap sebagaipemeriksaan baku emas, walaupun tidak selalu dapat membuktikan adanyaperadangan akut. Hal tersebut menimbulkan dugaan adanya patogenesis lain yangbelum diketahui. Beberapa penelitian menemukan adanya korelasi antara sel mastdengan saraf enterik pada apendisitis akut. Tujuan penelitian ini adalah melihatkepadatan sel mast dan jaringan saraf, serta korelasi derajat kepadatan sel mastdengan derajat kepadatan jaringan saraf pada dinding apendisitis akut. Bahan dancara kerja: Penelitian observasional analitik potong lintang dilakukan pada 97sediaan histopatologi apendisitis akut yang dikelompokkan menjadi apendisitis akutfokal, supuratif, gangrenosa dan perforatif. Penilaian sel mast menggunakan pulasanToluidine blue dan penilaian jaringan saraf menggunakan pulasan IHK S100.Kemudian dilakukan penilaian korelasi derajat kepadatan sel mast dengan derajatkepadatan saraf enterik yang masing-masing dikelompokkan menjadi 4 derajat, padalapisan submukosa dan muskularis, menggunakan uji Sommers'd. Hasil: Kepadatansel mast/lpb lebih tinggi pada apendisitis akut fokal (3,9±1,3) dibandingkanapendisitis akut supuratif-gangrenosa. Sedangkan kepadatan jaringan saraf enterik/lpblebih tinggi pada apendisitis akut supuratif-gangrenosa (3,7±0,9). Terdapat korelasikuat antara derajat kepadatan sel mast dengan derajat kepadatan jaringan saraf enterikpada lapisan muskularis apendisitis akut (p<0,05; r=0,733). Sedangkan pada lapisansubmukosa terdapat korelasi lemah antara kedua variabel tersebut (p>0,05; r=0,118).Tidak terdapat perbedaan kepadatan sel mast dan kepadatan jaringan saraf yangbermakna pada kelompok apendisitis akut (p>0,05). Kesimpulan: Kepadatan selmast tertinggi terdapat pada apendisitis akut fokal, sedangkan kepadatan jaringansaraf tertinggi pada apendisitis akut supuratif-gangrenosa. Terdapat korelasi kuatantara derajat kepadatan sel mast dengan derajat kepadatan jaringan saraf enterikpada lapisan muskularis, sedangkan korelasi lemah terdapat pada lapisan submukosa apendisitis akut.

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Background: Histopathologic examination is the gold standard for diagnosis of acute

appendicitis, although no obvious histopathological signs of acute inflamation shown.

Therefore other unknown pathogenesis is suspected. Several studies prove there is

correlation between mast cells and enteric nerve system on acute appendicitis. The

aims of this study are to see the density of mast cell and enteric nerve and to evaluate

correlation between grade of mast cell density and enteric nerve density on

histopathologically acute appendicitis. Material and methods: A cross-sectional

retrospective study was conducted on 97 histopathologically acute appendicitis which

grouped as acute focal, acute suppurative, gangrenous (phlegmonous) and

perforative. All sections were subjected to toluidine blue stain for mast cell and S100

stain for enteric nerve. The density of mast cell and enteric nerve were designed into

4 grades. A correlation test between grade of mast cell density and grade of enteric

nerve density were studied in submucosa and muscularis using Somers?d correlation

test. Results: The highest densities of mast cell/hpf (3,9±1,3) and enteric nerve/hpf

(3,7±0,9) were found in acute focal appendicitis and suppurative-gangrenous

appendicitis respectively. There was strong correlation between grade of mast cell

density and enteric nerve density in muscularis (p<0,05; r=0,733), whereas the

submucosal layer had the weak one (p>0,05; r=0,118). There was no significant

difference for mast cell and enteric nerve density on each group (p>0,05).

Conclusion: The highest densities of mast cell and enteric nerve were found in acute

focal appendicitis and suppurative-gangrenous appendicitis respectively. There was

strong correlation between grade of mast cell density and grade of enteric nerve

density in muscularis layer of acute appendicitis, meanwhile the weak correlation was

on submucosa."

"This book is a comprehensive account of imaging of acute appendicitis and other appendiceal diseases. Background information is first provided on clinical presentation, perforation and negative appendectomy rates, and treatment options. The role of each imaging modality – radiography, ultrasound, CT, and MRI – is then considered separately in adults and children with suspected acute appendicitis. Many high-quality illustrations are included, and detailed information is provided on appropriate protocols and radiation saving. Further chapters addresses the spontaneously resolving and chronic appendicitis as well as other appendiceal lesions and review the findings of evidence-based medicine and cost-effectiveness analyses. Emergency physicians, pediatricians, surgeons, and radiologists will all find this book to be an excellent source of information and guidance."