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"Jengkol <'Pi thecolobium -i iringa (Jack) Prain. ex King.)merupakan salah satu tanaman yang digunakan sebagai obattradisional, tetapi sampai saat ini belum banyak penelitianilmiah terhadap tanaman jengkol. Salah satu efek tanamanjengkol yang banyak digunakan di masyarakat adalah untukpenyakit diabetes mellitus. Penelitian ini dilakukan untukmengetahui apakah ada efek hipoglikemik papagan kulitbatang pohon jengkol pada kelinci dengan metode testoleransi glukosa secara oral.Papagan kulit batang pohon jengkol diberi secara oraldengan menggunakan sonde lambung. Kelinci dibagi atas 4kelompok. Kelompok pertama diberi air dengan volumepemberian 1 ml/kg BB, kelompok kedua diberi suspensitolbutamid 250 mg/kg BB, kelompok ketiga diberi rebusanpapagan kulit batang pohon jengkol konsentrasi 10% b/vdengan dosis 1 ml/kg BB, kelompok keempat diberi ekstraketanol papagan kulit batang pohon jengkol konsentrasi' 200%b/v dengan dosis 1 ml/kg BB. Toleransi glukosa kelincipercobaan yang diberi papagan kulit batang pohon jengkoldibandingkan dengan toleransi glukosa kelinci percobaanyang diberi air sebagai kontrol.Hasil statistik memperlihatkan rebusan papagan kulitbatang pohon jengkol tidak memperlihatkan efek hipoglikemikAyang bermakna, kecuali pada jam ke 3 terhadap kelompokkontrol dan pada jam ke 4 terhadap kelompok ekstrak etanol.

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Jengkol t-.hftf>n1obium iiringa (Jack) Prain. ex King.)

has been used as a traditional medicine, but so, far it has

not been proved scientifically. It is used empirically for

the treatment of Diabetes mellitus. Therefore this

experiment has been carried out to know whether jengkol

stem barks has actually the antidiabetic effect.

In this experiment 24 rabbits were used, these animals

were induced by 1 ml/kg body weight using 50% glucose

solution. The first group was received 2 ml/kg body weight

water as a control group, the second group was given 250 mg

tolbutamid per kg body weight as a standard treatment

group, the third group received 1 ml jengkol stem barks

boiled solution 10% wieght/volume (w/v) per kg body weight

and the fourth group was given jengkol stem barks ethanol

extract 200% w/v in dose of 1 ml per kg body weight. Those

preparation were given orally using intragastric tube. The

blood glucose level were measured by glucose tolerance test

using double beam spectrophotometers at 1, l^/s, 2, 3, 4

dan 5 hours after treatments.

The datas were statistically analysed using anova and

followed by tukey test. Stem barks boiled solution did not

show hipoglikemic effect significantly differrence from

other treatments at those observation interval except at +3

A

hours was significantly different from control group and +5

hours from ethanol extract group."

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Vitamin D memiliki peran dalam implantasi plasenta dan meningkatkan sensitivitas insulin di sel target.  Pada plasenta, VDR ditemukan di vili trofoblas, desidua, otot polos sel pembuluh darah plasenta, dan nukleus sel stroma vili plasenta. Melalui peningkatan sensitivitas insulin, vitamin D dapat memengaruhi kadar glukosa di jaringan plasenta. Insulin akan menstimulasi GLUT4 pada plasenta untuk pengambilan glukosa ke dalam sel. Penelitian ini bertujuan untuk mengetahui hubungan kadar vitamin D dan kadar glukosa dalam jaringan plasenta. Penelitian ini merupakan studi awal dengan desain potong lintang dengan sampel berupa 10 jaringan plasenta kehamilan normal. Setiap sampel diukur kadar vitamin D dan kadar glukosanya lalu dilakukan uji korelasi. Kadar vitamin D diukur dengan metode ELISA sedangkan kadar glukosa diukur dengan metode spektofotometri. Uji korelasi dilakukan dengan uji Pearson menggunakan SPSS versi 20. Hasil uji korelasi kadar vitamin D dan kadar glukosa menunjukkan kecenderungan korelasi positif lemah menuju sedang dengan korelasi Pearson r=0,397. Namun, hasil uji memberikan p=0,128 sehingga secara statistika tidak bermakna. Hasil penelitian ini dapat digunakan sebagai acuan untuk penelitian selanjutnya dengan besar sampel minimal, yaitu 48 sampel. 

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Vitamin D has a role in placental implantation and increases insulin sensitivity in target cells. In the placenta, VDR is found in trophoblast villi, decidua, smooth muscle cells of the placental vessels, and nuclei of placental villous stromal cells. Through increased insulin sensitivity, vitamin D can affect glucose levels in placental tissue. Insulin stimulates GLUT4 on the placenta for glucose intake. This study aimed to determine the relationship of vitamin D levels and glucose levels in placental tissue. This study was a preliminary study with a cross-sectional design with a sample of 10 normal pregnancy placental tissues. Vitamin D levels were measured by the ELISA method while glucose levels were measured by spectrophotometric methods. Then performed a correlation test. Correlation test was carried out by Pearson test using SPSS version 20. The results of the correlation test of vitamin D levels and glucose levels showed a weak-to-moderate positive correlation with Pearson correlation r=0.397. However, the test results give p=0.128 that means statistically it’s not significant. The results of this study can be used as a reference for further research with a minimum sample size, which is 48 samples. 

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